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Second-Order Sufficient Conditions in the Sparse Optimal Control of a Phase Field Tumor Growth Model with Logarithmic Potential

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Abstract

This paper treats a distributed optimal control problem for a tumor growth model of viscous Cahn--Hilliard type. The evolution of the tumor fraction is governed by a thermodynamic force induced by a double-well potential of logarithmic type. The cost functional contains a nondifferentiable term like the L1L^1--norm in order to enhance the occurrence of sparsity effects in the optimal controls, i.e., of subdomains of the space-time cylinder where the controls vanish. In the context of cancer therapies, sparsity is very important in order that the patient is not exposed to unnecessary intensive medical treatment. In this work, we focus on the derivation of second-order sufficient optimality conditions for the optimal control problem. While in previous works on the system under investigation such conditions have been established for the case without sparsity, the case with sparsity has not been treated before. 2020 Mathematics Subject Classification 35K57, 37N25, 49J50, 49J52, 49K20, 49K40.
ESAIM: COCV 30 (2024) 13 ESAIM: Control, Optimisation and Calculus of Variations
https://doi.org/10.1051/cocv/2023084 www.esaim-cocv.org
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE
OPTIMAL CONTROL OF A PHASE FIELD TUMOR GROWTH
MODEL WITH LOGARITHMIC POTENTIAL
J¨
urgen Sprekels1and Fredi Tr¨
oltzsch2,*
Abstract. This paper treats a distributed optimal control problem for a tumor growth model of
viscous Cahn–Hilliard type. The evolution of the tumor fraction is governed by a thermodynamic force
induced by a double-well potential of logarithmic type. The cost functional contains a nondifferentiable
term like the L1–norm in order to enhance the occurrence of sparsity effects in the optimal controls, i.e.,
of subdomains of the space-time cylinder where the controls vanish. In the context of cancer therapies,
sparsity is very important in order that the patient is not exposed to unnecessary intensive medical
treatment. In this work, we focus on the derivation of second-order sufficient optimality conditions for
the optimal control problem. While in previous works on the system under investigation such conditions
have been established for the case without sparsity, the case with sparsity has not been treated before.
Mathematics Subject Classification. 35K57, 37N25, 49J50, 49J52, 49K20, 49K40.
Received June 22, 2023. Accepted November 15, 2023.
1. Introduction
Let α > 0, β > 0, χ > 0, and let R3denote some open and bounded domain having a smooth boundary
Γ = and the unit outward normal nwith associated outward normal derivative n. Moreover, we fix some
final time T > 0 and introduce for every t(0, T ) the sets Qt:= ×(0, t) and Qt:= ×(t, T ). We also set,
for convenience, Q:= QTand Σ := Γ ×(0, T ). We then consider the following optimal control problem:
(CP) Minimize the cost functional
J((µ, φ, σ),u) := b1
2ZZQ
|φbφQ|2+b2
2Z
|φ(T)bφ|2+b3
2ZZQ
(|u1|2+|u2|2) + κg(u)
=: J1((µ, φ, σ),u) + κg(u) (1.1)
Keywords and phrases: Optimal control, tumor growth models, logarithmic potentials, second-order sufficient optimality
conditions, sparsity.
1Weierstrass Institute for Applied Analysis and Stochastics, Mohrenstraße 39, D-10117 Berlin, Germany.
2Institut ur Mathematik, Technische Universit¨at Berlin, Straße des 17. Juni 136, D-10623 Berlin, Germany.
*Corresponding author: troeltzsch@math.tu-berlin.de
©
The authors. Published by EDP Sciences, SMAI 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
2J. SPREKELS AND F. TR ¨
OLTZSCH
subject to the state system
α∂tµ+tφµ=P(φ)(σ+χ(1 φ)µ)Hu1in Q, (1.2)
β∂tφφ+F
1(φ) + F
2(φ) = µ+χ σ in Q, (1.3)
tσσ=χφP(φ)(σ+χ(1 φ)µ) + u2in Q, (1.4)
nµ=nφ=nσ= 0 on Σ,(1.5)
µ(0) = µ0, φ(0) = φ0, σ(0) = σ0in ,(1.6)
and to the control constraint
u= (u1, u2) Uad.(1.7)
Here, g:L2(Q)2Ris a nonnegative, continuous and convex functional, which is typically of the sparsity-
enhancing form
g((u1, u2)) = ZZQ
(|u1|+|u2|).(1.8)
The constants b1and b2are nonnegative, while b3and κare positive; bφQand bφare given target functions.
