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Technological Profile of Microreactor Based on Patent Analysis
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Abstract and Figures
Since the concept of microreactor was first proposed in the 1980s, it has been entering the chemistry and chemical engineering fields at a high speed and is favored by both scientific and commercial fields. The development of microreactors has been extensively studied in the literature, but less analysis has been carried out from the perspective of industrial technology. This paper aims to identify, analyze, and map the technological profile of microreactors from the perspective of patents. Based on the text mining techniques, a quantitative analysis of 16,327 microreactor‐related patents in the Derwent Innovations Index database was conducted. The analysis reveals a consistent annual increase in the number of microreactor‐related patents from 1982 to 2021. Specifically, China emerges as the leading country in terms of patent disclosures, whereas the United States and the World Intellectual Property Organization (WIPO) play a crucial role in knowledge transfer. Moreover, this study identifies the technological evolution path for microreactors and analyzes in detail the key patents along this evolution path. Individuation, modularization, and greening are the developing directions of microreactor technology in the future. This research offers valuable guidance for researchers and industry professionals in decision‐making and driving advancements in microreactor technology.
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Metal‐Organic Frameworks (MOFs) represent a highly promising class of materials with diverse applications, particularly as catalytic materials. However, their synthesis typically yields powders available only at laboratory‐scale quantities, usually in the gram range or less. This study addresses the challenge of testing limited amounts of MOF catalysts for demanding applications, such as multiphase gas‐liquid‐solid reactions in flow, utilizing a packed‐bed microreactor. Specifically, we investigate the performance of a nanoparticle (NP) ‐immobilized Pd@UiO‐66 MOF catalyst in the selective semi‐hydrogenation of phenylacetylene to styrene, serving as a model reaction. Maintaining the Taylor flow regime upstream of the catalyst bed was crucial to ensure reproducible and reliable experimental results. We conducted 88 experiments at varying liquid flow rates, temperatures ranging from 15 to 45 °C, and relative pressures spanning 0.28 to 8 bar. Styrene selectivity within the range of 80–92.3 % was achieved at phenylacetylene conversions below 20 %. Notably, the optimal condition for styrene selectivity (70 %) was attained at 98.9 % phenylacetylene conversion under the lowest H2 pressure and highest temperature, demonstrating the significance of low H2 concentration for achieving optimal styrene selectivity. Remarkably, the catalyst exhibited stable activity and selectivity over a 20 h testing period, indicating its robust performance under prolonged reaction conditions. This study demonstrates the potential of the proposed catalyst testing system as a rapid and efficient approach for early‐stage exploration studies, particularly when limited quantities of catalyst, typically in the gram scale or less, are available.
In industry, m‐dinitrobenzene is mainly obtained by two‐step nitration of benzene, but still faces the problem of being heterogeneous and highly exothermic. In this work, a two‐step continuous‐flow nitration was developed in a microreactor, combining benzene nitration and mononitrobenzene nitration in series. The waste acid after the mononitrobenzene nitration stage was utilized in the benzene mononitration stage, and the waste acid in the benzene mononitration stage was treated and concentrated for reuse. The whole process consumes almost no sulfuric acid. Under optimal conditions, the yield of dinitrobenzene was more than 99.0 % and the selectivity of m‐dinitrobenzene was more than 91 % with a residence time of 4 min at 70 °C. In addition, the space‐time yield of the continuous microreactor was 800 times higher than the batch reactor. It provides a safe and efficient method for the industrial production of m‐dinitrobenzene.
Microreactors have gained widespread attention from academia and industrial researchers due to their exceptionally fast mass and heat transfer and flexible control. In this work, CiteSpace software was used to systematically analyze the relevant literature to gain a comprehensively understand on the research status of microreactors in various fields. The results show that the research depth and application scope of microreactors are continuing to expand. The top 10 most popular research fields are photochemistry, pharmaceutical intermediates, multistep flow synthesis, mass transfer, computational fluid dynamics, μ‐TAS (micro total analysis system), nanoparticles, biocatalysis, hydrogen production, and solid‐supported reagents. The evolution trends of current focus areas are examined, including photochemistry, mass transfer, biocatalysis and hydrogen production and their milestone literature is analyzed in detail. This article demonstrates the development of different fields of microreactors technology and highlights the unending opportunities and challenges offered by this fascinating technology.
