The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis

Full text

Journal of Ardabil University of Medical Sciences
Vol. 24, No. 1, Spring 2024, Pages: 92-106
This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.
Original article
The Effect of Physical Activity on Stress and Inflammation in
Mice with Rheumatoid Arthritis
Sheida Payamipour, Maghsoud Peeri *, Mohammad Ali Azarbayjani,
Forouzan Fattahi Masrour
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
*Corresponding author. Tel: +982165225439, Fax: +98216522543, E-mail: m.peeri@iauctb.ac.ir
ABSTRACT
Background: Rheumatoid arthritis is an autoimmune disease that gradually
destroys the synovial joints and leads to chronic inflammation. This autoimmune
disorder is associated with an increase in stress-related symptoms, including
anxiety and depression, and a decrease in social behaviors, which severely
reduces the patient's quality of life. Previous studies show that higher physical
activity during adolescence may lead to a decrease in neurobehavioral disorders
in adulthood. This study was conducted with the aim of evaluating the increase
of physical activity from early adolescence on stress-related behaviors and
inflammation in mice with rheumatoid arthritis.
Methods: Male mice were randomly exposed to a running wheel from early
adolescence to adulthood, and then rheumatoid arthritis was induced. Stress-
related behaviors, including anxiety, depression and social behavior were
investigated in animals. The level of interleukin 17 (IL-17) and interferon
gamma (IFN-γ) were also measured as important inflammatory markers in the
serum.
Results: The results showed that physical activity from early adolescence
significantly resulted in decreased stress in mice with rheumatoid arthritis. In
addition, the running wheel led to a decrease in the levels of (IL-17) and (IFN-γ)
in rheumatoid arthritis-induced mice as two important indicators of
inflammation.
Conclusion: This study shows that increased physical activity during
adolescence to adulthood may make mice resistant to increased stress and
inflammation caused by rheumatic arthritis.
Article info
Article history:
Received: Apr 26, 2024
Accepted: Jul 13, 2024
Keywords:
Exercise
Stress
Rheumatoid Arthritis
Inflammation
How to cite this article: Payamipour S, Peeri M, Azarbayjani MA, Fattahi Masrour F. The Effect of Physical
Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis. J Ardabil Univ Med Sci. 2024;24(1): 92-
106.
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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93 Payamipour S, et al.
Extended Abstract
Background: Rheumatoid arthritis is one of
the most common chronic autoimmune
inflammatory diseases. Due to its chronic,
painful and debilitating nature, this disease
has profound effects on quality of life.
Rheumatoid arthritis is associated with stress-
related disorders such as anxiety and
depression, with an estimated prevalence of
14% for anxiety and 16.8%–38.8% for
depression. Inflammatory factors such as
interleukin 17 (IL-17) and interferon- gamma
(IFN-γ) play a key role in the pathogenesis
and progression of rheumatoid arthritis. On
the other hand, there is a close relationship
between increased levels of IL-17 and IFN-γ
and stress-related disorders. During the last
few years, studies have shown that physical
activity and exercise as a non-
pharmacological solution to reduce stress in
humans and animals. However, their effects
on the condition of rheumatism have not been
fully determined. In this study, we aimed to
investigate the effect of physical activity
during adolescence to adulthood, which is a
very important period in brain development,
on the vulnerability of animals to stress-
related disorders and inflammation in mice
with rheumatoid arthritis.
Methods: Male BALB/c mice weighing 10-
11 grams (age 21 days) were kept in a quiet
room with a light-dark cycle of 12.12 hours
and standard conditions (temperature:
23.5±0.5 °C, humidity: 50-40%) and had free
access to food and water. Forty adolescent
mice were divided into 4 groups: healthy;
rheumatoid arthritis, exercise, and rheumatoid
arthritis+exercise. There were 10 mice in
each group. To perform physical activity,
exercise groups were exposed to a running
wheel from the age of 21 to 90 days. Two
adolescent male mice were housed in a
partitioned cage without physical contact, and
each animal had free access to a running
wheel. To induce rheumatoid arthritis, ten
days after stopping exercise, at the age of 100
and subsequently at 113 days, the animals
received type II collagen emulsion and
adjuvant subcutaneously. Healthy groups
received only vehicle. From the 10th day
after the first immunization, the development
of clinical symptoms was confirmed through
the increase in the thickness of the paw and
the joint of the right hind leg. The animals did
not exercise after inducing the disease. To
measure stress-related disorders, animals
were exposed to three behavioral tests
including an elevated plus maze (at the age of
127), a social interaction test (at the age of
129), and a forced swimming test (at the age
of 132). After completing the behavioral
tests, the mice were deeply anesthetized by a
combination of ketamine and xylazine. Then
blood was taken from the heart and the serum
was collected to measure IL-17 and IFN-γ
using the ELISA technique. Data were
analyzed using SPSS software version 26
under two-way analysis of variance. Tukey's
post hoc test was used for multiple
comparisons. The data are presented as
mean±standard error of the mean and p<0.05
was considered significant.
Results: Elevated plus maze, for the time
spent in the open arm, the analysis showed a
main effect of exercise (p=0.019) and
rheumatism (p<0.001), there was also a
significant interaction (p=0.004) between
exercise and rheumatism. In addition, for the
number of open arm entries, the analysis
showed a main effect of exercise (p=0.033)
and rheumatism (p<0.001), there was also a
significant interaction (p=0.004) between
exercise and rheumatism. Tukey's post hoc
test revealed that the induction of rheumatism
led to a decrease in the amount of time spent
(p<0.001) and the number of entries
(p<0.001) in the open arm compared to the
healthy mice. In addition, exercise in mice
with rheumatism led to a reduction in stress
by increasing the amount of time spent
(p<0.001) and the number of entries
(p<0.001) in the open arm compared to the
rheumatism group. Social behavior test, the
analysis showed a main effect of exercise
(p=0.037) and rheumatism (p<0.001), and an
interaction between exercise and rheumatism
(p=0.02) in the social interaction test. Tukey's
post hoc test showed that the induction of
rheumatism decreased the interaction time
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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94 Payamipour S, et al.
(p<0.001) in mice compared to the healthy
group. In addition, exercise increased social
behavior by increasing the interaction time
(p<0.001) in mice with rheumatism compared
to the rheumatism group. Forced swimming
test, the analysis revealed a main effect of
exercise (p=0.009) and rheumatism
(p<0.001). However, there was no significant
interaction between exercise and rheumatism
(p<0.05). Tukey's post hoc test indicated that
the induction of rheumatism increased
immobility time (p<0.01) in mice compared
to the healthy group. On the other hand,
exercise increased the level of immobility
time (p<0.05) and decreased stress in mice
with rheumatism compared to the rheumatism
group. These findings mean that exercise
from early adolescence can increase the
resistance of adult mice against stress-related
behaviors induced by rheumatism. Statistical
analysis of cytokine results showed a main
effect of exercise (p=0.011) and rheumatism
(p=0.001), and also a significant interaction
between exercise and rheumatism (p=0.001)
for IL-17. In addition, for IFN-γ, the analysis
revealed a main effect of exercise (p<0.001)
and rheumatism (p<0.001), there was also a
significant interaction between exercise and
rheumatism (p<0.001). Tukey's post hoc test
showed that the induction of rheumatism
resulted in a significant increase in both
cytokines IL-17 (p<0.001) and IFN-γ
(p<0.001) in serum compared to the healthy
mice. In addition, exercise decreased
inflammation in mice with rheumatism by
decreasing the amount of IL-17 (p<0.01) and
IFN-γ (p<0.001) in the serum compared to
the rheumatism group. This means that
exercise from early adolescence can increase
the resistance of adult mice against the
increase of inflammation caused by the
induction of rheumatism.
Conclusion: In the present study, the findings
showed that increasing physical activity as an
exercise strategy may play a role in reducing
the level of stress-related disorders in mice
suffering from rheumatism by reducing the
level of IL-17 and IFN-γ. Considering this
point that recent studies have shown that
exercise has beneficial effects on rheumatism
symptoms, these results can be approached as
an initial step to start clinical studies in the
future.
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هرود و ﺖﺴﯿﺑمرﺎﻬﭼ ،هرﺎﻤﺷلوا ،رﺎﻬﺑ1403
ﻂﯾاﺮﺷ ﺖﺤﺗ ﻪﻟﺎﻘﻣ ﻦﯾاCreative Commons Attribution-Non Commercial 4.0 International License.ﺖﺳا ﺮﺸﻧزﺎﺑ ﻞﺑﺎﻗ
ﻞﯿﺻا ﻪﻟﺎﻘﻣ
شﻮﻣ رد بﺎﻬﺘﻟا ناﺰﯿﻣ و سﺮﺘﺳا ﺮﺑ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺄﺗﺎﻫﻼﺘﺒﻣ ي ﻪﺑ
ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور
يﺮﯿﭘ دﻮﺼﻘﻣ ،رﻮﭘ ﯽﻣﺎﯿﭘ اﺪﯿﺷ
*
روﺮﺴﻣ ﯽﺣﺎﺘﻓ نازوﺮﻓ ،ﯽﻧﺎﺠﯾﺎﺑرذآ ﯽﻠﻋﺪﻤﺤﻣ ،
ناﺮﯾا ،ناﺮﻬﺗ ،ﯽﻣﻼﺳا دازآ هﺎﮕﺸﻧاد ،يﺰﮐﺮﻣ ناﺮﻬﺗ ﺪﺣاو ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ هوﺮﮔ
*.لﻮﺌﺴﻣ هﺪﻨﺴﯾﻮﻧ :ﻦﻔﻠﺗ02165225439:ﺲﮐﺎﻓ02165225439::ﮏﯿﻧوﺮﺘﮑﻟا ﺖﺴﭘm.peeri@iauctb.ac.ir
:ﺖﻓﺎﯾرد7/2/1403 :شﺮﯾﺬﭘ23/4/1403
ﻣﻪﻣﺪﻘ
ﯽﮑﯾ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣورزاﻊﯾﺎﺷﻦﯾﺮﺗيرﺎﻤﯿﺑ ﯽﺑﺎﻬﺘﻟا يﺎﻫ
ﺎﺸﻨﻣ ﺎﺑ ﻦﻣﺰﻣ ﻦﻤﯾادﻮﺧءمﻮﻠﻌﻣﺎﻧ يرﺎـﻤﯿﺑ ﻦـﯾا .ﺖﺳا
ﺐﺒــﺴﻣاﻮﺗﺎــﻧﯽﻧﺎــﻫي نارﺎــﻤﯿﺑ رد يرﺎﯿــﺴﺑ ﯽــﮑﯾﺰﯿﻓ
ﯽﻣﻃ زا ﻪﮐ ﺪﺷﺎﺑ ﻞـﺻﺎﻔﻣ دﺮـﮑﻠﻤﻋ رد لﻼﺘـﺧا ﻖـﯾﺮ رد
ﻦﯿﻨﺳﯽﻟﺎﺴﮔرﺰﺑ ﯽـﻣ نﺎـﺸﻧ ار دﻮﺧ ﺪـﻫد]1[ بﺎـﻬﺘﻟا .
ﻞﺻﺎﻔﻣﻦﮑﻤﻣﺖﺳاارﺬﮔ ﺪـﺷﺎﺑ ًﻻﻮـﻤﻌﻣ ﯽـﻟو ﻦﻣﺰـﻣ
هﺪﺷوﺮﯾدﺎﯾﺮﺠﻨﻣ دوزﻪﺑﺐﯾﺮﺨﺗﻞﺻﺎﻔﻣﯽﻣ .دﻮـﺷ
ًﺎﺒﯾﺮﻘﺗ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور عﻮﯿﺷ ﺎﺗ2 ﺖـﯿﻌﻤﺟ ﻞﮐ ﺪﺻرد
ﯽﻣ ﻞﻣﺎﺷ ار ﺎﯿﻧدا ﻪﺑ نادﺮﻣ ﺮﺑاﺮﺑ ﻪﺳ نﺎﻧز و ددﺮﮔ ﻦـﯾ
هﺪﯿﮑﭼ
:فﺪﻫ و ﻪﻨﯿﻣزﻪﻟﻻز ﻞﺻﺎﻔﻣ ﺞﯾرﺪﺗ ﻪﺑ ﻪﮐ ﺖﺳا ﯽﻨﻤﯾادﻮﺧ يرﺎﻤﯿﺑ ﮏﯾ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور زا ار ياﯽﻣ ﻦﯿﺑ بﺎـﻬﺘﻟا ﻪـﺑ ﺮـﺠﻨﻣ و دﺮﺑ
ﯽﻣ ﻦﻣﺰﻣ ﯽﻋﺎـﻤﺘﺟا يﺎﻫرﺎﺘﻓر ﺶﻫﺎﮐ و ﯽﮔدﺮﺴﻓا و باﺮﻄﺿا ﻞﻣﺎﺷ سﺮﺘﺳا ﺎﺑ ﻂﺒﺗﺮﻣ ﻢﺋﻼﻋ ﺶﯾاﺰﻓا ﺎﺑ ﯽﻨﻤﯾا دﻮﺧ لﻼﺘﺧا ﻦﯾا .دﻮﺷ
ﯽﻣ ﺶﻫﺎﮐ تﺪﺷ ﻪﺑ ار رﺎﻤﯿﺑ ﯽﮔﺪﻧز ﺖﯿﻔﯿﮐ ﻪﮐ ﺖﺳا هاﺮﻤﻫﯽﻣ نﺎﺸﻧ ﻪﺘﺷﺬﮔ تﺎﻌﻟﺎﻄﻣ .ﺪﻫد رد ﯽـﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﻪﮐ ﺪﻨﻫد
ﺟﻮﻧ نارودﯽﺒﺼﻋ تﻻﻼﺘﺧا ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣ ﺖﺳا ﻦﮑﻤﻣ ﯽﻧاﻮ
-
ﺶﯾاﺰـﻓا ﯽﺑﺎـﯾزرا فﺪـﻫ ﺎـﺑ ﻪﻌﻟﺎﻄﻣ ﻦﯾا .دﻮﺷ ﯽﻟﺎﺴﮔرﺰﺑ رد يرﺎﺘﻓر
شﻮﻣ رد بﺎﻬﺘﻟا و سﺮﺘﺳا ﺎﺑ ﻂﺒﺗﺮﻣ يﺎﻫرﺎﺘﻓر يور ﺮﺑ ﯽﻧاﻮﺟﻮﻧ نارود ﻞﯾاوا زا ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور ﻪـﺑ ﻼﺘـﺒﻣ يﺎﻫ
ﺖﺳا هﺪﺷ مﺎﺠﻧا.
