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Journal of Military Medicine
2024, Volume 26, Issue 2
Pages: 2258-2268
doi 10.30491/JMM.2024.1006614.1139
*Corresponding author: Mohamad Fashi, Email: m_fashi@sbu.ac.ir
The Effects of Weekly Variations in Resistance Training routine on Muscle
Thickness and Strength Adaptations in YoungMen
Mehdi Tayebi 1, Mohamad Fashi 1*, Afshar Jafari 1
1 Department of Biological Sciences in Sports, Faculty of Sports Sciences and Health, Shahid Beheshti University, Tehran, Iran
Received: 20 January 2024 Accepted: 20 April 2024
Abstract
Background and Aim: Given the significant relationship between muscle cross-sectional area (CSA) and
muscle strength, the primary objective for athletes involved in resistance training is to enhance muscle mass and
strength. Proper manipulation of training variables such as intensity, volume, frequency, exercise selection, rest
interval, and tempo are essential for maximizing exercise-induced muscle hypertrophy. The present study
examined the effects of weekly variations in resistance training on muscle thickness (MT) and strength adaptations
in young men.
Methods: This research included 30 participants (age: 21.37 ± 1.37 years, height: 174.48 ± 3.34 cm, weight:
72.13 ± 3.45 kg). They were randomly assigned into varying training groups whose training routine changed every
week (VAR) or traditional training groups that did not change (TRAD) for ten weeks. For the VAR group training
weeks were labeled as adaptation, metabolic stress, mechanical tension, muscle damage, and de-load week 2
cycles of this change occurred through the training intervention for them, but the TRAD group training routine
did not change through the study.
Results: Both the TRAD and VAR groups showed significant increases in the MT of the biceps brachii muscle
(BB) (VAR: P = 0.001; TRAD: P = 0.007), significant differences were observed between groups (P = 0.012).
Vastus lateralis (VL) MT increased significantly in both groups (P = 0.001), no significant difference was
observed between the two groups (P>0.05). Among the groups, lean body mass (LBM) increased significantly (P
= 0.001), TRAD group showed a significant decrease in body fat (P = 0.49), there was no significant change in
BMI of both groups (P>0.05). Both groups showed significant increase in bench press and back squat 1-RM
strength test (P = 0.001). Back squat showed a trivial non-significant difference between the groups (P = 0.072).
Conclusion: The results showed that changing resistance training methods weekly was more effective than
traditional resistance training for biceps hypertrophy. Nevertheless, the effects of VAR and TRAD exercises are
similar in the case of the latissimus dorsi muscle.
Keywords: Resistance Training, Muscle Hypertrophy, Mechanical Tension, Metabolic Stress, Muscle Damage.
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doi 10.30491/JMM.2024.1006614.1139
m_fashi@sbu.ac.ir
CSA
±±±
VARTRADVAR
TRAD
TRAD P VAR P BB
P (VL)
P <P
LBM P TRAD P VAR P
<P(1-RM)
P
VARTRAD
CSA
GPower
(1-β)
Varović
±±
±
±
VARTRAD
J Mil Med 2024, Volume 26, Issue 2
/
VARTRAD
/
VAR
/
VAR
/
VAR
/
VARTRAD
VAR
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TRAD
VARTRAD
MRI "
"
MRI
VL
BBRT
B-mode (Philips clearvue 550)
BB
1-RM
1-RM
1-RM
1-RM
BIA
DEXA
InBody 570 BIA
BMILBM
(BF)
JASP
017.2.1
≥ P
IR.SBU.REC.1402.007
P>TRADVAR
; VAR: P = TRAD: P =
P
P =
P>
J Mil Med 2024, Volume 26, Issue 2
BBVL
BMI(kg/𝑚2)
Bf %
LBM
(BF)BMI
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1-RM
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J Mil Med 2024, Volume 26, Issue 2
MAPKJNK
(C-jun N terminal Kinase)
mTOR
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Schoenfeld
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MRI
IR.SBU.REC.1402.007
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1. Herman JR, Rana SR, Chleboun GS, Gilders RM,