The term g(u) accounts for possible sparsity effects. Moreover, the set of admissible controls Uad is a nonempty,
closed and convex subset of the control space
U:= L(Q)2.(1.9)
We remark at this place that L(Q)2is the space in which the Fr´echet derivative of the control-to-state mapping
will turn out to exist. In contrast to this, the space L2(Q)2seems to be more natural in the discussion of second-
order sufficient optimality conditions. This phenomenon is part of the well-known two-norm discrepancy. To
overcome this difficulty, we need to work with both these spaces simultaneously.
The state system (1.2)–(1.6) constitutes a simplified and relaxed version of the four-species thermodynami-
cally consistent model for tumor growth originally proposed by Hawkins-Daruud et al. in [38] that additionally
includes the chemotaxis-like terms χσ in (1.3) and χφin (1.4). Let us briefly review the role of the occur-
ring symbols. The primary (state) variables φ, µ, σ denote the tumor fraction, the associated chemical potential,
and the nutrient concentration, respectively. Furthermore, the additional term α∂tµcorresponds to a parabolic
regularization of equation (1.2), while β∂tφis the viscosity contribution to the Cahn–Hilliard equation. The
nonlinearity Pdenotes a proliferation function, whereas the positive constant χrepresents the chemotactic
sensitivity and provides the system with a cross-diffusion coupling.
The evolution of the tumor fraction is mainly governed by the nonlinearities F1and F2whose derivatives
occur in (1.3). Here, F2is smooth, typically a concave function. As far as F1is concerned, we admit in this
paper functions of logarithmic type such as
F1,log(r) =
(1 + r) ln(1 + r) + (1 r) ln(1 r) for r(1,1)
2 ln(2) for r {−1,1}.
+for r∈ [1,1]
(1.10)
We assume that F=F1+F2is a double-well potential. This is actually the case if F2(r) = k(1 r2) with a
sufficiently large k > 0. Note also that F
1,log(r) becomes unbounded as r 1 and r1.
The control variable u2occurring in (1.4) can model either an external medication or some nutrient supply,
while u1, which occurs in the phase equation (1.2), models the application of a cytotoxic drug to the system.
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 3
Usually, u1is multiplied by a truncation function H(φ) in order to have the action only in the spatial region
where the tumor cells are located. Typically, one assumes that H(1) = 0,H(1) = 1, and H(φ) is in between
if 1<φ<1; see [29,35,41,42] for some insights on possible choices of H. Also in [15,17,54], this kind
of nonlinear coupling between u1and φhas been admitted. For our analysis, we have decided to make a
simplification because the inclusion of the nonlinearity H(φ) leads in the Lipschitz estimates below for the first
and second Fechet derivatives of the control-to-state operator to numerous additional terms causing tedious
estimations that go beyond the scope of this paper without bringing new insights. We have thus chosen to
simplify the original system somewhat by assuming that H=H(x, t) is a bounded nonnegative function that
does not depend on φ. We stress the fact that this simplification does not have any impact on the validity of
the results from [17] to be used below.
As far as well-posedness is concerned, the above model was already investigated in the case χ= 0 in [69],
and in [25] with α=β=χ= 0. There the authors also pointed out how the relaxation parameters αand βcan
be set to zero, by providing the proper framework in which a limit system can be identified and uniquely solved.
We also note that in [13] a version has been studied in which the Laplacian in the equations (1.2)–(1.4) has
been replaced by fractional powers of a more general class of selfadjoint operators having compact resolvents.
A model which is similar to the one studied in this note was the subject of [15,54].
For some nonlocal variations of the above model we refer to [27,28,47]. Moreover, in order to better
emulate in-vivo tumor growth, it is possible to include in similar models the effects generated by the fluid flow
development by postulating a Darcy law or a Stokes–Brinkman law. In this direction, we refer to [11,24,27,29
33,35], and we also mention [36], where elastic effects are included. For further models, discussing the case
of multispecies, we refer the reader to [21,27]. The investigation of associated optimal control problems also
presents a wide number of results of which we mention[10,13,15,22,23,28,34,37,42,4852,54,56].