رﺎﮐ شور :شﻮﻣﻧ ﻞﯾاوا زا ﺮﻧ يﺎﻫ ﻪـﺑ ﺲﭙـﺳ و ﺪـﻨﺘﻓﺮﮔ راﺮـﻗ ﯽﻓدﺎـﺼﺗ ترﻮـﺻ ﻪـﺑ راود خﺮـﭼ ضﺮـﻌﻣ رد ﯽﻟﺎﺴﮔرﺰﺑ ﺎﺗ ﯽﻧاﻮﺟﻮ
.ﺪـﺷ ﯽـﺳرﺮﺑ تﺎﻧاﻮﯿﺣ رد ﯽﻋﺎﻤﺘﺟا رﺎﺘﻓر و ﯽﮔدﺮﺴﻓا ،باﺮﻄﺿا ﻞﻣﺎﺷ سﺮﺘﺳا ﺎﺑ ﻂﺒﺗﺮﻣ يﺎﻫرﺎﺘﻓر .ﺪﻧﺪﺷ ﻼﺘﺒﻣ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﺢﻄﺳ17 مﺮﺳ رد ﯽﺑﺎﻬﺘﻟا ﻢﻬﻣ يﺎﻫﺮﮐرﺎﻣ ناﻮﻨﻋ ﻪﺑ ﻢﻫ ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا وﺪﻧﺪﺷ هﺪﯿﺠﻨﺳ.
ﻪﺘﻓﺎﯾﺎﻫ: ﻞـﺑﺎﻗ رﻮـﻃ ﻪﺑ ﯽﻧاﻮﺟﻮﻧ نارود ﻞﯾاوا زا ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ رد سﺮﺘـﺳا ﺶﻫﺎـﮐ ﻪـﺑ ﺮـﺠﻨﻣ ﯽﻬﺟﻮـﺗ
شﻮﻣﯽﻣ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ يﺎﻫ ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﺢﻄﺳ ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣ راود خﺮﭼ ،نآ ﺮﺑ هوﻼﻋ .دﻮﺷ17 ﻪـﺑ ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا و
ا ﻢﻬﻣ ﺺﺧﺎﺷ ود ناﻮﻨﻋشﻮﻣ رد بﺎﻬﺘﻟﺪﺷ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ يﺎﻫ.
ﻪﺠﯿﺘﻧيﺮﯿﮔ: نﺎﺸﻧ ﻪﻌﻟﺎﻄﻣ ﻦﯾاداد بﺎـﻬﺘﻟا ناﺰﯿﻣ ﺶﯾاﺰﻓا زا ﺖﺳا ﻦﮑﻤﻣ ﯽﻟﺎﺴﮔرﺰﺑ ﺎﺗ ﯽﻧاﻮﺟﻮﻧ نارود رد ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﻪﮐ
ﺷﺎﻧ سﺮﺘﺳا و يﺮﯿﮔﻮﻠﺟ ﻢﺴﯿﺗﺎﻣور يرﺎﻤﯿﺑ زا ﯽﺪﻨﮐ.
هژاو:يﺪﯿﻠﮐ يﺎﻫبﺎﻬﺘﻟا ،ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ،سﺮﺘﺳا ،شزرو
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96ﻞﯿﺑدرا ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ هرودمرﺎﻬﭼ و ﺖﺴﯿﺑ ،هرﺎﻤﺷلوا،رﺎﻬﺑ1403
ﯽﻣ ﻼﺘﺒﻣ يرﺎﻤﯿﺑ ﺪﻧﻮﺷ]2[ﺎﻣ ﻞﯿﻟد ﻪﺑ يرﺎﻤﯿﺑ ﻦﯾا . ﺖﯿﻫ
هﺪﻨﻨﮐ ناﻮﺗﺎﻧ و كﺎﻧدرد ،ﻦﻣﺰﻣ ﺮـﺑ ﯽﻘﯿﻤﻋ تاﺮﯿﺛﺄﺗ ،نآ
ﯽﮔﺪﻧز ﺖﯿﻔﯿﮐ يﺪﻌﺑ ﺪﻨﭼ ﯽﺳرﺮﺑ .دراد ﯽﮔﺪﻧز ﺖﯿﻔﯿﮐ
ﻪــﺑ ﺮــﺠﻨﻣ ﺎــﻬﻨﺗ ﺖﯿﻌــﺿو ﻦــﯾا ﻪــﮐ ﺖــﺳا هداد نﺎــﺸﻧ
ﯽﻤﻧ ﯽﮑﯾﺰﯿﻓ ﺖﯾدوﺪﺤﻣ ﻪـﺒﻨﺟ ﺮﺑ ﻪﮑﻠﺑ دﻮﺷ ﺮـﮕﯾد يﺎـﻫ
ﮑﻠﻤﻋ ﺪﻨﻧﺎﻤﻫ ﯽﮔﺪﻧز ﺖﯿﻔﯿﮐ ﯽﻋﺎـﻤﺘﺟا و ﯽﺘﺧﺎﻨﺸﻧاور دﺮ
،درد ﺖـﻠﻋ ﻪﺑ نارﺎﻤﯿﺑ ﻦﯾا ،ﺮﮕﯾد ترﺎﺒﻋ ﻪﺑ .ﺖﺳا ﺮﺛﻮﻣ
رﺎـﭼد ﻪـﻧازور ﺖـﯿﻟﺎﻌﻓ و ﺖـﮐﺮﺣ ﺖﯾدوﺪـﺤﻣ ،ﯽﮕﺘﺴﺧ
ﻤﻋ رد لﻼﺘــﺧا تﺎــﺳﺎﺴﺣا و ﯽــﻧاور ،ﯽﻧﺎﻤــﺴﺟ دﺮــﮑﻠ
ﯽــﻣ لﻼﺘــﺧا نﺎــﺸﯿﮔﺪﻧز ﺖــﯿﻔﯿﮐ رد ﻪــﺠﯿﺘﻧ رد ،ﺪﻧﻮــﺷ
ﯽﻨﻌﻣﯽﻣ دﻮﺟو ﻪﺑ يراد ﺪﯾآ]3[.
ﻣ تﻻﻼﺘﺧا ﺎﺑ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﺪـﻨﻧﺎﻣ سﺮﺘـﺳا ﺎﺑ ﻂﺒﺗﺮ
ﯽﻨﯿﻤﺨﺗ عﻮﯿﺷ ﺎﺑ ،ﺖﺳا هاﺮﻤﻫ ﯽﮔدﺮﺴﻓا و باﺮﻄﺿا14
ﺪــﺻرد و باﺮﻄــﺿا ياﺮــﺑ8/38
-
8/16 ﺪــﺻرد ياﺮــﺑ
نارﺎـﻤﯿﺑ رد ﺐﻠﻏا ﯽﻧاور ﯽﺒﺼﻋ تﻻﻼﺘﺧا ﻦﯾا .ﯽﮔدﺮﺴﻓا
ﯽﻗﺎـﺑ ﻪﺘﺧﺎﻨـﺷﺎﻧ ترﻮـﺻ ﻪـﺑ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ
ﯽﻤﻧ راﺮﻗ نﺎﻣرد ﺖﺤﺗ و هﺪﻧﺎﻣ ﺪﻧﺮﯿﮔ]4[ تﻻﻼﺘﺧا ﻦﯾا .
ﻂﺒﺗﺮـﻣ ﻢـﺴﯿﺗﺎﻣور ﺖﻓﺮـﺸﯿﭘ و مواﺪـﺗ رد سﺮﺘـﺳا ﺎـﺑ
ﺪـﻣﺎﯿﭘ و يرﺎﻤﯿﺑ ﻦﯾا ﻢﺋﻼﻋ زا ﯽﮑﯾ و ﺖﺳا ﺮﺛﺆﻣ ﯽﻠﺼﻔﻣ
ﯽﻣ نآ ﯽﻨﯿﻟﺎﺑ و ﯽﺘﺧﺎﻨـﺸﻧاور ﺶـﺨﺑ ود ﻞﻣﺎﺷ ﻪﮐ ﺪﺷﺎﺑ
ﯽﺒﺼﻋ تﻻﻼﺘﺧا ﻦﯾا عﻮﻗو .ﺖﺳا ﯽﺘﺧﺎﻨﺷ ﺖﺴﯾز
-
يرﺎﺘﻓر
ﻞـﻣاﻮﻋ زا ﯽـﮑﯾ ﯽﻠـﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد
يرﺎﻤﯿﺑ ﻦﯾا ﯽﻨﯿﻟﺎﺑ ﻢﺋﻼﻋ ﺪﯾﺪﺸﺗﯽﻣ ﻪـﺑ ﻪـﺟﻮﺗ ﺎـﺑ .ﺪﺷﺎﺑ
ﻻﺎـﺑ نﺪـﺑ بﺎﻬﺘﻟا ﺢﻄﺳ يرﺎﻤﯿﺑ ﻦﯾا رد ﻪﮑﻨﯾا ﯽـﻣ و دور
و ﯽﮔدﺮـﺴﻓا و باﺮﻄـﺿا ﺶﯾاﺰـﻓا ﻦﯿـﺑ ﯽﮑﯾدﺰﻧ ﻪﻄﺑار
ﻦﯾﺮـﺘﻤﻬﻣ زا ﯽـﮑﯾ ،دراد دﻮـﺟو نﺪﺑ رد بﺎﻬﺘﻟا ﺶﯾاﺰﻓا
ﻢﺴﯿﻧﺎﮑﻣ يﺎﻫ رد ﯽـﺳﺮﺘﺳا تﻻﻼﺘﺧا ﻦﯾا زوﺮﺑ رد ﺮﯿﮔرد
ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ ﯽـﻣ ﺶﯾاﺰـﻓا ﺪـﻧاﻮﺗ
ﺪﺷﺎﺑ بﺎﻬﺘﻟا ﺢﻄﺳ]5[.
يرﺎﻤﯿﺑ ﻪﻌﺳﻮﺗ و ﺖﻓﺮﺸﯿﭘ رد ﻞﻣاﻮﻋ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور
،ﻪﻧﻮﻤﻧ ناﻮﻨﻋ ﻪﺑ .ﺪﻧراد ﯽﺳﺎﺳا ﺶﻘﻧ ﯽﺑﺎﻬﺘﻟا ﻦﯿﮐﻮﻟﺮﺘﻨﯾا
17
1
ﻦﯿﮐﻮﺘﯿﺳ ﮏﯾ ﺶﯿـﭘ ﺰﻧژﻮﺗﺎـﭘ رد ﻪـﮐ ﺖـﺳا ﯽﺑﺎـﻬﺘﻟا
دراد ﺶــﻘﻧ ﯽﺑﺎــﻬﺘﻟا و ﯽﻨﻤﯾادﻮــﺧ يرﺎــﻤﯿﺑ ﻦﯾﺪــﻨﭼ]6[.
1
Interleukin 17
تاﺮﺛا ﯽﻫﺎﮕﺸﯾﺎﻣزآ تﺎﻌﻟﺎﻄﻣ ﻦﯿﮐﻮﻟﺮﺘﻨﯾا17 ﺮﺑ ار عاﻮﻧا
لﻮﻠﺳهدﺮﮐ ﯽﯾﺎﺳﺎﻨﺷ ﻒﻠﺘﺨﻣ يﺎﻫ ار نآ ﺶـﻘﻧ ﻪـﮐ ﺪـﻧا
يرﺎﯿـﺴﺑ ﻦﻣﺰـﻣ ﻞﺣاﺮﻣ ﺮﺧاوا و ﻪﯿﻟوا ﯽﯾﺎﻘﻟا ﻞﺣاﺮﻣ رد
يرﺎﻤﯿﺑ زاﯽﻣ نﺎﺸﻧ ﻦﻤﯾادﻮﺧ يﺎﻫ ﺪـﻫد]7[. ﺮـﺑ هوﻼـﻋ
ﻊﯾﺎﺷ ناﻮﻨﻋ ﻪﺑ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور رد ،ﻦﯾا يرﺎـﻤﯿﺑ ﻦﯾﺮﺗ
،ﻦﻣﺰـﻣ ﯽﺑﺎـﻬﺘﻟا ﻦﻤﯾادﻮﺧ ﻦﯿﮐﻮـﻟﺮﺘﻨﯾا17 ﺐـﯾﺮﺨﺗ ﻪـﺑ
ﻪﻟﻻز ﻞﺻﺎﻔﻣ ياﯽﻣ ﮏﻤﮐ و ﺪـﻨﮐ ﯽـﻣ ﻪـﺑ ﺮـﺠﻨﻣ ﺪـﻧاﻮﺗ
دﻮـﺷ ناﻮﺨﺘـﺳا ﺶﯾﺎﺳﺮﻓ و فوﺮﻀﻏ يرﺎﺘﺧﺎﺳ ﺐﯿﺳآ
]8[ . ﻦﯿﮐﻮﻟﺮﺘﻨﯾا17ﻦﯿﮐﻮﺘﯿﺳ ﺪﯿﻟﻮﺗ ﺶﯾاﺰﻓا ﺎﺑ يﺎﻫ ﺮﮕﯾد
ﺎـﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا هﮋﯾو ﻪﺑ ،ﯽﺑﺎﻬﺘﻟا
2
ءﺎـﺸﻏ بﺎـﻬﺘﻟا ﺚـﻋﺎﺑ
ﻪﻟﻻزﯽﻣ يا دﻮﺷ]9[ .يﻮﺳ زا ﻦﯿـﺑ ﯽﮑﯾدﺰﻧ طﺎﺒﺗرا ﺮﮕﯾد
ﻦﯿﮐﻮــﻟﺮﺘﻨﯾا ﺢﻄــﺳ ﺶﯾاﺰــﻓا17ــﻓﺮﺘﻨﯾا و ﺎــﺑ ﺎــﻣﺎﮔ نوﺮ
ﺖﺳا هﺪﺷ هﺪﻫﺎﺸﻣ ﯽﮔدﺮﺴﻓا و باﺮﻄﺿا]10،11[.
