This chapter provides a comprehensive examination of the confluence of Artificial Intelligence (AI) and Blockchain, which are two of the most notable technical advancements in our day. This explores the distinct methods in which the powerful data processing skills of AI and the solid security features of Blockchain might be merged to transform different sectors. The combination of AI and Blockchain is examined through real-world implementations in healthcare to enhance patient care and safeguard data, in supply chain management to enhance transparency and efficiency, in finance to detect fraud and ensure secure transactions, and in legal systems to automate and secure contract management. The chapter delves into the obstacles and potential future developments of integrating AI with Blockchain. It highlights the possibility of AI to enhance the intelligence and autonomy of Blockchain systems, while highlighting the role of Blockchain in guaranteeing the trustworthiness and consistency of AI applications. The integration of these methods has the potential to develop advanced, protected, and streamlined systems, hence enabling the emergence of inventive solutions in data administration and industrial processes.