Sparsity in the optimal control theory of partial differential equations is a very active field of research. The
use of sparsity-enhancing functionals goes back to inverse problems and image processing. Soon after the seminal
paper [57], many results were published. We mention only very few of them with closer relation to our paper, in
particular [1,39,40], on directional sparsity, and [5] on a general theorem for second-order conditions; moreover,
we refer to some new trends in the investigation of sparsity, namely, infinite horizon sparse optimal control (see,
e.g., [43,44]), and fractional order optimal control (cf. [46], [45]). These papers concentrated on first-order
optimality conditions for sparse optimal controls of single elliptic and parabolic equations. In [3,4], first- and
second-order optimality conditions have been discussed in the context of sparsity for the (semilinear) system of
FitzHugh–Nagumo equations. Moreover, we refer to the measure control of the Navier–Stokes system studied
in [2].
The optimal control problem (CP) has recently been investigated in [17] for the case of logarithmic potentials
F1and without sparsity terms, where second-order sufficient optimality conditions have been derived using the
τ–critical cone and the splitting technique as described in the textbook [58]. In [54] and [18], sparsity terms
have been incorporated, where in the latter paper not only logarithmic nonlinearities but also nondifferentiable
double obstacle potentials have been admitted. However, second-order sufficient optimality conditions have not
been derived.
The derivation of meaningful second-order conditions for locally optimal controls of (CP) in the logarithmic
case with sparsity term is the main object of this paper. In particular, we aim at constructing suitable critical
cones which are as small as possible. In our approach, we follow the recent work [55] on the sparse optimal
control of Allen–Cahn systems, which was based on ideas developed in [4].
The paper is organized as follows. In the next section, we list and discuss our assumptions, and we collect
known results from [18] concerning the properties of the state system (1.2)–(1.6) and of the control-to-state oper-
ator. In Section 3, we study the optimal control problem. We derive first-order necessary optimality conditions
and results concerning the full sparsity of local minimizers, and we establish second-order sufficient optimality
conditions for the optimal control problem (CP). In an appendix, we prove auxiliary results that are needed
for the main theorem on second-order sufficient conditions.
Prior to this, let us fix some notation. For any Banach space X, we denote by ∥·∥Xthe norm in the space X,
by Xits dual space, and by ·,· Xthe duality pairing between Xand X. For any 1 p and k0, we
4J. SPREKELS AND F. TR ¨
OLTZSCH
denote the standard Lebesgue and Sobolev spaces on by Lp(Ω) and Wk,p(Ω), and the corresponding norms
by ∥·∥Lp(Ω) =∥·∥pand ∥·∥Wk,p(Ω) , respectively. For p= 2, they become Hilbert spaces, and we employ
the standard notation Hk(Ω) := Wk,2(Ω). As usual, for Banach spaces Xand Ythat are both continuously
embedded in some topological vector space Z, we introduce the linear space XYwhich becomes a Banach
space when equipped with its natural norm vXY:= vX+vY, for vXY. Moreover, we recall the
definition (1.9) of the control space Uand introduce the spaces
H:= L2(Ω), V := H1(Ω), W0:= {vH2(Ω) : nv= 0 on Γ}.(1.11)
Furthermore, by ( ·,·) and ∥·∥we denote the standard inner product and related norm in H, and, for
simplicity, we also set ·,· := ·,· V.
Throughout the paper, we make repeated use of older’s inequality, of the elementary Young inequality
ab δ|a|2+1
4δ|b|2a, b R,δ > 0,(1.12)
as well as of the continuity of the embeddings H1(Ω) Lp(Ω) for 1 p6 and H2(Ω) C0(Ω).
We close this section by introducing a convention concerning the constants used in estimates within this
paper: we denote by Cany positive constant that depends only on the given data occurring in the state system
and in the cost functional, as well as on a constant that bounds the (L(Q)×L(Q))–norms of the elements of
Uad. The actual value of such generic constants Cmay change from formula to formula or even within formulas.
Finally, the notation Cδindicates a positive constant that additionally depends on the quantity δ.
2. General setting and properties of the control-to-state
operator
In this section, we introduce the general setting of our control problem and state some results on the state
system (1.2)–(1.6) and the control-to-state operator that in its present form have been established in [17,18].
We make the following assumptions on the data of the system.
(A1) α, β, χ are positive constants.
