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Antioxidants for Skin Health

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Abstract

Antioxidants play a pivotal role in maintaining skin health and integrity, combating the deleterious effects of oxidative stress induced by environmental aggressors such as UV ra-diation, pollution, and lifestyle factors. This paper reviews the contributions of key antioxidants, including Vitamin C, Vitamin E, Vitamin A, green tea extract, Coenzyme Q10, Resveratrol, Selenium, and Polyphenols, in skin health care. Vitamin C, known for its collagen synthesis promotion and photoprotection properties, alongside Vitamin E, a lipid-soluble antioxidant, syn-ergistically works to neutralize free radicals and repair damaged skin cells. Vitamin A, in the form of retinol, plays a critical role in skin cell regeneration and the maintenance of skin integ-rity. Green tea extract, rich in Polyphenols, offers anti-inflammatory and anticarcinogenic prop-erties, making it a potent ingredient for skin protection. Coenzyme Q10, a naturally occurring antioxidant in the body, aids in energy production for cell repair and regeneration, while Resveratrol, found in grapes and berries, provides anti-ageing benefits by enhancing skin's re-sistance to oxidative stress. Selenium, an essential mineral, contributes to the protection of skin cells from oxidative damage. The incorporation of these antioxidants in skincare products and dietary sources is discussed, highlighting the importance of a holistic approach in skincare re-gimes. The paper emphasizes the synergy between topical applications and dietary intake of antioxidants, advocating for a comprehensive strategy for promoting skin health and preventing age-related skin alterations. Method For the review article, a variety of search engines and databases were used to identify relevant articles. Furthermore, for biomedical literature focusing on antioxidants and their ef-fects on skin health, PubMed was used. Moreover, to access a wide range of scholarly articles, including those related to dermatology and skincare, Google Scholar was used. Scopus provides comprehensive coverage of peer-reviewed literature across various scientific disciplines. Web of Science identifies high-impact articles and research on antioxidants in skincare. In addition, for accessing full-text articles on antioxidants and their applications in dermatology, Science Direct was used. The inclusion criteria for the review paper were as follows: only studies pub-lished in peer-reviewed journals were included to ensure the credibility and reliability of the information. Articles published in English were considered, to avoid language-related biases and ensure comprehension. Studies published within the last 10 years were included to provide the most current insights into antioxidant research in skincare. Articles must specifically focus on the role of antioxidants (Vitamin C, Vitamin E, Vitamin A, green tea extract, Coenzyme Q10, Resveratrol, Selenium, Polyphenols) in skin health care. Both experimental studies (in vivo and in vitro) and clinical trials were included to provide a comprehensive overview of the antioxidant effects. Full-text articles were included to allow for thorough data extraction and analysis. The exclusion criteria for the review paper were as follows: Publications that were not peer-re-viewed, such as editorials, opinion pieces, and non-scholarly articles, were excluded. Articles published in languages other than English were excluded due to potential translation challenges and to maintain consistency. Studies that did not focus on the specified antioxidants or their impact on skin health were excluded. Duplicate publications were excluded to avoid redundancy in the review. Articles with insufficient or incomplete data were excluded to ensure the quality and reliability of the review findings.

