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Cosmetic, Nutrition, and Drug Value of Carica papaya: A Review
Abstract
Papaya is an evergreen plant which offers different food, nutrition and therapeutic values for human beings. The fruit is delicious and nutritious. The different parts of the plant such as leaves, seeds, peel, blooms, bark, root, and squash have beneficial activities. It is used for the cure of a variety diseases including digestive disorders, constipation, expulsion of worms, antibacterial, corns, sinuses, skin inflammation, antifertility, dengue fever, warts, glandular tumors, blood pressure, diabetic, anti-HIV, invigorate regenerative organs. It is also used as nutraceutical agent. The present work emphasis on major characteristics of chemical constituents, nutritional components, health and medical benefits of papaya.
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Hypertension is one of the major cardiovascular diseases leading to serious health consequences including cardiovascular events such as stroke and even death. These may also include significant damages to the body’s most organs like heart, kidneys and brain. This deadly disease requires proper treatment drugs with lower cost and fewer adverse effects. In this study, Ficus religiosa fruit has been selected as a candidate plant and its fruit extract was used to perform different pharmacological tests in hypertensive rat model. It was observed that the extract decreased the heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) moderately in comparison to deoxycorticosterone acetate (DOCA) in ethanol‑induced hypertensive rats. These effects were similar to that of atenolol, a standard antihypertensive drug. While testing liver function, it was seen that SGOT and SGPT levels were reduced significantly. The creatinine value was decreased to 0.43±0.2 U/L from 2.9±1.3 U/L (induced by DOCA) and 2.6±1.6 U/L (induced by ethanol). While observing cardiovascular parameters, the fruit extract given at dose of 400 mg/kg, lowered total Cholesterol (TC) to 97 mg/dl from 176 mg/dl, low-density lipoprotein (LDL) to 40 mg/dl from 75 mg/dl and Triglycerides (TG) to 61 mg/dl from 118 mg/dl. The increased values were induced by DOCA. In the same test, the high-density lipoprotein (HDL) was increased to 80 mg/dl from 44 mg/dl. These changes were comparable to those of the standard drug Atenolol. F. religiosa fruit contains different chemical constituents such as isofucosterol, leucopelargonidin, quercetin and beta sitosterol as reported earlier. Molecular docking studies with some of these constituents showed good binding affinity with the targeted protein (receptor) as compared to the standard drugs. Additionally, all the compounds have satisfied Lipinski’s rules and other pharmacokinetic parameters. Moreover, they showed no adverse effects in aquatic and non-aquatic environments. We, thus, conclude that F. religiosa fruit extract could be taken for the discovery of a safe alternative for managing hypertension. Dhaka Univ. J. Pharm. Sci. 23(1): 23-36, 2024 (June)
Background:
Diabetes mellitus is one of the most notable health dilemmas. Analyzing plants for new antidiabetic remedies has become an impressive territory for life science researchers. Gynura procumbens has long been used to treat diabetes. Thus, we strived to ascertain the hypoglycemic potentiality of extract of leaves of G. procumbens by in vivo and in silico approaches.
Methods:
Fresh leaves of G. procumbens were collected and shade-dried to prepare ethanolic extracts to evaluate pharmacological parameters. Diabetes was induced in rats via injecting alloxan through the intraperitoneal route at a dose of 150 mg/kg body weight. Humalyzer 3000 was used to perform a biochemical assay of collected samples from rats. Anti-hyperglycemic activity study along with overdose toxicity test was performed. The pharmacological activity of this plant was also evaluated through a molecular docking study. This in silico study investigated the binding affinity of natural ligands from G. procumbens against glycoside hydrolase enzymes.
Results:
We detected a peak plasma concentration of G. procumbens at 3 hours 45 minutes that is roughly similar to the peak plasma concentration of metformin. Again, in OGTT and anti-hyperglycemic tests, it has been ascertained that both plant extract and metformin can exert significant (P < 0.05) and highly significant (P < 0.01) hypoglycemic activity in a dose-dependent manner. Metformin exhibited better therapeutic efficacy than that of plant extract, but it possessed null statistical significance. Also, our safety profile expressed that, similar to metformin, the plant extract can restore the disturbed pathological state in a dose-oriented approach with a wide safety margin. In silico study also validated the potentialities of natural constituents of G. procumbens. Conclusion. This study suggested that G. procumbens can be considered as potential antidiabetic plant. Robust and meticulous investigation regarding plant chemistry and pharmacology in the future may bring about a new dimension that will aid in discovering antidiabetic drugs from this plant in the diabetes management system.