(A2) F=F1+F2, where F2C5(R) has a Lipschitz continuous derivative F
2, and where F1:R[0,+]
is convex and lower semicontinuous and satisfies F1(0) = 0, F1|(1,1) C5(1,1), as well as
lim
r↘−1F
1(r) = −∞ and lim
r1F
1(r)=+.(2.1)
(A3) PC3(R)W3,(R) and HL(Q) are nonnegative and bounded.
(A4) The initial data satisfy µ0, σ0H1(Ω) L(Ω), φ0W0, as well as
1<min
x
φ0(x)max
x
φ0(x)<1.(2.2)
(A5) With fixed given constants ui, uisatisfying ui< ui,i= 1,2, we have
Uad ={u= (u1, u2) U :uiuiuia.e. in Qfor i= 1,2}.(2.3)
(A6) R > 0 is a constant such that Uad UR:= {u U :uU< R}.
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 5
Remark 2.1. Observe that (A3) implies that the functions P, P , P ′′ are Lipschitz continuous on R. Let us
also note that F1=F1,log satisfies (A2). Moreover, (2.2) implies that initially there are no pure phases. Finally,
(A6) just fixes an open and bounded subset of Uthat contains Uad.
The following result is a consequence of [18], Theorem 2.3.
Theorem 2.2. Suppose that the conditions (A1)(A6) are fulfilled. Then the state system (1.2)(1.6)has for
every u= (u1, u2) URa unique strong solution (µ, φ, σ)with the regularity
µH1(0, T ;H)C0([0, T ]; V)L2(0, T ;W0)L(Q),(2.4)
φW1,(0, T ;H)H1(0, T ;V)L(0, T ;W0)C0(Q),(2.5)
σH1(0, T ;H)C0([0, T ]; V)L2(0, T ;W0)L(Q).(2.6)
Moreover, there is a constant K1>0, which depends on , T, R, α, β and the data of the system, but not on the
choice of u UR, such that
µH1(0,T ;H)C0([0,T ];V)L2(0,T ;W0)L(Q)
+φW1,(0,T ;H)H1(0,T ;V)L(0,T ;W0)C0(Q)
+σH1(0,T ;H)C0([0,T ];V)L2(0,T ;W0)L(Q)K1.(2.7)
Furthermore, there are constants r, r, which depend on , T, R, α, β and the data of the system, but not on
the choice of u UR, such that
1< rφ(x, t)r<1for all (x, t)Q. (2.8)
Also, there is some constant K2>0having the same dependencies as K1such that
max
i=0,1,2,3
P(i)(φ)
L(Q)+ max
i=0,1,2,3,4,5max
j=1,2
F(i)
j(φ)
L(Q)K2.(2.9)
Finally, if ui URare given controls and (µi, φi, σi)the corresponding solutions to (1.2)(1.6), for i= 1,2,
then, with a constant K3>0having the same dependencies as K1,
µ1µ2H1(0,T ;H)C0([0,T ];V)L2(0,T ;W0)+φ1φ2H1(0,T ;H)C0([0,T ];V)L2(0,T ;W0)
+σ1σ2H1(0,T ;H)C0([0,T ];V)L2(0,T ;W0)K3u1u2L2(Q)2.(2.10)
Remark 2.3. Condition (2.8), known as the separation property, is especially important for the case of singular
potentials such as F1=F1,log, since it guarantees that the phase variable φalways stays away from the critical
values 1,1. The singularity of F
1is therefore no longer an obstacle for the analysis, as the values of φrange
in some interval in which F
1is smooth.
