Conference PaperPDF Available

DİKKAT EKSİKLİĞİ VE HİPERAKTİVİTE BOZUKLUĞUNDA AKDENİZ DİYETİ: BİLİMSEL KANITLAR VE YENİ PERSPEKTİFLER MEDITERRANEAN DIET IN ATTENTION DEFICIT HYPERACTIVITY DISORDER: SCIENTIFIC EVIDENCE AND NEW PERSPECTIVES

Authors:
Sümeyye Begüm Atalan at Kastamonu University
Sümeyye Begüm Atalan
Funda Işık at Kastamonu University
Funda Işık
Download full-text PDF
Read full-text
Download citation
Content uploaded by Sümeyye Begüm Atalan
Author content
All content in this area was uploaded by Sümeyye Begüm Atalan on Feb 13, 2025
Content may be subject to copyright.
7th International İzmir Congress on Medicine, Nursing,
Midwifery, and Health Sciences || Congress Proceedings Book
http://www.izmircongress.comhttp://www.bztturanpublishinghouse.com/
ISBN: 978-9952-8545-5-8
DOI: https://doi.org/10.30546/19023.978-9952-8545-5-8.2025.01.
676
DİKKAT EKSİKLİĞİ VE HİPERAKTİVİTE
BOZUKLUĞUNDA AKDENİZ DİYETİ: BİLİMSEL
KANITLAR VE YENİ PERSPEKTİFLER
Sümeyye Begüm Atalan1*, Funda Işık2



ÖZET



  

           
  
          
  
   
          
       

          
          

Anahtar kelimeler:        

MEDITERRANEAN DIET IN ATTENTION DEFICIT HYPERACTIVITY
DISORDER: SCIENTIFIC EVIDENCE AND NEW PERSPECTIVES
ABSTRACT
     


ISBN: 978-9952-8545-5-8
DOI: https://doi.org/10.30546/19023.978-9952-8545-5-8.2025.01.
7th International İzmir Congress on Medicine, Nursing, Midwifery,
and Health Sciences || Congress Proceedings Book
http://www.izmircongress.comhttp://www.bztturanpublishinghouse.com/
677
            








     


Keywords:       

GİRİŞ
          
          
          
 
 


  


Diyet Modelleri ve Dikkat Eksikliği/Hiperaktivite Bozukluğu





  
           
  

  
 


   
           

    
7th International İzmir Congress on Medicine, Nursing,
Midwifery, and Health Sciences || Congress Proceedings Book
http://www.izmircongress.comhttp://www.bztturanpublishinghouse.com/
ISBN: 978-9952-8545-5-8
DOI: https://doi.org/10.30546/19023.978-9952-8545-5-8.2025.01.
678
  
  



           
      
            




         
           
            




   

 



Akdeniz Diyeti ve Dikkat Eksikliği/Hiperaktivite Bozukluğu
          



   


     


       

           

       
   
         

ISBN: 978-9952-8545-5-8
DOI: https://doi.org/10.30546/19023.978-9952-8545-5-8.2025.01.
7th International İzmir Congress on Medicine, Nursing, Midwifery,
and Health Sciences || Congress Proceedings Book
http://www.izmircongress.comhttp://www.bztturanpublishinghouse.com/
679









            
           
         


Sonuç ve Öneriler
          


  

         

          

         
        

          


KAYNAKÇA

North Clin Istanb 9

    
Nutrition 28

Nutrition Reviews
83

Asia Pac J Clin
Nutr 27
7th International İzmir Congress on Medicine, Nursing,
Midwifery, and Health Sciences || Congress Proceedings Book
http://www.izmircongress.comhttp://www.bztturanpublishinghouse.com/
ISBN: 978-9952-8545-5-8
DOI: https://doi.org/10.30546/19023.978-9952-8545-5-8.2025.01.
680

Clin Nutr ESPEN
47


J Aect Disord 313
  
BMC Pediatr
22

Curr Nutr Rep 12


Nutr Neurosci 25

              Pediatrics
129

Molecules
26
           
Pediatrics 139

   
    
Nutrients 14

    
    
