Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients

ArticleinJournal of dermatological science 57(1):51-6 · October 2009with21 Reads
Impact Factor: 3.42 · DOI: 10.1016/j.jdermsci.2009.09.010 · Source: PubMed


    Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4+CD25+ regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.