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The Biophoton Emission in Biotechnological and Chemical Research: from Meta-Epistemology and Meaning to Experiment. Part 1
Abstract
The review describes the rationale for the feasibility of assessing the biophoton emissions in chemical and biotechnological research and existing methods. In Part 1, we will present the analysis of Meta-Epistemology methods for assessing the biophoton emission. The following stages in the history of the development of methods are identified: First discoveries and formulation of the problem. Pre-paradigm phase. Pre-technical stage (80s of the 18th century – 30s of the 20th century); – Pre-paradigm phase. Technical stage (30s–60s of the XX century); Paradigm scientific phase. The stage of accumulation of scientific data (the 60s–00s of the XX century) is the paradigm scientific phase. Stage of digital technologies and systematic scientific analysis (XXI century). Part 2 will describe the technological features of the methodology and parameters for assessing biophotons, which will allow the use of biophoton emissions in experiments in biotechnological research.
... The control sample was tap water from Sofia exposed to 350-600 Hz, 20-40 kHz [26], and 7 Schumann frequencies [27]. Device for CCGD spectral analysis Gas discharge emission for CCGD spectral analysis [1,21,24,28,29] was investigated in a dark room. It was registered with photosensitive paper or color film placed on a transparent Hostaphan electrode, with an 87 mm diameter. ...
... The investigation, employing the CCGD spectral analysis method [28,29], was conducted on the electric glow of two samples. The control sample was with tap water, from Sofia, Bulgaria. ...
... The electrode was positively charged, and the negative electrode was brought closer until a corona breakdown voltage occurred. The results of Fig. 3 The method for brightness estimation from the CCGD emission research was developed [28][29][30]. ...
... Electromagnetic biophotonic mechanisms are a component of intracellular communication and extracellular communication [5,28,55]. Biophoton signaling is involved in the formation of the morphogenetic field of organ tissue cells and is a component of non-chemical information transfer between organs and parts of the human body [56][57][58]. The biological life of cells, tissues and organs in the human body is connected and determined by the quantum mechanical state of membrane cellular structures and their generation of electromagnetic fields [59]; the cessation of the generation of electromagnetic processes in cell membranes leads to cell death. ...
... Nowadays, ideas about the role of biophotons in the human body have expanded. They play key roles in intracellular communication and in information transfer between organs and segments of the body through the mechanisms of biophoton signaling [5,28,56,57]. Therefore, the working concept that the standing electromagnetic waves/solitons of SRs transmit information to standing electromagnetic waves/photons in the human body requires serious consideration and is promising. ...
... This is a new preliminary hypothesis. As part of the scientific discussion, we would like to note that there is scientific evidence that the transfer of energy in the human body is carried out using photons that are in a state of standing wave/solitons [5,28,56,57]. Biophotons are solitons inside the human body. SRs are solitons at the planetary level. ...
Featured Application
This review should strengthen the transdisciplinary dialogue between scientists for further studying the influence of the Earth’s magnetic field on the human body. This review should draw attention to the issue among biomedical scientists and physicians.
Abstract
(1) Background: The interaction between the human body and the Earth’s magnetic field at Schumann resonances (SRs) is one of the important fundamental questions of science that continues to be studied. The aim of this study was to create a working theoretical foundation for the interaction of the human body with SRs. (2) Methods: Extensive research was carried out in the literature with the aim of comprehensively presenting data on SRs and creating a working concept of their interaction with the human body. (3) Results: General data on SRs, a theoretical basis for justifying their interaction with the human body, possible mechanisms of influence and research results on the functioning of human internal organs were presented. (4) An interaction of the human body with SRs exists and has been scientifically proven. This interaction has been studied most significantly between SRs and the human nervous system. SRs affect functional indicators of the cardiovascular system: heart rate and blood pressure. Studying the influence of SRs on the course and pathogenesis of non-communicable diseases is a promising direction. Low-frequency SRs decrease the risk of developing acute myocardial infarction, and there is a tendency for them to promote cases of chronic kidney disease. SRs are an important external natural factor influencing the human body.
... The resulting glow is localized within and around contact area of the thumb or water or solution drop. The electromagnetic spectral range is 380-495 and 570-750 nm (Ignatov et al., 2015;Nevoit et al., 2024;Antonov, 1995). ...
The effects of biophysical fields on water and model systems of aqueous solutions have been investigated. In two of three experimental models, an electric field was applied under conditions of corona gas discharge. The biophysical influence was exerted on 120 mL water samples. Following exposure to the biophysical fields, drops of the treated water were analyzed using corona gas discharge at the air-liquid interface. The control sample comprised water drops that were not exposed to biophysical fields. In the first method, the corona glow was examined as a function of the dielectric permittivity of the water. In the second method, brightness histograms of the corona discharge were analyzed. The third experimental approach utilized a physiological solution containing 0.9% sodium chloride (NaCl). The comprehensive analysis, incorporating these three methodologies, facilitates a robust evaluation of the effects of biophysical fields on liquid systems.
A fragment of the results of a theoretical analytical systematisation of existing scientific data on the electromagnetic mechanisms of cellular signaling is presented. This is a continuation of the theoretical development of the magneto-electrochemical theory of metabolism (2019–2025). The aim of the theoretical research was to create a concept of electromagnetic communication of cells, to deepen fundamental knowledge, and to find new promising approaches to solving the problem of chronic noncommunicable diseases. General scientific methods of system analysis of literature review were applied in the study, which resulted in a working promising model of the concept of electromagnetic cellular communication. The article is focused on biophotonic signaling and the role of the extracellular matrix in its implementation. The research shows that the concept of biophoton signaling is a promising working model for scientific discussion and for further study into the role of electromagnetic fields in the phenomenon of biological cell life in vivo. The state of the extracellular matrix is an important biological aspect for the implementation of the phenomena of life and health and the quantum pathogenesis of noncommunicable diseases.