ﺶﻫﺎـﮐ رﻮﻈﻨﻣ ﻪﺑ ﻪﮐ ﺖﺳا هداد نﺎﺸﻧ ﺪﯾﺪﺟ تﺎﻌﻟﺎﻄﻣ
يرﺎــﻤﯿﺑ ﺖﯿﻌــﺿو دﻮــﺒﻬﺑ و بﺎــﻬﺘﻟا ﺢﻄــﺳ ﻢــﺴﯿﺗﺎﻣور
شور زا هدﺎﻔﺘــﺳا ،ﯽﻠــﺼﻔﻣ و ﯽــﯾوراد ﯽﻧﺎــﻣرد يﺎــﻫ
ﺖـﯿﻟﺎﻌﻓ مﺎـﺠﻧا ﻪـﮐ يرﻮـﻃ ﻪـﺑ ،دراد ﺖـﯿﻤﻫا ﯽﺷزرو
ﺎﻤﯿﺑ ﻦﯾا ﺖﯿﻌﺿو دﻮﺒﻬﺑ ﻪﺑ ﺮﺠﻨﻣ ﯽﺷزرو نارﺎﻤﯿﺑ رد ير
ﯽﻣددﺮﮔ]12،13[ . ،ﺮـﯿﺧا لﺎـﺳ ﺪﻨﭼ ﯽﻃ ﻦـﯾا ﻦﯿـﻘﻘﺤﻣ
ﻪﻌﻟﺎﻄﻣ داد نﺎـﺸﻧ نارﺎﮑﻤﻫ و ﺪـﻧ ﻧﺪـﺑ ﺖـﯿﻟﺎﻌﻓ ﻪـﮐ و ﯽ
ﺮﯿﻏ رﺎﮑﻫار ﮏﯾ ناﻮﻨﻋ ﻪﺑ شزرو ﺶﻫﺎـﮐ ياﺮـﺑ ﯽﯾوراد
ﯽﻧاﻮـﯿﺣ و ﯽﻧﺎـﺴﻧا تﺎﻌﻟﺎﻄﻣ ﻪﺟﻮﺗ درﻮﻣ سﺮﺘﺳا ﺢﻄﺳ
ﺖﺳا ﻪﺘﻓﺮﮔ راﺮﻗ دﺪﻌﺘﻣ]22
-
14[ . تاﺮـﺛا لﺎـﺣ ﻦـﯾا ﺎـﺑ
ـﻤﯿﺑ ﻂﯾاﺮﺷ رد ﺎﻬﻧآ رﻮـﻃ ﻪـﺑ ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور يرﺎ
رﻮـﻈﻨﻣ ﻪـﺑ ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد .ﺖﺳا هﺪﺸﻧ ﺺﺨﺸﻣ ﻞﻣﺎﮐ
ﺎـــﺗ ﯽﻧاﻮـــﺟﻮﻧ نارود رد ﯽـــﮑﯾﺰﯿﻓ ﺖـــﯿﻟﺎﻌﻓ ﺶﯾاﺰـــﻓا
ﺰــﻐﻣ ﻪﻌــﺳﻮﺗ رد ﯽــﻤﻬﻣ رﺎﯿــﺴﺑ هرود ﻪــﮐ ﯽﻟﺎــﺴﮔرﺰﺑ
ﯽــﻣ ــﭼ زا ،ﺪــﺷﺎﺑ ﺎــﺗ ﺖــﺳا هﺪــﺷ هدﺎﻔﺘــﺳا راود خﺮ
ﺐﯿﺳآ بﺎـﻬﺘﻟا و ﯽـﺳﺮﺘﺳا تﻻﻼﺘـﺧا ﻪﺑ تﺎﻧاﻮﯿﺣ يﺮﯾﺬﭘ
ﻣور يرﺎــﻤﯿﺑ زا ﯽــﺷﺎﻧ ﯽﻟﺎــﺴﮔرﺰﺑ رد ﯽﻠــﺼﻔﻣ ﻢــﺴﯿﺗﺎ
.دﻮﺷ ﯽﺳرﺮﺑ
2
Interferon Gamma
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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سﺮﺘﺳا ﺮﺑ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺄﺗ...رﻮﭘ ﯽﻣﺎﯿﭘ اﺪﯿﺷنارﺎﮑﻤﻫ و97
رﺎﮐ شور
تﺎﻧاﻮﯿﺣ
و يدﺎﯿﻨﺑ تﺎﻌﻟﺎﻄﻣ عﻮﻧ زا ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ﯽـﺑﺮﺠﺗ عﻮـﻧ
ﯽــﻣ.ﺪــﺷﺎﺑ ،ﺮــﺿﺎﺣ ﺶﻫوﮋــﭘ ياﺮــﺟا رﻮــﻈﻨﻣ ﻪــﺑ اﺪــﺘﺑا
شﻮﻣ داﮋﻧ ﺮﻧ يﺎﻫBalbc نزو ﺎـﺑ11
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10 ﻦـﺳ) مﺮـﮔ
21 تﺎﻧاﻮﯿﺣ ﻪﻧﺎﺧ زا (ﯽﮔزور» ﯽﺘﺧﺎﻨﺷ تﻻﻼﺘﺧا ﻪﺴﺳﻮﻣ
) يرﻻﺎــﺳ يرﺎــﺘﻓر وSICBD«( مﺎــﻤﺗ و ﺪﻧﺪــﺷ ﻪــﯿﻬﺗ
ﺶﯾﺎﻣزآ ﮏـﯾ رد تﺎﻧاﻮﯿﺣ .ﺪﺷ مﺎﺠﻧا ﻪﺴﺳﺆﻣ ﻦﯾا رد ﺎﻫ
رﻮـﻧ ﻪـﺧﺮﭼ ﺎـﺑ ﺖﮐﺎﺳ قﺎﺗا
-
ﯽﮑﯾرﺎـﺗ12/12 و ﺖﻋﺎـﺳ
:ﺎـﻣد) دراﺪﻧﺎﺘﺳا ﻂﯾاﺮﺷ5/0±5/23 ،داﺮﮕﯿﺘﻧﺎـﺳ ﻪـﺟرد
:ﺖﺑﻮﻃر40
-
50 دازآ ﯽـﺳﺮﺘﺳد و ﺪﻧﺪـﺷ يراﺪﻬﮕﻧ (%
ﺪﻨﺘﺷاد بآ و اﺬﻏ ﻪﺑ]14[. شﻮـﻣ ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد يﺎـﻫ
ﺖﯿﺳﺎﺴﺣ ﻪﮐ ﺮﻧ ﺎـﻘﻟا ياﺮﺑ يﺮﺘﻬﺑء ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور
ﺪﺷ هدﺎﻔﺘﺳا ﺪﻧرادﺪﻧ ﻪـﺘﯿﻤﮐ ﺪـﯿﯾﺎﺗ درﻮـﻣ ﻞﺣاﺮﻣ ﻪﯿﻠﮐ .
ﺎـﺑ يرﺎـﺳ ﺪﺣاو ﯽﻣﻼﺳا دازآ هﺎﮕﺸﻧاد قﻼﺧا و ﺶﻫوﮋﭘ
قﻼــﺧا ﺪــﮐIR.IAU.SARI.REC.1401.183 راﺮــﻗ
.ﺖﻓﺮﮔ
هوﺮﮔتﺎﻧاﻮﯿﺣ يﺪﻨﺑ
داﺪﻌﺗ ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد40 ﻪﺑ ناﻮﺟﻮﻧ شﻮﻣ ﺮﺳ4 هوﺮﮔ
:ﺪﻧﺪــﺷ ﻢﯿــﺴﻘﺗ هوﺮــﮔﯽــﻤﻧ شزرو :لوا لﻼــﺣ و ﺪــﻨﻨﮐ
ﯽﻣ ﺖﻓﺎﯾردﯽﻤﻧ شزرو :مود هوﺮﮔ ؛(ﻢﻟﺎﺳ) ﺪﻨﻨﮐ ﺪـﻨﻨﮐ
ﯽـﻣ ﯽﻠـﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ و ؛(ﻢـﺴﯿﺗﺎﻣور) ﺪﻧﻮـﺷ
ﯽﻣ شزرو :مﻮﺳ هوﺮﮔ ﯽـﻣ ﺖﻓﺎﯾرد لﻼﺣ و ﺪﻨﻨﮐ ﺪـﻨﻨﮐ
)شزرو ﯽـﻣ شزرو :مرﺎـﻬﭼ هوﺮﮔ ؛( ﻪـﺑ ﻼﺘـﺒﻣ و ﺪـﻨﻨﮐ
ﯽﻣ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور رد .(ﻢـﺴﯿﺗﺎﻣور +شزرو) ﺪﻧﻮـﺷ
ﮔ ﺮﻫ داﺪﻌﺗ هوﺮ10.دراد راﺮﻗ شﻮﻣ ﺮﺳ
ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ
هوﺮﮔ ،ﻻﺎﺑ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﺖﻬﺟ يﺎﻫ زا ،ﯽﺷزرو
ﻦــﺳ21 ﺎــﺗ90 راﺮــﻗ راود خﺮــﭼ ضﺮــﻌﻣ رد ﯽــﮔزور
ﺪﻨﺘﻓﺮﮔ]17[. ود ،ﻪﺻﻼﺧ رﻮﻃ ﻪﺑ رد ﺮـﻧ ناﻮﺟﻮﻧ شﻮﻣ
ﻦﺸﯿﺗرﺎﭘ ﺲﻔﻗ ﮏﯾيﺪﻨﺑ) هﺪﺷ ،تﺎﻨﺑﺮﮐ ﯽﻠﭘ20×38×58
ﯽﺘﻧﺎﺳﯽﮑﯾﺰﯿﻓ سﺎﻤﺗ نوﺪﺑ (ﺮﺘﻣ ﺮﻫ و ﺪﻧﺪﺷ هداد راﺮﻗ
خﺮـﭼ ﮏـﯾ ﻪـﺑ دازآ ﯽـﺳﺮﺘﺳد شﻮﻣ :ﺮـﻄﻗ) راود14
:ضﺮﻋ ؛ﺮﺘﻣ ﯽﺘﻧﺎﺳ5 ﻪـﮐ ﯽـﻫوﺮﮔ .ﺖـﺷاد (ﺮﺘﻣ ﯽﺘﻧﺎﺳ
دﺮــﮑﻧ شزرو ﺲــﻔﻗ ضﺮــﻌﻣ رد ﺪــﻧدﻮﺑ ه ﺎــﺑ ﯽﯾﺎــﻫ
خﺮﭼيﺎﻫ .ﺪﻨﺘﻓﺮﮔ راﺮﻗ هﺪﺷ ﻞﻔﻗ راود
ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يﺎﻘﻟا
ﻒـﻗﻮﺗ زا ﺲـﭘ زور هد ،ﯽﻠـﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يﺎﻘﻟا ﺖﻬﺟ
ﻦـــﺳ رد ،شزرو100 رد ﺎـــﺒﻗﺎﻌﺘﻣ و113 ،ﯽـــﮔزور
نﻮﯿـﺴﻟﻮﻣا تﺎﻧاﻮﯿﺣ ترﻮـﺻ ﻪـﺑ ار ﺖـﻧاﻮﺟدا و نژﻼـﮐ
ﺮﯾز نژﻼـﮐ زا نﻮﯿﺴﻟﻮﻣا ﺐﯿﮐﺮﺗ .ﺪﻧدﺮﮐ ﺖﻓﺎﯾرد يﺪﻠﺟ
عﻮﻧII)Chondrex ﻞـﻣﺎﮐ ﺖـﻧاﻮﺟدا و (هﺪﺤﺘﻣ تﻻﺎﯾا ،
)Sigma Co ﺰﺗ .دﻮـﺑ هﺪﺷ ﻞﯿﮑﺸﺗ (هﺪﺤﺘﻣ تﻻﺎﯾا ، ﻖـﯾر
ﺮﯾز تﺎـﻧاﻮﯿﺣ مد ﻪﯾﺎﭘ رد ﻪﯿﺣﺎﻧ ﻪﺳ رد نﻮﯿﺴﻟﻮﻣا يﺪﻠﺟ
ﺪﺷ مﺎﺠﻧا]23[ رد نژﻼﮐ .1/0 ﻞـﺣ ﮏﯿﺘـﺳا ﺪﯿﺳا رﻻﻮﻣ
ﺮـﻫ و ﺪـﺷ ﺐﯿﮐﺮﺗ ﻞﻣﺎﮐ ﺖﻧاﻮﺟدا زا يوﺎﺴﻣ ﻢﺠﺣ ﺎﺑ و
شﻮــﻣ100 ﺖــﻓﺎﯾرد ار نﻮﯿــﺴﻟﻮﻣا ﻦــﯾا زا ﺮــﺘﯿﻟوﺮﮑﯿﻣ
هوﺮﮔ .دﺮﮐ ﻂـﻘﻓ ﻢﻟﺎﺳ تﺎﻧاﻮﯿﺣ100 ﺪﯿـﺳا ﺮـﺘﯿﻟوﺮﮑﯿﻣ
) ﮏﯿﺘﺳا1/0 زا .ﺪـﻧدﺮﮐ ﺖـﻓﺎﯾرد لﻼﺣ ناﻮﻨﻋ ﻪﺑ (رﻻﻮﻣ
ﺤﺗ ﻦﯿﻟوا زا ﺲﭘ ﻢﻫد زور ﻪﻠﯿـﺳﻮﺑ ﯽـﻨﻤﯾا ﻢﺘـﺴﯿﺳ ﮏﯾﺮ
زا ﯽﻨﯿﻟﺎـﺑ ﻢـﺋﻼﻋ ﺖﻓﺮﺸﯿﭘ ،ﺖﻧاﻮﺟدا و نژﻼﮐ نﻮﯿﺴﻟﻮﻣا
ﺖﺳار ﺐﻘﻋ يﺎﭘ ﻞﺼﻔﻣ و ﻪﺠﻨﭘ ﺖﻣﺎﺨﺿ ﺶﯾاﺰﻓا ﻖﯾﺮﻃ
يرﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺑا زا ﺲﭘ تﺎﻧاﻮﯿﺣ .ﺖﻓﺮﮔ راﺮﻗ ﺪﯿﯾﺎﺗ درﻮﻣ
هدﺮﮑﻧ شزرو.ﺪﻧا
تﺎﻧاﻮﯿﺣ رد سﺮﺘﺳا ﺶﺠﻨﺳ
هوﻼﻌﺑ ﻊﻔﺗﺮﻣ زﺎﻣ ﺖﺴﺗيا ﻞﮑـﺷ
1
: زور ﺖـﻔﻫ و ﺖـﺴﯿﺑ
زا ﺲﭘ،ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يﺎﻘﻟا ﻦـﺳ رد تﺎـﻧاﻮﯿﺣ127
ﻄﺿا ﺢﻄﺳ ﺶﺠﻨﺳ درﻮﻣ ﯽﮔزور زﺎﻣ ﺖﺴﺗ ﻂﺳﻮﺗ باﺮ
هوﻼﻌﺑ ﻊﻔﺗﺮﻣيا .ﺪـﻨﺘﻓﺮﮔ راﺮﻗ ﻞﮑﺷ ياراد هﺎﮕﺘـﺳد ﻦـﯾا
ﻪﺘـﺴﺑ يوزﺎـﺑ ﺎﺗ ود و زﺎﺑ يوزﺎﺑ ﺎﺗ ود ﻞﻣﺎﺷ ،وزﺎﺑ رﺎﻬﭼ
ﺎـﻫوزﺎﺑ دﺎـﻌﺑا .ﺖـﺳا (+) ﺖـﺒﺜﻣ ﺖـﻣﻼﻋ ﻞﮑﺷ ﻪﺑ5×30
ﯽﺘﻧﺎﺳﺮﺘﻣ ﻪﺘـﺴﺑ يﺎﻫوزﺎﺑ و هدﻮﺑ هراﻮـﯾد ياراد ﻪـﺑ يا
يﺪﻨﻠﺑ15هدﻮﺑ ﺮﺘﻣ ﯽﺘﻧﺎﺳ ياﺮﺑ زﺎﺑ يﺎﻫوزﺎﺑ ﻪﮑﯿﻟﺎﺣ رد
ﻮﻠﺟ ﻪـﺒﻟ ياراد شﻮـﻣ ندﺎـﺘﻓا زا يﺮﯿﮔ يا عﺎـﻔﺗرا ﻪـﺑ1
ﯽﺘﻧﺎﺳدﻮﺑ ﺮﺘﻣ يﺰﮐﺮﻣ هدوﺪﺤﻣ ﮏﯾ ﻪﺑ وﺮﻫار رﺎﻬﭼ .ﺪﻧ
دﺎﻌﺑا ﻪﺑ5×5ﯽﻣ ﯽﻬﺘﻨﻣ ﺮﺘﻣ ﯽﺘﻧﺎﺳ زا زﺎـﻣ عﺎﻔﺗرا .ﺪﻧﻮﺷ
ﻦﯿﻣز50 دﻮـﺑ ﺮﺘﻣ ﯽﺘﻧﺎﺳ. ﻮـﻣش ﺎـﻫ نورد دوﺪـﺤﻣه
1
Elevated Plus Maze
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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98ﻞﯿﺑدرا ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ هرودمرﺎﻬﭼ و ﺖﺴﯿﺑ ،هرﺎﻤﺷلوا،رﺎﻬﺑ1403
ﺷ هداد راﺮﻗ زﺎﻣ يﺰﮐﺮﻣﺪ .ﺪﻧ ﮏـﯾ ﻂـﺳﻮﺗ ﺐﺳﺎﻨﻣ رﻮﻧ
ﭗـﻣﻻ100 عﺎـﻔﺗرا رد ﻪـﮐ ﯽـﺗاو120 ﯽﺘﻧﺎـﺳ زا يﺮـﺘﻣ
ﺰﮐﺮﻣزﺎﻣ داﺪـﻌﺗ و نﺎـﻣز تﺪﻣ .ﺪﺷ ﻦﯿﻣﺎﺗ ،دراد راﺮﻗ
تﺪﻣ رد زﺎﺑ يﺎﻫوزﺎﺑ رد شﻮﻣ رﻮﻀﺣ تﺎﻌﻓد5 ﻪﻘﯿﻗد
ﺺﺧﺎﺷ ناﻮﻨﻋ ﻪﺑ ﺪـﺷ ﻪـﺘﻓﺮﮔ ﺮﻈﻧ رد سﺮﺘﺳا ﺶﻫﺎﮐ
]24[.