Objective: Carica papaya Linn. belonging to the family of Caricaceae is a well-known fruit and medicinal plant that has been widely used for a long time to cure various types of infectious disease especially in South Asian countries. The current study was aimed to evaluate the antibacterial properties of crude latex of C. papaya. Methods: The screening of antibacterial activity of latex was evaluated against one Gram-positive bacterium Bacillus subtilis and three Gram-negative pathogenic bacterial strains as Escherichia coli, Agrobacterium sp and Rhizobium sp. Ciprofloxacin was used as a control for investigating the bacterial species. Antibacterial activity was expressed in terms of the radius of zone inhibition. Latex of this plant was tested in seven doses (1, 2, 5, 7, 10, 15 and 20 mg/disk) and it was found that the antibacterial activity was dose dependent and a significant difference was also observed in case of different bacterial stains. Results: The results demonstrated noticeable inhibition of the bacterial growth against the tested organisms. In case of Agrobacterium sp. 20 mg of latex showed the average of 20.66 mm zone of inhibition and for E. coli this value was 16 mm for the same concentration of latex. The rest of the two bacterial species showed comparative resistance to papaya latex. Conclusion: It is concluded that the latex of C. papaya probably contains some valuable antibacterial compounds that are crucial forinhibiting the growth of a wide variety of bacteria, especially Gram-negative bacteria and suggesting this for applying the treatment of a variety of bacterial infections. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.
Four quinolone–terpene alkaloids, chelerybulgarine (1), 2 0-episimulanoquinoline (3), 2,11-didemethoxy-vepridimerine B (4), and rhetsidimerine (5) were isolated from the root bark of Zanthoxylum rhetsa DC. Chelerybulgarine (1) is a C–C linked terpene alkaloid where the C-6 of dihydrochelerythrine is linked to C-11 of the sesquiterpenoid 10b-methoxybulgarene. 2 0-Episimulanoquinoline is a dimeric alkaloid containing dihydrochelerythrine and 8-methoxy-N-methylflindersine moieties, whereas 2,11-didemethoxyvepridimerine B and rhetsidimerine are dimeric prenylated quinolone alkaloids. Seven of the isolated compounds exhibited weak cytotoxicity when tested against a panel of six human stomach-cancer cell lines.
Dengue is a viral disease that today affects a vast number of people in over 125 countries and is responsible for a sizable number of deaths. In the absence of an effective antiviral drug to treat the disease, various treatments are being investigated. Studies have indicated that the juice of the leaves of the Carica papaya plant from the family Caricaceae could help to increase the platelet levels in these patients. This review describes some of the published studies on this topic. The search was done independently by the two authors using PubMed, Google and the library database and included relevant articles of the last 10 years. A total of 7 studies were included in this review, which were one animal study, one case report, three case series and two randomized controlled trials. Although many of the studies and case reports published in literature lack adequate information, some of the studies do raise the possibility that this treatment could be an important option in the future. Further large-scale studies could establish the usefulness or ineffectiveness of this natural product in the treatment of dengue.
Dengue virus belongs to the virus family Flaviviridae. Dengue hemorrhagic disease caused by dengue virus is a public health problem worldwide. The viral non structural 2B and 3 (NS2B-NS3) protease complex is crucial for virus replication and hence, it is considered to be a good anti-viral target. Leaf extracts from Carica papaya is generally prescribed for patients with dengue fever, but there are no scientific evidences for its anti-dengue activity; hence we intended to investigate the anti-viral activity of compounds present in the leaves of Carica papaya against dengue 2 virus (DENV-2). We analysed the anti-dengue activities of the extracts from Carica papaya by using bioinformatics tools. Interestingly, we find the flavonoid quercetin with highest binding energy against NS2B-NS3 protease which is evident by the formation of six hydrogen bonds with the amino acid residues at the binding site of the receptor. Our results suggest that the flavonoids from Carica papaya have significant anti-dengue activities.
ADME - Absorption, distribution, metabolism and excretion, BBB - Blood brain barrier, CYP - Cytochrome P450, DENV - - Dengue virus, DHF - Dengue hemorrhagic fever, DSS - Dengue shock syndrome, GCMS - - Gas chromatography- Mass spectrometry, MOLCAD - Molecular Computer Aided Design, NS - Non structural, PDB - Protein data bank, PMF - Potential Mean Force.