The publication of the results of a theoretical study on the conceptualization of Bioelectronic Medicine continues a series of articles on the role of electromagnetic processes in the implementation of the phenomenon of life. The authors, based on modern biophysical fundamental knowledge about the structure and functioning of the human body at the micro level of its structure (nanolevel and deeper) and the concepts of the Magnetoelectrochemical theory of metabolism, developed the main ideological concepts of the scientific direction “Bioelectronic Medicine” as a component for the further development of complex medicine. General scientific methods and theoretical methods were used in this theoretical study. The result of this theoretical research was the extrapolation of modern biophysical fundamental data on the structure of the microcosm of matter to medical knowledge about humans. It is proposed to call the resulting scientific direction the term “Bioelectronic medicine”. A conceptualization of the obtained fundamental ideas was made, three basic concepts and seven main aspects of “Bioelectronic Medicine” were formulated.
Biophotons are an ultra-weak emission of photons in the visible energy range from living matter. In this work, we study the emission from germinating seeds using an experimental technique designed to detect light of extremely small intensity. The emission from lentil seeds and single bean was analyzed during the whole germination process in terms of the different spectral components through low pass filters and the different count distributions in the various stages of the germination process. Although the shape of the emission spectrum appears to be very similar in the two samples used in our experiment, our analysis can highlight the differences present in the two cases. In this way, it was possible to correlate the various types of emissions to the degree of development of the seed during germination.
The results of a theoretical study of the role of biophotons in electromagnetic process of realizing the phenomenon of life are presented in the article. This article is a continuation of the theoretical study of the team of authors, which was published in the Journal of Complexity in Health Sciences, Vol. 5, Issue 1, 2022, p. 22-34 and Vol. 5, Issue 2, 2022, p. 45-57. The aim of the theoretical study was to generalize the available scientific physical and biological knowledge of modern science about the role of biophotons in the electromagnetic processes of the phenomenon of life at the cellular level in order to deepen the fundamental knowledge of Complex Medicine. This study is a fragment of research work on “Development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Noncommunicable Diseases based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). General scientific methods and theoretical methods were used in this theoretical study. Based on the results of this fragment of the theoretical study, twelve conclusions were formulated. The formulated conclusions conceptualize such basic questions as: all living cells at the nanoscale consist of electromagnetic fields and generate electromagnetic fields, cell signaling and all cellular processes are due to electromagnetic interactions, ultra-weak photon emission is a universal optical phenomenon for all cells and plays an important role in communication and in cell life throughout the body.
This study aims to explore the potential of the Electrophotonic Emission Analysis (EPEA) method as an instrumental approach for studying stress in biomedical research. Specifically, the study focuses on assessing the stress levels of Ukrainian military personnel returning from the front using the EPEA method. Materials and methods: A total of 96 individuals participated in this open, non-randomized, exploratory, non-controlled, comparative study. Among them, 26 were military personnel, while the rest belonged to the comparison groups. The EPEA analysis was conducted using a certified hardware and software measuring device called Bio-Well 2.0 (United States). Results: The study found a significant decrease (p<0.0001) in energy levels, with both the military personnel group (41±4.25 J) and the functionally healthy individuals group (57.38±20.78 J) showing similar results. Among the participants, 62% of military personnel and 95% of patients with non-communicable diseases demonstrated optimal energy levels, while 38% and 5% respectively showed reductions. The stress levels measured were 3.69±0.62 cu for military personnel, 3.69±0.62 cu for functionally healthy individuals, and 3.99±1.17 cu for patients with non-communicable diseases. Conclusions: The EPEA method proved effective in instrumentally detecting increased levels of stress and anxiety in 96% of military personnel, 93% of functionally healthy individuals, and 87% of patients with non-communicable diseases in the study. It is of fundamental importance for scientific and systemic medicine to establish that changes in biophoton emission can be observed in patients with non-communicable diseases, including military personnel. Significant differences in total energy levels were found between patients and functionally healthy individuals, with EPEA results showing 41±4.25 J and 43.86±4.87 J respectively for patients and functionally healthy people (p<0.0001). Electro-photonic emission analysis is a promising, valid, accessible instrumental method for biomedical research.
Ultra-weak bioluminescence, also known as ultra-weak photon emission (UPE), is one of the functional characteristics of biological organisms, characterized by specialized, low-energy level luminescence. Researchers have extensively studied UPE for decades, and the mechanisms by which UPE is generated and its properties have been extensively investigated. However, there has been a gradual shift in research focus on UPE in recent years toward exploring its application value. To better understand the application and trend of UPE in biology and medicine, we have conducted a review of relevant articles in recent years. Among the several topics covered in this review is UPE research in biology and medicine (including traditional Chinese medicine), primarily focused on UPE as a promising non-invasive tool for diagnosis and oxidative metabolism monitoring as well as a potential tool for traditional Chinese medicine research.