ﯽﻋﺎﻤﺘﺟا ﻞﻣﺎﻌﺗ ﺖﺴﺗ
1
:ﻓر ﻦﯾا ياﺮﺑ ﻢﻬﻣ ﺺﺧﺎﺷ ﮏﯾ رﺎﺘ
ﯽـﻣ ﯽﮔدﺮـﺴﻓا و باﺮﻄﺿا ﯽﺑﺎﯾزرا رد تﺎـﻧاﻮﯿﺣ .ﺪـﺷﺎﺑ
ﻦــﺳ129 ،ﯽــﮔزور29 ﻢــﺴﯿﺗﺎﻣور يﺎــﻘﻟا زا ﺲــﭘ زور
راﺮــﻗ ﯽﻋﺎــﻤﺘﺟا رﺎــﺘﻓر ﺢﻄــﺳ ﺶﺠﻨــﺳ درﻮــﻣ ﯽﻠــﺼﻔﻣ
ﻪـﺒﻌﺟ ﮏـﯾ رد ﻪﮐ دﻮﺑ ترﻮﺻ ﻦﯾﺪﺑ رﺎﮐ شور .ﺪﻨﺘﻓﺮﮔ
ﻊﺑﺮﻣ50×80×80ﺘﻧﺎﺳ ﮏـﯾ ضﺮـﻌﻣ رد ناﻮﯿﺣ ﺮﻫ ﺮﺘﻤﯿ
ﺎﻧ شﻮﻣراﺮﻗ ﺎﻨﺷآﯽﻣﺮﯿﮔ تﺪﻣ ﻪﺑ و د7 راﺪـﻘﻣ ﻪﻘﯿﻗد
ﺖــﻗو ﺮﮕﯾﺪــﮑﯾ ﺎــﺑ ﻞــﻣﺎﻌﺗ رد تﺎــﻧاﻮﯿﺣ ﻪــﮐ ﯽﻧﺎــﻣز
ﻧارﺬﮔهﺪ ﺪﻧا ﻢـﻫ يور ،ﺲـﻤﻟ ،ﺐـﯿﻘﻌﺗ ،نﺪـﯿﯾﻮﺑ ﻞﻣﺎﺷ
ﻓر ﺺﺧﺎﺷ ناﻮﻨﻋ ﻪﺑ ﺮﮕﯾﺪﮑﯾ نﺪﯾﺮﭘ ﺮﻈﻧ رد ﯽﻋﺎﻤﺘﺟا رﺎﺘ
ﺪـﺷ ﻪﺘﻓﺮﮔ ندﻮـﺑ ﻦﯿﯾﺎـﭘ . نﺎـﺸﻧ ﻞـﻣﺎﻌﺗ نﺎـﻣز هﺪـﻨﻫد
سﺮﺘﺳا ﺶﻫﺎﮐدﻮﺑ]15[.
يرﺎﺒﺟا يﺎﻨﺷ ﺖﺴﺗ
2
: ﻦﺳ رد تﺎﻧاﻮﯿﺣ132 ،ﯽﮔزور32
ﺶﺠﻨـﺳ درﻮـﻣ ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور يﺎـﻘﻟا زا ﺲﭘ زور
.ﺪﻨﺘﻓﺮﮔ راﺮﻗ ﯽﮔدﺮﺴﻓا رﺎﺘﻓر ﺢﻄﺳ ﮏـﯾ رد ﺖـﺴﺗ ﻦﯾا
ﻪﺴﻠﺟ6ﻪﻘﯿﻗداي.ﺪﺷ مﺎﺠﻧا ﻪـﺸﯿﺷ ﻪﻧاﻮﺘـﺳا ﮏﯾا ي ﻪـﺑ
ﺮﻄﻗ10عﺎﻔﺗراو ﺮﺘﻣ ﯽﺘﻧﺎﺳ25ﯽﺘﻧﺎﺳﺮﺘﻣ ﻖـﻤﻋ ﻪﺑ15
ﯽﺘﻧﺎﺳ يﺎﻣد ﺎﺑ بآ ﺮﺘﻣ25 ناﻮـﻨﻋ ﻪـﺑ داﺮﮕﯿﺘﻧﺎـﺳ ﻪﺟرد
ناﻮﯿﺣ يﺎﻨﺷ ﻞﺤﻣ ﻪﺑ ناﻮﯿﺣ .ﺖﻓﺮﮔ راﺮﻗ هدﺎﻔﺘﺳا درﻮﻣ
و ﺪــﺷ هداد راﺮــﻗ نﻮــﻣزآ فﺮــﻇ ﻞــﺧاد ﯽــﻣارآ
تﺪﻣ رد ناﻮﯿﺣ ﯽﺘﮐﺮﺣ ﯽﺑ نﺎﻣز4 ﺖـﺒﺛ ﯽﯾﺎـﻬﺘﻧا ﻪﻘﯿﻗد
ﻒـﯾﺮﻌﺗ ترﻮـﺻ ﻦﯾا ﻪﺑ ﯽﺘﮐﺮﺣ ﯽﺑ .ﺪﺷ ﯽـﻣ دﻮـﺷ ﻪـﮐ
ﻖﻠﻌﻣ دﻮﻤﻋ ﺖﯿﻌﺿو ﮏﯾ رد ،بآ رد ناﻮﯿﺣﯽﻣ دﻮـﺷو
ﺮﻫ .دﻮﺸﻧ هﺪﻫﺎﺸﻣ ﯽﻓﺎﺿا ﺖﮐﺮﺣ ﭻﯿﻫ تﺪـﻣ ﻦـﯾا ﻪـﭼ
ﺪﺷﺎﺑ ﺮﺘﻤﮐ نﺎﻣزنﺎﺸﻧ ناﻮـﯿﺣ ﻪـﮐ ﺖـﺳا ﻦـﯾا هﺪـﻨﻫد
دراد يﺮﺘﻤﮐ سﺮﺘﺳا]25[.
1
Social Interaction Test
2
Forsed Swim Test
ﻦﯿﮐﻮﺘﯿﺳ ﺶﺠﻨﺳ و يﺮﯿﮕﻧﻮﺧ يﺎﻫ ﯽﺑﺎﻬﺘﻟا
ﺖـﺴﺗ ﻞـﯿﻤﮑﺗ زا ﺲﭘ شﻮـﻣ ،يرﺎـﺘﻓر يﺎـﻫ ﻂـﺳﻮﺗ ﺎـﻫ
) ﻦﯿﻣﺎﺘﮐ ﺐﯿﮐﺮﺗ50ﯽﻠﯿﻣ(مﺮﮔﻮﻠﯿﮐ ﺮﺑ مﺮﮔو ﻦـﯾزﻼﯾاز
)5ﯽﻠﯿﻣﯽﺑ (مﺮﮔﻮﻠﯿﮐ ﺮﺑ مﺮﮔ .ﺪﻧﺪﺷ هداد ﻖﯿﻤﻋ ﯽﺷﻮﻫ
ﺮﮑﯿﻣ رد و ﻪﺘﻓﺮﮔ ﺐﻠﻗ زا نﻮﺧ ﺲﭙﺳ ﻪﺑ ﻞﯾﺮﺘﺳا بﻮﯿﺗو
تﺪﻣ20 زا هدﺎﻔﺘـﺳا ﺎـﺑ ﺲﭙـﺳ .ﺪـﺷ هداد راﺮﻗ ﻪﻘﯿﻗد
رود ﺎـــﺑ ژﻮﯿﻔﯾﺮﺘﻧﺎـــﺳ8000 مﺮـــﺳ ﻪـــﻘﯿﻗد رد رود
ﻦﯿﮐﻮــﻟﺮﺘﻨﯾا ﺶﺠﻨــﺳ رﻮــﻈﻨﻣ ﻪــﺑ و يزﺎــﺳاﺪﺟ17 و
اﺰـﯾﻻا ﯽﺠﻨـﺳرﻮﻧ ﮏـﯿﻨﮑﺗ زا هدﺎﻔﺘـﺳا ﺎﺑ ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا
ﺶﺠﻨـﺳ ﻞـﻤﻌﻟا رﻮﺘـﺳد .ﺖـﻓﺮﮔ راﺮـﻗ هدﺎﻔﺘـﺳا درﻮﻣ
ﻦﯿﮐﻮﺘﯿــﺳ ﺎــﻫﺖــﯿﮐ سﺎــﺳا ﺮــﺑــﻫ يﺎ ﺖﮐﺮــﺷ ﺖﺧﺎــﺳ
Abcamﻪﻧﻮﻤﻧ مﺎﻤﺗ ،ﻪﮐ ترﻮﺻ ﻦﯾﺪﺑ .ﺪﺷ مﺎﺠﻧا ﻪـﺑ ﺎﻫ
يراﺮﮑﺗ ﻪﻧﻮﻤﻧ ود ترﻮﺻ
3
.ﺪﻨﺘﻓﺮﮔ راﺮﻗ هدﺎﻔﺘﺳا درﻮﻣ
ﺮﻌﻣ ﯽﻣﺎﻤﺗ اﺪﺘﺑافﻪﻧﻮﻤﻧ و ،ﺎﻫدراﺪﻧﺎﺘﺳا ،ﺎﻫ مﺮـﺳ يﺎـﻫ
،ﺪــﻌﺑ ﻪــﻠﺣﺮﻣ رد .ﺪﻧﺪــﺷ هدﺎــﻣآ هدﺎﻔﺘــﺳا ﺖــﻬﺟ50
ﻪﻧﻮﻤﻧ زا ﺮﺘﯿﻟوﺮﮑﯿﻣ ـﻫﺎﭼ ﻪـﺑ ﺎﻫدراﺪﻧﺎﺘـﺳا و ﺎـﻫﮏ يﺎـﻫ
ﺖﯿﻠﭘوﺮﮑﯿﻣ راﺪﻘﻣ و هﺪﺷ ﻪﻓﺎﺿا50 ﻞـﺘﮐﻮﮐ ﺮﺘﯿﻟوﺮﮑﯿﻣ
ﯽﺘﻧآ ﻦﯿﮐﻮـﻟﺮﺘﻨﯾا يدﺎﺑ17 ﺮـﻫ ﻪـﺑ ﺎـﻣﺎﮔ نوﺮـﻓﺮﺘﻨﯾا ﺎـﯾ
ﺪﺷ ﻪﻓﺎﺿا ﮏﻫﺎﭼ ﻪـﺑ ﺖﯿﻠﭘوﺮﮑﯿﻣ ،ﻪﻠﺣﺮﻣ ﻦﯾا رد . تﺪـﻣ
ﮏﯾ ﺎـﺑ ﺮﮑﯿـﺷ ﮏـﯾ يور قﺎﺗا يﺎﻣد رد ﺖﻋﺎﺳ400 رود
راﺮﻗ ﻪﻘﯿﻗد رد ﺶﺧﺮﭼﺪﺷ هدادﻫﺎﭼ مﺎﻤﺗ ﺲﭙﺳ .ﮏ ﺎـﻫ
ﻪﻠﯿﺳﻮﺑ ﻪﺒﺗﺮﻣ ﻪﺳ350 ﺮﻓﺎـﺑ ﺮـﺘﯿﻟوﺮﮑﯿﻣPT
4
ﻮـﺸﺘﺴﺷ
راﺪـﻘﻣ ،ﻪـﻠﺣﺮﻣ ﻦـﯾا زا ﺪﻌﺑ .ﺪﺷ هداد100 ﺮـﺘﯿﻟوﺮﮑﯿﻣ
لﻼﺣTMB
5
تﺪﻣ ﻪﺑ و ﻪﻓﺎﺿا ﮏﻫﺎﭼ ﺮﻫ ﻪﺑ10 ﻪـﻘﯿﻗد
ﺎــﺑ ﺮﮑﯿــﺷ يور ﺮــﺑ ﮏــﯾرﺎﺗ ﻂﯿــﺤﻣ ﮏــﯾ رد400 رود
ﺲﭙــﺳ و هداد راﺮــﻗ ﻪــﻘﯿﻗد رد ﺶﺧﺮــﭼ راﺪــﻘﻣ100
ﻒﻗﻮﺘﻣ لﻮﻠﺤﻣ ﺮﺘﯿﻟوﺮﮑﯿﻣ ﻪﻓﺎـﺿا ﮏـﻫﺎﭼ ﺮـﻫ ﻪﺑ هﺪﻨﻨﮐ
ﺪــﯾدﺮﮔ ا ﺲــﭘ ،ﯽﯾﺎــﻬﺘﻧا ﻪــﻠﺣﺮﻣ رد . ﻪــﻘﯿﻗد ﮏــﯾ ز
جﻮﻣ لﻮﻃ رد ﺖﯿﻠﭘوﺮﮑﯿﻣ450.ﺪﺷ ﺖﺋاﺮﻗ ﺮﺘﻣ ﻮﻧﺎﻧ
هداد ﻞﯿﻠﺤﺗ ﺎﻫ
راﺰــﻓا مﺮــﻧ زا هدﺎﻔﺘــﺳا ﺎــﺑ ﻪــﻌﻟﺎﻄﻣ ﻦــﯾا ردSPSS-26
هداد ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ ﻪﻓﺮﻃ ود ﺲﻧﺎﯾراو ﺰﯿﻟﺎﻧآ ﺖﺤﺗ ﺎﻫ
3
Duplicate
4
Prothrombin Time
5
3,3',5,5'-Tetramethylbenzidine
