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ANIMAL HUSBANDRY & VETERINARY SCIENCE | REVIEW ARTICLE
Application of nanotechnology in animal
nutrition: Bibliographic review
Yohannes Gelaye
1
*
Abstract: Nanotechnology is the science and engineering that involves designing,
synthesizing, characterizing, and applying materials in devices and systems for
nanometer-scale matter control. This review explores the application of nanotech-
nology in animal nutrition. Its applications in this field encompass the administra-
tion of nutrients, probiotics, and the diagnosis and treatment of diseases through
drug delivery. Nanoparticles can be classified into inorganic (nano-minerals), organic
(proteins, fat, and sugar nanomolecules), emulsions, dispersions, and nanoclays
nanopolymers. The feeding of nanoparticles has demonstrated improvements in
digestive efficiency, immunity, milk, meat, and egg quality. Nano-minerals offer low
dose usage and improved bioavailability, making them an effective antibiotic
alternative and can also be incorporated into natural feed ingredients. Enzyme
nanoparticles are protein aggregates that show their unique properties (optical,
electrical). Nanotechnology is utilized in feed processing to deliver nutrients to
target organs through methods like encapsulation, chelating, packing, and nano-
tubes without altering taste or color. Nanoparticles could be prepared using
Yohannes Gelaye
ABOUT THE AUTHOR
Yohannes Gelaye is a lecturer and researcher in
the Department of Horticulture, College of
Agriculture and Natural resources, Debre Markos
University, Ethiopia. He did his Master’s degree in
Horticulture at Bahir Dar University, Ethiopia.
Since December 2014, Yohannes is working at
Debre Markos University and teaching courses
like Plant biotechnology, Plant propagation,
Design and agricultural experimentation,
Vegetable and fruit crops production and man-
agement, Ornamental horticulture, Plant phy-
siology, Coffee production, processing and quality
control, Crop protection, and Nutrition sensitive
agriculture. His research interest is
Biotechnology, Biochar in agriculture, Adapting to
drought stress, Byproduct utilization, Climate
change induced disease and pests, Drought
induced physio-morphological, molecular and
biochemical changes, Agro-nanotechnology,
Artificial Intelligence, Crops and soil improve-
ment, Postharvest science and technology, Food
safety, and Nutrition, and food security.
PUBLIC INTEREST STATEMENT
Nanotechnology primarily used in animal nutri-
tion to produce nanominerals, particularly trace
elements with limited bioavailability, which
reduce intestinal mineral antagonism, excretion,
and environmental contamination. Nanotubes
are used to detect estradiol antibodies during
oestrus, revolutionizing the veterinary and ani-
mal science fields by providing in-depth infor-
mation about organisms’ inner bodies.
Nanotechnology also improved various aspects
of veterinary medicine, including disease detec-
tion, treatment, vaccine development, drug
administration, and addressing nutrition and
reproductive issues. Moreover, nanoparticles can
be integrated into smart systems, comprehend-
ing medicinal and imaging chemicals and pos-
sessing stealth properties by adjusting their size,
surface properties, and composition. In general,
nanotechnology has the potential to transform
agriculture and livestock development through
resolving animal health, production, nutrition,
reproduction, and hygienic practices and making
it a new avenue for the new era.
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution
License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribu-
tion, and reproduction in any medium, provided the original work is properly cited. The terms on
which this article has been published allow the posting of the Accepted Manuscript in
a repository by the author(s) or with their consent.
Received: 04 July 2023
Accepted: 28 November 2023
*Corresponding author: Yohannes
Gelaye, College of Agriculture and
Natural Resources, Debre Markos
University, Debre Markos, Amhara, P.
O. Box. 269, Ethiopia
E-mail: yohanes_gelaye@dmu.edu.et
Reviewing editor:
Pedro González-Redondo, University
of Seville, Spain
Additional information is available at
the end of the article
Page 1 of 16
nanotools in nanotechnique such as precipitation, emulsion cross-linking, spray-
drying, emulsion-droplet coalescence, etc. Nanoparticle synthesis is performed by
physical (high-energy ball milling, vapor deposition), chemical methods (forming
colloids), and biological methods. Despite nanotechnology applications having
potential contributions to simplify life and enhance the animal industry in feed,
health, and production, the challenges in human, animal, and environmental issues
are also stated as the side effects of the technology.
Subjects: Agriculture & Environmental Sciences; Plant & Animal Ecology; Soil Sciences
Keywords: animal feed; nanotechnology; nano-mineral; enzyme nanoparticles
1. Introduction
The term “Nano” stems from the Greek word “nanos” which means “dwarf” and was originally just
a prefix substituting the factor of 10
−9
for SI units (Grunwald, 2017). Nanotechnology involves
designing, synthesizing, characterizing, and applying materials for nanoscale control in devices and
systems, typically ranging from 1–100 nm (Pundir, 2015). It is a remarkable and rising technology
with enormous potential to transform the agriculture and livestock sectors around the world
(Marappan et al., 2017). Nanotechnology was developed to reduce the particle size to a couple
nanometers in size (Loghman et al., 2012; Ognik et al., 2016). Nanotubes, nanofibres, nanorods,
nanoparticles, and thin films have all been studied to identify their characteristics and possible
uses (Pundir, 2015). Nanoparticles are the most extensively studied among all nanomaterials.
Nano sensors, nanomaterials, microfluidics, and bioanalytical devices are examples of nanotech-
nology devices employed to enhance animal health, production, reproduction, disease treatment,
and prevention (Kroubi et al., 2010; Tarafdar et al., 2013). By improving the production methods,
the application of nanotechnology will revolutionize the livestock industry (Fesseha et al., 2020).
Nanotechnology uses in animal nutrition encompass the delivery of vitamins, mineral supple-
ments, probiotics, and drugs, disease detection and treatment (Fesseha et al., 2020).
Nanotechnology is used in animal feed in the form of nanominerals, nanoenzymes, as well as
additional additives (Fesseha et al., 2020; Marappan et al., 2017; Pundir, 2015). Nanoparticles
enhance nutrient absorption by reducing bivalent cations’ antagonistic impact, especially in tiny
minerals, making them beneficial for livestock and poultry nutrition and improved feed and
supplemental utilization (Marappan et al., 2017).
Despite the potential of nanotechnology to simplify life and enhance various aspects of animal
industries, including feed, health, and production, the use of nanoparticles is accompanied by
challenges in human, animal, and environmental concerns. Hence, this review thoroughly assesses
the application of nanotechnology in the field of animal nutrition.
2. Methodology
In the course of performing a literature review, the author employed various strategies. Reputable
journals from Scopus, Web of Science, and PubMed databases were utilized for the compilation of
this review. Additionally, the inclusion criteria primarily focused on articles published after 2019,
with the exception of relevant facts and books.
3. Nano-technology and animal nutrition
3.1. Application of nanotechnology in animal nutrition
The use of various nanoparticles in the administration of medications, nutrition, probiotics, vita-
mins, and additives is a prime instance of nanotechnology in the feeding of animals (Fesseha et al.,
2020; Marappan et al., 2017). Nanoparticles have also been used in poultry feed to reduce the
amount of harmful bacteria in the chicken microbiome, while other types of nanoparticles have
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been proven to increase the growth of beneficial bacteria, hence improving performance as well as
growth (Mahmoud, 2012). Employing the microencapsulation enhances the solubility of fat-soluble
additives in feed, improve taste, and reduces the need for fat, salt, sugar, and preservatives (Weiss
et al., 2010). Nanoparticles exhibit unique transport and uptake characteristics, resulting in
increased absorption efficiencies (Zha et al., 2008). Notably, nanoparticles can be ingested directly
through feed and water or integrated into feed packaging (Fesseha et al., 2020). Consequently,
these nanoparticles have higher bioavailability, a lower dosage rate, and more sustained interac-
tions with other substances.
3.1.1. Nano minerals
Nano-minerals provide low-dose antibiotic alternatives, improve growth, remove residues, reduce
pollutants, and produce pollution-free animal products (Hett, 2004; Schmidt, 2009). The size of
mineral nanoparticles should be smaller than 100 nanometers, which lets molecules to be taken
faster than bigger particle size minerals and meet mineral demands to improve the efficiency of
production (King et al., 2018; Tatli Seven et al., 2018; Wen et al., 2006). Furthermore, minerals as
nanoparticles minimize intestinal mineral antagonism, lessening excretion and contamination.
Although numerous nanominerals find applications in animal nutrition, Table 1 presents some
specific examples.
3.2. Types of nano particles
Nanoparticles are reported to be divided into inorganic, organic emulsion, dispersion, and nano-
clays as illustrated on Figure 1, based on the chemical characteristics they possess (Al-Beitawi
et al., 2017; Bunglavan et al., 2014). Inorganic nanoparticles, including minerals, are used in
nutrition, feed, and packaging industries for various applications, including feed packaging, water
purification, antimicrobial packaging, and feed storage (Al-Beitawi et al., 2017; Bunglavan et al.,
2014). By encapsulating proteins, fat, and sugar, organic nanoparticles improve feed functioning
while enhancing nutritional value and bioavailability. They are employed as tiny particles and
liposomes within feeds, as well as biosensors, identification markers, shelf-life extenders, and
antimicrobials in feed packaging techniques (Ahmadi & Rahimi, 2011). Nano-emulsions, on the
contrary, can stabilize and transfer active substances by enclosing the functional feed elements in
an oil/water boundary or a continuous state (Agnihotri et al., 2004).
Metals, polymers, natural chemicals, and nanostructured materials are the four areas of nano-
technology (Niemiec et al., 2021). Nanoparticles, a powder form of solid metal, can be utilized in
various biotechnical applications by altering their physical characteristics through various engi-
neering methods (Halperin, 1986). These particles have caught the curiosity of medical profes-
sionals due to their possible applications in imaging and antiseptic medications that lyse Gram-
positive and Gram-negative walls of bacteria (Ramasamy et al., 2016). Certain metal nanoparticles
are possibly better suited for external use to prevent buildup in the body, since a particular species
might trigger detrimental dose toxicity reactions, although this is not necessarily possible
(AshaRani et al., 2009; Kawata et al., 2009; Travan et al., 2009). Metal’s non-biodegradability is
another major barrier for these particles.
Polymeric nanoparticles are synthesized or fractured into nanoparticle-sized bits that can be
grafted onto other materials, potentially increasing biocompatibility and disintegration (Travan
et al., 2009). Biocompatibility is highly useful to the medical and feed sectors because it has few to
no detrimental effects on patients or customers, and polymeric nanoparticles with dose toxic
effects, like metal nanoparticles, would have needed to be addressed (You et al., 2007).
3.3. Nano feed additives and its application in animal nutrition
Nano-additives are reported to be found in protein micelles, capsules, and natural feed ingredients
(Khalid & Arif, 2022). Nano-capsules are also mentioned to enhance the bioavailability of essential
oils, flavors, antioxidants (Ozogul et al., 2022). Encapsulating nanoparticles were used to protect
minerals and micronutrients from oxidation and reducing unpleasant taste (Galanakis, 2019).
