Tang JY, Parimi N, Wu A et al.Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men. Cancer Causes Control 21:387-391

Children's Hospital of Oakland Research Institute, USA.
Cancer Causes and Control (Impact Factor: 2.74). 11/2009; 21(3):387-91. DOI: 10.1007/s10552-009-9470-4
Source: PubMed


To determine the relationship between 25(OH) vitamin D levels and non-melanoma skin cancer (NMSC), we performed a nested case–control study in ambulatory, elderly men enrolled in the Osteoporotic Fractures in Men (MrOS) Study. Health habit and medical history, including self-reported history of NMSC were recorded and 25(OH)D levels were measured on serum collected at baseline from a random sample of Caucasian MrOS subjects. Mean age (73 ± 5), BMI, daily vitamin D and calcium intake were similar in the men with (n = 178) and without NMSC (n = 930), but higher levels of 25(OH)D were associated with a decreased risk of having a history of NMSC (P
= 0.04). Men in the highest quintile of 25(OH)D (>30 ng/mL) had 47% lower odds of NMSC (95% CI: 0.30–0.93, p = 0.026) compared to those in the lowest quintile. Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.

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    • "The VDR play a crucial role in the DNA damage repair pathways as well [23]. The studies that tried to provide evidence on the effect of vitamin D on skin cancer risk have produced inconsistent results so far [25] [26] [27] [28]. Other studies investigated the association of vitamin D blood levels with prognosis of CM, with results that, although inconclusive , seem to suggest a beneficial effect [29] [30]. "
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    ABSTRACT: Vitamin D is formed mainly in the skin upon exposure to sunlight and can as well be taken orally with food or through supplements. While sun exposure is a known risk factor for skin cancer development, vitamin D exerts anti-proliferative and pro-apoptotic effects on melanocytes and keratinocytes in vitro. To clarify the role of vitamin D in skin carcinogenesis, we performed a review of the literature and meta-analysis to evaluate the association of vitamin D serum levels and dietary intake with cutaneous melanoma (CM) and non-melanoma skin cancer (NMSC) risk and melanoma prognostic factors. Twenty papers were included for an overall 1420 CM and 2317 NMSC. The summary relative risks (SRRs) from random effects models for the association of highest versus lowest vitamin D serum levels was 1.46 (95% confidence interval (CI) 0.60-3.53) and 1.64 (95% CI 1.02-2.65) for CM and NMSC, respectively. The SRR for the highest versus lowest quintile of vitamin D intake was 0.86 (95% CI 0.63-1.13) for CM and 1.03 (95% CI 0.95-1.13) for NMSC. Data were suggestive of an inverse association between vitamin D blood levels and CM thickness at diagnosis. Further research is needed to investigate the effect of vitamin D on skin cancer risk in populations with different exposure to sunlight and dietary habits, and to evaluate whether vitamin D supplementation is effective in improving CM survival.
    Full-text · Article · Jul 2014 · European journal of cancer (Oxford, England: 1990)
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    • "In support of our findings that elevated plasma 25-OH-vitD may be used as a risk factor for non-melanoma skin cancer and melanoma, a previous cohort study demonstrated that elevated plasma 25-OH-vitD levels associate with increased risk of non-melanoma skin cancer (Asgari et al., 2010). However, other case–control and cohort studies have shown an inverse relationship between plasma 25-OH-vitD and risk of non-melanoma and melanoma skin cancer (Tang et al., 2010; Newton-Bishop et al., 2011). Contrary to the latter studies, a randomized study did not show the expected decreased risk of non-melanoma and melanoma skin cancer with vitamin D supplementation (Tang et al., 2011a), although a post hoc analysis did show that supplementing with vitamin D and calcium reduced the risk of melanoma in cases with a history of non-melanoma skin cancer. "
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    ABSTRACT: Sun exposure is a major risk factor for skin cancer and is also an important source of vitamin D. We tested the hypothesis that elevated plasma 25-hydroxyvitamin D (25-OH-vitD) associates with increased risk of non-melanoma and melanoma skin cancer in the general population. We measured plasma 25-OH-vitD in 10,060 white individuals from the Danish general population. During 28 years of follow-up, 590 individuals developed non-melanoma skin cancer and 78 developed melanoma skin cancer. Increasing 25-OH-vitD levels, by clinical categories or by seasonally adjusted tertiles, were associated with increasing cumulative incidence of non-melanoma skin cancer (trend P=2 × 10(-15) and P=3 × 10(-17)) and melanoma skin cancer (P=0.003 and P=0.001). Multivariable adjusted hazard ratios of non-melanoma skin cancer were 5.04 (95% confidence interval (CI): 2.78-9.16) for 25-OH-vitD 50 vs. <25 nmol l(-1), and 4.02 (2.45-6.60) for top versus bottom tertile. Multivariable adjusted hazard ratios of melanoma skin cancer were 4.7 (0.96-23.3) for 25-OH-vitD 50 vs. <25 nmol l(-1), and 6.3 (1.38-28.8) for top versus bottom tertile. The absolute 20-year risk was 11% for non-melanoma skin cancer and 1.5% for melanoma skin cancer, in participants with age >60 years, 25-OH-vitD winter levels 50 nmol l(-1), and performing outdoor exercise. In conclusion, we show that increasing levels of 25-OH-vitD are associated with increased risk of non-melanoma and melanoma skin cancer.Journal of Investigative Dermatology advance online publication, 29 November 2012; doi:10.1038/jid.2012.395.
    Preview · Article · Nov 2012 · Journal of Investigative Dermatology
    • "The incidence of breast cancer prospectively correlated negatively with serum 25(OH)D levels (Abbas et al., 2008) as well as the incidence of colon cancer (Yin et al., 2009a). Further, vitamin D status correlated negatively with the incidence of nonmelanoma skin cancer (Tang et al., 2010) and positively with the survival of melanoma skin cancer patients (Newton- Bishop et al., 2009). The effect of vitamin D status in prostate cancer is less certain (Yin et al., 2009b). "
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    ABSTRACT: Vitamin D is a potent immune modulator, keeping the T-cell compartment in a more tolerogenic state. Multiple sclerosis (MS), a disease in which an autoreactive T-cell response contributes to inflammation in the central nervous system, has been associated with vitamin D deficiency. The effects of vitamin D on the immune system are believed to be an important driver of this association. In this chapter, we elaborate on vitamin D as a modulator of the T-cell response. This discussion will be placed in the perspective of MS as a T-cell-mediated disease and in the perspective of the numerous association studies on vitamin D deficiency and multiple health outcomes. We conclude that there is a firm experimental and epidemiological basis supporting the model of vitamin D as a physiological immune modulator, on which intervention studies assessing clinical and immunological outcome measures should be designed.
    No preview · Article · Jan 2011 · Vitamins & Hormones
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