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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سﺮﺘﺳا ﺮﺑ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺄﺗ...رﻮﭘ ﯽﻣﺎﯿﭘ اﺪﯿﺷنارﺎﮑﻤﻫ و99
ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ .ﺪﻧﺪﺷ ﯽﮐﻮﺗﻪﺴﯾﺎﻘﻣ ياﺮﺑ ﻪﻧﺎﮔﺪﻨﭼ يﺎﻫ
هداد .ﺪــﺷ هدﺎﻔﺘــﺳاﻦﯿﮕﻧﺎــﯿﻣ ترﻮــﺻ ﻪــﺑ ﺎــﻫ± يﺎــﻄﺧ
ا و هﺪـﺷ ﻪﺋارا ﻦﯿﮕﻧﺎﯿﻣ دراﺪﻧﺎﺘﺳ05/0<p ﯽـﻨﻌﻣ رد راد
.ﺪﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ
ﻪﺘﻓﺎﯾﺎﻫ
ﺖﺴﺗهوﻼﻌﺑ هزﺎﻣاﻞﮑﺷ ي
ود نﻮـﻣزآ ،زﺎـﺑ يوزﺎـﺑ رد نﺪـﺷ يﺮﭙـﺳ نﺎﻣز ياﺮﺑ
ﯽﻣ نﺎﺸﻧ ﻪﻓﺮﻃ شزرو ﯽﻠـﺻا تاﺮﺛا ﺮﺑ هوﻼﻋ ﻪﮐ ﺪﻫد
)019/0=p ) ﯽﻠــﺼﻔﻣ ﻢــﺴﯿﺗﺎﻣور و (001/0<p ﻦﯿــﺑ ،(
ﯽــﻨﻌﻣ ﺮــﺛا ﯽﻠــﺼﻔﻣ ﻢــﺴﯿﺗﺎﻣور و شزرو ﯽﻠﻣﺎــﻌﺗ راد
)004/0=p داﺪــﻌﺗ ياﺮــﺑ ،نآ ﺮــﺑ هوﻼــﻋ .دراد دﻮــﺟو (
نﺎﺸﻧ ﻪﻓﺮﻃ ود نﻮﻣزآ ،زﺎﺑ يوزﺎﺑ ﻪﺑ دورو تﺎﻌﻓدداد
) شزرو ﯽﻠــﺻا تاﺮــﺛا ﺮــﺑ هوﻼــﻋ ﻪــﮐ033/0=p و (
) ﯽﻠــــﺼﻔﻣ ﻢــــﺴﯿﺗﺎﻣور001/0<p و شزرو ﻦﯿــــﺑ ،(
ﯽــﻨﻌﻣ ﺮــﺛا ﯽﻠــﺼﻔﻣ ﻢــﺴﯿﺗﺎﻣور) ﯽﻠﻣﺎــﻌﺗ راد004/0=p (
.دراد دﻮﺟو
وز ﻪﺴﯾﺎﻘﻣ رﻮﻈﻨﻣ ﻪﺑهوﺮﮔ ﻦﯿﺑ ﯽﺟ رد ﻪﻌﻟﺎﻄﻣ درﻮﻣ ﺎﻫ
ﺎﺑ طﺎﺒﺗرا هوﻼـﻌﺑ زﺎـﻣ ﺖﺴﺗ رد سﺮﺘﺳا ناﺰﯿﻣا ﻞﮑـﺷ ي
داﺪـﻌﺗ و هﺪـﺷ يﺮﭙـﺳ نﺎـﻣز ناﺰـﯿﻣ ﺮﺘﻣارﺎﭘ ود ياﺮﺑ
ﯽﮐﻮـﺗ ﯽـﺒﯿﻘﻌﺗ نﻮـﻣزآ زا زﺎﺑ يﺎﻫوزﺎﺑ ﻪﺑ دورو تﺎﻌﻓد
رادﻮﻤﻧ) ﺪﺷ هدﺎﻔﺘﺳا1 رادﻮﻤﻧ .(1 ﯽـﻣ نﺎﺸﻧ ﻪـﮐ ﺪـﻫد
ز ناﺰـﯿﻣ ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يﺎﻘﻟا نﺎـﻣ
) هﺪـــﺷ يﺮﭙـــﺳ001/0p< دورو تﺎـــﻌﻓد داﺪـــﻌﺗ و (
)001/0p<شﻮﻣ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد زﺎﺑ يوزﺎﺑ ﻪﺑ ( ﻢﻟﺎﺳ يﺎﻫ
شﻮﻣ رد شزرو ،ﻦﯾا ﺮﺑ هوﻼﻋ .ﺖﺳا هﺪﺷ ﻪﺑ ﻼﺘﺒﻣ يﺎﻫ
هﺪـﺷ يﺮﭙﺳ نﺎﻣز ناﺰﯿﻣ ﺶﯾاﺰﻓا ﺎﺑ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور
)001/0p<) دورو تﺎـــﻌﻓد داﺪـــﻌﺗ و (001/0p< ﻪـــﺑ (
ور هوﺮـﮔ ﺎـﺑ ﻪـﺴﯾﺎﻘﻣ رد زﺎﺑ يوزﺎﺑ ﻪـﺑ ﺮـﺠﻨﻣ ﻢـﺴﯿﺗﺎﻣ
ﻪـﮐ ﺖـﺳا ﯽـﻨﻌﻣ ناﺪﺑ ﻦﯾا .ﺖﺳا هﺪﺷ سﺮﺘﺳا ﺶﻫﺎﮐ
ﯽﻣ ﯽﻧاﻮﺟﻮﻧ ﻞﯾاوا زا شزروشﻮﻣ ﺖﻣوﺎﻘﻣ ﺪﻧاﻮﺗ يﺎـﻫ
يرﺎــﻤﯿﺑ يﺎــﻘﻟا زا ﯽــﺷﺎﻧ سﺮﺘــﺳا ﺮــﺑاﺮﺑ رد ار ﻎﻟﺎــﺑ
.ﺪﻫد ﺶﯾاﺰﻓا ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور
رادﻮﻤﻧ1هوﻼﻌﺑ ﻊﻔﺗﺮﻣ زﺎﻣ ﺖﺴﺗ رد سﺮﺘﺳا ﺮﯾدﺎﻘﻣ تاﺮﯿﯿﻐﺗ . ،ﻞﮑﺷ ﯽﯾا"ﻒﻟا"هﺪﻨﻫد نﺎﺸﻧ و زﺎﺑ يوزﺎﺑ رد نﺪﺷ يﺮﭙﺳ نﺎﻣز"ب" داﺪﻌﺗ هﺪﻨﻫد نﺎﺸﻧ
ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ﮏﯾ .زﺎﺑ يوزﺎﺑ ﻪﺑ دورو تﺎﻌﻓد05/0P< ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ود ؛01/0P< ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ﻪﺳ ؛001/0P<
ﯽﻋﺎﻤﺘﺟا رﺎﺘﻓر ﺖﺴﺗ
نﺎﺸﻧ ﻪﻓﺮﻃ ود نﻮﻣزآداد ﯽﻠـﺻا تاﺮـﺛا ﺮـﺑ هوﻼﻋ ﻪﮐ
) شزرو037/0=pــﺴﯿﺗﺎﻣور و () ﯽﻠــﺼﻔﻣ ﻢ001/0<p ،(
ﯽـﻨﻌﻣ ﺮـﺛا ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور و شزرو ﻦﯿﺑ ﯽﻠﻣﺎـﻌﺗ راد
)02/0=p رد ( .دراد دﻮـــﺟو ﯽﻋﺎـــﻤﺘﺟا ﻞـــﻣﺎﻌﺗ ﺖـــﺴﺗ
ﻪﺑهوﺮﮔ ﻦﯿﺑ ﯽﺟوز ﻪﺴﯾﺎﻘﻣ رﻮﻈﻨﻣ ﯽـﺒﯿﻘﻌﺗ نﻮـﻣزآ ،ﺎـﻫ
رادﻮﻤﻧ) ﯽﮐﻮﺗ2(ﻒﻟا نﺎـﺸﻧداد ﻢـﺴﯿﺗﺎﻣور يﺎـﻘﻟا ﻪـﮐ
يرﺎــﺘﻓر ﻞــﻣﺎﻌﺗ نﺎــﻣز ﺶﻫﺎــﮐ ﻪــﺑ ﺮــﺠﻨﻣ ﯽﻠــﺼﻔﻣ
)001/0p<ﻪﺴﯾﺎﻘﻣ رد (شﻮﻣ ﺎﺑ .ﺖـﺳا هﺪﺷ ﻢﻟﺎﺳ يﺎﻫ
يرﺎــﺘﻓر ﻞــﻣﺎﻌﺗ نﺎــﻣز ﺶﯾاﺰــﻓا ﺎــﺑ شزرو ،ًﺎﻓﺎــﻀﻣ
)001/0p<شﻮﻣ رد ( ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ يﺎﻫ
رﺎـﺘﻓر ﺶﯾاﺰـﻓا ﻪﺑ ﺮﺠﻨﻣ ﻢﺴﯿﺗﺎﻣور هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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100ﻞﯿﺑدرا ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ هرودمرﺎﻬﭼ و ﺖﺴﯿﺑ ،هرﺎﻤﺷلوا،رﺎﻬﺑ1403
ﺷ ﯽﻋﺎﻤﺘﺟاﺪ ﻞـﯾاوا زا شزرو ﻪﮐ ﺖﺳا ﯽﻨﻌﻣ ناﺪﺑ ﻦﯾا .