The results of a theoretical study of the role of water in electromagnetic generation and in the process of realizing the phenomenon of life are presented in the article. This article is a continuation of the theoretical study of the team of authors, which was published in the Journal of Complexity in Health Sciences, Vol. 5, Issue 1, 2022, p. 22-34. The aim of the theoretical study was to generalize the available scientific physical and biological knowledge of modern science about the role of water in the electromagnetic processes of the phenomenon of life at the cellular level in order to deepen the fundamental knowledge of Complex Medicine. This study is a fragment of research work on “Development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Noncommunicable Diseases based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). General scientific methods and theoretical methods were used in this theoretical study. The main conclusions of the theoretical study were made as follows: 1) Тhe “30/11 helix” is the main most typical fragmentary element of water self-organization into fractal structures and it forms energy-intensive fractal crystalline filamentous water structures in living biological systems, supported by energy constantly coming from biopolymers, and forming large constantly growing hierarchical structures that unite all the water of a living organism in a dynamic balance of opposite processes of destruction and growth of its energy-intensive crystalline structures; 2) Water has a key role in the process of transmission and perception of the coherent energy of a soliton through self-organizing fractal energy-intensive paramagnetic crystalline structures in living biological systems; 3) The phenomenon of biological life at the micro level is characterized by the presence of a state of water binding/organization into energy-intensive crystalline structures due to the constant supply of coherent energy from biopolymers and stops when this energy flow disappears, which corresponds to the onset of the phenomenon of biological death and is manifested by the degradation of energy-intensive fractal crystalline self-organization of water to an unbound water state. solution devoid of so-called biological anomalies.
The evidence linking nature and human wellbeing is compelling. Yet, there is a lack of understanding regarding which aspects of nature contribute to wellbeing and the role biodiversity plays specifically. This knowledge gap hampers our ability to understand and manage natural environments from an ecological perspective to improve human wellbeing. To investigate the impact of biodiversity on wellbeing in a range of contexts, there is a need for a psychometric scale. Here, we present BIO-WELL, a novel, reliable and validated self-reported wellbeing scale designed to investigate the biodiversity-health/wellbeing relationship. We describe the conceptual foundation, empirical development and psychometric evaluation of BIO-WELL. We detail five studies, involving 2962 participants, describing the steps taken in the scale's development: (1) a series of deliberative workshops to identify how people conceptualise biodiversity metrics and attributes, and the impact these have on wellbeing; (2) an in-depth qualitative analysis of biodiversity-focused stem questions and wellbeing response items, assessed through an expert panel, focus groups and cognitive interviewing techniques; (3) combined methods associated with classical test theory (e.g. factor analysis) and more modern measurement approaches drawn from item response theory to develop the scale; (4) a confirmatory factor analysis alongside classical test and item response theories to evaluate the scale; and (5) scale validation including discriminant/convergent, concurrent and predictive. The studies demonstrate that BIO-WELL is a valid and reliable scale with strong psychometric properties. We discuss ways it could be applied in research, policy and practice to further develop our conceptual and empirical understanding of the biodiversity-health relationship and assess the effectiveness of related interventions.
The results of a theoretical study of the role of cell membranes in electromagnetic generation and in the process of realizing the phenomenon of life are presented in the article. The aim of the theoretical study was to summarize the existing scientific physical and biological knowledge of modern science about the electromagnetic processes of the phenomenon of life at the cellular level in order to deepen the fundamental knowledge of complex medicine. This study is a fragment of research work on “The development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Noncommunicable Diseases based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). General scientific methods and theoretical methods were used in this theoretical study. The main conclusions of the theoretical study were made as follows: 1) Cell membranes can be considered one of the main morphological structures of electromagnetic generation at the cellular level. 2) Cell viability is ensured by electromagnetic generation and electromagnetic generation of cells can be considered as a separate important function of membranes in addition to those already defined, as it provides signaling. 3) The end result of electromagnetic generation of cell membranes and all molecules of the cell is its own electromagnetic fields, which have a millimeter wavelength range with a frequency of 1010-1011 Hz and they are a quantum mechanical result of electromagnetic generations, perform the information-energy function in intercellular interaction in vivo.
Introduction:
Is Primo Vascular System (PVS) a paradox? Finding the connection between PVS as a carrier of information and the body's reactions at the micro and macro levels will be the starting point in understanding the meaning of life as such.
Before the past of pvs knowledge:
The initial phase of medicine in all cultures is reduced to the transfer of specific energy by special pathways throughout the body! This is the case in China, India, Japan, Korea, Tibet, etc. Undoubtedly, the five articles by B. H. Kim published in the early 1960s are considered to be the past of PVS.
Strange present:
PVS studies after 2002 are accepted as a present. Most of the articles on the topic are in journals with editors-in-chief originating and/or accepting the achievements of Eastern medicine. Is the science of PVS local since its research is in journals that publish mainly articles on Eastern medicine? Why few of the articles concerning PVS are in Western medicine journals?
Pvs:
All substances, objects, biological objects generate a weak electromagnetic radiation typical for each of them which is a passport of the information. PVS has all the data to be the main carrier of information. Information medicine and Quantum Biology can serve as a basis for medicine and biomedical sciences, and it should explain the processes that exist for the change of DNA and organisms in.
This review contains information on the development of magnetic biology, one of the multidisciplinary areas of biophysics. The main historical facts are presented and the general observed properties of magnetobiological phenomena are listed. The unavoidable presence of nonspecific magnetobiological effects in the everyday life of a person and society is shown. Particular attention is paid to the formation of theoretical concepts in magnetobiology and the state of the art in this area of research. Some details are provided on the molecular mechanisms of the nonspecific action of a magnetic field on organisms. The prospects of magnetobiology for the near and distant future are discussed.
Objective:
The aim: Of this publication is to evaluate the results of EPEA in functionally healthy respondents and patients with NCDs to deepen fundamental knowledge of Systemic Medicine, increase the effectiveness of measures to prevent and treat NCDs by improving their diagnosis and prevention through the introduction of modern science-intensive technologies.
Patients and methods:
Materials and methods: 114 respondents were included in an open non-randomized controlled study. 66 сcomorbid patients (71% - men; median age - 61(43; 80) years) with verified Ischemic Heart Disease: functional class II-III angina pectoris were included in the Main Group. 78 functionally healthy young people (23% - men; median age - 23(20; 30) years) who did not play sports regularly were a Control Group. EPEA was made on a digital software hardware device Bio-Well 2.0 (Bio-Well 2.0, Russia-USA).
