Production of interleukin-10 in asthmatic children after Beta-1-3-glucan

Maternal and Child Department of Universidade Federal de Pernambuco, Brazil.
Allergologia et Immunopathologia (Impact Factor: 1.74). 07/2009; 37(4):188-92. DOI: 10.1016/j.aller.2009.02.005
Source: PubMed


Beta-1-3 Glucan is a polysaccharide extracted from Saccharomyces cerevisiae with a possible immunomodulating action that may have a favourable action on asthma symptoms and other allergic diseases. An experimental study carried out using a murine respiratory model detected a decrease in pulmonary tissue eosinophilia, as well as an increase in Interleukin-10 (IL-10) after glucan use.
This open, exploratory study with blind outcome evaluation included asthmatic children between 6 and 12 years of age with mild to moderate persistent asthma and inadequate disease control (rescue medication needed more than twice a week) in spite of inhaled budesonide 400 microg/day. After a four week run-in period, subcutaneous Beta-1-3-glucan injections were given weekly for the first four weeks and then every two weeks for the last four weeks. IL-10 levels, measured by the immunoenzymatic method (ELISA), were compared before and after glucan administration.
Twenty patients (14 male and 6 female) were included. Mean IL-10 levels were 6.4 pg/ml and 11.3 pg/ml before and after glucan, respectively (p = 0.02). There was also a reduction of asthmatic symptoms score at the end of study.
This is the first study which shows that subcutaneous particulate Beta-1-3-glucan increases serum IL-10 levels in asthmatics. The possibility of glucan being able to modulate allergic sensitisation and having a beneficial action in restoring Th2 function should be assessed by means of properly planned controlled clinical trials, as it may represent a new therapeutic strategy.

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Available from: José Angelo Rizzo, Mar 18, 2015
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    • "The effect of ß-glucans on total IgE levels has not been previously reported. Application of ß-glucan (imunoglukan) in a group of asthmatic patients yielded an increased production of anti-allergic tolerogenic cytokine interleukin 10 (Sarinho et al., 2009). We also observed the effect of pleuran on the peripheral blood eosinophilia. "
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