ﯽﻣ ﯽﻧاﻮﺟﻮﻧشﻮﻣ ﺖﻣوﺎﻘﻣ ﺪﻧاﻮﺗ ﺮـﺑاﺮﺑ رد ار ﻎﻟﺎﺑ يﺎﻫ
ﻢــﺴﯿﺗﺎﻣور يرﺎــﻤﯿﺑ يﺎــﻘﻟا زا ﯽــﺷﺎﻧ سﺮﺘــﺳا ﺶﯾاﺰــﻓا
.ﺪﻫد ﺶﯾاﺰﻓا ﯽﻠﺼﻔﻣ
يرﺎﺒﺟا يﺎﻨﺷ ﺖﺴﺗ
نﺎﺸﻧ ﻪﻓﺮﻃ ود نﻮﻣزآدادﻪﮐ ﯽﻠـﺻا تاﺮـﺛا ﻪـﭼ ﺮـﮔا
) شزرو009/0=p) ﯽﻠــﺼﻔﻣ ﻢــﺴﯿﺗﺎﻣور و (001/0<p (
ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور و شزرو ﻦﯿﺑ لﺎﺣ ﻦﯾا ﺎﺑ ،دراد دﻮﺟو
ﯽﻨﻌﻣ ﺮﺛا رﻮـﻈﻨﻣ ﻪـﺑ .ﺖـﺳا ﻪﺘـﺷاﺪﻧ دﻮـﺟو ﯽﻠﻣﺎﻌﺗ راد
هوﺮـﮔ ﻦﯿـﺑ ﯽﺟوز ﻪﺴﯾﺎﻘﻣ ﯽﮐﻮـﺗ ﯽـﺒﯿﻘﻌﺗ نﻮـﻣزآ ،ﺎـﻫ
رادﻮﻤﻧ)2(ب نﺎﺸﻧداد ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور يﺎـﻘﻟا ﻪﮐ
ﯽــﺑ نﺎــﻣز ﺶﯾاﺰــﻓا ﻪــﺑ ﺮــﺠﻨﻣ) ﯽــﺘﮐﺮﺣ01/0p< رد (
شﻮﻣ ﺎﺑ ﻪﺴﯾﺎﻘﻣ ،ﺮـﮕﯾد يﻮﺳ رد .ﺖﺳا هﺪﺷ ﻢﻟﺎﺳ يﺎﻫ
شﻮﻣ رد شزرو ﺎـﺑ ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور ﻪـﺑ ﻼﺘـﺒﻣ يﺎﻫ
ﯽﺑ نﺎﻣز ﺶﻫﺎﮐ) ﯽﮐﺮﺤﺗ05/0p<ﻪﺴﯾﺎﻘﻣ رد ( هوﺮﮔ ﺎﺑ
ﺶﻫﺎــﮐ و ﺪــﯿﻣا ﺢﻄــﺳ ﺶﯾاﺰــﻓا ﻪــﺑ ﺮــﺠﻨﻣ ﻢــﺴﯿﺗﺎﻣور
زا شزرو ﻪﮐ ﺖﺳا ﯽﻨﻌﻣ ناﺪﺑ ﻦﯾا .ﺖﺳا هﺪﺷ سﺮﺘﺳا
ﯽﻣ ﯽﻧاﻮﺟﻮﻧ ﻞﯾاواشﻮﻣ ﺖﻣوﺎﻘﻣ ﺪﻧاﻮﺗ رد ار ﻎﻟﺎـﺑ يﺎﻫ
ﻢﺴﯿﺗﺎﻣور يرﺎﻤﯿﺑ يﺎﻘﻟا زا ﯽﺷﺎﻧ سﺮﺘﺳا ﺶﯾاﺰﻓا ﺮﺑاﺮﺑ
.ﺪﻫد ﺶﯾاﺰﻓا ﯽﻠﺼﻔﻣ
رادﻮﻤﻧ2(ﻒﻟا) ﯽﻋﺎﻤﺘﺟا رﺎﺘﻓر ﺮﯾدﺎﻘﻣ تاﺮﯿﯿﻐﺗ . ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ﮏﯾ .(ب) يرﺎﺒﺟا يﺎﻨﺷ ﺖﺴﺗ رد سﺮﺘﺳا و05/0P< ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ود ؛
01/0P< ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ﻪﺳ ؛001/0P<
ﻦﯿﮐﻮﺘﯿﺳﺎﻫ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ياﺮﺑ17 نﺎـﺸﻧ ﻪـﻓﺮﻃ ود نﻮﻣزآ ، داد ﻪـﮐ
) شزرو ﯽﻠﺻا تاﺮﺛا ﺮﺑ هوﻼﻋ011/0=p ﻢـﺴﯿﺗﺎﻣور و (
) ﯽﻠﺼﻔﻣ001/0=p و شزرو ﻦﯿﺑ ،( ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور
ﯽﻨﻌﻣ ﺮﺛا) ﯽﻠﻣﺎﻌﺗ راد001/0=p ﺮـﺑ هوﻼـﻋ .دراد دﻮﺟو (
نﺎـﺸﻧ ﻪﻓﺮﻃ ود نﻮﻣزآ ،ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا ياﺮﺑ ،نآداد
) شزرو ﯽﻠــﺻا تاﺮــﺛا ﺮــﺑ هوﻼــﻋ ﻪــﮐ001/0<p و (
) ﯽﻠــــﺼﻔﻣ ﻢــــﺴﯿﺗﺎﻣور001/0<p و شزرو ﻦﯿــــﺑ ،(
ﯽـﻨﻌﻣ ﺮـﺛا ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور ) ﯽﻠﻣﺎـﻌﺗ راد001/0<p (
.دراد دﻮﺟو
رﻮﻈﻨﻣ ﻪﺑهوﺮﮔ ﻦﯿﺑ ﯽﺟوز ﻪﺴﯾﺎﻘﻣ ﯽﺒﯿﻘﻌﺗ نﻮﻣزآ زا ﺎﻫ
رادﻮﻤﻧ) ﺪﺷ هدﺎﻔﺘﺳا ﯽﮐﻮﺗ3 رادﻮﻤﻧ .(3ﯽﻣ نﺎﺸﻧ ﺪﻫد
ود ﺮـﻫ ﺶﯾاﺰـﻓا ﻪـﺑ ﺮﺠﻨﻣ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يﺎﻘﻟا ﻪﮐ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﻦﯿﮐﻮﺘﯿﺳ17)001/0p< ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا و (
)001/0p< شﻮـﻣ ﺎـﺑ ﻪﺴﯾﺎﻘﻣ رد مﺮﺳ رد ( ﻢﻟﺎـﺳ يﺎـﻫ
شزرو ،ﻦﯾا ﺮﺑ هوﻼﻋ .ﺖﺳا هﺪﺷردشﻮﻣ ﻪﺑ ﻼﺘﺒﻣ يﺎﻫ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﻦﯿﮐﻮﺘﯿﺳ ناﺰﯿﻣ ﺶﻫﺎﮐ ﺎﺑ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور
17)01/0p<) ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا و (001/0p< مﺮـﺳ رد (
بﺎـﻬﺘﻟا ﺶﻫﺎـﮐ ﻪﺑ ﺮﺠﻨﻣ ﻢﺴﯿﺗﺎﻣور هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد
ﻞـﯾاوا زا شزرو ﻪـﮐ ﺖـﺳا ﯽﻨﻌﻣ ناﺪﺑ ﻦﯾا .ﺖﺳا هﺪﺷ
ﯽﻣ ﯽﻧاﻮﺟﻮﻧشﻮﻣ ﺖﻣوﺎﻘﻣ ﺪﻧاﻮﺗ ﺮـﺑاﺮﺑ رد ار ﻎﻟﺎﺑ يﺎﻫ
اﺰﻓا ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يرﺎﻤﯿﺑ يﺎﻘﻟا زا ﯽﺷﺎﻧ بﺎﻬﺘﻟا ﺶﯾ
.ﺪﻫد ﺶﯾاﺰﻓا
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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سﺮﺘﺳا ﺮﺑ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺄﺗ...رﻮﭘ ﯽﻣﺎﯿﭘ اﺪﯿﺷنارﺎﮑﻤﻫ و101
رادﻮﻤﻧ3 ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﺮﯾدﺎﻘﻣ تاﺮﯿﯿﻐﺗ .17 ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ﮏﯾ .(ب) ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا و (ﻒﻟا)05/0P< ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ ﺖﻣﻼﻋ ود ؛01/0P< ﺖﻣﻼﻋ ﻪﺳ ؛
ﺎﺑ ﺖﺳا ﺮﺑاﺮﺑ001/0P<
ﺚﺤﺑ
داد نﺎﺸﻧ ﻪﻌﻟﺎﻄﻣ ﻦﯾا ﺞﯾﺎﺘﻧﮐ ﯽﻠـﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يﺎﻘﻟا ﻪ
ﺶﯾاﺰﻓا ﻪﺑ ﺮﺠﻨﻣﯽﻨﻌﻣ شﻮـﻣ رد سﺮﺘﺳا راد ﺪـﺷ ﺎـﻫ .
ﺮﺑ هوﻼﻋا ،ﻦﯾاداد نﺎﺸﻧ ﺞﯾﺎﺘﻧ ﻦﯾ نارود زا شزرو ﻪـﮐ
يﺮﯾﺬـﭘ ﺐﯿـﺳآ ﺶﻫﺎﮐ ﻪﺑ ﺮﺠﻨﻣ ﯽﻟﺎﺴﮔرﺰﺑ ﺎﺗ ﯽﻧاﻮﺟﻮﻧ
شﻮﻣ ﺶﯾاﺰـﻓا ﻪـﺑ ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور ﻪـﺑ ﻼﺘـﺒﻣ يﺎـﻫ
ﺮـﮕﯾد ترﺎـﺒﻋ ﻪـﺑ .ﺖﺳا هﺪﺷ يرﺎﻤﯿﺑ زا ﯽﺷﺎﻧ سﺮﺘﺳا
ﯿﻓ ﺖــﯿﻟﺎﻌﻓرد ﯽــﮑﯾﺰ ﺶﻫﺎــﮐ ﺚــﻋﺎﺑ ﯽﻧاﻮــﺟﻮﻧ نارود
ﯽﻨﻌﻣشﻮﻣ سﺮﺘﺳا ﺢﻄﺳ راد ﻢـﺴﯿﺗﺎﻣور ﻪـﺑ ﻼﺘﺒﻣ يﺎﻫ
ﺷﺪ ﺞﯾﺎﺘﻧ ﻪﮐ ﺖﺳا ﻦﯾا ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد ﻢﻬﻣ تﺎﮑﻧ زا ﯽﮑﯾ .
ﺖــﺴﺗ ﻪــﺳ زا هدﺎﻔﺘــﺳا ﺎــﺑ ﯽﻬﺑﺎــﺸﻣ ﺶﺠﻨــﺳ توﺎــﻔﺘﻣ
ﻣآ ﺖﺳﺪﺑ سﺮﺘﺳاﺪ .
ﻦﯿـﺑ رد ﯽﮔدﺮـﺴﻓا و باﺮﻄﺿا ﺪﻨﻧﺎﻣ ﯽﺳﺮﺘﺳا تﻻﻼﺘﺧا
ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ ﻞـﯾﻻد زا ﯽـﮑﯾ ﻪـﮐ ﯽﻠـﺼﻔﻣ
ﯽﻣ ﺰﯿﻧ يرﺎﻤﯿﺑ تﺪﺷ ﺶﯾاﺰﻓا ﻪـﺑ ﺮـﺠﻨﻣ ،ﺪـﺷﺎﺑ ﺪـﻧاﻮﺗ
ﯽـﻣ نارﺎـﻤﯿﺑ ﻦـﯾا رد ﯽﮔﺪﻧز ﺖﯿﻔﯿﮐ ﺶﻫﺎﮐ ] دﻮـﺷ4[ .
ﯽـﺳرﺮﺑ ﺎـﺑ ﻪﻄﺑار رد ﯽﻤﺠﺴﻨﻣ ﯽﻧاﻮﯿﺣ ﻪﻌﻟﺎﻄﻣ ،ﻪﭼﺮﮔا
و باﺮﻄﺿا ﻞﺜﻣ ﯽﺳﺮﺘﺳا تﻻﻼﺘﺧا يور ﺮﺑ شزرو ﺮﯿﺛﺎﺗ
ﯽﻧﺎـﺴﻧا ﺪﻫاﻮـﺷ لﺎـﺣ ﻦـﯾا ﺎـﺑ ،دراﺪـﻧ دﻮﺟو ﯽﮔدﺮﺴﻓا
اد دﻮﺟوﯽﻣ نﺎﺸﻧ ﻪﮐ در و ﯽﻧﺪـﺑ ﺖـﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﺪﻫد
ﯽﺒـﺼﻋ تﻻﻼﺘـﺧا ﻦـﯾا ﺶﻫﺎـﮐ رد ﺖـﺳا ﻦﮑﻤﻣ شزرو
اد ﺶﻘﻧهدﺎﯿﭘ ،ﻪﻧﻮﻤﻧ ناﻮﻨﻋ ﻪﺑ .ﺪﺷﺎﺑ ﻪﺘﺷ و يزاﻮﻫ يور
دﻮــﺒﻬﺑ ﺚــﻋﺎﺑ ﻪــﺘﻔﻫ هدزاود تﺪــﻣ ﻪــﺑ بآ رد شزرو
ﻪـﺑ ﻼﺘﺒﻣ داﺮﻓا رد ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ و ﯽﮔدﺮﺴﻓا و باﺮﻄﺿا
ﺖـﺳا هﺪـﺷ ﺖﯾﺮﺗرآﻮﺌﺘـﺳا ﺎﯾ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور]26[ .
ﻪﻌﻟﺎﻄﻣ ،ﻦﯾا ﺮﺑ هوﻼﻋا ﻪﺑ شزرو ﻪﮐ هداد نﺎﺸﻧ ﺮﮕﯾد ي
ﯽﮕﺘـﺴﺧ ،دﺎـﯾز ﺎـﺗ ﻂـﺳﻮﺘﻣ تﺪﺷ ﺎﺑ ﻪﺘﻔﻫ ﺖﺴﯿﺑ تﺪﻣ
ﻦـﺴﻣ داﺮـﻓا رد ار ﯽﮔدﺮـﺴﻓا ﻢﺋﻼﻋ و ﯽﻨﻫذ و ﯽﻤﺴﺟ
ﺖـﺳا هداد ﺶﻫﺎﮐ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ]27[. رد
يﺎـﺗ تﺎـﻨﯾﺮﻤﺗ ﻪـﮐ ﺪـﺷ ﺺﺨﺸﻣ ،يﺮﮕﯾد ﻪﻌﻟﺎﻄﻣ ﯽـﭼ
1
ﮔدﺮـﺴﻓا و باﺮﻄـﺿا ﺶﻫﺎﮐ ﺚﻋﺎﺑ تﺰـﻋ ﺶﯾاﺰـﻓا و ﯽ
ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد هﺰﯿﮕﻧا و ﺲﻔﻧ ﯽـﻣ دﻮـﺷ