Nutr Neurosci 21


Clin Nutr ESPEN 36

Int J Mol Sci 25



Nutrients 16

Eur J
Clin Nutr 72
ResearchGate has not been able to resolve any citations for this publication.
Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder
Article
Full-text available
  • Sep 2024
Background/Objectives: Attention deficit hyperactivity disorder (ADHD) is the most common childhood-onset neurodevelopmental disorder, characterized by difficulty maintaining attention, impulsivity, and hyperactivity. While the cause of this disorder is still unclear, recent studies have stated that heredity is important in the development of ADHD. This is linked to a few comorbidities, including depression, criminal behavior, and anxiety. Although genetic factors influence ADHD symptoms, there are also non-genetic factors, one of which is oxidative stress (OS), which plays a role in the pathogenesis and symptoms of ADHD. This review aims to explore the role of OS in ADHD and its connection to antioxidant enzyme levels, as well as the gut–brain axis (GBA), focusing on diet and its influence on ADHD symptoms, particularly in adults with comorbid conditions. Methods: The literature search included the main available databases (e.g., Science Direct, PubMed, and Google Scholar). Articles in the English language were taken into consideration and our screening was conducted based on several words such as “ADHD”, “oxidative stress”, “diet”, “gut–brain axis”, and “gut microbiota.” The review focused on studies examining the link between oxidative stress and ADHD, the role of the gut–brain axis, and the potential impact of dietary interventions. Results: Oxidative stress plays a critical role in the development and manifestation of ADHD symptoms. Studies have shown that individuals with ADHD exhibit reduced levels of key antioxidant enzymes, including glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), as well as a diminished total antioxidant status (TOS) compared to healthy controls. Additionally, there is evidence of a close bidirectional interaction between the nervous system and gut microbiota, mediated by the gut–brain axis. This relationship suggests that dietary interventions targeting gut health may influence ADHD symptoms and related comorbidities. Conclusions: Oxidative stress and the gut–brain axis are key factors in the pathogenesis of ADHD, particularly in adults with comorbid conditions. A better understanding of these mechanisms could lead to more targeted treatments, including dietary interventions, to mitigate ADHD symptoms. Further research is required to explore the therapeutic potential of modulating oxidative stress and gut microbiota in the management of ADHD.
View
Attention Deficit Hyperactivity Disorder (ADHD) and Polyphenols: A Systematic Review
Article
Full-text available
Polyphenols are natural compounds also contained in daily consumed foods that show their efficacy in different clinical fields. Both pre-clinical and clinical studies demonstrated that polyphenols may manage neuroinflammation and oxidative stress processes tightly connected to neurodegenerative diseases and mental disorders. Thus, a neuroinflammatory state may influence the neurotransmitters pathways, such as the noradrenergic, glutamatergic, serotoninergic, and, in particular, dopaminergic ones, whose impairment is strongly associated with attention deficit hyperactivity disorder (ADHD). Therefore, the aim of the present systematic review is to provide an overview of the clinical outcomes’ changes following ADHD treatment with polyphenols alone and in combination with the traditional drugs. This review was conducted according to PRISMA guidelines and recorded on PROSPERO with the number CRD42023438491; PubMed, Scopus, and Web of Science were used as search-engines to lead our research until June 2023. The inclusion criteria were articles written in English, including clinical, placebo-controlled, and case-control trials. We excluded reviews, metanalyses, background articles, and papers published in other languages. To avoid any bias, Rayyan software (COPYRIGHT © 2022 RAYYAN) was used to organize the work and manage the literature review. After screening, 10 studies were included, with a total of 556 patients that met the established inclusion criteria. The data obtained from these studies showed that polyphenols rebalanced oxidative stress pathways through different mechanisms, are effective for the treatment of ADHD both alone and in combination with traditional drugs, and are able to reduce symptoms as well as the side effects related to the use of conventional therapies. Finally, a positive effect of using polyphenols for ADHD prevention could be hypothesized.
View
Nutrition in the Management of ADHD: A Review of Recent Research
Article
Full-text available
  • Jul 2023
Purpose of Review Various nutrients and diet quality have been suggested to be involved in the pathophysiology of ADHD. The purpose of this review was to examine data from recent cohort studies and dietary interventions to determine whether nutrition may play a role in the management of ADHD. Recent Findings Preliminary evidence suggests that minerals might have beneficial effects on ADHD symptomatology. Probiotics might offer novel strategies to prevent or treat ADHD. Inverse associations between adherence to “healthy” diets and ADHD symptoms have been observed. Children with ADHD responding to the few-foods diet (or oligoantigenic diet) with an elimination of individually identified food items show substantially improved behavior and cognitive functioning. Summary Evidence from recent research does not allow any recommendations regarding the use of micronutrients or probiotics in the management of ADHD. The few-foods diet may become an additional therapeutic option for children with ADHD.
View