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Table 1. List of nano-minerals used in animal nutrition
No. List of nano-minerals and associated attributes Ref.
1 Manganese nanoparticles enhance chicken growth
performance, antioxidant status, and bone attributes without
affecting feed intake, weight gain, or efficiency.
Mn is described for proper antioxidant and immune system
function.
Mn is also reported as cofactor of transferases, lyase,
hydrolysis, and oxidoreductases, essential for mitochondrial
antioxidant system, apoptosis, bone development, and cell
structure
Patra and Lalhriatpuii (2020)
Palomares (2022)
Pasquini et al. (2022).
2 Calcium and phosphorus are crucial for bone growth in
animals and poultry. Nano-minerals can improve feed
conversion efficiency and body weight gain by 50%, but
decrease calcium and phosphorus excretion.
Nano-minerals provide low-dose antibiotic possibilities,
increase growth, eliminate residues, reduce pollutants, and
make pollutant-free animal products.
Furthermore, plant-based diets contain substantial amounts
of inaccessible P phytates (60–80% of total P), which are not
utilized efficiently by chickens due to the absence of phytase
enzymes.
Hassan et al. (2016), Samanta
et al. (2019)
Selle et al. (2009)
Baharuddin et al. (2009)
3 Selenium is crucial for development, fertility, immune system,
hormone metabolism, cell proliferation, and antioxidant
defense. Nano-Se supplementation improves pH, ammonia,
fatty acid levels, fertility, sperm quality, and egg production in
layer chickens.
Nano-Se at 0.3 mg/g dry food was reported to have greater
physiological effects in layer chicks.
Similarly, purine derivative nutrition utilization and urinary
excretion were dramatically enhanced by nano-Se
supplementation.
Ghaffarizadeh et al. (2022)
Nabi et al. (2020)
Shi et al. (2011)
4 Chromium is vital for insulin sensitivity and metabolism in
animals. Nanocomposite in pigs reduces glucose, cholesterol,
and fatty acid content, while increasing protein and
lipoprotein production. Chromium propionate improves egg
production and reduces heat exhaustion in poultry.
Chromium has been suggested as it promotes insulin
sensitivity in cells by activating insulin receptor kinase
function.
Egg quality, Cr persistence in the body, in the eggshell, and
levels in the liver has all been observed to improve as a result
of Cr-picolinate nanoparticle supplementation.
Bakshi and Panigrahi (2022)
Anderson (2003)
Hassan et al. (2020)
5 Copper is essential for metabolic activity, physiological
functions, immunological responses, connective tissue
development, and nerve function. Inorganic Cu sulphate and
CuO nanoparticles improve growth performance, immunity,
and reduce inflammatory responses in poultry.
Cu nanoparticles included in basal meals decreased intake
without influencing laying hen body weight, egg output,
mass, or quality. Grill chicken with Cu supplementation
lowered growth performance but decreased excretion.
Through fast absorption, toxicity, and interaction, nano-Cu
improves animal production performance.
Rossi et al. (2020)
Patra and Lalhriatpuii (2020)
6 Silver nanoparticles in weaned pigs reduce coliform content,
pathogen concentration, bacterial counts, growth,
antibacterial capability, lymphatic organ weight, newborn
weight loss, and liver lesions in grilled meats.
A nanosilver feed additive substantially reduces the bacterial
count in the digestive tract of poultry, lowering E. coli,
Streptococcus, Salmonella, and mesophilic bacteria.
Nano-silver supplementation of 20, 40, and 60 ppm feeds
resulted in a dose-dependent reduction in the weight of the
lymphatic organs.
Fondevila et al. (2009)
Bhanja and Verma, (2021)
Al-Sultan et al. (2022)
(Continued)
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Liposomal nano vesicles are stated to transport nutrients, enzymes, flavors, and antibacterial
agents in food (Pateiro et al., 2021). Proteins and substances are also expressed to encapsulate
nano-additives in micelles and oil spheres coated with bipolar molecules (Prasad et al., 2022).
These are also stated to be suspended in water or encapsulated in oil, and nano-capsules contain
omega-3 fish oil with unpleasant flavor (Liao et al., 2021).
Feed additives are essential raw materials in the modern feed industry, improving nutritional
value, animal production efficiency, health, cost reduction, and product quality (Pandey et al.,
2019).
3.4. Enzyme nanoparticles (ENPs) and its application in animal nutrition
Enzyme nanoparticles are described as clustered, protein-like structures with 10–100 nm
dimensions, offering stability, biocompatibility, conductivity, and sensitivity (Xing et al.,
2022). This particles have a variety of characteristics that improve enzyme-based sensor
performance by enhancing the surface area (Eivazzadeh-Keihan et al., 2022). Nanoparticles
are reported to cause denaturation and function loss due to protein/enzyme binding (Riley
et al., 2022). To address this issue, enzyme molecules were aggregated to form nanoparticles
and cross-linked within themselves in a regulated manner prior to immobilization (Liu et al.,
2022). As a result, a potential technique for biosensor generation with increased analytical
performance in terms of detection limit and current response has emerged (Thapa et al.,
2022). Enzyme nanoparticles of horseradish peroxidase, glucose, cholesterol, and uricase
were characterized for amperometric biosensor construction (Phetsang et al., 2019).
Additionally, enzyme nanoparticles are reported to possess high catalytic activity and thermal
stability (Khizar et al., 2022). Trypsin and chymotrypsin single enzyme nanoparticles are also
stated by researchers (Hegedüs et al., 2020). Furthermore, enzyme nanoparticles are also
reported to preserve activity and enhance thermal stability (Liu et al., 2022). Recent studies
show that enzyme nanoparticles improve temperature tolerance and cellulose degradation (Gu
et al., 2022). Animal feed enzymes break down indiscriminate components in feed products,
potentially causing reduced meat or egg production, poor feed efficiency, and digestive issues
(Islam et al., 2023).
3.5. Feed processing
Nanoscale particles are reported to have higher surface area, efficient nutrient absorption, and are
ultrafine (Mobasser & Firoozi, 2016). Nanotechnology advances functional feed by encapsulating
valuable ingredients, preventing loss during processing, and effectively delivering nutrients (Tiwari,
2022). The crucial element in the technology is the inclusion of nano capsules in the feed to deliver
nutrients (Fajardo et al., 2022). The 50 nm nano-chelates are reported to efficiently deliver nutri-
ents without affecting feed color or taste (Ahmed et al., 2023).
No. List of nano-minerals and associated attributes Ref.
7 Nano-zinc supplementation enhances broiler bird immune
status and bioavailability, inhibiting mycotoxic fungi growth
and mycotoxins, reducing feed treatment hazards.
Hussan et al. (2022)
8 Iron is crucial for hemoglobin and oxygen transport, while Fe
nanoparticles may improve chicken growth, haematology,
and immunity. Research on their use is limited, but high doses
can cause embryonic growth retardation and nerve damage.
Fe nanoparticles and Fe-sulfate diets in quail breeders did not
affect feed intake, egg mass production, quality, fertility, or
chick growth.
Scott et al. (2018)
Turgud and Narinç (2022)
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3.6. Green synthesis
The process that produces nanoparticles from plants is called “green synthesis”, and due to the
fact that this technique uses plant extracts that contain proteins, carbohydrates, polyphenols,
alkaloids, terpenoids, and other substances (Nadaf et al., 2022). Furthermore, the metal ions are
stabilized by these molecules, and these plant sources, which were exploited by different research-
ers to synthesize these nanoparticles are as follows: Geranium (Pelargonium graveolens) has been
used to produce green nanogold and silver particles from an array of plant resources (Khan et al.,
2022), Lemongrass (Cymbopogon flexuosus) leaf extracts (Fiore et al., 2022), Camphor tree
(Cinnamommum camphora) (Lee et al., 2022), neem (Azadirachta indica) (Reddy & Neelima,
2022), Aloe barbadensis (Aloe vera) (Cuvas-Limón et al., 2022), tamarind (Tamarindus indica)
(Hasan et al., 2022), Okra (Abelmoschus esculentus) (Sarwar et al., 2022), and extracts of Amla
fruit (Emblica officinalis) (Kaushik et al., 2022; Majeed et al., 2022), oat (Avena sativa) (Azevedo
et al., 2022), alfalfa (Medicago sativa) (Ahmadi et al., 2022), soaked Bengal gram bean (Cicer
arietinum) (Rizvi et al., 2022) and Concoction (Piper nigrum) (Bawazeer et al., 2022). Plants such
as alfalfa (Medicago sativa) and Chinese mustard (Brassica juncea) were used for silver and Ag-Au-
Cu alloy nanoparticle synthesis (Song et al., 2022). Lemon extract is reported to be used as
a reducing agent for producing manganese acetate, and curcumin serves as a stabilizing agent
(Nguyen et al., 2022).
The environmentally friendly synthesis of nanoscale metals involves obtaining a plant extract,
combining it with metal salt solution, reducing metallic particles, and performing filtration (Liu
et al., 2023). This technique produces various metallic nanoparticles, including green ones, used in
cosmetics, pharmaceuticals, appliances, food, aquaculture research, and agricultural goods
(Kumar et al., 2023).
3.7. Preparation of enzyme nanoparticles to add in the animal diet
According to reports, enzyme nanoparticles are stated to be prepared through ethanol, glutar-
aldehyde, and cysteine/cysteamine treatment (Javid et al., 2022). Bovine serum albumin (BSA)
proteins were aggregated into nanoparticles to produce soluble proteins through emulsification in
plant oil (Taha et al., 2022); desolvation in ethanol or with natural salts, then cross-linking with
glutaraldehyde (Li et al., 2008); anhydrous ethanol, glutaraldehyde, and ethanolamine’s simple
coacervation (Shahidi & Hossain, 2022) and high pressure cross-linking in water and oil emulsion
(Li et al., 2022). Nevertheless, so far, ethanol desolvation as well as concomitant glutaraldehyde
cross-linking have been used to produce the enzyme nanoparticles (Fuchs et al., 2010).
Figure 1. Summary of some
types of nano particles.
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Nanoparticles exhibit unique physical, chemical, and biological properties compared to larger
particles, including material strength, solubility, conductivity, optical properties, thermal behavior,
and catalytic activity (Alhashmi Alamer & Beyari, 2022; Khan & Hossain, 2022; Napagoda et al.,
2022). In addition, nanoparticles have a larger surface-to-volume ratio as well as a greater number
of atoms at the surface, which determine their main attributes (Haase et al., 2022; Joudeh & Linke,
2022). Nanoparticles’ structures and characteristics have significantly changed due to larger sur-
face curvatures, more catalytically active sites, and more surface flaws (Lai et al., 2022). When
compared to its bulk components, the physical and chemical characteristics of nanoparticles may
alter their biological consequences.
Various methods for nanoparticle synthesis, such as physical, chemical, reactive precipitation,
sol-gel, microemulsion, sonochemical, and supercritical chemical processing, have been developed
and extensively documented in the literature (Prakash et al., 2022).
