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Evidências científicas para uma boa noite de sono: o potencial da Cannabis e do lúpulo para o tratamento da insônia

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        o
potencial da Cannabis e do lúpulo para o tratamento da
insônia
       
     
     
      
     
       
     

       
Artigo de Capa
Revista A Flora - ISSN 2764-7501 Número 12 - Agosto/2024
6

         
      
ou manter o sono por pelo menos três noites por

       
      
 
       
         

      
 
      
     
      
     
      
       

       
     
     

     
     
      

¹ ² e ¹,²
¹Lato Sensu 
²


1
2
3
4
5
Estágio 1 - SONO NREM
Período de transição entre a vigília e o sono,
ou seja, adormecimento.
Duração de 5 a 10 minutos, o despertar
pode ocorrer facilmente e é comum haver
alucinações hipnagógicas.
Os músculos começam a relaxar e a
respiração diminui a intensidade
Ainda que o sono esteja leve, já há desconexã
o
do cérebro com estímulos externos, como
barulhos e toques físicos.
Duração de 20 a 30 minutos, sendo o mais
longo estágio NREM
Correspondendo a cerca de 80% do período
total de sono.
Ocorre diminuição significativa da temperatur
a
e da frequência respiratória e cardíaca.
Estágio 3 - SONO NREM
Consiste em um sono significativamente
profundo, com baixa atividade cerebral,
ondas lentas no eletroencefalograma (EEG)
e torna-se escasso na segunda metade da
noite.
Durante essa fase, ocorrem processos
importantes de regeneração celular e
consolidação de memória.
Sono se apresenta, de fato, profundo, com
importante reposição energética e com
predomínio das ondas lentas no EEG.
Ocorre a liberação de hormônios essenciais,
como o hormônio do crescimento.
SONO REM
Corresponde a cerca de 1/4 do sono total e
ocorre, em média, a cada 90 minutos.
Caracterizado pelo aumento significativo da
atividade cerebral, ao passo que também
implica em hipotonia muscular máxima.
Durante essa fase ocorre a maior incidência
dos sonhos.
No decorrer do tempo de sono, o período
REM, que se repete de 5 a 6 vezes durante a
noite, vai se tornando mais longo e intenso,
sendo importante para a consolidação do
sono e processamentos emocionais.
FASES DO SONO
Estágio 2 - SONO NREM
Estágio 4 - SONO NREM
Artigo de Capa
Número 12 - Agosto/2024
7
Revista A Flora - ISSN 2764-7501
      
       

      
        
       
      
    
       
       
      
        
os pacientes com sintomas persistentes acabam por

       
      
     
     
     
dependência e dificuldade de condução devido a efeitos
  

      
          
      


      
controlados para o tratamento da insônia tem sido

de tratamentos complementares tem levado ao
     
Cannabis sativa
      Humulus
lupulus
Humulus lupulus
Humulus lupulus      
       
  
     
o valor econômico da planta deriva de sua aplicação
    



         





Artigo de Capa
Número 12 - Agosto/2024
8
       
      
         
    
        
  
as primeiras variedades cultivadas comercialmente no
        
       
          
        
Para saber mais

    Naturalis Historia   
          lupus
salictarius       
        
        
        
         
        
        
     
        
     
      
          
       
     
        
       
        
 
mencionou seus efeitos diuréticos e o botânico alemão


      
      
       

tem sido usado na medicina tradicional ocidental para o
      
        
      
      Valeriana ocinalis
      
        
   Melissa ocinalis
  Matricaria chamomilla  
Passiora incarnata     Ziziphus jujuba

         
     
     α  
       
    
       
     
   
      
      
Revista A Flora - ISSN 2764-7501
Humulus lupulus

Artigo de Capa
Número 12 - Agosto/2024
9
Dependendo da variedade do lúpulo e da época
       
    

   in vitro e em animais
      
       

efeito sedativo do lúpulo usado isoladamente ou em

        
       
      
       
     
      
      
   Piper methysticum 
   Hypericum perforatum 
Revista A Flora - ISSN 2764-7501
    
    
      
       
Cannabis sativa
 Cannabis sativa     

      
        


  Cannabis sativa  

 



Artigo de Capa
Número 12 - Agosto/2024
10
Revista A Flora - ISSN 2764-7501
  

V. ocinalis
H. lupulus
in vitro

e subtipos de receptores de melatonina


 de H. lupulus e sua fração rica

β



α
e antidepressivos
β



variedades de H. lupulus








H. lupulus

Coturnix coturnix





















Zizyphus
H. lupulus











Valeriana ocinalis
Passiora incarnata
H. lupulus






H. lupulus





Diminuição dos sintomas


Humulus lupulus
 C. sativa      
      
    
      
      


Diferentes variedades da planta são cultivadas contendo
       
     
       
   
     
     
     
     
      

