Poster

Biofilm and pqs System Inhibition Properties of Norlichexanthone against Pseudomonas aeruginosa

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Abstract

Pseudomonas aeruginosa, opportunistic and drug resistant pathogen, is associated with high morbidity and mortality rates. Quorum Sensing (QS) system is a bacterial communication system to sense their population density in their surrounding milieu via signal molecules. Several virulence factors and related bacterial behaviors including biofilm formation are regulated by QS. P. aeruginosa utilizes four hierarchically related QS pathways such as pqs signaling system; has great importance in the pathogenesis of infections via controlling virulence factors such as pyocyanin, elastase etc. Moreover, P. aeruginosa forms biofilm by secreting extracellular matrix for surface attaching. It has been reported that biofilm forms are more resistant up to 1000-3000 times to antibiotics compared to their planktonic forms. Most researchers have focused on QS inhibition as an alternative strategy to overcome drug resistance. Natural and synthetic QS inhibitors have been reported up to date.

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