This chapter explores current artificial intelligence (AI), radiomics, and computational modeling applications in skull base surgery. AI advancements are providing opportunities to improve diagnostic accuracy, surgical planning, and postoperative care. Currently, computational models can assist in diagnosis, simulate surgical scenarios, and improve safety during surgical procedures by identifying critical structures. AI-powered technologies, such as liquid biopsy, machine learning, radiomic analysis, computer vision, and label-free optical imaging, aim to revolutionize skull base surgery. AI-driven advancements promise safer, more precise, and effective surgeries, improving patient outcomes and preoperative assessment.