Hageman FC, Hikida RS, et al. Correlation between
muscle fiber cross-sectional area and strength gain
using three different resistance-training programs in
college-aged women. The Journal of Strength &
Conditioning Research. 2010;24:1. doi:10.3390/
ijerph16244897
2. Jones EJ, Bishop PA, Woods AK, Green JM.
Cross-sectional area and muscular strength: a brief
review. Sports Medicine. 2008;38:987-94. doi:10.2
165/00007256-200838120-00003
3. Bernárdez-Vázquez R, Raya-González J, Castillo
D, Beato M. Resistance Training Variables for
Optimization of Muscle Hypertrophy: An Umbrella
Review. Frontiers in sports and active living.
2022;4:949021. doi:10.3389/fspor.2022.949021
4. Schoenfeld BJ. The mechanisms of muscle
hypertrophy and their application to resistance
training. The Journal of Strength & Conditioning
Research. 2010;24(10):2857-72. doi:10.1519/JSC.
0b013e3181e840f3
5. Joanisse S, Lim C, McKendry J, Mcleod JC,
Stokes T, Phillips SM. Recent advances in
understanding resistance exercise training-induced
skeletal muscle hypertrophy in humans.
F1000Research. 2020;9:F1000 Faculty Rev-141.
doi:10.12688/f1000research.21588.1
6. Erskine RM, Jones DA, Maffulli N, Williams AG,
Stewart CE, Degens H. What causes in vivo muscle
specific tension to increase following resistance
training? Experimental Physiology. 2011;96(2):145-
55. doi:10.1113/expphysiol.2010.053975
7. Kraemer WJ, Ratamess NA, Hymer WC, Nindl
BC, Fragala MS. Growth hormone (s), testosterone,
insulin-like growth factors, and cortisol: roles and
integration for cellular development and growth with
exercise. Frontiers in Endocrinology. 2020;11:33.
doi:10.3389/fendo.2020.00033
8. Vissing K, Brink M, Lønbro S, Sørensen H,
Overgaard K, Danborg K, et al. Muscle adaptations
to plyometric vs. resistance training in untrained
young men. The Journal of Strength & Conditioning
Research. 2008;22(6):1799-810. doi:10.1519/JSC.
0b013e318185f673
9. Carey Smith R, Rutherford O. The role of
metabolites in strength training: I. A comparison of
eccentric and concentric contractions. European
Journal of Applied Physiology and Occupational
Physiology. 1995;71:332-6. doi:10.1007/BF00240
413
10. Oranchuk DJ, Storey AG, Nelson AR, Cronin
JB. Scientific basis for eccentric quasi-isometric
resistance training: a narrative review. The Journal
of Strength & Conditioning Research. 2019;33(10):
2846-59. doi:10.1519/JSC.0000000000003291
11. Anderson AB, Owens JG, Patterson SD, Dickens
JF, LeClere LE. Blood flow restriction therapy: from
development to applications. Sports Medicine and
Arthroscopy Review. 2019;27(3):119-23. doi:10.10
97/JSA.0000000000000240
12. Krzysztofik M, Wilk M, Wojdała G, Gołaś A.
Maximizing muscle hypertrophy: a systematic
review of advanced resistance training techniques
and methods. International Journal of Environmental
Research and Public Health. 2019;16(24):4897.
doi:10.3390/ijerph16244897
13. Saito Y, Chikenji TS, Matsumura T, Nakano M,
Fujimiya M. Exercise enhances skeletal muscle
regeneration by promoting senescence in fibro-
adipogenic progenitors. Nature Communications.
2020;11(1):889. doi:10.1038/s41467-020-14734-x
14. Maeo S, Huang M, Wu Y, Sakurai H, Kusagawa
Y, Sugiyama T, et al. Greater hamstrings muscle
hypertrophy but similar damage protection after
training at long versus short muscle lengths.