Results:
Results: Significant differences in AEFE indicators in functionally healthy individuals and patients with NCDs were established. Qualitative indicators of AEFE (indicators of area, intensity, energy of emission) were significantly higher in functionally healthy individuals compared to patients with NCDs. Geometric indicators of AEFE (indicators of length of contours and radii of luminescence) were significantly higher in patients with NCDs than in healthy individuals, which confirmed the visually uneven and more complex contour of luminescence of the fingers in them.
Conclusion:
Conclusions: AEFE parameters have significant differences in functionally healthy individuals and patients with NCDs. AEFE is a fundamentally new promising approach to assessing the level of activity of metabolic processes at the tissue level in living biological systems, including in the normal human body and in patients with NCDs.
We study the emission of photons from germinating seeds using an experimental technique designed to detect light of extremely small intensity. We analyze the dark count signal without germinating seeds as well as the photon emission during the germination process. The technique of analysis adopted here, called diffusion entropy analysis (DEA) and originally designed to measure the temporal complexity of astrophysical, sociological and physiological processes, rests on Kolmogorov complexity. The updated version of DEA used in this paper is designed to determine if the signal complexity is generated either by non-ergodic crucial events with a non-stationary correlation function or by the infinite memory of a stationary but non-integrable correlation function or by a mixture of both processes. We find that dark count yields the ordinary scaling, thereby showing that no complexity of either kinds may occur without any seeds in the chamber. In the presence of seeds in the chamber anomalous scaling emerges, reminiscent of that found in neuro-physiological processes. However, this is a mixture of both processes and with the progress of germination the non-ergodic component tends to vanish and complexity becomes dominated by the stationary infinite memory. We illustrate some conjectures ranging from stress induced annihilation of crucial events to the emergence of quantum coherence.
Objective:
The aim of the publication is to substantiate a conceptual system of views on the role of internal electromagnetic fields and the scientific feasibility of studying the direction of their possible use as a diagnostic indicator in the examination of patients with NCDs.
Patients and methods:
Materials and methods: The of the presented data was carried out during a search study of methods for the rapid assessment of valeological status, prenosological early diagnosis of NCDs, analysis of existing methods for studying the electromagnetic phenomena of the human body.
Results:
Review: The authors systematized the existing technical capabilities and instrumental methods in the framework of systemic medicine. The article proposes a working classification of methods, justifies the choice of methods for further research.
Conclusion:
Conclusions: 1) The study of the electromagnetic component of the human body as a diagnostic indicator in the examination of patients with NCDs is a relevant and promising scientific direction at the present stage. 2) Methods for assessing heart rate variability in a short recording, computerized hardware segmental diagnostics, a computerized digital study of Gas-discharge Electrophotonic Analysis, determination of the PBS-activity of body tissues were selected to further examine the value of their diagnostic parameters in examining patients with NCDs in the first and second levels of therapeutic care.
Once regarded solely as the energy source of the cell, nowadays mitochondria are recognized to perform multiple essential functions in addition to energy production. Since the discovery of pathogenic mitochondrial DNA defects in the 1980s, research advances have revealed an increasing number of common human diseases, which share an underlying pathogenesis involving mitochondrial dysfunction. A major factor in this dysfunction is reactive oxygen species (ROS), which influence the mitochondrial-nuclear crosstalk and the link with the epigenome, an influence that provides explanations for pathogenic mechanisms. Regarding these mechanisms, we should take into account that mitochondria produce the majority of ultra-weak photon emission (UPE), an aspect that is often ignored – this type of emission may serve as assay for ROS, thus providing new opportunities for a non-invasive diagnosis of mitochondrial dysfunction. In this article, we overviewed three relevant areas of mitochondria-related research over the period 1960–2020: (a) respiration and energy production, (b) respiration-related production of free radicals and other ROS species, and (c) ultra-weak photon emission in relation to ROS and stress. First, we have outlined how these research areas initially developed independently of each other – following that, our review aims to show their stepwise integration during later stages of development. It is suggested that a further stimulation of research on UPE may have the potential to enhance the progress of modern mitochondrial research and its integration in medicine.
It is well established that every living organism spontaneously emits photons referred to as ultra-weak photon emission (synonym biophotons or low-level chemiluminescence) which inherently embodies information about the wellbeing of the source. In recent years, efforts have been made to use this feature as a non-invasive diagnostic tool related to the detection of food quality, agriculture and biomedicine. The current study deals with stress resulting from wounding (mechanical injury) on Arabidopsis thaliana and how it modifies the spontaneous ultra-weak photon emission. The ultra-weak photon emission from control (non-wounded) and stressed (wounded) plants was monitored using different modes of ultra-weak photon emission measurement sensors like charge-coupled device (CCD) cameras and photomultiplier tubes (PMT) and the collected data were analyzed to determine the level of stress generated, photon emission patterns, and underlying biochemical process. It is generally considered that electronically excited species formed during the oxidative metabolic processes are responsible for the ultra-weak photon emission. In the current study, a high-performance cryogenic full-frame CCD camera was employed for two-dimensional in-vivo imaging of ultra-weak photon emission (up to several counts/s) and the spectral analysis was done by using spectral system connected to a PMT. The results show that Arabidopsis subjected to mechanical injury enhances the photon emission and also leads to changes in the spectral pattern of ultra-weak photon emission. Thus, ultra-weak photon emission can be used as a tool for oxidative stress imaging and can pave its way into numerous plant application research.
