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Influence of the rs4238001 Genetic Polymorphism of the SR-B1 Gene on Serum Lipid Levels and Response to Rosuvastatin in Myocardial Infarction Iraqi Patients

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Shaimaa Y. Abdulfattah
Shaimaa Y. Abdulfattah
Shaimaa Y. Abdulfattah
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Huda Alagely at Nahrain University
Huda Alagely
Farah T. Samawi
Farah T. Samawi
Farah T. Samawi
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Abstract

Scavenger receptor type B (SR-BI) is a receptor that binds both native and altered lipoproteins. It was revealed to facilitate utilization of high-density lipoprotein HDL and significantly affect the reverse transport of cholesterol. Therefore, the objectives were to identify the possible role of the genetic variant rs4238001 in patients with myocardial infarction (MI) on serum lipid level, and how this variant could impact the response of rosuvastatin drug. The genotyping of the rs4238001 genetic polymorphism of the SR-B1 gene was performed in 300 participants, including 150 MI patients treated with 20mg/day/4 weeks of rosuvastatin and 150 healthy control using Taq man probes (FAM and VIC) by Real-time PCR technique. The concentrations of the lipid profile were evaluated. The significance of the anthropometric data was revealed in the ejection fraction and smoking status (p < 0.05) between groups. The lipid profile shows either significant differences between control and MI patients (pre-treatment) or between pre-and post-treatment of MI patients (p < 0.05), but not HDL-c (p > 0.05). The minor allele frequency MAF% of the T allele and TT genotype were more frequent in MI patients than in controls (P = 0.173; OR = 3.62; 95% CI = 0.74–17.64). CC genotype was found to be associated with response to rosuvastatin therapy with a change of % (29.08 ± 53.2; p = 0.021). In the Iraqi population, the rs4238001 polymorphism of the SR-B1 gene is associated with variations in serum lipids, and the CC genotype of the SNP is related to higher HDL-C in the lipid-lowering rosuvastatin response.
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Vol.:(0123456789)
Biochemical Genetics (2024) 62:3557–3567
https://doi.org/10.1007/s10528-023-10613-4
1 3
ORIGINAL ARTICLE
Influence ofthers4238001 Genetic Polymorphism
oftheSR‑B1 Gene onSerum Lipid Levels andResponse
toRosuvastatin inMyocardial Infarction Iraqi Patients
ShaimaaY.Abdulfattah1· HudaSalmanAlagely1· FarahT.Samawi1
Received: 14 August 2023 / Accepted: 21 November 2023 / Published online: 22 December 2023
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023
Abstract
Scavenger receptor type B (SR-BI) is a receptor that binds both native and altered
lipoproteins. It was revealed to facilitate utilization of high-density lipoprotein HDL
and significantly affect the reverse transport of cholesterol. Therefore, the objec-
tives were to identify the possible role of the genetic variant rs4238001 in patients
with myocardial infarction (MI) on serum lipid level, and how this variant could
impact the response of rosuvastatin drug. The genotyping of the rs4238001 genetic
polymorphism of the SR-B1 gene was performed in 300 participants, including 150
MI patients treated with 20mg/day/4 weeks of rosuvastatin and 150 healthy control
using Taq man probes (FAM and VIC) by Real-time PCR technique. The concen-
trations of the lipid profile were evaluated. The significance of the anthropometric
data was revealed in the ejection fraction and smoking status (p < 0.05) between
groups. The lipid profile shows either significant differences between control and MI
patients (pre-treatment) or between pre-and post-treatment of MI patients (p < 0.05),
but not HDL-c (p > 0.05). The minor allele frequency MAF% of the T allele and TT
genotype were more frequent in MI patients than in controls (P = 0.173; OR = 3.62;
95% CI = 0.74–17.64). CC genotype was found to be associated with response to
rosuvastatin therapy with a change of % (29.08 ± 53.2; p = 0.021). In the Iraqi popu-
lation, the rs4238001 polymorphism of the SR-B1 gene is associated with variations
in serum lipids, and the CC genotype of the SNP is related to higher HDL-C in the
lipid-lowering rosuvastatin response.
Keywords Scavenger receptor type B (SR-B1) gene· Genetic polymorphism·
Myocardial infarction (MI)· Rosuvastatin
Abbreviations
(SR-BI) Scavenger receptor type B
* Shaimaa Y. Abdulfattah
Shaimaay26@gmail.com
1 Medical andMolecular Department, Biotechnology Research Center, Al-Nahrain University,
Jadriya,Baghdad, Iraq
Content courtesy of Springer Nature, terms of use apply. Rights reserved.
ResearchGate has not been able to resolve any citations for this publication.
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