In this article, we study the approximation properties of Durrmeyer-type sampling operators. We consider the composition of generalized sampling operators and Durrmeyer sampling operators. For the new composition operators, we provide the pointwise and uniform convergence, as well as the quantitative estimates in terms of the first-order modulus of continuity and K-functional. Moreover, we investigate the rate of convergence using weighted modulus of continuity. Also, difference estimates are provided for the operators. Additionally, we provide approximation results for the linear combinations of the composition operators. Finally, we discuss the rate of convergence for the operators via graphical example.