Oxidative stress is associated with skin ageing and disease in humans. However, it is difficult to evaluate the effects of oxidative stress on the skin in vivo using conventional invasive methods. In this study, we performed two-dimensional imaging of ultra-weak photon emission (UPE) generated by excited species in oxidative reaction to determine regional variations in oxidative stress in human facial skin and analysed the relationship between UPE intensity and biophysical properties in vivo. UPE imaging of the facial skin of volunteers revealed regional variations in oxidative stress. The nose, its surrounding regions, and the area between eyebrows showed higher UPE intensity than other facial regions, indicating high oxidative stress in these regions. In contrast, only the region surrounding the eyes showed age-related alterations in UPE intensity; moreover, wrinkle score in these regions was correlated with UPE intensity. These results suggest that oxidative stress in the skin induces wrinkle formation. UPE intensity was correlated with porphyrin score in the skin; however, no correlation was observed between UPE intensity and skin colour parameters. This study provides insights into the treatment of facial skin areas vulnerable to ageing and helps improve our understanding of topical skin diseases related to oxidative stress.
Acupuncture is one of the areas among the alternative therapies that arise high curiosity in the biomedical scientific community. It is particularly popular for treatment of chronic diseases and addictions. However, contrasting with its evidence-based effectiveness, the lack of reasonable explanations for its mode of action divides that scientific community. Difficulties also arise to those responsible for providing information for clinicians and professionals who wish to acquire competencies leading to the acupuncture practice and have a background based on biochemistry and physiology. The classic theories of nerve conduction do not fully explain how information is read and transmitted during the acupuncture treatment. Other theories have been proposed, but they are based on concepts such as biophotonic waves and quantum biochemistry that are difficult to read and understand by those who do not have knowledge in physics. It is the main objective of this review to provide a summary of the main theories and explanatory approaches to the signal transduction and conduction in acupuncture and to describe them in terms of their explanatory hypotheses, limitations, and weaknesses.
The most of the literature found support theories for neural conduction, including gate control. They explain the effects of acupuncture in pain relief; few studies have been conducted concerning the conduction based on biophotons. The primo vascular system has been referred as a possible anatomic support for conduction of information during an acupuncture treatment, which could be connected to biophoton transmission.
Spontaneous ultra-weak photon emission from living organisms, designated as biophoton emission, is a generally observed phenomenon irrespective of the organism species. Biophoton emission is attributed to the production of excited molecules in a metabolic biochemical reaction, especially in processes involving reactive oxygen species (ROS). Although many plant and mammal subjects have reportedly been used to study its application to biological measurements, biophoton emission properties of insects remain unclear. For this study, we strove to measure the variation of two-dimensional images of biophoton emission during the metamorphosis of lepidopterous insects as a moving picture to elucidate the physiological changes underlying the mechanism of drastic changes of morphological and ecological characteristics of the insects. We used our developed biophoton imaging system incorporating a cooled charge-coupled device (CCD) camera and a specially designed lens system to elucidate the spatiotemporal dynamics of biophoton emission during metamorphosis, larval–pupal ecdysis/pupation of Papilio protenor, suggesting its applicability for in vivo observation of physiological changes during the regulation of metamorphosis.
Background:
Spontaneous ultra-weak photon emission (UPE) is a common phenomenon in biological systems and has been linked to pathological states. Researchers have always considered ultra-weak photon emission a potential non-invasive diagnostic tool, but its application in the medical field is stagnant due to the lack of relevant data for pathological states.
Methods:
Ultra-weak photon signals from five body sites (forehead, neck, heart, stomach, and navel) in fifty patients with type 2 diabetes and sixty age-matched healthy subjects were measured using a moveable whole-body biophoton detection system. Photon signal is measured for 10 min and detected in bins of 50 ms by a photomultiplier with a range of 290-630 nm. Each signal is a time series of 12 000 elements. Various parameters including photon intensity, Q value, squeezed state parameters (|α|, θ, ø, r) and SSI were analyzed.
Results and conclusion:
we found significant differences in the abovementioned parameters between groups, and all subjects could be clustered into two groups according to the results obtained by principal component analysis. Methods and results from this study could be useful for constructing a UPE database for a range of diseases, which would promote the application of UPE in clinical diagnosis in the future.
Dielectrophoresis (DEP) is a label-free, accurate, fast, low-cost diagnostic technique that uses the principles of polarization and the motion of bioparticles in applied electric fields. This technique has been proven to be beneficial in various fields, including environmental research, polymer research, biosensors, microfluidics, medicine and diagnostics. Biomedical science research is one of the major research areas that could potentially benefit from DEP technology for diverse applications. Nevertheless, many medical science research investigations have yet to benefit from the possibilities offered by DEP. This paper critically reviews the fundamentals, recent progress, current challenges, future directions and potential applications of research investigations in the medical sciences utilizing DEP technique. This review will also act as a guide and reference for medical researchers and scientists to explore and utilize the DEP technique in their research fields.
Introduction:
Electrophotonic imaging (EPI), also known as gas discharge visualization, is a technique of capturing images of phenomena not quantifiable by the naked eye. Different sectors at the tip of fingers represent various organs and systems as per the Chinese system of acupuncture. The images from these fingertips can be used to determine the state of health. This is done with the help of a CCD camera fitted in the EPI equipment and the specific software relevant for analysis.
Aim:
To observe the correlation between EPI parameters and fasting blood sugar (FBS) levels in normal, prediabetic, and diabetic study participants.
Materials and methods:
A total of 102 participants were selected for this study from various yoga camps and Arogyadham at Swami Vivekananda Yoga Anusandhana Samsthana Yoga University, Bengaluru, India. The selected participants belonged to 3groups-normal, prediabetic, and diabetic-depending on the FBS levels. The distribution of participants was 29 normal, 13 prediabetic, and 60 diabetic.
Results:
Regression analysis in the case of prediabetics showed a significant relationship of FBS with pancreas and right kidney. In the case of normal participants, a significant relationship of FBS was found with area and form coefficient of the EPI gram. For diabetics, regression analysis showed significant relationship of FBS with immune organs, left kidney, area, intensity, and entropy of EPI grams.