]28[.ﻪﺘﻓﺎﯾ زا ﺖﯾﺎﻤﺣ رد يﺎﻫﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﻊﯿﺳو ﻢﺠﺣ ،
هداد نﺎﺸﻧ تﺎﻌﻟﺎﻄﻣ زا يﺪﺷر ﻪﺑ ور و ﺖـﯿﻟﺎﻌﻓ ﻪـﮐ ﺪﻧا
ﻻﺎــﺑ ﯽــﮑﯾﺰﯿﻓشور ﻖــﯾﺮﻃ زا توﺎــﻔﺘﻣ ﯽــﺷزرو يﺎــﻫ
ﯽﻣ ﯽـﯾورادﺮﯿﻏ ﯽﻧﺎـﻣرد يﮋﺗاﺮﺘﺳا ﮏﯾ ناﻮﻨﻋ ﻪﺑ ﺪﻧاﻮﺗ
ا ياﺮﺑ ] ﺪـﺷﺎﺑ ﯽﮔدﺮﺴﻓا و باﺮﻄﺿا ﯽﺒﺼﻋ تﻻﻼﺘﺧ22
-
21[. ﯽﻧاﻮـﺟﻮﻧ ﻞـﯾاوا زا ﺮﺗﻻﺎـﺑ ﯽﻧﺪـﺑ ﺖـﯿﻟﺎﻌﻓ ،ﻦﯾاﺮﺑﺎﻨﺑ
ﺖﺳا ﻦﮑﻤﻣ ياﺮﺑ ﯽﮔﺪﻧز ﮏﺒﺳ يﮋﺗاﺮﺘﺳا ﮏﯾ ناﻮﻨﻋ ﻪﺑ
زا ﯽــﺷﺎﻧ سﺮﺘــﺳا ﻪــﺑ ﺖﺒــﺴﻧ يﺮﯾﺬــﭘ ﺐﯿــﺳآ ﺶﻫﺎــﮐ
ﻪـﺘﻓﺮﮔ ﺮـﻈﻧ رد هﺪـﻨﯾآ رد ﯽﻠـﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور يرﺎﻤﯿﺑ
.دﻮﺷ
1
Tai Chi
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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102ﻞﯿﺑدرا ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ هرودمرﺎﻬﭼ و ﺖﺴﯿﺑ ،هرﺎﻤﺷلوا،رﺎﻬﺑ1403
ردﻪﺘﻓﺎﯾ ،ﻪﻌﻟﺎﻄﻣ ﻦﯾا ﺮﮕﯾد ﺖﻤﺴﻗﺎﻫ نﺎﺸﻧ داد يﺎﻘﻟا ﻪﮐ
ﻖـﯾﺮﻃ زا بﺎـﻬﺘﻟا ﺶﯾاﺰـﻓا ﻪـﺑ ﺮـﺠﻨﻣ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣر
ﺑﺮﺘﻨﯾا ﺢﻄﺳ ﺶﯾاﺰﻓا ﻦﯿﮐﻮ17 ﺪـﺷ ﺎـﻣﺎﮔ نوﺮـﻓﺮﺘﻨﯾا وه
شﻮﻣ رد ﻻﺎﺑ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﻪﮐ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ يﺎﻫ
ﯽﻨﻌﻣ ﻞﮑﺷ ﻪﺑ ار ناﺰﯿﻣ ﻦﯾا ﻪـﺑ .ﺖﺳا هداد ﺶﻫﺎﮐ يراد
ﺎـﺗ ﯽﻧاﻮـﺟﻮﻧ نارود رد راود خﺮﭼ شزرو ﺮﮕﯾد ترﺎﺒﻋ
رد ﻢـﺴﯿﺗﺎﻣور يﺎﻘﻟا زا ﯽﺷﺎﻧ ﯽﺑﺎﻬﺘﻟا ﺦﺳﺎﭘ زا ﯽﻟﺎﺴﮔرﺰﺑ
شﻮﻣ .ﺖﺳا هدﺮﮐ يﺮﯿﮔﻮﻠﺟ تﺪﺷ ﻪﺑ ﺎﻫ
ﻪﻨﯿﻣز بﺎﻬﺘﻟاﺴﯿﺳ ﺐﯿﺳآ زا يا ﮏـﯾ ﺎـﺑ ﯽﺘﻓﺎﺑ و ﯽﻨﻤﯾا ﻢﺘ
.ﺖـﺳا ﯽﯾﺎﯿﻤﯿـﺷﻮﯿﺑ ﻪﻄـﺳاو ﺪـﻨﭼ ﻦﯿـﺑ هﺪـﯿﭽﯿﭘ ﻞﻣﺎﻌﺗ
ﻦﯿﮐﻮﺘﯿﺳﻪﻄﺳاو ﺎﻫ ﻪـﮐ ﺪﻨﺘـﺴﻫ ﯽﻨﻤﯾا ﻢﺘﺴﯿﺳ ﻢﻬﻣ يﺎﻫ
ﺶﻨــﮐاو زا يرﺎــﺸﺑآ زﺎــﻏآ و ﮏــﯾﺮﺤﺗ ار ﯽﺑﺎــﻬﺘﻟا يﺎــﻫ
ﯽﻣﯽﻣ ﻪﮐ ﺪﻨﻨﮐ ﻪـﺑ ﮏـﯿﺘﯿﻟﻮﺌﺗوﺮﭘ ﺐﯿﺳآ ﻪﺑ ﺮﺠﻨﻣ ﺪﻧاﻮﺗ
ﺖﻓﺎﺑﺪﻨﮐ ﺖﯾاﺪﻫ ار ﺎﻫ]29[. هﺪـﺷ هداد نﺎـﺸﻧ نﻮـﻨﮐا
ــﮐ ﺖــﺳا ﻦﯿﮐﻮــﻟﺮﺘﻨﯾا ﻪ17 رد يرﻮــﺤﻣ ﻦﯿﮐﻮﺘﯿــﺳ ﮏــﯾ
يرﺎﻤﯿﺑ زا يرﺎﯿﺴﺑ ﺖـﺳا ﯽﻨﻤﯾادﻮﺧ يﺎﻫ]7[ . ،ﻦﯿـﻨﭽﻤﻫ
ﯽﮔﺪﯿﭽﯿﭘ ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا ﻪﻧﺎﮔود ﺶﻘﻧ ار يﺪـﯾﺪﺟ يﺎﻫ
ﺖﺴﯾز ردﻦﯿﮐﻮﺘﯿﺳ ﯽﺳﺎﻨﺷ ﺎـﺑ .ﺖـﺳا هدﺮـﮐ رﺎﮑـﺷآ ﺎﻫ
نﺎـﺸﻧ ،ﻢـﺴﯿﺗﺎﻣور بﺎـﻬﺘﻟا ﯽـﺑﺮﺠﺗ لﺪﻣ ﮏﯾ زا هدﺎﻔﺘﺳا
ﺢﻄـــﺳ يزﺎـــﺳدازآ ﻦﯿـــﺑ ﻪـــﮐ ﺖـــﺳا هﺪـــﺷ هداد
ﻨﯾاﻦﯿﮐﻮﻟﺮﺘ17 دﻮﺟو ﯽﻤﯿﻘﺘﺴﻣ ﻪﻄﺑار ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا و
] دراد9[ .ﻦﯿﭽﻟﺎﺑ
1
شراﺰـﮔ دﻮﺧ ﻪﻌﻟﺎﻄﻣ رد نارﺎﮑﻤﻫ و
ﺖﯿﻌــﺿو دﻮــﺒﻬﺑ ﺚــﻋﺎﺑ يزاﻮــﻫ ﻦﯾﺮــﻤﺗ ﻪــﮐ ﺪــﻧدﺮﮐ
ﻦﯿﮐﻮﺘﯿﺳ ﻦﯿﮐﻮـﻟﺮﺘﻨﯾا ﺪﻨﻧﺎﻣ ﯽﺑﺎﻬﺘﻟا يﺎﻫ17 ﯽـﻣ ددﺮـﮔ
]30[.اووزود ﻪﮑﯿﻟﺎﺣ رد
2
ﮏـﯾ ﻪﮐ ﺪﻧاد نﺎﺸﻧ نارﺎﮑﻤﻫ و
ﯽﻣﺮﺳ ﺢﻄﺳ ﺪﯾﺪﺷ شزرو ﻪﺴﻠﺟﯾاﻦﯿﮐﻮﻟﺮﺘﻨ17 رد ار
شﻮﻣ ﯽـﻣ ﺶﯾاﺰـﻓا ﺎﻫ ﻪـﺴﻠﺟ ﮏـﯾ ﻪـﮐ ﯽﻟﺎـﺣ رد ﺪـﻫد
ﻂﺳﻮﺘﻣ شزروشﻮﻣ رد ار نآ ﺪﯿﻟﻮﺗﻦﯾﺮﻤﺗ يﺎﻫ هﺪﯾد
ﯽــﻤﻧ ﺮــﯿﯿﻐﺗدﺮﮐ شراﺰــﮔ ﺎــﻬﻧآ .ﺪــﻫد ﺢﻄــﺳ ﻪــﮐ ﺪــﻧ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا17 ﺮﮕﻧﺎـﺸﻧ ﮏـﯾ ﺖﺳا ﻦﮑﻤﻣ ﺎﻤﺳﻼﭘ ﺎﯾ مﺮﺳ
رد دﺎـــﺣ بﺎـــﻬﺘﻟا ﻦﯿـــﯿﻌﺗ ياﺮـــﺑ ﺪـــﯿﻔﻣ ﯽﯾﺎﯿﻤﯿـــﺷﻮﯿﺑ
ﻪﭽﯿﻫﺎﻣ ] ﺪـﺷﺎﺑ ﯽﺘﻠﮑـﺳا يﺎﻫ31[. ﺎﯿـﺳرﺎﮔ ﻦﯿـﻨﭽﻤﻫ
3
و
1
Balchin
2
Duzova
3
García
ﻤﻫـــ ﺴﻠﺟ ﮏـﯾ ﻪـﮐ ﺪـﻧداد شراﺰﮔ نارﺎﮑ ــــ شزرو ﻪ
)ﮏﯾﺘﻋﺎﺳﻪ نﻮـﺧ شدﺮـﮔ ﺖـﻈﻠﻏ ﺮﺑ ( ﻦﯿﮐﻮـﻟﺮﺘﻨﯾا17
] ﺖﺷاﺪﻧ يﺮﯿﺛﺄﺗ32[ . نﺎـﻘﻘﺤﻣ ﻦﯾا تﺎﻌﻟﺎﻄﻣ ﻦﯿﺑ توﺎﻔﺗ
،ﺮﺿﺎﺣ ﻖﯿﻘﺤﺗ ﻞﺑﺎﻘﻣ ردﯽﻣ ﺪﻧاﻮﺗ و ﻦﯾﺮﻤﺗ عﻮﻧ زا ﯽﺷﺎﻧ
هرود لﻮـﻃ ﺪـﻨﻧﺎﻣ ﯽﺗﺎـﮑﻧ .ﺪـﺷﺎﺑ يرﺎـﻤﯿﺑ ﺖﯿﻌﺿو عﻮﻧ
ﻦــﺳ ،شزرو و تﺪــﺷ و ،ﯽــﺷزرو تﺎــﻨﯾﺮﻤﺗ مﺎــﺠﻧا
ﯽﻣ ﯽﯾاﺰﺴﺑ ﺶﻘﻧ نآ ندﻮﺑ يرﺎﺒﺟا ﺎﯾ يرﺎﯿﺘﺧا رد ﺪـﻧاﻮﺗ
و اووزود ﻪـﻌﻟﺎﻄﻣ رد ﻪـﮐ يرﻮﻃ ﻪﺑ .ﺪﺷﺎﺑ ﻪﺘﺷاد ﺞﯾﺎﺘﻧ
هدﻮـﺑ ﻂـﺳﻮﺘﻣ تﺪـﺷ ﺎـﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ عﻮﻧ نارﺎﮑﻤﻫ
]31[ﺎﯿﺳرﺎﮔ ﻪﻌﻟﺎﻄﻣ رد ﺰﯿﻧ و
4
ﺖﯿﻌﺿو عﻮﻧ نارﺎﮑﻤﻫ و
ﯽﺑ داﺮﻓا يرﺎﻤﯿﺑور يرﺎﻤﯿﺑ زا ﯽﺷﺎﻧ كﺮﺤﺗ دﻮﺑ ﻢﺴﯿﺗﺎﻣ
]32[. ﯽـﻨﻤﯾا و شزرو يور تﺎﻌﻟﺎﻄﻣ ﻞﯿـﺴﻧﺎﺘﭘ ﯽـﺳﺎﻨﺷ
ﺪﺿ نﺎﻣرد ﮏﯾ ناﻮﻨﻋ ﻪﺑ ار ﻢﻈﻨﻣ شزرو ياﺮـﺑ ﯽﺑﺎﻬﺘﻟا
ﯽـﻣ نﺎﺸﻧ ﻦﻣﺰﻣ ﯽﺑﺎﻬﺘﻟا يرﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ ،ﺪـﻫد
ياﺮـﺑ ﯽﻧﺎـﻣرد ﻞﯿﺴﻧﺎﺘﭘ ﺖﺳا ﻦﮑﻤﻣ ﯽﺷزرو ﻦﯾﺮﻤﺗ اﺬﻟ
يرﺎﻤﯿﺑ نﺎﻣرد.ﺪﺷﺎﺑ ﻪﺘﺷاد ﯽﺑﺎﻬﺘﻟا ﯽﺒﺼﻋ يﺎﻫ يرﺎﯿـﺴﺑ
ﺎﻌﻟﺎﻄﻣ زاﺶﯾاﺰﻓا ﻪﮐ ﺪﻧداد نﺎﺸﻧ ت ﻦﯿﮐﻮـﻟﺮﺘﻨﯾا17 رد
ﯽﻣ لﺎﻌﻓ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ داﺮﻓا دﻮﺷ]8
-
6[؛ ،ﻦﯾاﺮﺑﺎـﻨﺑ
ﺢـﺷﺮﺗ يرﺎـﻤﯿﺑ ﺖـﯿﻟﺎﻌﻓ ﯽﻨﯿﻟﺎـﺑ رﺎـﯿﻌﻣ ﻦﯿﮐﻮﺘﯿـﺳ ﻦـﯾا
ﯽﻣ ﻢﺴﯿﺗﺎﻣور ﻦﻣﺰﻣ و دﺎﺣ شزرو ﺖﯿﻟﺎﻌﻓ .ﺪﺷﺎﺑ ﺪﻧاﻮﺗ
و ﻮـﻧﻻ ﻞﺘـﺳﺎﮐ .دراد ﻦﯿﮐﻮﺘﯿـﺳ ﺪﯿﻟﻮﺗ ﺮﺑ ﯽﺗوﺎﻔﺘﻣ ﺮﯿﺛﺄﺗ
هداد نﺎـﺸﻧ نارﺎﮑﻤﻫ ﺪـﻧا ) دﺎـﺣ شزرو زا ﺲـﭘ ﻪـﮐ30
(ﻪـﺘﻔﻫ رد رﺎـﺑ ﻪﺳ ،ﻪﻘﯿﻗدا ﺎـﻣﺎﮔ نوﺮـﻓﺮﺘﻨﯾ رد ﺎﻤـﺳﻼﭘ
لﻮﻃ3 ﻪﺘﻓﺎﯾ ﺶﻫﺎﮐ ﻪﯾﺎﭘ ﺢﻄﺳ زا شزرو زا ﺲﭘ ﺖﻋﺎﺳ
) ﻦﻣﺰﻣ ﻦﯾﺮﻤﺗ زا ﺲﭘ ﺎﻣا ،ﺖﺳا8(يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺘﻔﻫ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﺢﻄﺳ17 ﺖﺳا ﻪﺘﻓﺎﯾ ﺶﻫﺎﮐ ﺎﻤﺳﻼﭘ]33[.
هداد نﺎـﺸﻧ ﻪﺘﺷﺬﮔ تﺎﻌﻟﺎﻄﻣ ﻦﻣﺰـﻣ سﺮﺘـﺳا ﻪـﮐ ﺪـﻧا
ــﺑ ﺮــﺠﻨﻣ ﯽﺑﺎــﻬﺘﻟا ﻦﯿﮐﻮﺘﯿــﺳ ﯽﻣﺮــﺳ ﺢﻄــﺳ ﺶﯾاﺰــﻓا ﻪ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا17 لﺎـﺘﻧوﺮﻓﺮﭘ و لاﺪـﮕﯿﻣآ ،ﭗـﻣﺎﮐﻮﭙﯿﻫ رد
شﻮﻣ رد ﺲﮑﺗرﻮﮐﯽﻣ ﺎﻫ ﻪـﺑ ﺮـﺠﻨﻣ ﺎـﺒﻗﺎﻌﺘﻣ ﻪـﮐ دﻮـﺷ
ا هﺪـﺷ تﺎـﻧاﻮﯿﺣ ﻦﯾا رد ﯽﮔدﺮﺴﻓا ﺢﻄﺳ ﺶﯾاﺰﻓا .ﺖـﺳ
نﺎـﺸﻧ ﺰـﯿﻧ ﻦﯿﮐﻮﺘﯿـﺳ ﻦـﯾا رﺎﻬﻣ ﺢﻄـﺳ ﺶﻫﺎـﮐ هﺪـﻨﻫد
شﻮﻣ رد ﯽﮔدﺮﺴﻓا سﺮﺘـﺳا ﺎـﺑ هﺪﺷ هداد ﻪﺟاﻮﻣ يﺎﻫ
4
García
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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سﺮﺘﺳا ﺮﺑ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺄﺗ...رﻮﭘ ﯽﻣﺎﯿﭘ اﺪﯿﺷنارﺎﮑﻤﻫ و103
ا هﺪﺷ ﺮـﯿﮔرد ﻢـﻬﻣ ﻪﯿﺣﺎﻧ ﻪﺳ ناﻮﻨﻋ ﻪﺑ ﯽﺣاﻮﻧ ﻦﯾا .ﺖﺳ
ﻪﺘﺧﺎﻨــﺷ ﯽﮔدﺮــﺴﻓا و باﺮﻄــﺿاﯽــﻣ دﻮــﺷ]34[. رد
ﯽﮔدﺮـﺴﻓا ﻪـﺑ ﻼﺘـﺒﻣ لﺎﺴﮔرﺰﺑ نارﺎﻤﯿﺑ ،ﯽﻨﯿﻟﺎﺑ تﺎﻌﻟﺎﻄﻣ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا حﻮﻄﺳ17 ﻪـﺑ ﺖﺒـﺴﻧ مﺮـﺳ رد ار يﺮﺗﻻﺎـﺑ
ﯽﮑﯿﻨﯿﻠﮐ تﺎﻌﻟﺎﻄﻣ ،نآ ﺮﺑ هوﻼﻋ .ﺪﻧداد نﺎﺸﻧ ﻢﻟﺎﺳ داﺮﻓا
ﻦﯿﮐﻮــﻟﺮﺘﻨﯾا ﺶــﻘﻧ ﺪــﯾﺆﻣ17ﺮــﺑ رد رد ﯽﮔدﺮــﺴﻓا زو
ﯽﻠـﺼﻔﻣ ﻢـﺴﯿﺗﺎﻣور ﻪـﺑ ﻼﺘـﺒﻣ نارﺎﻤﯿﺑ ﯽـﻣ ﺪـﺷﺎﺑ]35[.