The association between dietary polyphenol intake and attention-deficit hyperactivity disorder: a case-control study
Article
Full-text available
  • Dec 2022
  • BMC Pediatr
Background Previous research found that diets high in fruits and vegetables improved symptoms of attention deficit hyperactivity disorder (ADHD). Nevertheless, the relationship between dietary polyphenol intake and the risk of ADHD was not assessed. Objective The purpose of this study was to see if there was a relationship between dietary polyphenol intake and the risk of ADHD in children in preschool and elementary school. Methods A total of 400 children aged 4 to 12 years old participated in this case-control research (200 children with diagnosed ADHD and 200 healthy controls). The presence of ADHD was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders-V criteria. To calculate dietary polyphenol intake, a 168-item food frequency questionnaire and the Phenol-Explorer database were used. Results A significant negative association was observed between one unit increase in dietary polyphenol intake and risk of ADHD (OR: 0.995, 95% CI = 0.994 to 0.996, P < 0.001) in the crude model. This finding was still significant even after adjusting for body mass index, energy intake, socioeconomic status, gender, and age (OR: 0.992, 95% CI = 0.989 to 0.995, P < 0.001). Conclusion We found that the increased dietary intake of polyphenols is associated with a lower risk of ADHD in preschool and school children. Prospective studies are needed to corroborate these observations.
View
Do Children with Attention-Deficit/Hyperactivity Disorder Follow a Different Dietary Pattern than That of Their Control Peers?
Article
Full-text available
  • Mar 2022
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children and adolescents. A current area of interest is the association between ADHD and food consumption. The aim of this study was to determine the food consumption and dietary patterns of children with and without ADHD in relation to their age and ADHD presentation. The study involved 259 preschoolers aged 3 to 6 years old (57 with ADHD and 202 controls) and 475 elementary-school-age children, aged 10 to 12 years old (213 with ADHD and 262 controls) from Spain. ADHD was diagnosed in accordance with the Diagnostic and Statistical Manual of Mental Disorders (5th edition) from Schedule for Affective Disorders and Schizophrenia for School-Age Children interviews. Eating data were collected using a food consumption frequency questionnaire, and principal component analysis was carried out to analyze dietary patterns. Western-like, sweet, and healthy patterns were identified. The ADHD group was negatively associated with the healthy pattern (p < 0.001) and positively associated with the Western-like diet (p = 0.004). Children with inattentive presentation showed lower adherence (12.2%) to a healthy pattern than that of the control group (39.9%) (p < 0.001). There is an association between ADHD and dietary habits; children with inattentive presentation may particularly be at risk of unhealthy eating habits.
View
Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms
Article
Full-text available
Nutrition transition can be defined as shifts in food habits, and it is characterized by high-fat (chiefly saturated animal fat), hypercaloric and salty food consumption at the expense of dietary fibers, minerals and vitamins. Western dietary patterns serve as a model for studying the impact of nutrition transition on civilization diseases, such as obesity, which is commonly associated with oxidative stress and inflammation. In fact, reactive oxygen species (ROS) overproduction can be associated with nuclear factor-κB (NF-κB)-mediated inflammation in obesity. NF-κB regulates gene expression of several oxidant-responsive adipokines including tumor necrosis factor-α (TNF-α). Moreover, AMP-activated protein kinase (AMPK), which plays a pivotal role in energy homeostasis and in modulation of metabolic inflammation, can be downregulated by IκB kinase (IKK)-dependent TNF-α activation. On the other hand, adherence to a Mediterranean-style diet is highly encouraged because of its healthy dietary pattern, which includes antioxidant nutraceuticals such as polyphenols. Indeed, hydroxycinnamic derivatives, quercetin, resveratrol, oleuropein and hydroxytyrosol, which are well known for their antioxidant and anti-inflammatory activities, exert anti-obesity proprieties. In this review, we highlight the impact of the most common polyphenols from Mediterranean foods on molecular mechanisms that mediate obesity-related oxidative stress and inflammation. Hence, we discuss the effects of these polyphenols on a number of signaling pathways. We note that Mediterranean diet (MedDiet) dietary polyphenols can de-regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and NF-κB-mediated oxidative stress, and metabolic inflammation. MedDiet polyphenols are also effective in upregulating downstream effectors of several proteins, chiefly AMPK.
View
Dietary patterns are associated with attention-deficit hyperactivity disorder (ADHD) symptoms among preschoolers in South Korea: a prospective cohort study
Article
Full-text available
  • Sep 2020
  • NUTR NEUROSCI