To investigate the potential role of fresh Carica papaya (C. papaya) leaf extract on haematological and biochemical parameters and toxicological changes in a murine model.
In total 36 mice were used for the trial. Fresh C. papaya leaf extract [0.2 mL (2 g)/mouse] was given only to the test group (18 mice). General behavior, clinical signs and feeding patterns were recorded. Blood and tissue samples were collected at intervals. Haematological parameters including platelet, red blood cell (RBC), white blood cell (WBC), packed cell volume (PCV), serum biochemistry including serum creatinine, serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) were determined. Organs for possible histopathological changes were examined.
Neither group exhibited alteration of behavior or reduction in food and water intake. Similarly, no significant changes in SGOT, SGPT and serum creatinine levels were detected in the test group. Histopathological organ changes were not observed in either group of mice except in three liver samples of the test group which had a mild focal necrosis. The platelet count (11.33±0.35)×10(5)/µL (P=0.000 04) and the RBC count (7.97±0.61)×10(6)/µL (P=0.000 03) were significantly increased in the test group compared to that of the controls. However, WBC count and PCV (%) values were not changed significantly in the test group. The platelet count in the test group started to increase significantly from Day 3 (3.4±0.18×10(5)/µL), reaching almost a fourfold higher at Day 21 (11.3×10(5)/µL), while it was 3.8×10(5)/µL and 5.5×10(5)/µL at Day 3 and Day 21 respectively in the control. Likewise, the RBC count in the test group increased from 6×10(6)/µL to 9×10(6)/ µL at Day 21 while it remained near constant in the control group (6×10(6)/µL).
Fresh C. papaya leaf extract significantly increased the platelet and RBC counts in the test group as compared to controls. Therefore, it is very important to identify those chemicals of C. papaya leaves as it can be recommended to be used as a medication to boost thrombopoiesis and erythropoiesis in humans and in animals in which these cell lineages have been compromised.
Objective
To investigate the antimicrobial activity and phytochemical screening Ethanol, methanol, Ethyl acetate, acetone, chloroform, Petroleum ether, hexane, hot water, and extracts of Carica papaya.Methods
The aim of the present study was to evaluate the qualitative analysis of phytochemicals and antimicrobial activity of various solvent extracts of Carica papaya. The antimicrobial activities of different solvent extracts of Carica papaya were tested against the Gram-positive and Gram-negative bacterial strains and fungus by observing the zone of inhibition. The Gram-positive bacteria used in the test were Staphylococcus aureus, Bacillus cereus and Micrococcus luteus, and the Gram-negative bacteria were Escherichia coli, and Klebsiella pneumoniae, fungus like Aspergillus niger, Aspergillus flavus, Candida albicans, Candida tropicalis, Cryptococcus neoformans, and Candida kefyr.ResultsIt was observed that ethanol, methanol, ethyl acetate, aceton, chloroform, petroleum ether, hexane and aquas extracts showed activity against bacteria and fungus. The chloroform extract of Carica papaya showed more activity against Micrococcus luteus, zone of diameter 15.17±0.29mm and acetone extract of Carica papaya showed more activity against Candida albicans, zone of diameter 11.23±0.25mm compared to other solvent extracts.Conclusions
In this study chloroform extract in bacteria and acetone extract in fungus showed a varying degree of inhibition to the growth of tested organism, than Ethanol, methanol, Ethyl acetate, Petroleum ether, hexane and hot water extracts. The results confirmed the presence of antibacterial and antifungal activity of Carica papaya extract against various human pathogenic bacteria. Presences of phytochemical and antimicrobial activity are confirmed.
Understanding the interactions between pathogen, crop and vector are necessary for the development of disease control practices of vector-borne pathogens. For instance, resistant plant genotypes can help constrain disease symptoms due to infections and limit pathogen spread by vectors. On the other hand, genotypes susceptible to infection may increase pathogen spread owing to their greater pathogen quantity, regardless of their symptom status. In this study, we evaluated under greenhouse conditions the relative levels of resistance (i.e. relatively lower pathogen quantity) versus tolerance (i.e. less symptom severity) of 10 commercial grapevine (Vitis vinifera) cultivars to Pierce's disease etiological agent, the bacterium Xylella fastidiosa. Overall, no correlation was detected between pathogen quantity and disease severity, indicating the existence of among-cultivar variation in plant response to infection. Thompson Seedless and Barbera were the two most susceptible among 10 evaluated cultivars. Rubired showed the least severe disease symptoms and was categorized as one of the most resistant genotypes in this study. However, within each cultivar the degree of resistance/tolerance was not consistent across sampling dates. These cultivar and temporal differences in susceptibility to infection may have important consequences for disease epidemiology and the effectiveness of management protocols.