ﯽﻨﻌﻣ ﻪﻄﺑارﺰﯿﻧ ﺮﮕﯾد ﯽﯾا ﻪﻌﻟﺎﻄﻣ ﺶﯾاﺰﻓا ﻦﯿﺑ ﯽﺘﺒﺜﻣ راد
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا مﺮﺳ ﺢﻄﺳ17 رد باﺮﻄـﺿا ﻢﺋﻼﻋ تﺪﺷ و
داﺮـﻓا ﺎـﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ
هدﺮﮐ اﺪﯿﭘ ﻢﻟﺎﺳلﺎﺣ ﻦﯿﻤﻫ رد .ﺪﻧا، ﻦﯿﮐﻮﺘﯿـﺳ ﻦﯾا ﺢﻄﺳ
د رﻮﻃ ﻪﺑ باﺮﻄﺿا ﺎﺑ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور نارﺎﻤﯿﺑ مﺮﺳ ر
ﺖـﺳا هدﻮﺑ باﺮﻄﺿا نوﺪﺑ داﺮﻓا زا ﺮﺗﻻﺎﺑ ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ
]11[ .هداد نﺎﺸﻧ ﯽﻫﺎﮕﺸﯾﺎﻣزآ ﺪﻫاﻮﺷ ،ﺮﮕﯾد ﯽﯾﻮﺳ رد
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ﻦـﻄﺑ ﻪـﺑ ﺎـﻣﺎﮔ نوﺮـﻓﺮﺘﻨﯾا ﻢﯿﻘﺘﺴﻣ ﻖﯾرﺰﺗ ﻪﮐ ﺪﻧا يﺎـﻫ
نورﻮﻧ رد لﻼﺘﺧا ﻪﺑ ﺮﺠﻨﻣ ﺰﻐﻣ ﯽﺒﻧﺎﺟ و ﭗﻣﺎﮐﻮﭙﯿﻫ ﯽﯾاز
ﯽﮔدﺮـﺴﻓا رﺎـﺘﻓر زوﺮـﺑ شﻮـﻣ رد ﯽـﻣ ﺎـﻫ دﻮـﺷ]36[.
داﺮـﻓا رد ﯽﮔدﺮـﺴﻓا ﺎـﺑ ﻦﯿﮐﻮﺘﯿـﺳ ﻦﯾا ﯽﻣﺮﺳ ﺶﯾاﺰﻓا
ﺖـﺳا هﺪـﺷ هﺪﻫﺎـﺸﻣ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﻪﺑ ﻼﺘﺒﻣ]37[.
هدادﯽﻨﻌﻣ ﺶﻫﺎﮐ ﺎﻣ يﺎﻫﺖﻈﻠﻏ راد ﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾا رد
ﯽـﻣ نﺎـﺸﻧ ﻦﯾﺮﻤﺗ هرود ﮏﯾ زا ﺲﭘ ار ﺎﻤﺳﻼﭘ ﺎـﺑ .ﺪـﻫد
ﯽﺑﺎﻬﺘﻟا ﺮﺛا ﻪﺑ ﻪﺟﻮﺗﺎﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾاﻤﺗ ﻪﻣﺎﻧﺮﺑ ﻦﯾا ، ﯽـﻨﯾﺮ
ﻢــﺴﯿﺗﺎﻣور يرﺎــﻤﯿﺑ ﺖﯿﻌــﺿو يور ﺮــﺑ يﺪــﯿﻔﻣ ﺮﯿﺛﺄــﺗ
ﻦﯿﮐﻮﺘﯿـﺳ ﺮـﯿﯿﻐﺗ ﺮـﮔا هﮋـﯾو ﻪـﺑ ،ﺖـﺳا ﻪﺘﺷاد ﯽﻠﺼﻔﻣ
ﺎــﻣﺎﮔ نوﺮــﻓﺮﺘﻨﯾا .ﺪــﻧﺎﻤﺑ ﯽﻗﺎــﺑ ﯽﻧﻻﻮــﻃ تﺪــﻣ ياﺮــﺑ
گﺮﺒﺴﻨﯿﺘﺳا
1
شزرو زا ﺲـﭘ ﻪﮐ ﺪﻧاد نﺎﺸﻧ نارﺎﮑﻤﻫ و
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﺢﻄﺳ ،تﺪﻣ ﯽﻧﻻﻮﻃ17 و ﺎـﻣﺎﮔ نوﺮـﻓﺮﺘﻨﯾا
ﯽﻣ ﺶﻫﺎﮐ ﺪﺑﺎﯾ]38[. ﻦﯿﭽﻟﺎـﺑ
2
ـﮑﻤﻫ و ﺪـﯿﻔﻣ ﺮﯿﺛﺎـﺗ نارﺎ
ار ﯽﻠـﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور نارﺎﻤﯿﺑ ﯽﮔدﺎﻣآ ﺮﺑ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ
هداد نﺎﺸﻧ ﺪﻧا]30[. ﺪـﯿﻔﻣ ﺮﯿﺛﺄـﺗ ﻪـﺑ ،ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد
ﯽﺑﺎـﻬﺘﻟا يﺎـﻫرﻮﺘﮐﺎﻓ ﺢﻄـﺳ ﺶﻫﺎـﮐ ﺮـﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا17 و ﺎـﻣﺎﮔ نوﺮﻓﺮﺘﻨﯾارد يرﺎـﻤﯿﺑ ﺖﯿﻌـﺿو
ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣورﺪﯾدﺮﮔ نﺎﻋذا دﻮﺒﻬﺑ ﺚﻋﺎﺑ ﺮﯿﯿﻐﺗ ﻦﯾا .
1
Steensberg
2
Balchin
ﯿﻔﯿﮐ ﯽـﻣ نارﺎـﻤﯿﺑ ﯽﮔﺪـﻧز ﺖ ﺶﻫﺎـﮐ ﺮـﺑ هوﻼـﻋ .دﻮـﺷ
ﻦﯿﮐﻮﺘﯿـﺳ ﺶﻫﺎـﮐ ،ﯽﺑﺎـﻬﺘﻟا يﺎـﻫ يﺎـﻫرﺎﺘﻓر ﺎـﺑ ﻂﺒﺗﺮـﻣ
سﺮﺘﺳا ﻪﻣﺎﻧﺮﺑ ﮏﯾ ناﻮﻨﻋ ﻪﺑ ار يزاﻮﻫ ﻦﯾﺮﻤﺗ دﺮﮑﻠﻤﻋ ،
ﯽﻣ نﺎﺸﻧ ﯽﺷزرو ياراد ﻪـﻌﻟﺎﻄﻣ ﻦـﯾا لﺎـﺣ ﻦﯾا ﺎﺑ .ﺪﻫد
ﺖﯾدوﺪﺤﻣ ﯽﯾﺎﻫدﻮﺑ ﻦﯾا ﻪﻌﻟﺎﻄﻣ ﻦﯾا ﺖﯾدوﺪﺤﻣ ﻦﯿﻟوا .
دﻮﺑا رد ﺖﯿﺴﻨﺟ ﺶﻘﻧ ﻪﮐ ـﻣ ﻪـﻌﻟﺎﻄﻣ ﻦـﯾ ﯽـﺳرﺮﺑ درﻮ
ﺮﯿﺛﺎﺗ ﻞﻣﺎﻋ ﺖﺳا ﻦﮑﻤﻣ ﻪﮐ ﺖﻓﺮﮕﻧ راﺮﻗ .ﺪـﺷﺎﺑ يراﺬـﮔ
ﻦﯾا ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد مود ﺖﯾدوﺪﺤﻣ دﻮـﺑ تﺎـﻧاﻮﯿﺣ ﻪـﮐ
ﻪﺑدﺮﮐ شزرو يرﺎﯿﺘﺧا ترﻮﺻ لﺎﻤﺘﺣا ﻦﯾا ،يرﺎﺒﺟا ﻪﻧ ﺪﻧ
شزرو يرﺎـﺒﺟا تﺎـﻧاﻮﯿﺣ ﻪـﮐ ﯽﺗرﻮـﺻ رد دراد دﻮـﺟو
ﯽﻣ هﺪﯾد ﯽﺗوﺎﻔﺘﻣ ﺮﺛا ﺪﻧدﺮﮐﯽﻣﺪﺷ ﻦﯾا ﺞﯾﺎﺘﻧ ،ﻦﯾاﺮﺑﺎﻨﺑ .
ﻮﺻ رد ﻪﻌﻟﺎﻄﻣ ياﺮـﺟا و ﺖﯿﺴﻨﺟ ود ﺮﻫ زا هدﺎﻔﺘﺳا تر
ﻪـــﺴﯾﺎﻘﻣا يرﺎـــﺒﺟا و يرﺎـــﯿﺘﺧا ﯽـــﺷزرو شور ود ي
ﯽﻣﻪﺠﯿﺘﻧ ﻪﺑ ﺮﺠﻨﻣ ﺖﺴﻧاﻮﺗﻞﻣﺎﮐ يﺮﯿﮔ .دﻮﺷ يﺮﺗ
ﻪﺠﯿﺘﻧيﺮﯿﮔ
ﻪــﻌﻟﺎﻄﻣ ﻦﯿـﻟوا ناﻮــﻨﻋ ﻪـﺑ ﻪــﻌﻟﺎﻄﻣ ﺞﯾﺎـﺘﻧ ،عﻮـﻤﺠﻣ رد
ﺮﺑ ﻢﺠﺴﻨﻣ نﺎـﺸﻧ ﯽﻠﺼﻔﻣ ﻢﺴﯿﺗﺎﻣور ﯽﻧاﻮﯿﺣ لﺪﻣ يور
داد ﺖـﺳا ﻦـﮑﻤﻣ ﯽﮑﯾﺰﯿﻓ ﺖﯿﻟﺎﻌﻓ ﺶﯾاﺰﻓا ﻪﮐ ﻖـﯾﺮﻃ زا
ﻦﯿﮐﻮﻟﺮﺘﻨﯾا ﺢﻄﺳ ﺶﻫﺎﮐ17 ﯽـﺸﻘﻧ ﺎـﻣﺎﮔ نوﺮـﻓﺮﺘﻨﯾا و
شﻮﻣ رد سﺮﺘﺳا ﺢﻄﺳ ﺶﻫﺎﮐ رد ﻦـﯾا ﻪـﺑ ﻼﺘـﺒﻣ يﺎﻫ
ﯽﻣ ﺞﯾﺎﺘﻧ ﻦﯾا .ﺪﺷﺎﺑ ﻪﺘﺷاد يرﺎﻤﯿﺑ ﯽﻣﺎـﮔ نﻮﻨﻋ ﻪﺑ ﺪﻧاﻮﺗ
ﮏـﯾدﺰﻧ هﺪـﻨﯾآ رد ﯽﮑﯿﻨﯿﻠﮐ تﺎﻌﻟﺎﻄﻣ عوﺮﺷ ياﺮﺑ ﻪﯿﻟوا
.دﻮﺷ
ﯽﻟﺎﻣ ﯽﻣﺎﺣ
ﯽﻟﺎﻣ ﺖﯾﺎﻤﺣ ﻪﻌﻟﺎﻄﻣ ﻦﯾا.ﺖﺳا ﻪﺘﺷاﺪﻧ
ﻊﻓﺎﻨﻣ ضرﺎﻌﺗ
ﺖﺳا هﺪﺸﻧ شراﺰﮔ.
ﯽﻧادرﺪﻗ و ﺮﮑﺸﺗ
ياﺮـﺑ يرﻻﺎـﺳ يرﺎـﺘﻓر و ﯽﺘﺧﺎﻨـﺷ تﻻﻼﺘﺧا ﻪﺴﺳﻮﻣ زا
نﻮـﻣزآ مﺎـﺠﻧا و ﯽﻧاﻮـﯿﺣ لﺪﻣ ﺪﯿﻟﻮﺗ رد يرﺎﮑﻤﻫ يﺎـﻫ
ﯽــﻣ ﯽﻧادرﺪــﻗ يرﺎــﺘﻓر رﺎــﮐ ﻞــﺻﺎﺣ ﻪــﻟﺎﻘﻣ ﻦــﯾا .دﻮــﺷ
[ DOI: 10.61186/jarums.24.1.92 ] [ Downloaded from jarums.arums.ac.ir on 2025-04-28 ]
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104ﻞﯿﺑدرا ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ هرودمرﺎﻬﭼ و ﺖﺴﯿﺑ ،هرﺎﻤﺷلوا،رﺎﻬﺑ1403
نﺎﯾﺎﭘ ناﻮـﻨﻋ ﺖـﺤﺗ ﯽﺼﺼﺨﺗ ياﺮﺘﮐد ﻊﻄﻘﻣ ﻪﻣﺎﻧ» ﺮﯿﺛﺎـﺗ
ﺎــﺗ ﯽﻧاﻮــﺟﻮﻧ نارود رد راود خﺮــﭼ يرﺎــﯿﺘﺧا شزرو
ﺰﺑ رد ﯽﮔدﺮﺴﻓا و ﯽﺑاﺮﻄﺿا يﺎﻫرﺎﺘﻓر يور ﺮﺑ ﯽﻟﺎﺴﮔر
ﯽـﺷﻮﻣ لﺪـﻣ رد ﺪـﯿﺋﻮﺗﺎﻣور ﺖﯾﺮﺗرآ يرﺎﻤﯿﺑ لﺪﻣ « و
هرﺎﻤــــــــﺷ ﻪــــــــﺑ قﻼــــــــﺧا ﺪــــــــﮐ ياراد
IR.IAU.SARI.REC.1401.183ﯽﻣﺪﺷﺎﺑ.
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