Conclusion:
FBS correlates differently in the normal, prediabetic, and diabetic groups. In the prediabetic group, correlation of FBS with EPI parameters pancreas and right kidney is noteworthy and in line with latest findings in medical research.
Quantum mechanics is one of the great success stories of modern physics, making sense of the very small just as Einstein's theory of relativity made sense of the very large. But, for most students, the ideas that make quantum mechanics powerful can be confusing and counterintuitive. This volume in the Greenwood Guides to Great Ideas in Science series provides a history of quantum mechanics from the early breakthroughs of Planck and Einstein, at the beginning of the 20th century, to the present frontiers of quantum computing and quantum gravity. The approach is entirely non-technical, and is aimed at the general reader who may not have much mathematical background but who has a strong curiosity about some of the most important developments in modern science.
Quantum Mechanics: A Historical Perspectivetraces the history of this powerful theory, including: ; The early discoveries by Max Planck and Albert Einstein regarding the quantization of radiation ; The early quantum theory, including Neils Bohr's theory of the atom ; The birth of modern quantum mechanics through the work of Heisenberg, Schrodinger, Born, Dirac and others ; Applications of quantum mechanics in chemistry, nuclear physics, electronics, and many other areas ; Recent work in quantum computation and quantum information theory The book emphasizes the fact that despite the great success of quantum mechanics, many exciting intellectual frontiers remain open for further researchers to explore. It includes a glossary, a timeline, and a bibliography of accessible resources for further research.
This text is a modern introduction to the Standard Model of particle physics for graduate students and advanced undergraduate students. Assuming only prior knowledge of special relativity and non-relativistic quantum mechanics, it presents all aspects of the field, including step-by-step explanations of the theory and the most recent experimental results. Taking a pedagogical, first-principles approach, it demonstrates the essential tools for students to process and analyse experimental particle physics data for themselves. While relatively short compared to other texts, it provides enough material to be covered comfortably in a two-semester course. Some of the more technical details are given in optional supplementary boxes, while problems are provided at the end of each chapter. Written as a bridge between basic descriptive books and purely theoretical works, this text offers instructors ample flexibility to meet the needs of their courses.
Context:
While advances in the Western sciences have increased our understanding of the human biofield, few studies have examined the potential effects of sacred objects on its functioning.
Design and study participants:
This exploratory study examined the effects of a sacred object called the Sri Yantra / Durga Stone on the human biofield. Twelve women and five men were studied on three separate occasions using the Bio-Well device, which purportedly measures aspects of the biofield: baseline (the day before exposure to the sacred object), pre-exposure (immediately prior to exposure to the sacred object), and post-exposure (immediately following exposure to the sacred object). A set of a priori hypotheses examined outcome effects on a set of variables, including multiple physiological systems.
Results:
The overall Bio-Well energy state (Bio-Well variables are in units of joules) was significantly changed following exposure to the sacred object (p = 0.001). In addition, the cardiovascular, endocrine, musculoskeletal, digestive, urinogenital, and immune system readings showed significant changes (p's<0.003) while the nervous and respiratory system assessments were unchanged. Chakra (defined as a center of vital prana) energy was changed following exposure to the stone (p = 0.001), while chakra alignment was not (p = 0.145).
Conclusions:
The findings from this exploratory study suggest that short-term human exposure to this particular sacred object had significant effects on aspects of the human biofield.
The purpose of the study was to conceptualize a system of views on the role of internal electromagnetic fields in the human body to understand the essence of the course of metabolism, the phenomena of biological life and health. Materials and methods. General scientific methods (dismemberment and integration of elements of the studied system, imaginary experiment, logical, historical research, analysis, induction, deduction, and synthesis of knowledge) and theoretical methods (method of constructing theory, logical methods, and rules of normative nature) were used in this theoretical study. Results and discussion. The informative and analytical presentation of the magneto-electrochemical theory of metabolism, life and health is published in the article in the form of the main postulates and conclusions of the atomic and molecular levels of the structure of living biological systems, including humans. This is the first attempt by scientists to combine existing fundamental knowledge about the role of electromagnetic processes in the human body from the standpoint of Systemic Medicine. 12 postulates and 4 conclusions regarding the atomic level and 26 postulates and 6 conclusions regarding the molecular level of the structure of living biological systems, including humans, are presented. All materials are available for viewing in the monograph “Magneto-electrochemical theory of metabolism. Conceptualization”. Conclusion. The life of a biological system is a process of magneto-electric activation of its biomolecules, which starts and ensures their biochemical activity and determines structural integrity in their collective interaction of a single organism. Modern deepening of fundamental knowledge to the level of the course of magneto-electric processes at the molecular level in living biological systems is expedient to be fully integrated into medical science with a change of the electrochemical paradigm of metabolism to a magneto-electrochemical one. Knowledge and understanding of the quantum-mechanical features of the functioning of biopolymers in living systems, the understanding of the essence of their energy functioning, the organization of the form and role of electromagnetic components is the next step to deepening the fundamental knowledge of the pathogenesis of diseases of internal organs with a further approach to optimizing their treatment and prevention
Uniting the usually distinct areas of particle physics and quantum field theory, gravity and general relativity, this expansive and comprehensive textbook of fundamental and theoretical physics describes the quest to consolidate the elementary particles that are the basic building blocks of nature. Designed for advanced undergraduates and graduate students and abounding in worked examples and detailed derivations, as well as historical anecdotes and philosophical and methodological perspectives, this textbook provides students with a unified understanding of all matter at the fundamental level. Topics range from gauge principles, particle decay and scattering cross-sections, the Higgs mechanism and mass generation, to spacetime geometries and supersymmetry. By combining historically separate areas of study and presenting them in a logically consistent manner, students will appreciate the underlying similarities and conceptual connections across these fields. This title, first published in 2015, has been reissued as an Open Access publication on Cambridge Core.
