Tip60-ing the balance in DSB repair

ArticleinNature Cell Biology 11(11):1279-81 · November 2009with2 Reads
Impact Factor: 19.68 · DOI: 10.1038/ncb1109-1279 · Source: PubMed

    Abstract

    The tumour suppressor Tip60 is a histone acetyltransferase implicated in transcriptional control and DNA double-strand break repair. Tip60 binds to the heterochromatic histone mark H3K9me3, triggering acetylation and activation of DNA double-strand break repair factors.