In the absence of an effective treatment in modern medicine, efforts are being made to find suitable herbal remedies for hepatitis. This prospective experimental study was conducted in the department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka from July 2006 to June 2007 to evaluate the hepatoprotective effects of Carica papaya against carbon tetrachloride (CCl 4) induced hepatotoxicity and compared it with that of vitamin-E. Total 36 adult rats were used and they were divided into six equal groups namely A, B, C, D, E and F. All the rats were fed with normal diet and 2ml distilled water orally for 7 days. In addition, Group D received Carica papaya extract, Group E received olive oil and Group F received vitamin E orally per day for 7 days. On the seventh day CCl 4 was administered to all the rats except Group A and was sacrificed on 8th day of experiment. Serum bilirubin, alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase and hepatic histopathology were done thereafter. Carica papaya and vitamin E showed significant hepatoprotection against CCL 4 induced hepatotoxicity but Carica papaya showed more significant changes in ALP level than vitamin E. Prevention of hepatic necrosis and fatty degeneration were also observed in Carica papaya and vitamin E pretreated rats but there is no significant difference.
Bioactive compounds from vegetal sources are a potential source of natural antifungic. An ethanol extraction was used to obtain bioactive compounds from Carica papaya L. cv. Maradol leaves and seeds of discarded ripe and unripe fruit. Both, extraction time and the papaya tissue flour:organic solvent ratio significantly affected yield, with the longest time and highest flour:solvent ratio producing the highest yield. The effect of time on extraction efficiency was confirmed by qualitative identification of the compounds present in the lowest and highest yield extracts. Analysis of the leaf extract with phytochemical tests showed the presence of alkaloids, flavonoids and terpenes. Antifungal effectiveness was determined by challenging the extracts (LE, SRE, SUE) from the best extraction treatment against three phytopathogenic fungi: Rhizopus stolonifer, Fusarium spp. and Colletotrichum gloeosporioides. The leaf extract exhibited the broadest action spectrum. The MIC(50) for the leaf extract was 0.625 mg ml(-1) for Fusarium spp. and >10 mg ml(-1) for C. gloeosporioides, both equal to approximately 20% mycelial growth inhibition. Ethanolic extracts from Carica papaya L. cv. Maradol leaves are a potential source of secondary metabolites with antifungal properties.
This study was aimed at qualitative evaluation of the ethanol seed, leaf and pulp extracts of C. papaya for bioactive compounds and also to investigate their effect on the haematology in male albino rats. A 3 x 4 factorial experimental layout using randomized complete design was adopted. Results show that the phytochemicals found in seed, leaf and pulp were almost the same but however, in varying proportions. Present result also revealed that there were significant effects (p < 0.05) of the extracts on the heamatology of the treated rats, which was blamed on the varying and different variants ofbioactive compounds found in the extracts they were administered with. Suggestively, C. papaya extracts could be used to enhance the production of selected blood parameters, taking issue of dosage into consideration.
Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. The antihyperglycemic activity of leaves of Mangifera indica was evaluated with scientific approaches. The study was undertaken to investigate the antihyperglycemic, Oral Glucose Tolerance Test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Mangifera indica . The different extracts were administered intraperitoneally as a single dose of 150 mg kg<SUP>-1</SUP> b.wt. to normal, glucose induced and alloxan induced diabetic rats and found to reduce blood glucose level significantly (p<0.05). Beside these, the different fractions of Mangifera indica to the alloxan-induced diabetic rats resulted in the significant elevation of liver glycogen content which was decreased by 50.60% in diabetic control. The effects of plant extracts were compared with standard drug metformin. The phytochemical screening tests indicate the different constituents such as triterpines, alkaloids, flavonoids etc. are present in the plant which have the antidiabetic property. Thus, this investigation paves the way for plant based diabetic treatment and indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract of Mangifera indica have favorable effect in bringing down the severity of diabetes as well as increase glycogenesis activity by increasing the cellular uptake of glucose.
