Mycobacterium versus Streptomyces - we are different, we are the same. Curr Opinion Microbiol

Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Current opinion in microbiology (Impact Factor: 5.9). 10/2009; 12(6):699-707. DOI: 10.1016/j.mib.2009.10.003
Source: PubMed


At first glance, bacteria that belong to the two genera Streptomyces and Mycobacterium of the phylum Actinobacteria show no sign of similarity. Whereas Streptomyces species are generally classified as spore-forming, filamentous bacteria, species of the Mycobacterium genus have been considered non-sporulating, rod-like shaped. However, recent studies in genetics and cell biology of Streptomyces and Mycobacterium have revealed striking analogies in the developmental and morphological hallmarks of their life cycles. Understanding the mechanisms underlying these similarities, as well as variations in morphogenesis and development of these two groups of bacteria may not only provide important insights in the evolution of cell shapes in Actinobacteria, but also lead to medical interventions that impact human health.

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    • "Generally, comparative modelling as described here could lead to a more systematic approach towards the identification of suitable “universal hosts” for heterologous expression of gene clusters [47]–[49]. Specifically, this preliminary analysis already suggests that free-living mycobacteria might be an attractive starting point for the generation of a minimal actinobacterial genome for use in synthetic biology approaches [45], [46], especially as all three of them belong to the fast-growing mycobacteria. "
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    • "Strains of Streptomyces sp. are well known as good producers of extracellular recombinant proteins; these strains also have the ability to glycosylate their own proteins, as well as heterologous proteins [15-22]. Recent studies in genetics and cell biology have revealed analogies between Streptomyces sp. and Mycobacterium sp., both belonging to the phylum Actinobacteria [23]. Moreover, S. lividans allows the production, both in shake flasks [15] and in bioreactor [24], of large amounts of glycosylated rAPA suitable for biochemical studies and immunological assays. "
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    • "Compared to, for example B. subtilis spores, those of Streptomyces are less resistant (Flärdh and Buttner 2009). In a recent review Scherr and Nguyen (2009) discussed the similarities and differences between Mycobacterium and Streptomyces (Scherr and Nguyen 2009). Other actinomycetes bacteria produce non-motile spores without forming aerial hyphaes (Asano and Kawamoto 1986; Ara and Kudo 2006). "
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