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RETRACTION
TNFα Promotes Glioblastoma A172 Cell Mitochondrial Apoptosis via
Augmenting Mitochondrial Fission and Repression of MAPK–ERK–YAP
Signaling Pathways [Retraction]
Lu C, Chen X, Wang Q, Xu X, Xu B. Onco Targets Ther. 2018;11:7213–7227.
We, the Editors and Publisher of OncoTargets and Therapy, have retracted the following article.
Following publication of the article, concerns were raised about the duplication of images from Figures 1, 2, 3, 4, 5, and
6 with images from other unrelated articles. Specically,
●Images for Figure 1E have been duplicated with images for Figure 2a from Li X, Wu M, An D, et al. Suppression of
Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-
mediated mitochondrial ssion. J Cell Physiol. 2019;234:16238–16251. https://doi.org/10.1002/jcp.28287 and 5I
from Jieensinue S, Zhu H, Li G, et al. Tanshinone IIA reduces SW837 colorectal cancer cell viability via the
promotion of mitochondrial ssion by activating JNK-Mff signaling pathways. BMC Cell Biol. 2018;19:21. https://
doi.org/10.1186/s12860-018-0174-z.
●Images for Figure 2A have been duplicated with images for Figure 5H from Li R, Xin T, Li D, et al. Therapeutic
effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-
mediated mitophagy. Redox Biology. 2018;18:229–243. https://doi.org/10.1016/j.redox.2018.07.011.
●Images for Figure 3G have been duplicated with images for Figures 4A and 5C from Yu W, Xu M, Zhang T, et al.
Mst1 promotes cardiac ischemia–reperfusion injury by inhibiting the ERK-CREB pathway and repressing
FUNDC1-mediated mitophagy. J Physiol Sci. 2019;69:113–127. https://doi.org/10.1007/s12576-018-0627-3.
●Images for Figure 4A have been duplicated with images for Figure 2C from Zheng Z, Xiang S, Wang Y, et al.
NR4A1 promotes TNF-α-induced chondrocyte death and migration injury via activating the AMPK/Drp1/mito-
chondrial ssion pathway. International Journal of Molecular Medicine. 2020;45:151–161. https://doi.org/10.3892/
ijmm.2019.4398.
●Images for Figure 4D have been duplicated with images for Figure 4K from Qin R, Zhang L, Lin D, Xiao F, Guo L. Sirt1
inhibits HG-induced endothelial injury: Role of Mff-based mitochondrial ssion and F-actin homeostasis-mediated cellular
migration. International Journal of Molecular Medicine. 2019;44:89–102. https://doi.org/10.3892/ijmm.2019.4185.
●Images for Figure 5D have been duplicated with images for Figure 7d from Wang Q, Xu J, Li X, et al. Sirt3
modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1
signaling pathway. J Cell Physiol. 2019;234:23495–23506. https://doi.org/10.1002/jcp.28918.
●Images for Figure 5H have been duplicated with images for Figure 2A from Xie Y, Lv Y, Zhang Y, et al. LATS2
promotes apoptosis in non-small cell lung cancer A549 cells via triggering Mff-dependent mitochondrial ssion and
activating the JNK signaling pathway. Biomedicine & Pharmacotherapy. 2019;109:679–689. https://doi.org/10.
1016/j.biopha.2018.10.097; Figure 3A from Ouyang H, Zhou E, Wang H. RETRACTED ARTICLE: Mst1-Hippo
pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–
Drp1 axis. Onco Targets Ther. 2019;12:1147–1159. https://doi.org/10.2147/OTT.S193787 and Figure 5H from Li R,
Xin T, Li D, et al (2018).
●Images for Figure 6A have been duplicated with images for Figure 2A from Li J, Li N, Yan S, et al. Liraglutide
protects renal mesangial cells against hyperglycemia-mediated mitochondrial apoptosis by activating the ERK-Yap
OncoTargets and Therapy 2024:17 297–298 297
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OncoTargets and Therapy Dovepress
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Open Access Full Text Article
Received: 28 March 2024
Accepted: 28 March 2024
Published: 3 April 2024
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For personal use only.
signaling pathway and upregulating Sirt3 expression. Molecular Medicine Reports. 2019;19:2849–2860. https://doi.
org/10.3892/mmr.2019.9946.
●Images for Figure 6C have been duplicated with images for Figure 3I from Zhang W, Liu K, Pei Y, Ma J, Tan J,
Zhao J. Mst1 regulates non-small cell lung cancer A549 cell apoptosis by inducing mitochondrial damage via
ROCK1/F-actin pathways. International Journal of Oncology. 2018;53:2409–2422. https://doi.org/10.3892/ijo.
2018.4586; Figure 3g from Qin R, Lin D, Zhang L, Xiao F, Guo L. Mst1 deletion reduces hyperglycemia-
mediated vascular dysfunction via attenuating mitochondrial ssion and modulating the JNK signaling pathway.
J Cell Physiol. 2019;235:294–303. https://doi.org/10.1002/jcp.28969; Figure 5D from Xu P, Zhang G, Sha L, Hou
S. RETRACTED: DUSP1 alleviates cerebral ischaemia reperfusion injury via inactivating JNKMff pathways and
repressing mitochondrial ssion. Life Sciences. 2018;210:251–262. https://doi.org/10.1016/j.lfs.2018.08.049 and
Figure 5g from Li X, et al (2019).
●Images for Figure 6F have been duplicated with images for Figure 1d from Zhang Y, Wang M, Xu X, Liu Y, Xiao
C. Matrine promotes apoptosis in SW480 colorectal cancer cells via elevating MIEF1-related mitochondrial
division in a manner dependent on LATS2-Hippo pathway. J Cell Physiol. 2019;234:22731–22741. https://doi.
org/10.1002/jcp.28838 and Figure 1I from Zhang L, Li S, Wang R, et al. Anti-tumor effect of LATS2 on liver
cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway. Biomedicine &
Pharmacotherapy. 2019;114:108825. https://doi.org/10.1016/j.biopha.2019.108825.
The authors did not respond to our queries and were unable to provide an explanation for the duplicated images or
provide data for the study. As verifying the validity of published work is core to the integrity of the scholarly record, we
are therefore retracting the article and the authors were notied of this.
We have been informed in our decision-making by our editorial policies and COPE guidelines.
The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page
as “Retracted”.
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