Morinda Citrifolia (Noni) Reduces Cancer Risk in Current Smokers by Decreasing Aromatic DNA Adducts

College of Medicine at Rockford, University of Illinois Chicago, Rockford, Illinois 61107, USA.
Nutrition and Cancer (Impact Factor: 2.32). 09/2009; 61(5):634-9. DOI: 10.1080/01635580902825605
Source: PubMed


Quantitative determination of aromatic DNA adducts in peripheral blood lymphocytes (PBLs) of current smokers is an useful surrogate biomarker for the evaluation of environmental carcinogen exposure or chemopreventive intervention. In this study, we examined the impact of Tahitian Noni Juice (TNJ) on the aromatic DNA adducts of PBLs, before and after a 1-mo intervention, using (32)P postlabeling assay. Of 283 enrolled, 203 smokers completed the trial. Aromatic DNA adducts levels in all participants were significantly reduced by 44.9% (P < 0.001) after drinking 1 to 4 oz of TNJ for 1 mo. Dose-dependent analyses of aromatic DNA adduct levels showed reductions of 49.7% (P < 0.001) in the 1-oz TNJ group and 37.6% (P < 0.001) in the 4-oz TNJ group. Gender-specific analyses resulted in no significant differences in the 4-oz TNJ groups. Interestingly, the 1-oz TNJ group showed a reduction of 43.1% (P < 0.001) in females compared with 56.1% (P < 0.001) in males. The results suggest that drinking 1 to 4 oz of TNJ daily may reduce the cancer risk in heavy cigarette smokers by blocking carcinogen-DNA binding or excising DNA adducts from genomic DNA.

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    • "The antioxidant activity of noni juice was found to be associated with increased endurance in athletes [9]. In a human clinical trial involving heavy cigarette smokers, consumption of noni juice resulted in lowered plasma concentrations of superoxide anion radicals (SAR) and lipid hydroperoxides [10]. Further, consumption of noni juice also decreased the level of lipid peroxidation-derived DNA adducts in the lymphocytes of heavy smokers [11]. "
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    • "However, many of the isolated compounds remain unexamined in this regard. Published reports suggest that noni fruits have chemopreventive activity against some types of cancers (Taskin et al., 2009; Wang et al., 2009) but which compound(s) from noni are responsible has not been determined. "
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