Owing to Theorem 2.2, the control-to-state operator
S:u= (u1, u2)7→ (µ, φ, σ)
is well defined as a mapping between U=L(Q)2and the Banach space specified by the regularity results (2.4)–
(2.6). We now discuss its differentiability properties. For this purpose, some functional analytic preparations
6J. SPREKELS AND F. TR ¨
OLTZSCH
are in order. We first define the linear spaces
X:= X×e
X×X, where
X:= H1(0, T ;H)C0([0, T ]; V)L2(0, T ;W0)L(Q),
e
X:= W1,(0, T ;H)H1(0, T ;V)L(0, T ;W0)C0(Q),(2.11)
which are Banach spaces when endowed with their natural norms. Next, we introduce the linear space
Y:= (µ, φ, σ) X :α∂tµ+tφµL(Q), β∂tφφµL(Q),
tσσ+χφL(Q),(2.12)
which becomes a Banach space when endowed with the norm
(µ, φ, σ)Y:= (µ, φ, σ)X+αtµ+tφµL(Q)+β∂tφφµL(Q)
+tσσ+χφL(Q).(2.13)
Finally, we put
Z:= H1(0, T ;H)C0([0, T ]; V)L2(0, T ;W0),(2.14)
Z:= Z×Z×Z. (2.15)
For fixed (µ, φ, σ), we first discuss an auxiliary result for the linear initial-boundary value problem
α∂tµ+tφµ=λ1[P(φ)(σχφ µ) + P(φ)(σ+χ(1 φ)µ)φ]
λ2Hh1+λ3f1in Q, (2.16)
β∂tφφµ=λ1[χ σ F′′(φ)φ] + λ3f2in Q, (2.17)
tσσ+χφ=λ1[P(φ)(σχφ µ)P(φ)(σ+χ(1 φ)µ)φ]
+λ2h2+λ3f3in Q, (2.18)
nµ=nφ=nσ= 0 on Σ,(2.19)
µ(0) = λ4µ0, φ(0) = λ4φ0, σ(0) = λ4σ0in ,(2.20)
which for λ1=λ2= 1 and λ3=λ4= 0 coincides with the linearization of the state equation at ((µ, φ, σ),
(u
1, u
2)). We remark at this place that the functions h1, h2play the role of control increments, while the role
of (f1, f2, f3) will be become clear during the proof of a number of Lipschitz properties (see, e.g., (2.37)–(2.39),
(2.42)–(2.43)). We have the following result.
Lemma 2.4. Suppose that λ1, λ2, λ3, λ4 {0,1}are given and that the assumptions (A1)(A6) are fulfilled.
Moreover, let u= (u
1, u
2) URbe given and (µ, φ, σ) = S(u). Then (2.16)(2.20)has for every h=
(h1, h2)L2(Q)2and (f1, f2, f3)L2(Q)3a unique solution (µ, φ, σ )Z×e
X×Z. Moreover, the linear
mapping
((h1, h2),(f1, f2, f3)) 7→ (µ, φ, σ) (2.21)
is continuous from L2(Q)2×L2(Q)3into Z×e
X×Z. Moreover, if hL(Q)2and (f1, f2, f3)L(Q)3, in
addition, then it holds (µ, φ, σ) Y, and the mapping (2.21)is continuous from L(Q)2×L(Q)3into Y.
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 7
Proof. The existence result and the continuity of the mapping (2.21) between the spaces L(Q)2×L(Q)3
and Ydirectly follow from the statement of [17], Lemma 4.1 and Remark 4.2. Moreover, from the estimates
(4.36)–(4.38) and (4.43) in [17] we can conclude that the mapping (2.21) is also continuous between the spaces
L2(Q)2×L2(Q)3and Z×e
X×Z.
Now let u= (u
1, u
2) URbe arbitrary and (µ, φ, σ) = S(u). Then, according to [17], Theorem 4.4, the
control-to-state operator Sis twice continuously Fr´echet differentiable at uas a mapping from Uinto Y.
Moreover, for every h= (h1, h2) U , the first Fr´echet derivative S(u) L(U,Y) of Sat uis given by the
identity S(u)[h]=(ηh, ξh, θh), where (ηh, ξh, θh) Y is the unique solution to the linearization of the state
system given by the initial-boundary value problem (2.16)–(2.20) with λ1=λ2= 1 and λ3=λ4= 0.
Remark 2.5. Observe that, in view of the continuity of the embedding Y Z×e
X×Z, the operator S(u)
L(U,Y) also belongs to the space L(U, Z ×e
X×Z) and, owing to the density of Uin L2(Q)2, can be extended
continuously to an element of L(L2(Q)2, Z ×e
X×Z) without changing its operator norm. Denoting the extended
operator still by S(u), we see that the identity S(u)[h]=(ηh, ξh, θh) is also valid for every hL2(Q)2,
only that (ηh, ξh, θh)Z×e
X×Z, in general. In addition, it also follows from the proof of [17], Lemma 4.1
that there is a constant K4>0, which depends only on Rand the data, such that
∥S(u)[h]Z×
e
X×ZK4hL2(Q)2for all u URand every hL2(Q)2.(2.22)
Next, we show a Lipschitz property for the extended operator S.
