For a complex smooth log pair
(Y,D), if the quasi-projective manifold
admits a complex polarized variation of Hodge structures with local unipotent monodromies around
D or admits an integral polarized variation of Hodge structures, whose period map is quasi-finite, then we prove that
(Y,D) is algebraically hyperbolic in the sense of Demailly, and that the generalized big Picard
... [Show full abstract] theorem holds for U: any holomorphic map from the punctured unit disk to U extends to a holomorphic map of the unit disk into Y. This result generalizes a recent work by Bakker-Brunebarbe-Tsimerman, in which they proved that if the monodromy group of the above variation of Hodge structures is arithmetic, then U is Borel hyperbolic: any holomorphic map from a quasi-projective variety to U is algebraic.