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... However, newer stabilized forms of vitamin C, such as ascorbyl tetraisopalmitate and tetrahexyldecyl ascorbate, have been developed. These derivatives are more stable, easily penetrate the skin, and provide enhanced brightening, anti-inflammatory, and antioxidant effects [15][16][17]. ...
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The disruption of the skin barrier and immune function has been linked to several skin conditions, including atopic dermatitis (AD), psoriasis, and acne. Both resident and non-resident immune cells, along with the skin’s barrier system, play crucial roles in innate immunity. Recent research on skin microbiota has enhanced our understanding of the interactions between these microorganisms and skin immune cells. Vitamins, as essential micronutrients, have been shown to possess antioxidant, anti-inflammatory, and antimicrobial properties. The immunomodulatory effects of vitamins may help prevent the progression of skin diseases, making it important to explore their immunopharmacology, particularly in relation to skin conditions. Additionally, it is necessary to investigate the molecular and cellular markers influenced by these vitamins and their derivatives. This review focuses on key vitamins (A, B, C, D, and E) taken as nutritional supplements, examining the findings and potential implications for skin immunity, health, and disease.
... It also exerts additional effects by inhibiting angiogenesis, modulating cell cycle pathways, and triggering selective apoptosis [15]. Through these actions, resveratrol mitigates oxidative stress, neutralizes free radicals, and boosts the activity of endogenous antioxidant enzymes, ultimately protecting cells from oxidative damage-a critical factor in the aging process [16]. ...
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Aging is a multifaceted biological process marked by the gradual deterioration of physiological systems, heightened susceptibility to illnesses, and eventual mortality. With the increasing proportion of older individuals worldwide, interest in strategies to decelerate aging and support healthy longevity has intensified. Resveratrol, a naturally occurring polyphenol present in grapes, berries, and various plant-derived foods, has attracted widespread attention for its potential anti-aging properties. This compound exerts its effects through multiple pathways, such as activating sirtuins, combating oxidative stress, improving mitochondrial performance, exerting anti-inflammatory effects, and protecting telomeres. Research has indicated that resveratrol can alleviate age-related conditions, including neurodegenerative diseases, cardiovascular disorders, sarcopenia, cancer, and diabetes mellitus, as evidenced by both animal studies and human clinical trials. Despite its promising potential as an anti-aging agent, further investigation is necessary to determine appropriate dosages, long-term safety, and efficacy in humans. This review provides an overview of the mechanisms underlying resveratrol’s actions, its impact on age-associated diseases, and its prospects as a therapeutic option for enhancing longevity and quality of life.
... Vitamin E, a lipid-soluble antioxidant, helps neutralize free radicals and supports cell repair. 24 Vitamin D is vital for both the innate and adaptive immune systems and is extensively studied in autoimmune diseases due to its common deficiency in this patient population. 25 Ensuring adequate intake of these vitamins is key to supporting both skin health and overall immune function in individuals with psoriasis, most importantly our pediatric psoriasis patients. ...
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Recent studies have increasingly focused on investigating the impact of anti-inflammatory dietary patterns, particularly emphasizing the Mediterranean diet, on the severity and progression of pediatric psoriasis. This review comprehensively examines a wide range of studies that explore the correlation between dietary intake patterns and clinical outcomes in children with psoriasis, providing a detailed synthesis of current evidence. It critically evaluates the role of specific anti-inflammatory nutrients such as polyphenols, omega-3 fatty acids, and vitamins A, D, and E, emphasizing their mechanisms in reducing inflammatory markers and modulating immune responses specific to pediatric psoriasis. Additionally, the review provides an in-depth assessment of the safety, feasibility, and long-term adherence to these dietary patterns, considering factors like dietary compliance, nutritional adequacy, and potential adverse effects. By offering a nuanced analysis, this review aims to substantiate the potential efficacy of anti-inflammatory diets as adjunctive therapies for pediatric psoriasis management, identifying existing research gaps and suggesting avenues for future investigations to optimize dietary interventions in clinical settings.
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Introduction Resveratrol synthase (RS) is a key enzyme involved in the synthesis of stilbene and resveratrol. Resveratrol has many biological pharmacological activities that are beneficial to human health including anti-cancer, cardiovascular protection, estrogen regulation, antibacterial, antiviral, and reduction of tissue and organ damage. In plants, RS catalyzes the production of resveratrol, which helps to protect against fungal and bacterial diseases. Methods We analyzed RS homologues from peanuts (Arachis hypogaea L.) during infection by plant viruses and fungi. The peanut RS gene was cloned and characterized. The peanut RS gene was cloned into the pEAQ-HT-DEST3 plant binary expression vector and transiently expressed in Nicotiana benthamiana. Results Sequence analysis of the protein revealed a conserved stilbene synthase activity domain. The protein displayed high phylogenetic identity to RS from A. hypogaea (100%), Vitis vinifera (72.42%), and Polygonum cuspidatum (69.51). The results showed that RS expression in plants significantly contributed to infection by turnip mosaic virus (TuMV) and silghtly contributed to viral infection of tobacco mosaic virus (TMV). However, no significant influence of RS expression on infection by tobacco vein mottling virus (TVMV) was observed. Expression of the RS gene was transiently increased upon fungal infection of Botrytis cinerea in N. benthamiana. Discussion This finding suggests that transient expression of the RS gene could significantly contribute to infection by turnip mosaic virus (TuMV) and improve the resistance of N. benthamiana to B. cinerea.
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