A claim is often made that medical neutrality requires that health workers practicing in conflict settings or in situations of political violence refrain from taking a position on controversies of a political, racial, religious, or ideological nature. The admonition is also applied to human rights documentation and reporting and advocating for political change. That position, however, is highly problematic, in part because the phase is “medical neutrality” is not contained in international law and because has at least three different meanings: immunity from attack, impartiality, and political neutrality. More importantly, refraining from political engagement is inconsistent with contemporary medical ethics, including obligations to prevent abuses, report those that take place, and advance health equity. Moreover, the humanitarian principle of humanity, on which the purported obligation is predicated, is not morally grounded and lacks the status of the companion principles of humanity and impartiality. These principles both justify and encourage health professionals to engage in political matters that can protect the rights and health of patients and the larger populations. In taking such stances, health professionals can employ decision-making processes that account for possibly conflicting values and obligations and assessing the benefits, burdens, and risks of alternative courses of action.