In the knowledge that human ultra-weak photon emission (UPE) is mainly due to the metabolic oxidative stress processes that the skin cells undergo in the presence of reactive oxygen species (ROS), external stressors (like UV radiation), but also internal stressors (like diseases or brain activity) might strongly influence the UPE. This manuscript revises the scientific advances focused on the influence of internal factors on the human UPE. According to literature, the UPE seems to be influenced by some diseases (including diabetes, hemiparesis, protoporphyria, or a typical cold), and even by the cerebral intention/relaxation (brain activity/meditation). These allow to consider UPE as a natural and promising non-invasive spectroscopic tool for helping during the diagnosis of a variety of illnesses or stress- / mood-state disorders. Nonetheless, further research is required for answering some still unresolved controversial points.
Bioelectronic medicine aims to interface electronic technology with biological components and design more effective therapeutic and diagnostic tools. Advances in nanotechnology have moved the field forward improving the seamless interaction between biological and electronic components. In the lab many of these nanobioelectronic devices have the potential to improve current treatment approaches, including those for cancer, cardiovascular disorders, and disease underpinned by malfunctions in neuronal electrical communication. While promising, many of these devices and technologies require further development before they can be successfully applied in a clinical setting. Here, we highlight recent work which is close to achieving this goal, including discussion of nanoparticles, carbon nanotubes, and nanowires for medical applications. We also look forward toward the next decade to determine how current developments in nanotechnology could shape the growing field of bioelectronic medicine.
This article is categorized under:
• Therapeutic Approaches and Drug Discovery > Emerging Technologies
• Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
• Diagnostic Tools > Biosensing
Abstract
Nanomaterial development fuels progress in bioelectronic medicine and has allowed new applications in biological actuation, electroceutics, and electroanalytics.
The goal of this essay is to discuss the future of discovery in particle physics. Its primary motivation is the 2019 European Strategy update, which aims to determine the future experimental and theoretical priorities for particle physics. A key question is to understand what the standard theory (Standard Model) of particle physics really is, which the author argues has been a foggy notion for several decades which he clarifies. It then is to decide what motivated beyond the Standard Model theories are to be targeted by experiment. This book brightly exposes these theories, and puts current particle physics research into its historical context and points the way toward future work.
Objective:
Introduction: The authors focus on the unresolved problem of NCDs and on the relevance of further scientific research in accordance with the current physics-biological level of knowledge about the structure and functioning of the human body. In the course, emphasis is placed on the need for further study of methods for assessing the bioelectromagnetic field of the human body as a potential "tool" for a possible solution of the NCD problem in the framework of system medicine. The aim is to assess the level of development of the methodology and substantiate the scientific feasibility of further exploring the possibilities of the clinical application of these methods for assessing the bioelectromagnetic field of the human body in the algorithms for examining and managing patients with NCDs to study valeological status and objective monitoring of physical phenomena in the clinic of internal diseases.
Patients and methods:
Materials and methods: The analysis of the literature data was carried out in the course of a search study of methods for the rapid assessment of valeological status as a fragment of the initiative research project "Development of algorithms and technology for introducing a healthy lifestyle in patients with non-communicable diseases based on the study of psycho-emotional status" (State registration No. 0116U007798, UDC 613:616-052:159.942:616-03).
Results:
Review: The gnoseological aspect of the development of the methodology for assessing the bioelectric and biomagnetic fields of the human body is described in the article. The conditional time stages of the methodology are highlighted and characterized in it. It was proposed to distinguish between periods: 1) cumulative (XIII-XVIII centuries), 2) cumulative-dynamic (XII-XX centuries), 3) modern (XXI century) 4) modern (prospective). Questions of the feasibility of further research assessing the bioelectromagnetic field of the human body are discussed.
Conclusion:
Conclusions: 1. The above gnoseological aspect of the 700-year-old methodology for studying the bioelectromagnetic field of a human body demonstrates a staged evolution of its development, the presence of a significant amount of cumulated scientific information, which requires rethinking as part of system medicine. This convinces us of the existence of a tendency of inevitable approaching the final stage of knowledge of the human bioelectromagnetic field with the widespread introduction of these techniques into the practical public health of the world. 2. The accumulated layer of scientific knowledge about the bioelectromagnetic component of the human body requires integration into fundamental medicine, transformation of the modern paradigm by creating a bioelectromagnetic-chemical concept of the exchange of matter and energy in the human body. 3. Further research on the assessment of the bioelectromagnetic field is relevant and can contribute to solving the NCD problem both at a fundamental level within the framework of system medicine and by optimizing the diagnostic assessment in patient management algorithms during diagnosis, treatment, primary and secondary prevention.
Living systems emit what is called ultraweak photon emission (UPE). This visually undetectable phenomenon has only been studied in humans for the last 30 years, finding that UPE is a complex process depending on multitude factors. Considering previous literature, this review discusses the current trends in the analysis of in vivo UPE from human beings. To this aim, Analytical Approaches Employed for UPE Measurement section focuses on the analytical techniques employed (photomultipliers and charged coupled device cameras), summarizing analytical conditions and reporting figures of merit reached to date. Then, Human UPE Depending on External Factors and Human UPE Depending on Internal Factors sections address external and internal factors, which have proved to affect UPE, pointing out the important influence on oxidative processes outside and inside the body, and also highlighting some personal states of the individuals affecting UPE. Last section is devoted to give a general view on the goals and achieved up to date regarding UPE measurement, emphasizing some potential applications as well as recommendations which include: use of UPE spectra information together with UPE intensity, larger populations (≈50–100 subjects), further studies on internal states of individuals, and use of statistical tools.
