The study reported in this paper focuses on the creation of captivating and innovative interactive science and technology museum exhibits by leveraging digital technology to support interdisciplinary collaborative design in the context of a rapidly evolving technological landscape. In introducing new prospects for science and technology museum exhibit design we focus on a specific theme-related question: How can the distinctive properties of graphene, a key future material, be made accessible in a high quality educational spatial experience through a collective, collaborative, and interdisciplinary design process that transcends boundaries of scale and conventional professional purview? To address this question, we first observed a multidisciplinary team comprising architects, material scientists, educational experts, and technology designers engaged in applied spatial interactive exhibit design for science and technology museums. Based on a critical analysis of this design process, we propose a new type of design workflow, leveraging the synergetic effects of interdisciplinary cooperation to foster novel types of digital spatial design approaches. The paper finally reports on the simulation and testing of the technical features of the designed exhibit and summarizes generalizable observations regarding the viability of the design process in broader contexts.