Medicine and Science in Sports and Exercise. 2021;
53(4):825. doi:10.1249/MSS.0000000000002523
15. Schoenfeld BJ. Does exercise-induced muscle
damage play a role in skeletal muscle hypertrophy?
The Journal of Strength & Conditioning Research.
2012;26(5):1441-53. doi:10.1519/JSC.0b013e318
24f207e
16. Franchi MV, Longo S, Mallinson J, Quinlan JI,
Taylor T, Greenhaff PL, et al. Muscle thickness
correlates to muscle cross-sectional area in the
assessment of strength training-induced hypertrophy.
J Mil Med 2024, Volume 26, Issue 2
Scandinavian Journal of Medicine & Science in
Sports. 2018;28(3):846-53. doi:10.1111/sms.12961
17. Miyatani M, Kanehisa H, Ito M, Kawakami Y,
Fukunaga T. The accuracy of volume estimates
using ultrasound muscle thickness measurements in
different muscle groups. European Journal of
Applied Physiology. 2004;91:264-72. doi:10.1007/
s00421-003-0974-4
18. Anusitviwat C, Vanitcharoenkul E, Chotiyarnwong
P, Unnanuntana A. Dual-frequency bioelectrical
impedance analysis is accurate and reliable to
determine lean muscle mass in the elderly. Journal
of Clinical Densitometry. 2023;26(1):90-6.
doi:10.1016/j.jocd.2022.12.006
19. Dehghan M, Merchant AT. Is bioelectrical
impedance accurate for use in large epidemiological
studies?. Nutrition Journal. 2008;7:26. doi:10.1186/
1475-2891-7-26
20. Varović D, Žganjer K, Vuk S, Schoenfeld BJ.
Drop-set training elicits differential increases in non-
uniform hypertrophy of the quadriceps in leg
extension exercise. Sports. 2021;9(9):119. doi:10.3
390/sports9090119
21. Fink J, Schoenfeld BJ, Kikuchi N, Nakazato K.
Effects of drop set resistance training on acute stress
indicators and long-term muscle hypertrophy and
strength. The Journal of Sports Medicine and
Physical Fitness. 2018;58(5):597-605. doi:10.237
36/S0022-4707.17.06838-4
22. de Camargo JB, Zaroni RS, Júnior AC, DE
OLIVEIRA TP, Trindade TB, Lopes CR, et al. Tri-
Set Training System Induces a High Muscle
Swelling with Short Time Commitment in
Resistance-Trained Subjects: A Cross-Over Study.
International Journal of Exercise Science. 2022;
15(3):561-9.
23. Schoenfeld BJ, Pope ZK, Benik FM, Hester GM,
Sellers J, Nooner JL, et al. Longer interset rest
periods enhance muscle strength and hypertrophy in
resistance-trained men. The Journal of Strength &
Conditioning Research. 2016;30(7):1805-12.
doi:10.1519/JSC.0000000000001272
24. De Almeida FN, Lopes CR, Conceição RM,
Oenning L, Crisp AH, De Sousa NM, et al. Acute
effects of the new method sarcoplasma stimulating
training versus traditional resistance training on total
training volume, lactate and muscle thickness.
Frontiers in Physiology. 2019;10:579. doi:10.3389/
fphys.2019.00579
25. Hirono T, Ikezoe T, Taniguchi M, Tanaka H,
Saeki J, Yagi M, et al. Relationship between muscle
swelling and hypertrophy induced by resistance
training. The Journal of Strength & Conditioning
Research. 2022;36(2):359-64. doi:10.1519/JSC.00
00000000003478
26. Schoenfeld BJ. Potential mechanisms for a role
of metabolic stress in hypertrophic adaptations to
resistance training. Sports Medicine. 2013;43:179-
94. doi:10.1007/s40279-013-0017-1
27. Wackerhage H, Schoenfeld BJ, Hamilton DL,
Lehti M, Hulmi JJ. Stimuli and sensors that initiate
skeletal muscle hypertrophy following resistance
exercise. Journal of Applied Physiology. 2019;
126(1):30-43. doi:10.1152/japplphysiol.00685.2018
28. Lopez P, Radaelli R, Taaffe DR, Newton RU,
Galvão DA, Trajano GS, et al. Resistance training
load effects on muscle hypertrophy and strength
gain: systematic review and network meta-analysis.