3.8. Mode of action
These nanoparticles can carry different components in a variety of environmental settings (Brewer
et al., 2022). The synthesis of nanoparticles and minerals using this approach provides two notable
advantages compared to conventional chemical methods (Kumar et al., 2017). Firstly, nanosized
particles play a crucial role in the targeted delivery of nanoparticles because they can more easily
traverse capillary walls (Wang et al., 2022). Secondly, as biodegradable ingredients are employed
in this process, there is no risk of environmental pollution or chemical accumulation (Tian et al.,
2022). According to (Mahdi et al., 2022) and (Alavi et al., 2022), nanoparticles increase biological
interactions, extend compound residence time, reduce intestinal clearance, penetrate tissues,
cross epithelial linings, and enable efficient uptake and delivery of active compounds.
Nanoparticles used for developing nanostructured materials are created from a variety of sources,
including naturally occurring substances like lipid- and protein-based nanoparticles (Harish et al.,
2022). Nanoparticles can encapsulate and adhere to functional groups, acting as carriers for
medications and nutrients (Mushtaq et al., 2022; Zhu et al., 2022). Nature-derived nanomaterials
can appear to be a safer option, but if they are not carefully developed or dispersed properly in
a biological system, they could cause hazardous or immunogenic reactions (Song et al., 2022).
3.9. Effect of inclusion nanoparticles on animal feed
3.9.1. Nutrient absorption and utilization
Natural or artificial nutrient nanoparticles can help cells absorb bioactive chemicals and stabilize
them (Awuchi et al., 2022). A bioactive ingredient can be added directly to feed, but doing so
includes a risk of deterioration and unavailability that can be avoided by using nanotechnology
(Sagar et al., 2022). Although they can more easily pass through the intestinal mucosa due to their
smaller size than microparticles, nanoparticles have a higher level of bioavailability than micro-
particles, especially in the digestive tract (Yun et al., 2013). By encapsulating nano particles with
natural nanonutrients and artificial nanoparticles like casein, it is typically possible for them to
bypass the body’s normal physiological pathways for nutrient transport via cell membranes and
distribution in tissues (Das et al., 2023). To enable transmission from mother to child, some casein
isoforms group together around calcium, protein, vitamin D, and other nutrients (Nadugala et al.,
2022). The advantages of nanonutritional supplements may also help weaning animals and fowl
grow larger. Previous studies by (Jia et al., 2018)) and (Wang et al., 2022) indicated that in mice
and turkey, calcium nanoparticles produced denser bone when compared to microcalcium, respec-
tively. By improving the bioavailability of the nutrient payload, nanoparticles designed for nutrient
delivery could facilitate this supplementation and boost animal growth rates (Gopi & Balakrishnan,
2022). Due to their small particle size and large surface area in the intestinal lumen, nanoparticles
often have better absorption (Kumari & Chauhan, 2022).
Nanotechnology revolutionizes animal production, breeding, disease treatment, and identity
preservation, transforming medicine delivery methods and disease diagnosis (Prabha et al.,
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2022). Scientific research has been primarily focused on developing effective vaccines and utilizing
nanoparticle technology in animal reproductive. Nanotechnology has significantly improved var-
ious aspects of veterinary medicine, including disease detection, treatment, vaccine development,
drug administration, and addressing nutrition and reproductive issues (Poddar & Kishore, 2022).
Ruminants can benefit from microminerals for improved digestion, metabolism, microbiota bal-
ance, and reproductive success.
3.9.2. Meat and egg quality
In addition, it has been explored whether utilizing nanoparticles could improve the quality of meat
and eggs. For example (Poddar & Kishore, 2022), demonstrated that Chromium nanoparticles (200
g/kg) were fed to Finish pigs, and they were 14.06% slimmer at slaughter than the control pigs.
Chitosan nanoparticles are also reported to improve pigs’ skeletal muscle mass and meat quality
by lowering fatty acid synthase activity (Xiong et al., 2022). The incorporation of nanomaterials to
animal feed or water can improve both the final product’s quality and the process of production,
such as the quality of broiler meat, egg yolks, and eggshells (Dong et al., 2022). Concentration of
nanoparticles makes sure that despite prolonged exposure, quality is not compromised (Mortensen
et al., 2022). Consumers are likely to still favour meat and eggs made from animals fed nanopar-
ticle supplements if they are improved or indistinguishable from the original product (Bhagat &
Singh, 2022). Nevertheless, before using the nanoparticle additive in animal production, it is crucial
to understand the role of the additive in a specific biological system and the byproducts from that
system to make sure it is safe for consumption (Dupuis et al., 2022).
3.9.3. Milk production and quality
By developing new methods for identifying foodborne pathogens and shortening the time needed
for drug withdrawal, nanotechnology can also assist and ensure that milk is of a quality that is safe
for human consumption (Shenashen et al., 2022). Low levels of tilmicosin extend the half-life of
the mastitis pathogen in mouse blood serum by employing hydrogenated castor oil-solid lipid
nanoparticle carriers (Kareem et al., 2022). Nano-composites using anti-S. Aureus antibodies, gold
nanoparticles, and magnetic nanoparticles can detect the presence of bacteria in milk in just forty
minutes (Sung et al., 2013). These nanocomposites have an intriguing attribute in the antibody,
whose selectivity and specificity may be altered to capture a range of diseases (Ozkan-Ariksoysal,
2022). Toxins in milk can be found utilizing polyclonal antibodies and gold nanoparticle immune
chromatographic strips within 10 minutes (using the cancer-causing aflatoxin M
1
) (Rastogi et al.,
2022). While removing potentially dangerous pollutants from milk has received most of the
attention, adding supplements containing nanoparticles directly to cow’s milk for human con-
sumption has generated some interest (Abdelnour et al., 2021). Comprising oyster shell nano
powder in milk is reported to raise the calcium concentration from 100 to 120 mg/mL, and the
level is better suited for growing youngsters and postmenopausal women (Abdelnour et al., 2021).
After 16 days of storage at 4°C, adding calcium from nanopowdered oyster shell to milk did not
have a negative impact on its sensory or physicochemical properties (Lee et al., 2015).
3.9.4. Immune responses of the gastrointestinal tract (GIT)
Innate defenses, acting as barriers, are present in the gut-associated lymphoid tissue (GALT)
aggregates of the gastrointestinal tract (GIT) (Madakka et al., 2020). The interpretation of nano
particle ingestion studies is influenced by the biological and physicochemical characteristics of the
GIT (Mittag et al., 2022). The biological effects of a particle are influenced by factors such as size,
surface area, number, aggregation/agglomeration state, charge, and surface coatings (Fubini et al.,
2010). The proposal suggests a set of minimal specifications for nanomaterial characterization for
toxicological investigations (Cebadero-Domínguez et al., 2022). Factors such as particle size, dis-
tribution, aggregation state, form, chemical composition, surface area, purity, and stability are
some of the key considerations (Bergin & Witzmann, 2013). Absorption and biological responses
are also impacted by oxidant production and rate of breakdown (Sun et al., 2022). In vivo
experiments can introduce significant heterogeneity due to species, strains, diet, housing, dosage
time, circadian rhythms, and endogenous microbiome (Lecour et al., 2022). Careful reporting of
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these factors can help to increase transparency and make it easier to reconcile inconsistent results
between studies (Liu et al., 2022). The Metabolomics Standards Initiative and arrive guidelines aim
to standardize metadata for in vivo experiment parameters in particle toxicity studies (Sumner
et al., 2007).
The gastrointestinal system, one of the largest immunological organs in the body, typically
accounts for up to 70% of an animal’s immune response activity (Choct, 2009). The performance
of animals is significantly influenced by a healthy gut. Thus, the performance of trace mineral
dietary supplements and effective management can help achieve this goal (Sampath et al., 2023).
3.10. Side effects of nanoparticles
Nanoparticles are reported to increase bioavailability risk, inflammatory gastrointestinal diseases,
altered nutrient bioavailability, and potential effects during heating or storage (Elnahal et al., 2022).
Linking experimental nanoparticle toxicity to real-world human health risks is challenging due to the
lack of precise environmental information (Bergin & Witzmann, 2013). It is especially challenging to
extrapolate results from in vivo toxicity studies’ higher shorter-term doses to the expected conse-
quences of chronic, minimum dose exposures (Doe et al., 2006). According to review done by (Yip et al.,
2022) consuming nanoparticles appeared to have low toxicity for in vivo tests. No side effects were
noted for silver nanoparticles at levels lower than 125 mg/kg (Yan et al., 2022). Up to 5,000 mg/kg of
TiO
2
nanoparticles were also reported to be tolerated without any negative effects (Javed et al., 2022).
In vitro studies show cytotoxicity and increased membrane permeability, while in vivo studies show no
effects except at high doses (Wang et al., 2021).
4. Challenges and limitations of nanotechnology
Nanotechnology advances disease detection, prevention, and treatment in animals, despite poten-
tial toxic side effects (Zain et al., 2022). It is possible that exposure to artificial nanoparticles will
have different consequences than exposure to naturally occurring nanoparticles (Kessler, 2011).
Because of their size or protective coatings, engineered nanoparticles are stated to be better to
avoid the body’s defenses (Liu & Huang, 2022).
Since nanoparticles are often incorporated in finished goods, they rarely come into touch with people,
animals, or the environment (Hemathilake & Gunathilake, 2022). Nanotechnologies face an array of
challenges, including risks to the environment from the release of nanoparticles into the environment,
risks to human health and safety (for both workers and consumers), risks related to the self-replication of
nanomachines and human enhancement, risks to business from the marketing of nanotechnology-
enabled products, and risks related to the protection of intellectual property (Chaturvedi et al., 2022).
Additional research is also required on the hazards to human health, for the animal health and the
environment brought on by exposure to manmade nanoparticles (Liu et al., 2022).
5. Review gaps and future lines of work
In the coming years, nanotechnology research is poised to revolutionize the realms of animal
nutrition, health, and production. With its profound influence on various aspects of human life,
nanotechnology is considered an impressive tool in contemporary society. A notable area of
progress in nanomedicine is the utilization of nanoparticles for the prevention, diagnosis, and
treatment of complex diseases such as cancer. The field of nanotechnology in animal production is
evolving and offering the potential to enhance livestock feed. Nevertheless, the substitution of
antibiotics in feed will necessitate time due to the imperative processes of in vivo testing and
adherence to regulatory requirements.
6. Conclusions and recommendations
In conclusion, nanotechnology presents a promising avenue for enhancing the development of
livestock and poultry by improving aspects such as health, feed components, additives, feed
processing, food safety, and quality control, with a notable focus on mineral nanoparticles in
current research. However, there is a notable gap in the exploration of other nutrients at the
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
Page 9 of 16
nanoscale level. A potential alternative to the chemical synthesis of nanoparticles is the biological
method, showing promise in terms of effectiveness and biosafety to prevent harm to animals,
humans, and environmental ecosystems. Nevertheless, further extensive research is imperative to
fully understand and ensure the efficacy and safety of this approach.