The rapidly growing state of energy consumption and the urgency of mitigating the harmful effects of climate change have accelerated our transition to renewable energy. This paper proposes a multi-level framework for exploring the global competition to develop renewable energy technologies. Through a combination of text mining techniques and by analyzing a corpus of patents covering six renewable energy technologies from 1970 to 2019, we reveal the lifecycle of these technologies, the original sources of these technologies, their potential markets, and the different supply and demand patterns of the major countries/regions involved. The results show that solar and wind energy are currently the most widely used renewable energy sources, yet biomass is the only energy source still in its growing stage. China's patents have seen a rapid upward trend, spurred on by strong policy promotion, which runs counter to the decrease in patent applications seen in most other major countries in this area. However, China's technology imports still far outweigh its exports, indicating that there is still a sizeable gap between China and some of the more developed countries like the United States, Germany, France, and the United Kingdom in terms of high-quality, high-value patents. Accordingly, China, the United States, and Japan are currently the leading in the world's renewable energy markets. That said, the market potential of Europe, Canada, and Australia should not be underestimated. These and more themes are discussed from a political, economic, environmental, and global governance perspective. This paper provides useful insights into the global renewable energy technology landscape, particularly the competitive dynamics at play. The aim is to guide policy makers or managers on the next steps in our progress toward applying and using renewable energy at scale.
International patenting activities have long been used as an indicator of technology diffusion, but it is unclear whether international patent inflows promote or block technology innovations in recipient countries. Previous studies conclude that the commercial exploitation of patented inventions in foreign countries is expected to be associated with technology diffusion. However, international patents may also block imitations in foreign countries. To address the conflicting arguments, this study investigates the impact of international patent inflows on innovations in recipient countries using the solar PV industry as the empirical focus. This study finds that international patent inflows have a positive impact on innovations in recipient countries, but the positive impact is stronger for leading countries than latecomers. The findings indicate that international patenting activities may exaggerate the technology gap between leading and lagging countries, which suggests the importance of promoting institutionalized technology cooperation between leading and lagging countries.
In order to reveal the hotspots and trends of biological water treatment from the perspectives of scientific and technological innovation, both of the bibliometric review and patents analysis were performed in this study. The Web of Science Core Collection database and Derwent Innovation Index database recorded 30023 SCI papers and 50326 patents, respectively were analyzed via information visualization technology. The results showed that China ranked the first in both papers and patents, while the United States and Japan had advantages in papers and patents, respectively. It was concluded through literature metrology analysis that microbial population characteristics, biodegradation mechanism, toxicity analysis, nitrogen and phosphorus removal and biological treatment of micro-polluted wastewater were the research hotspots of SCI papers. Activated sludge process and anaerobic-aerobic combined process were the two mainstream technologies on the basis of patent technology classification analysis. Technology evolution path of biological water treatment was also elucidated in three stages based on the citation network analysis. Furthermore, the future directions including research on the law of interaction and regulation of biological phases and pollutants and the technology innovations towards the targeted biotransformation or selective biodegradation of pollutants and resource reuse of wastewater were prospected.
Globally, 80% of wastewater, among which 28% came from industry, returned to the ecosystem without treatment or reuse. The discharge of industrial wastewater poses public health and environmental concerns. The necessity and urgency of industrial wastewater treatment (IWT) will bring great challenges to most countries. This paper conducted the patent analysis combined with text mining to quantitatively analyze 11,840 patents related to IWT in the Derwent Innovations Index database. The results showed that: From 1973 to 2020, the number of patents related to IWT annually was increasing consistently. China ranked first in the number of patent publications. In contrast, the United States and some patent organizations, such as World Intellectual Property Organization, produced fewer patents, while they played more important roles in knowledge transfer. The core technology analysis suggested that method, device, material and related industry were hot topics. From activated sludge treatment technology, industrial wastewater treatment technology had gone through a development process from single technology treatment to combined technologies treatment. In the foreseeable future, research on devices for physical treatment, advanced oxidation processes, automated and energy-saving treatment systems were the promising directions.
Microfluidic devices have become a powerful tool for chemical and biologic applications. To control different functional parts on the microchip, valve plays a key role in the device. In conventional methods, physio-mechanical valves are usually used on microfluidic chip. Herein, we reported a chemo-mechanical switchable valve on microfluidic chip by using a thermally responsive block copolymer. The wettability changes of capillary with copolymer modification on inner surface were investigated to verify the function as a valve. Capillaries with modification of poly-(N-isopropylacrylamide-co-hexafluoroisopropyl acrylate) (P(NIPAAm-co-HFIPA)) with a 20% HFIPA was demonstrated capable of control aqueous solution stop or go through. Then short capillaries with copolymer modification were integrated in microchannels as valves. With the temperature changing around lower critical solution temperature (LCST), the integrated chemo-mechanical switchable valve exhibited excellent “OPEN–CLOSE’’ behavior for microflow control. After optimization of the block copolymer sequences and molar ratio, a switching time as low as 20 s was achieved. The developed micro valve was demonstrated effective for flow control on microchip.