Objective: This study examined the antioxidant and anticancer potential activities of the hexane fraction from the male flower of Carica papaya L., which is long been known to be a very important source of nutraceutical and pharmaceutical.Methods: Standard fractioned (fraction) method with phytochemical screening. The antioxidant activity was carried out using the α,α-diphenyl-β- picrylhydrazyl method and the anticancer potential activity was carried out using 3-(4,5-dimethythiazol-. 2-yl)-2,5-diphenyl tetrazolium bromide assay to check the cytotoxic activity on WiDr (colon cancer cell) and Vero cell (normal cell).Result: Phytochemical screening of the hexane fraction from the male flower of papaya shows a strong sign of triterpenoids and steroids; while the IC50 of antioxidant value was 100.81±1.180 μg/ml. Cytotoxic effect shows that the hexane fraction of papaya male flower had selectivity to WiDr cell (colon cancer cell).Conclusion: This study provides evidence that C. papaya L. male flower possesses antioxidant activity, as well as cytotoxic and chemopreventive properties. It might be beneficial as medicinal plant as an antioxidant and anticancer nutraceutical and pharmaceutical sources.
Using controlled in vivo and in vitro pharmacological methods, we evaluated the safety of papaya (Carica papaya) consumption in pregnancy with reference to its common avoidance during pregnancy in some parts of Asia. Ripe papaya (Carica papaya L. (Caricaecae) blend (500 ml/l water) was freely given to four groups of Sprague-Dawley rats at different stages of gestation (days 1-5, 6-11, 12-17 and 1-20). The control group received water. The effect of ripe papaya juice and crude papaya latex on pregnant and non-pregnant rats' uteri was also evaluated using standard isolated-organ-bath methods. The daily volumes (ml) of ripe papaya blend consumed by the treated group were significantly (P<0.05) more than water consumed by the control (control 40.3 (sd 11.6) v. treated 64 (sd 19.0)). There was no significant difference in the number of implantation sites and viable fetuses in the rats given ripe papaya relative to the control. No sign of fetal or maternal toxicity was observed in all the groups. In the in vitro study, ripe papaya juice (0.1-0.8 ml) did not show any significant contractile effect on uterine smooth muscles isolated from pregnant and non-pregnant rats; conversely, crude papaya latex (0.1-3.2 mg/ml) induced spasmodic contraction of the uterine muscles similar to oxytocin (1-64 mU/ml) and prostaglandin F(2 alpha) (0.028-1.81 microm). The response of the isolated rat uterine smooth muscles to 0.2 mg crude papaya latex/ml was comparable to 0.23 microm prostaglandin F(2 alpha) and 32 mU oxytocin/ml. In the 18-19 d pregnant rat uterus, the contractile effect of crude papaya latex was characterized by tetanic spasms. The results of the present study suggest that normal consumption of ripe papaya during pregnancy may not pose any significant danger. However, the unripe or semi-ripe papaya (which contains high concentration of the latex that produces marked uterine contractions) could be unsafe in pregnancy. Though evaluation of potentially toxic agents often relies on animal experimental results to predict risk in man, further studies will be necessary to ascertain the ultimate risk of unripe papaya-semi-ripe papaya consumption during pregnancy in man.
The purpose of the study was to investigate antibacterial activity of ripe and unripe Carica papaya on selected micro-organisms. Cultures of micro-organisms were routinely maintained in nutrient agar slants at 4 degrees C. Extracts of immature, mature and ripe Carica papaya fruit were obtained by separately grinding factions of the epicarp, endocarp and seeds and filtering them through gauze. Sensitivity tests were conducted by adding 0.06 ml of extract to agar wells (6 mm diameter) prepared from 20 ml agar seeded with 10(6) cells/ml suspension of one of the eight organisms per plate. The inoculated plates were allowed to equilibrate at 4 degrees C for 1 hour, incubated at 37 degrees C for 24 hours, and zones of inhibition measured in millimetres. Anti-bacterial activity was expressed in terms of the radius of zone of inhibition. Seed extracts from the fruit showed inhibition in the following order: B cereus > E coli > S faecalis > S aureus > P vulgaris > S flexneri. No significant difference was found in bacterial sensitivity between immature, mature and ripe fruits. No inhibition zone was produced by epicarp and endocarp extracts. Carica papaya seeds contain anti-bacterial activity that inhibits growth of gram-positive and gram-negative organisms. Observed activity was independent of stage of fruit maturity. Carica papaya has antibacterial effects that could be useful in treating chronic skin ulcers to promote healing.
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