Acknowledgments
The author acknowledges the potential editors and
reviewers for their valuable input on the manuscript.
Funding
This work was not supported by any funding.
Author details
Yohannes Gelaye
1
E-mail: yohanes_gelaye@dmu.edu.et
ORCID ID: http://orcid.org/0000-0002-6772-0198
1
College of Agriculture and Natural Resources, Debre
Markos University, Debre Markos, Ethiopia.
Disclosure statement
No potential conflict of interest was reported by the
author(s).
Author contribution
Concept, synthesis, write-up
Availability of data and materials
The dataset that supports the findings of this review is
included in the article.
Supplementary material
Supplemental data for this article can be accessed online
at https://doi.org/10.1080/23311932.2023.2290308
Citation information
Cite this article as: Application of nanotechnology in ani-
mal nutrition: Bibliographic review, Yohannes Gelaye,
Cogent Food & Agriculture (2024), 10: 2290308.
References
Abdelnour, S. A., Alagawany, M., Hashem, N. M.,
Farag, M. R., Alghamdi, E. S., Hassan, F. U., Bilal, R. M.,
Elnesr, S. S., Dawood, M. A., Nagadi, S. A.,
Elwan, H. A. M., ALmasoudi, A. G., & Attia, Y. A. (2021).
Nanominerals: Fabrication methods, benefits and
hazards, and their applications in ruminants with
special reference to selenium and zinc nanoparticles.
Animals, 11(7), 1916. https://doi.org/10.3390/
ani11071916
Agnihotri, S. A., Mallikarjuna, N. N., & Aminabhavi, T. M.
(2004). Recent advances on chitosan-based
micro-and nanoparticles in drug delivery. Journal of
Controlled Release, 100(1), 5–28. https://doi.org/10.
1016/j.jconrel.2004.08.010
Ahmadi, F., & Rahimi, F. (2011). The effect of different
levels of nano silver on performance and retention of
silver in edible tissues of broilers. World Applied
Sciences Journal, 12, 1–4. https://www.semanticscho
lar.org/paper/The-effect-of-different-levels-of-Nano-
Silver-on-of-Ahmadi-Rahimi/
00c0b57beed4df0c7fc54aa5fa54df197ae43390
Ahmadi, A., Shahidi, S.-A., Safari, R., Motamedzadegan, A.,
& Ghorbani-HasanSaraei, A. (2022). Evaluation of
stability and antibacterial properties of extracted
chlorophyll from alfalfa (medicago sativa L.). Food
and Chemical Toxicology, 163, 112980. https://doi.
org/10.1016/j.fct.2022.112980
Ahmed, J., Vasagam, K. K., & Ramalingam, K. (2023).
Nanoencapsulated Aquafeeds and Current uses in
Fisheries/Shrimps: A review. Applied Biochemistry and
Biotechnology, 195(11), 7110–7131. https://doi.org/
10.1007/s12010-023-04418-9
Alavi, M., Kamarasu, P., McClements, D. J., & Moore, M. D.
(2022). Metal and metal oxide-based antiviral nano-
particles: Properties, mechanisms of action, and
applications. Advances in Colloid and Interface
Science, 102726, 102726. https://www.sciencedirect.
com/science/article/abs/pii/S0001868622001282.
https://doi.org/10.1016/j.cis.2022.102726
Al-Beitawi, N. A., Momani Shaker, M., El-Shuraydeh, K. N.,
& Bláha, J. (2017). Effect of nanoclay minerals on
growth performance, internal organs and blood bio-
chemistry of broiler chickens compared to vaccines
and antibiotics. Journal of Applied Animal Research,
45(1), 543–549. https://doi.org/10.1080/09712119.
2016.1221827
Alhashmi Alamer, F., & Beyari, R. F. (2022). Overview of
the influence of silver, gold, and titanium nanoparti-
cles on the physical properties of PEDOT: PSS-coated
cotton fabrics. Nanomaterials, 12(9), 1609. https://
doi.org/10.3390/nano12091609
Al-Sultan, S. I., Hereba, A. R. T., Hassanein, K. M., Abd-
Allah, S. M., Mahmoud, U. T., & Abdel-Raheem, S. M.
(2022). The impact of dietary inclusion of silver
nanoparticles on growth performance, intestinal
morphology, caecal microflora, carcass traits and
blood parameters of broiler chickens. Italian Journal
of Animal Science, 21(1), 967–978. https://doi.org/10.
1080/1828051X.2022.2083528
Anderson, R. A. (2003). Chromium and insulin resistance.
Nutrition Research Reviews, 16(2), 267–275. https://
doi.org/10.1079/NRR200366
AshaRani, P., Low Kah Mun, G., Hande, M. P., &
Valiyaveettil, S. (2009). Cytotoxicity and genotoxicity
of silver nanoparticles in human cells. Agricultural
Science & Technology Nano, 3(2), 279–290. https://
doi.org/10.1021/nn800596w
Awuchi, C. G., Morya, S., Dendegh, T. A., Okpala, C. O. R., &
Korzeniowska, M. (2022). Nanoencapsulation of food
bioactive constituents and its associated processes:
A revisit. Bioresource Technology Reports, 19, 101088.
https://www.sciencedirect.com/science/article/abs/
pii/S2589014X22001451. https://doi.org/10.1016/j.
biteb.2022.101088
Azevedo, C. F., Nascimento, M., Carvalho, I. R.,
Nascimento, A. C. C., de Almeida, H. C. F., Cruz, C. D., &
da Silva, J. A. G. (2022). Updated knowledge in the
estimation of genetics parameters: A Bayesian
approach in white oat (Avena sativa L.). Euphytica, 218
(4), 43. https://doi.org/10.1007/s10681-022-02995-0
Baharuddin, A. S., Wakisaka, M., Shirai, Y., Abd-Aziz, S.,
Abdul, R., & Hassan, M. (2009). Co-composting of
empty fruit bunches and partially treated palm oil
mill effluents in pilot scale. International Journal of
Agricultural Research, 4(2), 69–78. https://doi.org/10.
3923/ijar.2009.69.78
Bakshi, A., & Panigrahi, A. K. (2022). Chromium contam-
ination in soil and its bioremediation: An overview.
Advances in Bioremediation and Phytoremediation for
Sustainable Soil Management: Principles, Monitoring
and Remediation, 229–248. https://doi.org/10.1007/
978-3-030-89984-4_15
Bawazeer, S., Khan, I., Rauf, A., Aljohani, A. S.,
Alhumaydhi, F. A., Khalil, A. A., Qureshi, M. N.,
Ahmad, L., & Khan, S. A. (2022). Black pepper (Piper
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
Page 10 of 16
nigrum) fruit-based gold nanoparticles (BP-AuNPs):
Synthesis, characterization, biological activities, and
catalytic applications–A green approach. Green
Processing and Synthesis, 11(1), 11–28. https://doi.
org/10.1515/gps-2022-0002
Bergin, I. L., & Witzmann, F. A. (2013). Nanoparticle toxi-
city by the gastrointestinal route: Evidence and
knowledge gaps. International Journal of Biomedical
Nanoscience and Nanotechnology, 3(1/2), 163–210.
https://doi.org/10.1504/IJBNN.2013.054515
Bhagat, S., & Singh, S. (2022). Nanominerals in nutri-
tion: Recent developments, present burning issues
and future perspectives. Food Research
International, 160, 111703. https://doi.org/10.
1016/j.foodres.2022.111703
Bhanja, S., & Verma, S. (2021). Prospects of nano
minerals in poultry nutrition. Indian Journal of
Poultry Science, 56(1), 1–8. https://doi.org/10.5958/
0974-8180.2021.00006.4
Brewer, A., Dror, I., & Berkowitz, B. (2022). Electronic
waste as a source of rare earth element pollution:
Leaching, transport in porous media, and the effects
of nanoparticles. Chemosphere, 287, 132217. https://
doi.org/10.1016/j.chemosphere.2021.132217
Bunglavan, S. J., Garg, A., Dass, R., & Shrivastava, S.
(2014). Use of nanoparticles as feed additives to
improve digestion and absorption in livestock.
Livestock Research International, 2(3), 36–47. https://
d1wqtxts1xzle7.cloudfront.net/82068395/5-
lriArticle_1-libre.pdf?1647111564=&response-con
tent-disposition=inline%3B+filename%3DUse_of_
nanoparticles_as_feed_additives_t.pdf&Expires=
1702366214&Signature=AJ-ixko7-2RRDI5IopYvo~
R5lc9xGhdJVrFCKaZCNDE1C1YriptIjfF07aISIDBd0Tac
hoTw8F3LZ8ckiZVobT9zT-N–NpN~
3PXqB6Z0Z83UkmAOglJMtOElTQndydpqtMdPpl4ipud
zGnAfG2g6fs8CFXgfslcJAsP08V8tebDyUTR19BuHeSC
h6LTPxtU9Z2CuvMitUOGVQphznfortuGnVL1InEnnA
d6vqg9JMewGktB~
joUsT1wbbdE2vBecKv8b0iHP15SA1bff5X3f-
9oelujbUSi5fql13ZhYCOALJ0CH77yu8QMkt~rLAEA-
i0vMmEdKirn-0kouobWKQ__&Key-Pair-Id=
APKAJLOHF5GGSLRBV4ZA
Cebadero-Domínguez, Ó., Jos, A., Cameán, A. M., &
Cătunescu, G. M. (2022). Hazard characterization of
graphene nanomaterials in the frame of their food
risk assessment: A review. Food & Chemical
Toxicology, 164, 113014. https://www.sciencedirect.
com/science/article/pii/S0278691522002125. https://
doi.org/10.1016/j.fct.2022.113014
Chaturvedi, R., Sharma, A., Sharma, K., & Saraswat, M.
(2022). Nanotech Science as well as its multifunc-
tional implementations. Recent Trends in Industrial
and Production Engineering: Select Proceedings of
ICCEMME, 2021, 217–228. https://link.springer.com/
chapter/10.1007/978-981-16-3330-0_18
Choct, M. (2009). Managing gut health through nutrition.
British Poultry Science, 50(1), 9–15. https://doi.org/10.
1080/00071660802538632
Cuvas-Limón, R. B., Ferreira-Santos, P., Cruz, M.,
Teixeira, J. A., Belmares, R., & Nobre, C. (2022). Novel
bio-functional aloe vera beverages fermented by
probiotic enterococcus faecium and lactobacillus
lactis. Molecules, 27(8), 2473. https://doi.org/10.3390/
molecules27082473
Das, A., Adhikari, S., Deka, D., Baildya, N., Sahare, P.,
Banerjee, A., Paul, S., Bisgin, A., & Pathak, S. (2023).