Objectives: Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurobehavioral disorder in children. There are limited studies for diet or dietary supplement effects on ADHD in preschool children in Asia. This study aimed to determine the association between dietary patterns in 4-year-old children and ADHD symptoms in 6-year-old children. Methods: We estimated dietary intake in 4-year-old children using a food frequency questionnaire. Using 33 food groups, major dietary patterns were identified in relation to the consumption of sweets, vegetables, meats, and carbohydrates. Parents of 6-year-old children used the Korean version of the ADHD Rating Scale for ADHD symptom assessment. Results: A sweet dietary pattern was associated with a higher risk of attention deficit (AD) (relative risk [RR], 1.34; confidence interval [CI], 1.17-1.55), hyperactivity (RR, 1.40; CI, 1.19-1.64), and ADHD symptoms (RR, 1.37; CI, 1.23-1.52). A vegetable dietary pattern was associated with a lower risk of ADHD symptoms (RR, 0.81; CI, 0.72-0.90). Food item analysis of the sweet dietary pattern showed that intake scores for chocolate, chips, and fruit jams positively correlated with AD, hyperactivity, and ADHD symptoms. Discussion: These findings can be useful to further understand the roles of dietary factors in ADHD.
View
A plant-based dietary score and attention deficit/hyperactivity disorder in Iranian children: A case-control study
Article
  • Jun 2022
  • J AFFECT DISORDERS
Objective Attention-deficit hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder with a prevalence of 5 % among children and adolescents worldwide. Plant foods have a protective effect against inflammation and oxidative stress which both are involved in psychiatric disorders pathophysiology including ADHD. Accordingly, we investigated the association between plant-based diet (PDI) and ADHD. Methods This case-control study was conducted on 345children and adolescents 7–13 years old in Yazd, Iran. Subjects were categorized into the case (n = 113) and control groups (n = 232) based on matching age and sex. To diagnose ADHD, the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSMIV-TR) was used. Food frequency questionnaire was used to measure food intake. The association of PDI with ADHD was examined by logistic regression. Results Children in the highest quartile of PDI compared to the lowest quartile had a higher energy and macronutrient intake, calcium, zinc, iron, vitamin B12, B6, and folic acid. After adjusting for potential confounders, a significant decreasing trend in the odds of ADHD across increasing quartiles of the PDI (P-trend = 0.001) was observed. In addition, children in the fourth quartile of PDI had 68 % lower odds of ADHD than the first quartile. This association remained significant after further adjustment for BMI (OR: 0.32;95 % CI: 0.13–0.79; P for trend: 0.001). Conclusion We found that PDI is associated with lower risk of ADHD in children. Cohort and clinical studies are necessary to approve our results.
View
Adherence to Mediterranean diet and Attention-deficit/hyperactivity disorder in children: a case control study
Article
  • Nov 2021
Objective Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders. The Mediterranean diet as a plant-based diet has a beneficial effect on mental health. The present study was designed to investigate the association between adherence to Mediterranean diet and odds of ADHD in Iranian children. Methods This age and gender matched case-control study was conducted on 360 children 7–13 years old in Yazd, Iran. Children were categorized into new diagnosed case (n = 120) and control groups (n = 240). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSMIV-TR) was used to diagnose ADHD. A validated food frequency questionnaire was used to measure food intake. The association of adherence to the Mediterranean with the odds ratio of ADHD examined by logistic regression. Results After adjusting for potential confounders including energy intake, parents’ educational level, economic status, family history ADHD and physical activity, the children in the highest tertile of adherence to Mediterranean diet had a lower odd of ADHD (odds ratio [OR]: 0.49; 95% Confidence Interval [CI]: 0.27-0.89) compared to the children in the lowest. In addition, an association was observed between increasing trend adherence to Mediterranean diet and decrease odds of ADHD after full adjustments (P for trend < 0.001). Conclusion We found that higher adherence to Mediterranean diet containing vegetables, legumes, fruits and nuts, grains, and fish could decrease the odds of ADHD in primary school children. Further studies are suggested to approve our vision.
View
Empirically derived dietary patterns and food groups intake in relation with Attention Deficit/Hyperactivity Disorder (ADHD): A systematic review and meta-analysis
Article
  • Feb 2020
Background and aims Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent chronic psychiatric condition in children world wide. This study was aimed to provide an overview of food groups and dietary patterns in ADHD children as a systematic review. Methods The relation between dietary patterns and this disorder was also investigated through meta-analysis. Databases including Google Scholar, SCOPUS, ISI Web of science, and PubMed were searched up to June 2017. Studies on posteriori derived dietary patterns and food intakes of ADHD children were included. The achieved Relative Risks (RR) and Odds Ratio (OR) were pooled together for ADHD to compare the most and the least adherence to major dietary patterns. The heterogeneity was assessed by Cochran's Q test and I-squared methods. Results This systematic review consisted of 6 dietary patterns and 6 foods or macronutrients studies. In this regard, 6 dietary patterns studies (n: 8816) were included in the meta-analysis. The pooled analysis established that “healthy” dietary pattern significantly decreased the risk of ADHD (OR: 0·63; 95% CI: 0·41, 0·96), whereas “Western” (OR: 1.92; 95% CI: 1.13, 3.26; p:0.016) and “junk food” (OR: 1.51; 95% CI: 1.06, 2.16; p: 0.024) dietary patterns increased it. Conclusions “Healthy” dietary pattern highly loaded with vegetables, fruits, legumes, and fish has decreased the odds of ADHD up to 37%. In addition, adherence to “junk food” pattern containing sweetened beverages and desserts as well as “Western” dietary pattern including red meat, refined grains, processed meats, and hydrogenated fat increased it.
View