Artigo de Capa
Número 12 - Agosto/2024
11
C. sativa
 
   C. sativa      


       
       


   C. sativa    
       


 C. sativa

      
       

Cannabis passou a ser estudada
     
      
     
     



      
      C. sativa
        

      

Revista A Flora - ISSN 2764-7501
       
principais canabinoides presentes na Cannabis sativa


Artigo de Capa
Número 12 - Agosto/2024
12
     
propriedades sedativas através da sua ação direta no
      
     
     
    
       
    
     
        
      
   
         
      
    
       

      
     
     
      
      
     
     


     Cannabis 

        
  
  Cannabis medicinal por outros recursos
      
      


Revista A Flora - ISSN 2764-7501

uso da Cannabis

         

        
         
          


          


        
         

      

  Cannabis      
      
  
       
         
      

de Cannabis com maior teor deste canabinoide é
     
  Cannabis medicinal cresce a cada ano
      
      
       
     Cannabis e o uso da
        
     
Artigo de Capa
Número 12 - Agosto/2024
13
Revista A Flora - ISSN 2764-7501
  
C. sativa

acordo com a preferência do

 
Variedades de C. sativa



por meio de aplicativo de


 





Cannabis




observacional e aberto























spray oromucoso











Óleo de Cannabis










 Cannabis sativa
Artigo de Capa
Número 12 - Agosto/2024
14

       
      

        
  
     


      
        H.
lupulus e da C. sativa
       
     




Revista A Flora - ISSN 2764-7501
PARA SABER MAIS:PARA SABER MAIS:
       


  et al Humulus lupulus 
       


  et al     
      


et al


 
       
  Revista
         


   

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Cannabis as a medicine was used before the Christian era in Asia, mainly in India. The introduction of cannabis in the Western medicine occurred in the midst of the 19th century, reaching the climax in the last decade of that century, with the availability and usage of cannabis extracts or tinctures. In the first decades of the 20th century, the Western medical use of cannabis significantly decreased largely due to difficulties to obtain consistent results from batches of plant material of different potencies. The identification of the chemical structure of cannabis components and the possibility of obtaining its pure constituents were related to a significant increase in scientific interest in such plant, since 1965. This interest was renewed in the 1990's with the description of cannabinoid receptors and the identification of an endogenous cannabinoid system in the brain. A new and more consistent cycle of the use of cannabis derivatives as medication begins, since treatment effectiveness and safety started to be scientifically proven.
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Sleep disturbances are often cited as a primary reason for medicinal cannabis use and there is increasing clinical interest in the therapeutic potential of cannabinoids in treating sleep disorders. Burgeoning evidence suggests a role of the endocannabinoid system in regulating the circadian sleep-wake cycle, highlighting a potential avenue for developing novel therapeutics. Despite widespread use of cannabis products as sleep aids globally, robustly designed studies verifying efficacy in sleep-disordered populations are limited. While some study outcomes have suggested cannabinoid utility in insomnia disorder and sleep apnea, most studies to date are limited by small sample sizes, lack of rigorously controlled study designs, and high risk of bias. This critical review summarises the current evidence for the use of cannabinoids as a treatment for sleep disorders, and provides an overview of endocannabinoid modulation of sleep-wake cycles, and the sleep-modulating effects of plant-derived cannabinoids such as Δ⁹-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN). The review also discusses practical considerations for clinicians regarding cannabinoid formulations, routes of administration, respiratory concerns, dosing, potential side effects, drug interactions, and effects relevant to driving, tolerance, and withdrawal. While current interest in, and uptake of, medicinal cannabis use for sleep disorders may have surpassed the evidence-base, there is a strong rationale for continued investigation into the therapeutic potential of cannabinoids.
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The recent trend for legalization of medicinal cannabis and cannabinoid-containing products, together with their soporific effects, has led to a surge of interest of their potential therapeutic role in the management of some common sleep disorders, such as insomnia, sleep disordered breathing, and restless legs syndrome, and less common disorders such as narcolepsy and parasomnias. Although much of the pre-clinical and clinical data were derived from studies with relatively small sample sizes and limited by biases in assessment, and in clinical trials lack of allocation concealment, as a whole, the results indicate a potential therapeutic role for cannabinoids in the management of some sleep disorders. Clinical trials are underway for insomnia and obstructive sleep apnea management, but there remains a substantial need for rigorous large multi-center studies to assess the dose, efficacy, and safety of the various types of cannabinoids on sleep disorders. This review aims to summarize the modulatory effects of cannabinoids on sleep physiology and provide a critical evaluation of the research on their potential therapeutic benefit in various sleep disorders.
Brasil e impulsionando a indústria cervejeira
Brasil e impulsionando a indústria cervejeira. Revista A Flora, v. 3, n. 1, p. 5-8, 2023. https://www.revistaaflora.com.br/ano3-vol3-n1.