An updated review on the role of nanoformulated
phytochemicals in colorectal cancer. Medicina, 59(4),
685. https://doi.org/10.3390/medicina59040685
Doe, J. E., Boobis, A. R., Blacker, A., Dellarco, V.,
Doerrer, N. G., Franklin, C., Goodman, J. I.,
Kronenberg, J. M., Lewis, R., McConnell, E. E.,
Mercier, T., Moretto, A., Nolan, C., Padilla, S.,
Phang, W., Solecki, R., Tilbury, L., van Ravenzwaay, B.,
& Wolf, D. C. (2006). A tiered approach to systemic
toxicity testing for agricultural chemical safety
assessment. Critical Reviews in Toxicology, 36(1),
37–68. https://doi.org/10.1080/10408440500534370
Dong, Y., Zhang, K., Han, M., Miao, Z., Liu, C., & Li, J.
(2022). Low level of dietary organic trace minerals
improved egg quality and modulated the status of
eggshell gland and intestinal microflora of laying
hens during the late production stage. Frontiers in
Veterinary Science, 9, 920418. https://doi.org/10.
3389/fvets.2022.920418
Dupuis, V., Cerbu, C., Witkowski, L., Potarniche, A.-V.,
Timar, M. C., Żychska, M., & Sabliov, C. M. (2022).
Nanodelivery of essential oils as efficient tools
against antimicrobial resistance: A review of the
type and physical-chemical properties of the deliv-
ery systems and applications. Drug Delivery, 29(1),
1007–1024. https://doi.org/10.1080/10717544.
2022.2056663
Eivazzadeh-Keihan, R., Noruzi, E. B., Chidar, E., Jafari, M.,
Davoodi, F., Kashtiaray, A., Gorab, M. G., Hashemi, S. M.,
Javanshir, S., & Cohan, R. A. (2022). Applications of
carbon-based conductive nanomaterials in biosensors.
Chemical Engineering Journal, 442, 136183. https://doi.
org/10.1016/j.cej.2022.136183
Elnahal, A. S., El-Saadony, M. T., Saad, A. M., Desoky, E.-
S. M., El-Tahan, A. M., Rady, M. M., AbuQamar, S. F., &
El-Tarabily, K. A. (2022). The use of microbial inocu-
lants for biological control, plant growth promotion,
and sustainable agriculture: A review. European
Journal of Plant Pathology, 162(4), 759–792. https://
doi.org/10.1007/s10658-021-02393-7
Fajardo, C., Martinez-Rodriguez, G., Blasco, J.,
Mancera, J. M., Thomas, B., & De Donato, M. (2022).
Nanotechnology in aquaculture: Applications, per-
spectives and regulatory challenges. Aquaculture
and Fisheries, 7(2), 185–200. https://doi.org/10.
1016/j.aaf.2021.12.006
Fesseha, H., Degu, T., & Getachew, Y. (2020).
Nanotechnology and its application in animal produc-
tion: A review. Veterinary Medicine – Open Journal, 5(2),
43–50. https://doi.org/10.17140/VMOJ-5-148
Fiore, V., Badagliacco, D., Sanfilippo, C., Pirrone, R.,
Siengchin, S., Rangappa, S. M., & Botta, L. (2022).
Lemongrass plant as potential sources of reinforce-
ment for biocomposites: A preliminary experimental
comparison between leaf and culm fibers. Journal of
Polymers and the Environment, 30(11), 4726–4737.
https://doi.org/10.1007/s10924-022-02545-8
Fondevila, M., Herrer, R., Casallas, M., Abecia, L., &
Ducha, J. (2009). Silver nanoparticles as a potential
antimicrobial additive for weaned pigs. Animal Feed
Science and Technology, 150(3–4), 259–269. https://
doi.org/10.1016/j.anifeedsci.2008.09.003
Fubini, B., Ghiazza, M., & Fenoglio, I. (2010). Physico-
chemical features of engineered nanoparticles rele-
vant to their toxicity. Nanotoxicology, 4(4), 347–363.
https://doi.org/10.3109/17435390.2010.509519
Fuchs, S., Kutscher, M., Hertel, T., Winter, G., Pietzsch, M., &
Coester, C. (2010). Transglutaminase: new insights
into gelatin nanoparticle cross-linking. Journal of
Microencapsulation, 27(8), 747–754. https://doi.org/
10.3109/02652048.2010.518773
Galanakis, C. M. (2019). Trends in non-alcoholic beverages
academic press. Book, 2020. https://www.sciencedir
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
Page 11 of 16
ect.com/book/9780128169384/trends-in-non-
alcoholic-beverages#book-info
Ghaffarizadeh, A., Sotoudeh, E., Mozanzadeh, M. T.,
Sanati, A. M., & Ghasemi, A. (2022). Supplementing
dietary selenium nano-particles increased growth,
antioxidant capacity and immune-related genes
transcription in Pacific whiteleg shrimp (Penaeus
vannamei) juveniles. Aquaculture Reports, 25,
101215. https://doi.org/10.1016/j.aqrep.2022.101215
Gopi, S., & Balakrishnan, P. (2022). Handbook of
Nutraceuticals and natural. Products Wiley Online
Library.
Grunwald, P. (2017). Biocatalysis and nanotechnology CRC
press. ISBN: 978-1-119-74683-6. https://www.wiley.
com/en-us/Handbook+of+Nutraceuticals+and
+Natural+Products%2C+2+Volume+Set-
p-9781119746836.
Gu, Y., Yuan, L., Li, M., Wang, X., Rao, D., Bai, X., Shi, K.,
Xu, H., Hou, S., & Yao, H. (2022). Co-immobilized
bienzyme of horseradish peroxidase and glucose
oxidase on dopamine-modified cellulose–chitosan
composite beads as a high-efficiency biocatalyst for
degradation of acridine. RSC Advances, 12(35),
23006–23016. https://doi.org/10.1039/D2RA04091C
Haase, F. T., Bergmann, A., Jones, T. E., Timoshenko, J.,
Herzog, A., Jeon, H. S., Rettenmaier, C., &
Cuenya, B. R. (2022). Size effects and active state
formation of cobalt oxide nanoparticles during the
oxygen evolution reaction. Nature Energy, 7(8),
765–773. https://doi.org/10.1038/s41560-022-
01083-w
Halperin, F. W. (1986). Quantum size effects in metal
particles. Reviews of Modern Physics, 58(3), 533.
https://doi.org/10.1103/RevModPhys.58.533
Harish, V., Tewari, D., Gaur, M., Yadav, A. B., Swaroop, S.,
Bechelany, M., & Barhoum, A. (2022). Review on
nanoparticles and nanostructured materials:
Bioimaging, biosensing, drug delivery, tissue engi-
neering, antimicrobial, and agro-food applications.
Nanomaterials, 12(3), 457. https://doi.org/10.3390/
nano12030457
Hasan, M. N., Chand, N., Naz, S., Khan, R. U., Ayaşan, T.,
Laudadio, V., & Tufarelli, V. (2022). Mitigating heat
stress in broilers by dietary dried tamarind
(Tamarindus indica L.) pulp: Effect on growth and
blood traits, oxidative status and immune response.
Livestock Science, 264, 105075. https://doi.org/10.
1016/j.livsci.2022.105075
Hassan, M., Ding, W., Shi, Z., & Zhao, S. (2016). Methane
enhancement through co-digestion of chicken man-
ure and thermo-oxidative cleaved wheat straw with
waste activated sludge: AC/N optimization case.
Bioresource Technology, 211, 534–541. https://doi.
org/10.1016/j.biortech.2016.03.148
Hassan, S., Hassan, F.-U., & Rehman, M. S.-U. (2020).
Nano-particles of trace minerals in poultry nutrition:
Potential applications and future prospects.
Biological Trace Element Research, 195(2), 591–612.
https://doi.org/10.1007/s12011-019-01862-9
Hegedüs, I., Vitai, M., Jakab, M., & Nagy, E. (2020). Study
of prepared α-chymotrypsin as enzyme nanoparti-
cles and of biocatalytic membrane reactor. Catalysts,
10(12), 1454. https://doi.org/10.3390/catal10121454
Hemathilake, D., & Gunathilake, D. (2022). Agricultural
productivity and food supply to meet increased
demands, future foods. Elsevier.
Hett, A. (2004). Nanotechnology: Small matter, many
unknowns. Swiss re, https://www.nanowerk.com/
nanotechnology/reports/reportpdf/report93.pdf.
Hussan, F., Krishna, D., Preetam, V. C., Reddy, P., &
Gurram, S. (2022). Dietary supplementation of nano
zinc oxide on performance, carcass, serum and meat
quality parameters of commercial broilers. Biological
Trace Element Research, 200(1), 348–353. https://doi.
org/10.1007/s12011-021-02635-z
Islam, M. R., Martinez-Soto, C. E., Lin, J. T.,
Khursigara, C. M., Barbut, S., & Anany, H. (2023).
A systematic review from basics to omics on bacter-
iophage applications in poultry production and
processing. Critical Reviews in Food Science and
Nutrition, 63(18), 3097–3129. https://doi.org/10.1080/
10408398.2021.1984200
Javed, R., Ain, N. U., Gul, A., Arslan Ahmad, M., Guo, W.,
Ao, Q., & Tian, S. (2022). Diverse biotechnological
applications of multifunctional titanium dioxide
nanoparticles: An up-to-date review. IET
Nanobiotechnology, 16(5), 171–189. https://doi.org/
10.1049/nbt2.12085
Javid, A., Amiri, H., Kafrani, A. T., & Rismani-Yazdi, H.
(2022). Post-hydrolysis of cellulose oligomers by cel-
lulase immobilized on chitosan-grafted magnetic
nanoparticles: A key stage of butanol production
from waste textile. International Journal of Biological
Macromolecules, 207, 324–332. https://doi.org/10.
1016/j.ijbiomac.2022.03.013
Jia, J., Ahmed, I., Liu, L., Liu, Y., Xu, Z., Duan, X., Li, Q.,
Dou, T., Gu, D., Rong, H., Wang, K., Li, Z., Talpur, M. Z.,
Huang, Y., Wang, S., Yan, S., Tong, H., Zhao, S. . . .
Su, Z. (2018). Selection for growth rate and body size
have altered the expression profiles of somatotropic
axis genes in chickens. PLoS One, 13(4), e0195378.
https://doi.org/10.1371/journal.pone.0195378
Joudeh, N., & Linke, D. (2022). Nanoparticle classification,
physicochemical properties, characterization, and
applications: A comprehensive review for biologists.
Journal of Nanobiotechnology, 20(1), 262. https://doi.
org/10.1186/s12951-022-01477-8
Kareem, E. H., Dawood, T. N., & Al-Samarai, F. R. (2022).
Application of nanoparticle in the Veterinary
medicine. Magna Scientia Advanced Research and
Reviews, 4(1), 027–038. https://doi.org/10.30574/
msarr.2022.4.1.0082
Kaushik, J., Yadav, M., Sharma, N., Jindal, D. K., Joshi, K.,
Dahiya, M., & Deep, A. (2022). Phytochemical analysis
and in vitro evidence of antimalarial, antibacterial,
antifungal, antioxidant and anti-inflammatory activ-
ities of ethanol extract of Emblica officinalis fruit.