It is now well established that all living systems emit a weak but permanent photon flux in the visible and ultraviolet range. This biophoton emission is correlated with many, if not all, biological and physiological functions. There are indications of a hitherto-overlooked information channel within the living system. Biophotons may trigger chemical reactivity in cells, growth control, differentiation and intercellular communication, i.e. biological rhythms. The basic experimental and theoretical framework, the technical problems and the wide field of applications in the food industry, medicine, pharmacology, environmental science and basic sciences are presented in this book, which also includes the rapidly growing literature.
This book is written by the most outstanding international scientists familiar with this topic who have been working in this field for many years.
Most of the specialists working in this interdisciplinary field of physics, biology, biophysics and medicine are associated with "The International Institute of Biophysics" (IIB), in Neuss, Germany, where basic research and possibilities for applications are coordinated. The growth in this field is indicated by the increase in financial support, interest from the scientific community and frequency of publications.
Audience: The scientists of IIB have presented the most essential background and applications of biophotonics in these lecture notes in biophysics, based on the summer school lectures by this group. This book is devoted to questions of elementary biophysics, as well as current developments and applications. It will be of interest to graduate and postgraduate students, life scientists, and the responsible officials of industries and governments looking for non-invasive methods of investigating biological tissues.
This book is a comprehensive account of five extended modules covering the key branches of twentieth-century theoretical physics, taught by the author over a period of three decades to students on bachelor and master university degree courses in both physics and theoretical physics. The modules cover nonrelativistic quantum mechanics, thermal and statistical physics, many-body theory, classical field theory (including special relativity and electromagnetism), and, finally, relativistic quantum mechanics and gauge theories of quark and lepton interactions, all presented in a single, self-contained volume. In a number of universities, much of the material covered (for example, on Einstein's general theory of relativity, on the BCS theory of superconductivity, and on the Standard Model, including the theory underlying the prediction of the Higgs boson) is taught in postgraduate courses to beginning PhD students. A distinctive feature of the book is that full, step-by-step mathematical proofs of all essential results are given, enabling a student who has completed a high-school mathematics course and the first year of a university physics degree course to understand and appreciate the derivations of very many of the most important results of twentieth-century theoretical physics.
If you look through a number of contemporary textbooks and introductions of biophysics, in order to find out what exactly biophysics is and what the field covers, you will be quite bewildered. Even the titles of the books with their diversity of names for the field, which include, besides biophysics itself, “Medical Physics ”, “Medical and Biological Physics”, “Physical Biology”,“Physical Bases of Medicine and Biology”, and “Molecular Biology ”, already show the existence of different interpretations and tendencies.
This chapter provides a background knowledge of some of the basic concepts and mathematical tools of quantum mechanics and matrix mechanics that are used in subsequent chapters. Without going into mathematical details, the reader is introduced to topics such as time-dependent and time-independent Schrödinger wave equations and their solution in spherical polar coordinates. The concepts of atomic orbitals, spin orbitals, and the charge-cloud interpretation of the wavefunction, which are basics to the development of quantum chemistry, have been developed by considering the problem of hydrogen-like atoms. Heisenberg’s operator formalism of quantum mechanics, operator representation of classical dynamical variables, general properties of linear operators, commutation relations, eigenvalues, eigenvectors, and expectation values have been described. This is followed by linear vector space, Dirac’s ket and bra notations and matrix representation of operators. Since the problems of quantum mechanics need approximate methods for their solution, both the perturbation theory and the variation method have been described. A brief outline of general principles of molecular symmetry and representation of point group is given at the end of the chapter to familiarize the reader with this powerful tool for simplifying several problems in quantum chemistry and for drawing general conclusions about molecular properties without calculations.
There are submitted data on the possibility of applying the Kirlian effect in modeling of nonequilibrium conditions with gas electric discharge simulating primary atmosphere are submitted. The physical basis and technique of visualization of gas discharge luminescence in alternating electric fields of high electrical voltage (5–30 kV) and frequency (10–150 kHz) as well as electrosynthesis of organic molecules are presented. We submitted data on research by colour coronal spectral Kirlian analysis and IR-spectroscopy of water samples of various origin and various degree of water purification and water processing, and also samples of hot mineral, sea and mountain water from various sources of Bulgaria. It was measured the average energy of hydrogen bonds between H2O molecules in the process of cluster formation (dimer, trimer) compiles – 0,10670,0011 eV.
Ultra-weak photon emission (UPE), often designated as biophoton emission, is generally observed in a wide range of living organisms, including human beings. This phenomenon is closely associated with reactive oxygen species (ROS) generated during normal metabolic processes and pathological states induced by oxidative stress. Application of UPE extracting the pathophysiological information has long been anticipated because of its potential non-invasiveness, facilitating its diagnostic use. Nevertheless, its weak intensity and UPE mechanism complexity hinder its use for practical applications. Spectroscopy is crucially important for UPE analysis. However, filter-type spectroscopy technique, used as a conventional method for UPE analysis, intrinsically limits its performance because of its monochromatic scheme. To overcome the shortcomings of conventional methods, the authors developed a polychromatic spectroscopy system for UPE spectral pattern analysis. It is based on a highly efficient lens systems and a transmission-type diffraction grating with a highly sensitive, cooled, charge-coupled-device (CCD) camera. Spectral pattern analysis of the human body was done for a fingertip using the developed system. The UPE spectrum covers the spectral range of 450-750nm, with a dominant emission region of 570-670nm. The primary peak is located in the 600-650nm region. Furthermore, application of UPE source exploration was demonstrated with the chemiluminescence spectrum of melanin and coexistence with oxidized linoleic acid.