Medicine and Science in Sports and Exercise.
2021;53(6):1206-16. doi:10.1249/MSS.00000000
00002585
29. Kubo K, Ikebukuro T, Yata H. Effects of 4, 8,
and 12 repetition maximum resistance training
protocols on muscle volume and strength. The
Journal of Strength & Conditioning Research. 2021;
35(4):879-85. doi:10.1519/JSC.0000000000003575
30. Lasevicius T, Ugrinowitsch C, Schoenfeld BJ,
Roschel H, Tavares LD, De Souza EO, et al. Effects
of different intensities of resistance training with
equated volume load on muscle strength and
hypertrophy. European Journal of Sport Science.
2018;18(6):772-80. doi:10.1080/17461391.2018.
1450898
31. Campos GE, Luecke TJ, Wendeln HK, Toma K,
Hagerman FC, Murray TF, et al. Muscular
adaptations in response to three different resistance-
training regimens: specificity of repetition
maximum training zones. European Journal of
Applied Physiology. 2002;88:50-60. doi:10.1007/
s00421-002-0681-6
32. Burd NA, Andrews RJ, West DW, Little JP,
Cochran AJ, Hector AJ, et al. Muscle time under
tension during resistance exercise stimulates
differential muscle protein sub‐fractional synthetic
responses in men. The Journal of Physiology. 2012;
590(2):351-62. doi:10.1113/jphysiol.2011.221200
33. Wilk M, Zajac A, Tufano JJ. The Influence of
Movement Tempo During Resistance Training on
Muscular Strength and Hypertrophy Responses: A
Review. Sports Medicine. 2021;51(8):1629-50.
doi:10.1007/s40279-021-01465-2
34. Schoenfeld BJ, Ogborn DI, Krieger JW. Effect
of repetition duration during resistance training on
muscle hypertrophy: a systematic review and meta-
analysis. Sports Medicine. 2015;45(4):577-85.
doi:10.1007/s40279-015-0304-0
35. Baz-Valle E, Schoenfeld BJ, Torres-Unda J,
Santos-Concejero J, Balsalobre-Fernández C. The
effects of exercise variation in muscle thickness,
maximal strength and motivation in resistance
trained men. PLoS One. 2019;14(12):e0226989.
doi:10.1371/journal.pone.0226989
36. de Vasconcelos Costa BD, Kassiano W, Nunes
JP, Kunevaliki G, Castro-E-Souza P, Rodacki A, et
al. Does Performing Different Resistance Exercises
for the Same Muscle Group Induce Non-
homogeneous Hypertrophy?. International Journal
of Sports Medicine. 2021;42(09):803-11. doi:10.10
55/a-1308-3674
37. Kassiano W, Nunes JP, Costa B, Ribeiro AS,
Schoenfeld BJ, Cyrino ES. Does Varying Resistance
Exercises Promote Superior Muscle Hypertrophy
and Strength Gains? A Systematic Review. The
Journal of Strength & Conditioning Research. 2022;
36(6):1753-62. doi:10.1519/JSC.0000000000004258
38. de Freitas MC, Gerosa-Neto J, Zanchi NE, Lira
FS, Rossi FE. Role of metabolic stress for enhancing
muscle adaptations: Practical applications. World
Journal of Methodology. 2017;7(2):46-54. doi:10.5
662/wjm.v7.i2.46
39. Mirzoev TM. Mechanotransduction for muscle
protein synthesis via mechanically activated ion
channels. Life. 2023;13(2):341. doi:10.3390/life
13020341
40. Stožer A, Vodopivc P, Bombek LK.
Pathophysiology of exercise-induced muscle
damage and its structural, functional, metabolic, and
clinical consequences. Physiological Research.
2020;69(4):565-98. doi:10.33549/physiolres.9343
71