Anti-Infective Agents, 20(4), 70–79. https://doi.org/
10.2174/2211352520666220318091023
Kawata, K., Osawa, M., & Okabe, S. (2009). In vitro toxicity
of silver nanoparticles at noncytotoxic doses to
HepG2 human hepatoma cells. Environmental
Science & Technology, 43(15), 6046–6051. https://doi.
org/10.1021/es900754q
Kessler, R. (2011). Engineered nanoparticles in consumer
products: Understanding a new ingredient. National
Institute of Environmental Health Sciences. https://
doi.org/10.1289/ehp.119-a120
Khalid, M. Y., & Arif, Z. U. (2022). Novel biopolymer-based
sustainable composites for food packaging applica-
tions: A narrative review. Food Packaging and Shelf Life,
33, 100892. https://doi.org/10.1016/j.fpsl.2022.100892
Khan, S., & Hossain, M. K. (2022). Classification and prop-
erties of nanoparticles, nanoparticle-based polymer
composites. Elsevier.
Khan, F., Shariq, M., Asif, M., Siddiqui, M. A., Malan, P., &
Ahmad, F. (2022). Green nanotechnology:
Plant-mediated nanoparticle synthesis and
application. Nanomaterials, 12(4), 673. https://doi.
org/10.3390/nano12040673
Khizar, S., Elaissari, A., Al-Dossary, A. A., Zine, N., Jaffrezic-
Renault, N., & Errachid, A. (2022). Advancement in
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
Page 12 of 16
nanoparticle-based biosensors for point-of-care
in vitro diagnostics. Current Topics in Medicinal
Chemistry, 22(10), 807–833. https://doi.org/10.2174/
1568026622666220401160121
King, T., Osmond McLeod, M. J., & Duffy, L. L. (2018).
Nanotechnology in the food sector and potential
applications for the poultry industry. Trends in Food
Science & Technology, 72, 62–73. https://doi.org/10.
1016/j.tifs.2017.11.015
Kroubi, M., Daulouede, S., Karembe, H., Jallouli, Y.,
Howsam, M., Mossalayi, D., Vincendeau, P., &
Betbeder, D. (2010). Development of a nanoparticulate
formulation of diminazene to treat African
trypanosomiasis. Nanotechnology, 21(50), 505102.
https://doi.org/10.1088/0957-4484/21/50/505102
Kumari, A., & Chauhan, A. K. (2022). Iron nanoparticles as
a promising compound for food fortification in iron
deficiency anemia: A review. Journal of Food Science
and Technology, 59(9), 3319–3335. https://doi.org/10.
1007/s13197-021-05184-4
Kumar, A., Shah, S. R., Jayeoye, T. J., Kumar, A., Parihar, A.,
Prajapati, B., Singh, S., & Kapoor, D. U. (2023). Biogenic
metallic nanoparticles: Biomedical, analytical, food
preservation, and applications in other consumable
products. Frontiers in Nanotechnology, 5, 1175149.
https://doi.org/10.3389/fnano.2023.1175149
Kumar, P., Singh, P., Kumar, D., Prakash, V., Hussain, M., &
Das, A. (2017). A novel application of micro-EDM
process for the generation of nickel nanoparticles
with different shapes. Materials and Manufacturing
Processes, 32(5), 564–572. https://doi.org/10.1080/
10426914.2016.1244832
Lai, W., Ma, Z., Zhang, J., Yuan, Y., Qiao, Y., & Huang, H.
(2022). Dynamic evolution of active sites in electro-
catalytic CO2 reduction reaction: Fundamental
understanding and recent progress. Advanced
Functional Materials, 32(16), 2111193. https://doi.org/
10.1002/adfm.202111193
Lecour, S., Du Pré, B. C., Bøtker, H. E., Brundel, B. J.,
Daiber, A., Davidson, S. M., Ferdinandy, P., Girao, H.,
Gollmann-Tepeköylü, C., Gyöngyösi, M.,
Hausenloy, D. J., Madonna, R., Marber, M., Perrino, C.,
Pesce, M., Schulz, R., Sluijter, J. P. G., Steffens, S. . . .
Young, M. E. (2022). Circadian rhythms in ischaemic
heart disease: Key aspects for preclinical and trans-
lational research: Position paper of the ESC working
group on cellular biology of the heart. Cardiovascular
Research, 118(12), 2566–2581. https://doi.org/10.
1093/cvr/cvab293
Lee, Y., Ahn, S., Chang, Y., & Kwak, H. (2015).
Physicochemical and sensory properties of milk sup-
plemented with dispersible nanopowdered oyster
shell during storage. Journal of Dairy Science, 98(9),
5841–5849. https://doi.org/10.3168/jds.2014-9105
Lee, S.-H., Kim, D.-S., Park, S.-H., & Park, H. (2022).
Phytochemistry and applications of Cinnamomum
camphora essential oils. Molecules, 27(9), 2695.
https://doi.org/10.3390/molecules27092695
Liao, W., Badri, W., Dumas, E., Ghnimi, S., Elaissari, A.,
Saurel, R., & Gharsallaoui, A. (2021).
Nanoencapsulation of essential oils as natural food
antimicrobial agents: An overview. Applied
Sciences, 11(13), 5778. https://doi.org/10.3390/
app11135778
Li, J., Fu, J., Ma, Y., He, Y., Fu, R., Qayum, A., Jiang, Z., &
Wang, L. (2022). Low temperature extrusion promotes
transglutaminase cross-linking of whey protein isolate
and enhances its emulsifying properties and water
holding capacity. Food Hydrocolloids, 125, 107410.
https://doi.org/10.1016/j.foodhyd.2021.107410
Li, F.-Q., Su, H., Wang, J., Liu, J.-Y., Zhu, Q.-G., Fei, Y.-B.,
Pan, Y.-H., & Hu, J.-H. (2008). Preparation and charac-
terization of sodium ferulate entrapped bovine serum
albumin nanoparticles for liver targeting. International
Journal of Pharmaceutics, 349(1–2), 274–282. https://
doi.org/10.1016/j.ijpharm.2007.08.001
Liu, A. A., Henin, S., Abbaspoor, S., Bragin, A., Buffalo, E. A.,
Farrell, J. S., Foster, D. J., Frank, L. M., Gedankien, T.,
Gotman, J., Guidera, J. A., Hoffman, K. L., Jacobs, J.,
Kahana, M. J., Li, L., Liao, Z., Lin, J. J., Losonczy, A. &
Zugaro, M. (2022). A consensus statement on detection
of hippocampal sharp wave ripples and differentiation
from other fast oscillations. Nature Communications, 13
(1), 6000. https://doi.org/10.1038/s41467-022-33536-x
Liu, W., & Huang, Y. (2022). Cell membrane-engineered
nanoparticles for cancer therapy. Journal of Materials
Chemistry B, 10(37), 7161–7172. https://doi.org/10.
1039/D2TB00709F
Liu, X., Hu, Y., Wei, B., Liu, F., Xu, H., Liu, C., Li, Y., & Liang, H.
(2022). Immobilized glucosyltransferase and sucrose
synthase on Fe3O4@ uio-66 in cascade catalysis for the
one-pot conversion of rebaudioside D from rebaudio-
side a. Process Biochemistry, 118, 323–334. https://doi.
org/10.1016/j.procbio.2022.05.004
Liu, L., Li, Y., AL-Huqail, A. A., Ali, E., Alkhalifah, T., Alturise, F.,
& Ali, H. E. (2023). Green synthesis of Fe3O4 nanopar-
ticles using Alliaceae waste (allium sativum) for
a sustainable landscape enhancement using support
vector regression. Chemosphere, 334, 138638. https://
doi.org/10.1016/j.chemosphere.2023.138638
Liu, F., Wei, B., Cheng, L., Zhao, Y., Liu, X., Yuan, Q., &
Liang, H. (2022). Co-immobilizing two glycosidases
based on cross-Linked enzyme aggregates to
enhance enzymatic properties for achieving high titer
icaritin biosynthesis. Journal of Agricultural and Food
Chemistry, 70(37), 11631–11642. https://doi.org/10.
1021/acs.jafc.2c04253
Liu, W., Worms, I. A., Jakšić, Ž., & Slaveykova, V. I. (2022).
Aquatic organisms modulate the bioreactivity of
engineered nanoparticles: Focus on biomolecular
corona. Frontiers in Toxicology, 4, 933186. https://doi.
org/10.3389/ftox.2022.933186
Loghman, A., Iraj, S. H., Naghi, D. A., & Pejman, M. (2012).
Histopathologic and apoptotic effect of nanosilver in
liver of broiler chickens. African Journal of
Biotechnology, 11(22), 6207–6211. https://doi.org/10.
5897/AJB11.1768
Madakka, M., Rajesh, N., & Rajeswari, J. (2020).
Immunocomposition of gastrointestinal tract of gut.
Immunotherapy for Gastrointestinal Malignancies,
17–39. https://link.springer.com/chapter/10.1007/
978-981-15-6487-1_2
Mahdi, M. A., Yousefi, S. R., Jasim, L. S., & Salavati-Niasari,
M. (2022). Green synthesis of DyBa2Fe3O7. 988/
DyFeO3 nanocomposites using almond extract with
dual eco-friendly applications: Photocatalytic and
antibacterial activities. International Journal of
Hydrogen Energy, 47(31), 14319–14330. https://doi.
org/10.1016/j.ijhydene.2022.02.175
Mahmoud, U. T. (2012). Silver nanoparticles in poultry
production. Journal of Advanced Veterinary Research,
2(4), 303–306. https://advetresearch.com/index.php/
AVR/article/view/202
Majeed, M., Mundkur, L., Paulose, S., &
Nagabhushanam, K. (2022). Novel emblica officinalis
extract containing β-glucogallin vs. metformin:
A randomized, open-label, comparative efficacy
study in newly diagnosed type 2 diabetes mellitus
patients with dyslipidemia. Food & Function, 13(18),
9523–9531. https://doi.org/10.1039/D2FO01862D
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
Page 13 of 16
Marappan, G., Beulah, P., Kumar, R. D., Muthuvel, S., &
Govindasamy, P. (2017). Role of nanoparticles in ani-
mal and poultry nutrition: Modes of action and appli-
cations in formulating feed additives and food
processing. International Journal of Pharmacology, 13
(7), 724–731. https://doi.org/10.3923/ijp.2017.724.731
Mittag, A., Singer, A., Hoera, C., Westermann, M.,
Kämpfe, A., & Glei, M. (2022). Impact of in vitro
digested zinc oxide nanoparticles on intestinal model
systems. Particle and Fibre Toxicology, 19(1), 1–15.
https://doi.org/10.1186/s12989-022-00479-6
Mobasser, S., & Firoozi, A. A. (2016). Review of nanotech-
nology applications in science and engineering.
Journal of Civil Engineering Urban, 6, 84–93. https://
www.researchgate.net/profile/Shariat-Mobasser/pub
lication/318752748_Review_of_Nanotechnology_
Applications_in_Science_and_Engineering/links/
597b4b6a4585151e35c0c379/Review-of-
Nanotechnology-Applications-in-Science-and-
Engineering.pdf
Mortensen, N. P., Pathmasiri, W., Snyder, R. W.,
Caffaro, M. M., Watson, S. L., Patel, P. R.,
Beeravalli, L., Prattipati, S., Aravamudhan, S., &
Sumner, S. J. (2022). Oral administration of TiO2
nanoparticles during early life impacts cardiac and
neurobehavioral performance and metabolite pro-
file in an age- and sex-related manner. Particle and
Fibre Toxicology, 19(1), 1–18. https://doi.org/10.
1186/s12989-021-00444-9
Mushtaq, F., Raza, Z. A., Batool, S. R., Zahid, M.,
Onder, O. C., Rafique, A., & Nazeer, M. A. (2022).
Preparation, properties, and applications of
gelatin-based hydrogels (GHs) in the environmental,
technological, and biomedical sectors. International
Journal of Biological Macromolecules, 218, 601–633.
https://doi.org/10.1016/j.ijbiomac.2022.07.168
Nabi, F., Arain, M., Hassan, F., Umar, M., Rajput, N.,
Alagawany, M., Syed, S., Soomro, J., Somroo, F., &
Liu, J. (2020). Nutraceutical role of selenium nano-
particles in poultry nutrition: a review. World’s Poultry
Science Journal, 76, 459–471. https://doi.org/10.
1080/00439339.2020.1789535
Nadaf, S. J., Jadhav, N. R., Naikwadi, H. S., Savekar, P. L.,
Sapkal, I. D., Kambli, M. M., & Desai, I. A. (2022).
Green synthesis of gold and silver nanoparticles:
Updates on research, patents, and future prospects.
OpenNano, 8, 100076. https://www.sciencedirect.
com/science/article/pii/S235295202200038X. https://
doi.org/10.1016/j.onano.2022.100076
Nadugala, B. H., Pagel, C. N., Raynes, J. K., Ranadheera, C.,
& Logan, A. (2022). The effect of casein genetic var-
iants, glycosylation and phosphorylation on bovine
milk protein structure, technological properties,
nutrition and product manufacture. International
Dairy Journal, 133, 105440. https://doi.org/10.1016/j.
idairyj.2022.105440
Napagoda, M., Jayathunga, D., & Witharana, S. (2022).
Introduction to nanotechnology, nanotechnology in
modern medicine. Springer.
Nguyen, N. T. T., Nguyen, L. M., Nguyen, T. T. T., Liew, R. K.,
Nguyen, D. T. C., & Van Tran, T. (2022). Recent
advances on botanical biosynthesis of nanoparticles
for catalytic, water treatment and agricultural appli-
cations: A review. Science of the Total Environment,
827, 154160. https://www.sciencedirect.com/science/
article/abs/pii/S0048969722012529. https://doi.org/
10.1016/j.scitotenv.2022.154160
Niemiec, T., Łozicki, A., Pietrasik, R., Pawęta, S.,
Rygało-Galewska, A., Matusiewicz, M., & Zglińska, K.
(2021). Impact of ag nanoparticles (AgNPs) and
multimicrobial preparation (EM) on the carcass,
mineral, and fatty acid composition of Cornu asper-
sum aspersum snails. Animals, 11(7), 1926. https://
doi.org/10.3390/ani11071926
Ognik, K., Stępniowska, A., Cholewińska, E., & Kozłowski, K.
(2016). The effect of administration of copper nano-
particles to chickens in drinking water on estimated
intestinal absorption of iron, zinc, and calcium.
Poultry Science, 95(9), 2045–2051. https://doi.org/10.
3382/ps/pew200
Ozkan-Ariksoysal, D. (2022). Current perspectives in gra-
phene oxide-based electrochemical biosensors for
cancer diagnostics. Biosensors, 12(8), 607. https://doi.
org/10.3390/bios12080607
Ozogul, Y., Karsli, G. T., Durmuş, M., Yazgan, H.,
Oztop, H. M., McClements, D. J., & Ozogul, F. (2022).
Recent developments in industrial applications of
nanoemulsions. Advances in Colloid and Interface
Science, 304, 102685. https://www.sciencedirect.
com/science/article/abs/pii/S0001868622000872.
https://doi.org/10.1016/j.cis.2022.102685
Palomares, R. A. (2022). Trace minerals supplementation
with Great Impact on Beef Cattle immunity and
health. Animals, 12(20), 2839. https://doi.org/10.
3390/ani12202839
Pandey, A. K., Kumar, P., & Saxena, M. (2019). Feed addi-
tives in animal health. Nutraceuticals in Veterinary
Medicine, 345–362. https://link.springer.com/chapter/
10.1007/978-3-030-04624-8_23
Pasquini, M., Grosjean, N., Hixson, K. K., Nicora, C. D.,
Yee, E. F., Lipton, M., Blaby, I. K., Haley, J. D., & Blaby-
Haas, C. E. (2022). Zng1 is a GTP-dependent zinc
transferase needed for activation of methionine
aminopeptidase. Cell Reports, 39(7), 110834. https://
doi.org/10.1016/j.celrep.2022.110834
Pateiro, M., Gómez, B., Munekata, P. E., Barba, F. J.,
Putnik, P., Kovačević, D. B., & Lorenzo, J. M. (2021).
Nanoencapsulation of promising bioactive com-
pounds to improve their absorption, stability, func-
tionality and the appearance of the final food
products. Molecules, 26(6), 1547. https://doi.org/10.
3390/molecules26061547
Patra, A., & Lalhriatpuii, M. (2020). Progress and prospect
of essential mineral nanoparticles in poultry nutrition
and feeding—A review. Biological Trace Element
Research, 197(1), 233–253. https://doi.org/10.1007/
s12011-019-01959-1
Phetsang, S., Jakmunee, J., Mungkornasawakul, P.,
Laocharoensuk, R., & Ounnunkad, K. (2019). Sensitive
amperometric biosensors for detection of glucose
and cholesterol using a platinum/reduced graphene
oxide/poly (3-aminobenzoic acid) film-modified
screen-printed carbon electrode. Bioelectrochemistry,
127, 125–135. https://doi.org/10.1016/j.bioelechem.
2019.01.008
Poddar, K., & Kishore, A. V. (2022). Nanotechnology in
animal production, emerging issues in climate smart
livestock production. Elsevier.
Prabha, A. S., Thangakani, J. A., Devi, N. R., Dorothy, R.,
Nguyen, T. A., Kumaran, S. S., & Rajendran, S. (2022).
Nanotechnology and sustainable agriculture.
Nanosensors for Smart Agriculture, Elsevier.
Prakash, M., Kavitha, H. P., Abinaya, S., Vennila, J. P., &
Lohita, D. (2022). Green synthesis of bismuth based
nanoparticles and its applications-A review.
Sustainable Chemistry and Pharmacy, 25, 100547.
https://doi.org/10.1016/j.scp.2021.100547
Prasad, R. D., Sahoo, A., Shrivastav, O. P., Charmode, N.,
Kamat, R., Kajave, N., Chauhan, J., Banga, S.,
Tamboli, U., & MS, P. (2022). A review on aspects of
nanotechnology in food science and animal nutrition.
ES Food & Agroforestry, 8, 12–46.
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
Page 14 of 16
Pundir, C. (2015). Enzyme nanoparticles Preparation,
characterisation, properties and applications, micro-
nano technologies series, Elsevier. Book. https://www.
sciencedirect.com/book/9780323389136/enzyme-
nanoparticles
Ramasamy, M., Kim, S., Lee, S. S., & Yi, D. K. (2016).
Recyclable photo-thermal nano-aggregates of mag-
netic nanoparticle conjugated gold nanorods for
effective pathogenic bacteria lysis. Journal of
Nanoscience and Nanotechnology, 16(1), 555–561.
https://doi.org/10.1166/jnn.2016.10603
Rastogi, S., Kumari, V., Sharma, V., & Ahmad, F. (2022). Gold
nanoparticle-based sensors in food safety applications.
Food Analytical Methods, 1–17. https://link.springer.
com/article/10.1007/s12161-021-02131-z
Reddy, I., & Neelima, P. (2022). Neem (Azadirachta indica):
A review on medicinal Kalpavriksha. International
Journal of Economic Plants, 9(1), 59–63. https://doi.
org/10.23910/2/2021.0437d
Riley, M. B., Strandquist, E., Weitzel, C. S., & Driskell, J. D.
(2022). Structure and activity of native and thiolated
α-chymotrypsin adsorbed onto gold nanoparticles.
Colloids and Surfaces B: Biointerfaces, 220, 112867.
https://doi.org/10.1016/j.colsurfb.2022.112867
Rizvi, N. B., Aleem, S., Khan, M. R., Ashraf, S., & Busquets, R.
(2022). Quantitative estimation of protein in sprouts
of Vigna radiate (mung Beans), lens culinaris (Lentils),
and Cicer arietinum (Chickpeas) by Kjeldahl and
Lowry methods. Molecules, 27(3), 814. https://doi.
org/10.3390/molecules27030814
Rossi, B., Toschi, A., Piva, A., & Grilli, E. (2020). Single
components of botanicals and nature-identical
compounds as a non-antibiotic strategy to amelio-
rate health status and improve performance in
poultry and pigs. Nutrition Research Reviews, 33(2),
218–234. https://doi.org/10.1017/
S0954422420000013
Sagar, N. A., Kumar, N., Choudhary, R., Bajpai, V. K.,
Cao, H., Shukla, S., & Pareek, S. (2022). Prospecting
the role of nanotechnology in extending the shelf-life
of fresh produce and in developing advanced
packaging. Food Packaging and Shelf Life, 34, 100955.
https://doi.org/10.1016/j.fpsl.2022.100955
Samanta, G., Mishra, S., Behura, N., Sahoo, G., Behera, K.,
Swain, R., Sethy, K., Biswal, S., & Sahoo, N. (2019).
Studies on utilization of calcium phosphate nano
particles as source of phosphorus in broilers. Animal
Nutrition and Feed Technology, 19(1), 77–88. https://
doi.org/10.5958/0974-181X.2019.00008.8
Sampath, V., Sureshkumar, S., Seok, W. J., & Kim, I. H.
(2023). Role and functions of micro and
macro-minerals in swine nutrition: A short review.
Journal of Animal Science and Technology, 65(3), 479.
https://doi.org/10.5187/jast.2023.e9
Sarwar, S., Akram, N. A., Saleem, M. H., Zafar, S.,
Alghanem, S. M., Abualreesh, M. H., Alatawi, A., Ali, S.,
& Sarker, U. (2022). Spatial variations in the bio-
chemical potential of okra [abelmoschus esculentus
L.(Moench)] leaf and fruit under field conditions. PLoS
One, 17(2), e0259520. https://doi.org/10.1371/jour
nal.pone.0259520
Schmidt, C. W. (2009). Nanotechnology-related environ-
ment, health, and safety research: Examining the
national strategy. National Institute of Environmental
Health Sciences, 117(4), A158–A161. https://doi.org/
10.1289/ehp.117-a158
Scott, A., Vadalasetty, K., Łukasiewicz, M., Jaworski, S.,
Wierzbicki, M., Chwalibog, A., & Sawosz, E. (2018,
February). Effect of different levels of copper
nanoparticles and copper sulphate on perfor-
mance, metabolism and blood biochemical
profiles in broiler chicken. Journal of Animal
Physiology and Animal Nutrition, 102(1), e364–
e373. https://doi.org/10.1111/jpn.12754
Selle, P. H., Cowieson, A. J., & Ravindran, V. (2009).
Consequences of calcium interactions with phytate
and phytase for poultry and pigs. Livestock Science,
124(1–3), 126–141. https://doi.org/10.1016/j.livsci.
2009.01.006
Shahidi, F., & Hossain, A. (2022). Preservation of aquatic
food using edible films and coatings containing
essential oils: A review. Critical Reviews in Food
Science and Nutrition, 62(1), 66–105. https://doi.org/
10.1080/10408398.2020.1812048
Shenashen, M. A., Emran, M. Y., El Sabagh, A., Selim, M. M.,
Elmarakbi, A., & El-Safty, S. A. (2022). Progress in
sensory devices of pesticides, pathogens, corona-
virus, and chemical additives and hazards in food
assessment: Food safety concerns. Progress in
Materials Science, 124, 100866. https://doi.org/10.
1016/j.pmatsci.2021.100866
Shi, L., Xun, W., Yue, W., Zhang, C., Ren, Y., Liu, Q.,
Wang, Q., & Shi, L. (2011). Effect of elemental
nano-selenium on feed digestibility, rumen fermen-
tation, and purine derivatives in sheep. Animal Feed
Science and Technology, 163(2–4), 136–142. https://
doi.org/10.1016/j.anifeedsci.2010.10.016
Song, M., Cui, M., Fang, Z., & Liu, K. (2022). Advanced
research on extracellular vesicles based oral drug
delivery systems. Journal of Controlled Release, 351,
560–572. https://doi.org/10.1016/j.jconrel.2022.09.043
Song, X., Fang, C., Yuan, Z.-Q., Li, F.-M., Sardans, J., &
Penuelas, J. (2022). Long-term alfalfa (Medicago
sativa L.) establishment could alleviate phosphorus
limitation induced by nitrogen deposition in the
carbonate soil. Journal of Environmental
Management, 324, 116346. https://doi.org/10.1016/
j.jenvman.2022.116346
Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H.,
Beger, R., Daykin, C. A., Fan, T. W.-M., Fiehn, O.,
Goodacre, R., Griffin, J. L., Hankemeier, T., Hardy, N.,
Harnly, J., Higashi, R., Kopka, J., Lane, A. N.,
Lindon, J. C., Marriott, P. & Thaden, J. J. (2007).
Proposed minimum reporting standards for chemical
analysis: Chemical analysis working group (CAWG)
metabolomics standards initiative (MSI).
Metabolomics, 3(3), 211–221. https://doi.org/10.1007/
s11306-007-0082-2
Sung, Y. J., Suk, H.-J., Sung, H. Y., Li, T., Poo, H., & Kim, M.-
G. (2013). Novel antibody/gold nanoparticle/mag-
netic nanoparticle nanocomposites for immuno-
magnetic separation and rapid colorimetric detection
of Staphylococcus aureus in milk. Biosensors and
Bioelectronics, 43, 432–439. https://doi.org/10.1016/j.
bios.2012.12.052
Sun, Y., Kinsela, A. S., Cen, X., Sun, S., Collins, R. N.,
Cliff, D. I., Wu, Y., & Waite, T. D. (2022). Impact of
reactive iron in coal mine dust on oxidant generation
and epithelial lung cell viability. Science of the Total
Environment, 810, 152277. https://doi.org/10.1016/j.
scitotenv.2021.152277
Taha, A., Casanova, F., Šimonis, P., Jonikaitė-
Švėgždienė, J., Jurkūnas, M., Gomaa, M. A., & Stirkė, A.
(2022). Pulsed electric field-assisted glycation of
bovine serum albumin/starch conjugates improved
their emulsifying properties. Innovative Food Science
& Emerging Technologies, 82, 103190. https://doi.org/
10.1016/j.ifset.2022.103190
Tarafdar, J., Sharma, S., & Raliya, R. (2013).
Nanotechnology: Interdisciplinary science of
applications. African Journal of Biotechnology, 12(3),
219–226. https://doi.org/10.5897/AJB12.2481
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
Page 15 of 16
Tatli Seven, P., Seven, I., Gul Baykalir, B., Iflazoglu Mutlu, S., &
Salem, A. Z. (2018). Nanotechnology and nano-propolis
in animal production and health: An overview. Italian
Journal of Animal Science, 17(4), 921–930. https://doi.
org/10.1080/1828051X.2018.1448726
Thapa, K., Liu, W., & Wang, R. (2022). Nucleic acid-based
electrochemical biosensor: Recent advances in probe
immobilization and signal amplification strategies.
Wiley Interdisciplinary Reviews: Nanomedicine and
Nanobiotechnology, 14(1), e1765. https://doi.org/10.
1002/wnan.1765
Tian, L., van Putten, R. J., & Gruter, G. J. M. (2022). Plastic
pollution. The role of (bio) degradable plastics and
other solutions. Biodegradable Polymers in the
Circular Plastics Economy, 59–81. https://doi.org/10.
1002/9783527827589.ch3
Tiwari, P. (2022). Nanotechnologies and sustainable
Agriculture for food and nutraceutical production: An
update, plant and nanoparticles. Springer.
Travan, A., Pelillo, C., Donati, I., Marsich, E.,
Benincasa, M., Scarpa, T., Semeraro, S., Turco, G.,
Gennaro, R., & Paoletti, S. (2009). Non-cytotoxic
silver nanoparticle-polysaccharide nanocompo-
sites with antimicrobial activity.
Biomacromolecules, 10(6), 1429–1435. https://doi.
org/10.1021/bm900039x
Turgud, F. K., & Narinç, D. (2022). Influences of dietary
supplementation with Maca (Lepidium meyenii) on
performance, parameters of growth curve and car-
cass characteristics in Japanese quail. Animals, 12(3),
318. https://doi.org/10.3390/ani12030318
Wang, L., Mello, D. F., Zucker, R. M., Rivera, N. A.,
Rogers, N. M., Geitner, N. K., Boyes, W. K., Wiesner, M. R.,
Hsu-Kim, H., & Meyer, J. N. (2021). Lack of detectable
direct effects of silver and silver nanoparticles on
mitochondria in mouse hepatocytes. Environmental
Science & Technology, 55(16), 11166–11175. https://
doi.org/10.1021/acs.est.1c02295
Wang, B., Wang, H., Li, Y., & Song, L. (2022). Lipid metabolism
within the bone micro-environment is closely associated
with bone metabolism in physiological and pathophy-
siological stages. Lipids in Health and Disease, 21(1),
1–14. https://doi.org/10.1186/s12944-021-01615-5
Wang, M., Zhao, J., Jiang, H., & Wang, X. (2022). Tumor-
targeted nano-delivery system of therapeutic RNA.
Materials Horizons, 9(4), 1111–1140. https://doi.org/
10.1039/D1MH01969D
Weiss, J., Gibis, M., Schuh, V., & Salminen, H. (2010). Advances
in ingredient and processing systems for meat and
meat products. Meat Science, 86(1), 196–213. https://
doi.org/10.1016/j.meatsci.2010.05.008
Wen, H.-W., DeCory, T. R., Borejsza-Wysocki, W., &
Durst, R. A. (2006). Investigation of
NeutrAvidin-tagged liposomal nanovesicles as uni-
versal detection reagents for bioanalytical assays.
Talanta, 68(4), 1264–1272. https://doi.org/10.1016/j.
talanta.2005.07.032
Xing, Y., Dorey, A., Jayasinghe, L., & Howorka, S. (2022). Highly
shape-and size-tunable membrane nanopores made
with DNA. Nature Nanotechnology, 17(7), 708–713.
https://doi.org/10.1038/s41565-022-01116-1
Xiong, R.-G., Zhou, D.-D., Wu, S.-X., Huang, S.-Y.,
Saimaiti, A., Yang, Z.-J., Shang, A., Zhao, C.-N.,
Gan, R.-Y., & Li, H.-B. (2022). Health benefits and side
effects of short-chain fatty acids. Foods, 11(18),
2863. https://doi.org/10.3390/foods11182863
Yan, X., Pan, Z., Chen, S., Shi, N., Bai, T., Dong, L., Zhou, D.,
White, J. C., & Zhao, L. (2022). Rice exposure to silver
nanoparticles in a life cycle study: Effect of dose
responses on grain metabolomic profile, yield, and
soil bacteria. Environmental Science: Nano, 9(6),
2195–2206. https://doi.org/10.1039/D2EN00211F
Yip, Y. J., Lee, S. S. C., Neo, M. L., Teo, S. L.-M., &
Valiyaveettil, S. (2022). A comparative investigation
of toxicity of three polymer nanoparticles on acorn
barnacle (amphibalanus amphitrite). Science of the
Total Environment, 806, 150965. https://doi.org/10.
1016/j.scitotenv.2021.150965
You, C.-C., Miranda, O. R., Gider, B., Ghosh, P. S., Kim, I.-B.,
Erdogan, B., Krovi, S. A., Bunz, U. H., & Rotello, V. M.
(2007). Detection and identification of proteins using
nanoparticle–fluorescent polymer ‘chemical nose’-
sensors. Nature Nanotechnology, 2(5), 318–323.
https://doi.org/10.1038/nnano.2007.99
Yun, Y., Cho, Y. W., & Park, K. (2013). Nanoparticles for oral
delivery: Targeted nanoparticles with peptidic ligands
for oral protein delivery. Advanced Drug Delivery
Reviews, 65(6), 822–832. https://doi.org/10.1016/j.
addr.2012.10.007
Zain, M., Yasmeen, H., Yadav, S. S., Amir, S., Bilal, M.,
Shahid, A., & Khurshid, M. (2022). Applications of
nanotechnology in biological systems and medicine,
nanotechnology for hematology, blood transfusion,
and artificial blood. Elsevier.
Zha, L. Y., Xu, Z. R., Wang, M. Q., & Gu, L. Y. (2008).
Chromium nanoparticle exhibits higher absorption
efficiency than chromium picolinate and chromium
chloride in Caco-2 cell monolayers. Journal of Animal
Physiology and Animal Nutrition, 92(2), 131–140.
https://doi.org/10.1111/j.1439-0396.2007.00718.x
Zhu, J., Zhang, Z., Wang, R., Zhong, K., Zhang, K.,
Zhang, N., Liu, W., Feng, F., & Qu, W. (2022). Review of
natural phytochemical-based self-assembled nanos-
tructures for applications in medicine. Acs Applied
Nano Materials, 5(3), 3146–3169. https://doi.org/10.
1021/acsanm.2c00056
Gelaye, Cogent Food & Agriculture (2024), 10: 2290308
https://doi.org/10.1080/23311932.2023.2290308
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