Lemma 2.6. The mapping S:U L(L2(Q)2, Z ×e
X×Z),u7→ S(u), is Lipschitz continuous in the following
sense: there is a constant K5>0, which depends only on Rand the data, such that, for all controls u1,u2 UR
and all increments hL2(Q)2,
(S(u1) S(u2)) [h]ZK5u1u2L2(Q)2hL2(Q)2.(2.23)
Proof. We put (µi, φi, σi) := S(ui), (ηi, ξi, θi) := S(ui)[h], i= 1,2, as well as
u:= u1u2, µ := µ1µ2, φ := φ1φ2, σ := σ1σ2,
η:= η1η2, ξ := ξ1ξ2, θ := θ1θ2.
Then it follows from (2.10) in Theorem 2.2 that
(µ, φ, σ)ZK3uL2(Q)2.(2.24)
Moreover, (η, ξ, θ) solves the problem
α∂tη+tξη=P(φ1)(θχξ η) + P(φ1)(σ1+χ(1 φ1)µ1)ξ+f1in Q, (2.25)
β∂tξξ=χθ F′′ (φ1)ξ+f2in Q, (2.26)
tθθ+χξ=P(φ1)(θχξ η)P(φ1)(σ1+χ(1 φ1)µ1)ξ+f3in Q, (2.27)
nη=nξ=nθ= 0 on Σ,(2.28)
η(0) = ξ(0) = θ(0) = 0 in ,(2.29)
which is of the form (2.16)–(2.20) with λ1=λ3= 1 and λ2=λ4= 0, and where
f1:= f3:= ((P(φ1)P(φ2))(θ2χξ2η2) + P(φ1)(σχφ µ)ξ2
8J. SPREKELS AND F. TR ¨
OLTZSCH
+ (P(φ1)P(φ2))(σ2+χ(1 φ2)µ2)ξ2,(2.30)
f2:= (F′′(φ1)F′′ (φ2))ξ2.(2.31)
We therefore conclude from Lemma 2.4 that
(η, ξ, θ)ZCf1L2(Q)+f2L2(Q).
Hence, the proof will be finished once we can show that
f1L2(Q)+f2L2(Q)CuL2(Q)2hL2(Q)2.(2.32)
To this end, we first use the mean value theorem, (2.9), older’s inequality, the continuity of the embedding
VL4(Ω), as well as (2.10) and (2.24), to find that
f22
L2(Q)CZZQ
|φ|2|ξ2|2CZT
0
φ2
4ξ22
4ds Cφ2
C0([0,T ];V)ξ22
C0([0,T ];V)
Cφ2
Z∥S(u2)[h]2
ZCu2
L2(Q)2h2
L2(Q)2.(2.33)
Here, we have for convenience omitted the argument sin the third integral. We will do this repeatedly in the
following. For the three summands on the right-hand side of (2.30), which we denote by A1, A2, A3, in this
order, we obtain by similar reasoning the estimates
ZZQ
|A1|2CZZQ
|φ|2|θ2χξ2η2|2CZT
0
φ2
4η22
4+ξ22
4+θ22
4ds
Cu2
L2(Q)2h2
L2(Q)2,(2.34)
ZZQ
|A2|2CZT
0
|ξ2|2|µ|2+|φ|2+|σ|2ds CZT
0
ξ22
4µ2
4+φ2
4+σ2
4ds
Cu2
L2(Q)2h2
L2(Q)2,(2.35)
ZZQ
|A3|2Cσ22
L(Q)+φ22
L(Q)+µ22
L(Q)+ 1ZZQ
|φ|2|ξ2|2
Cu2
L2(Q)2h2
L2(Q)2,(2.36)
where in the last estimate we also used (2.7) and (2.33). With this, the assertion is proved.
Next, we turn our interest to the second Fechet derivative S′′(u) of Sat u. Let h= (h1, h2) U and
k= (k1, k2) U. Then, (ηh, ξh, θh) := S(u)[h] and (ηk, ξ k, θk) := S(u)[k] both belong to Yand, by virtue
of [17], Theorem 4.6, (ν, ψ, ρ) = S′′ (u)[h,k] Y is the unique solution to the bilinearization of the state
system at ((µ, φ, σ),(u
1, u
2)), which is given by the linear initial-boundary value problem
α∂tν+tψν=P(φ)(ρχψ ν) + P(φ)(σ+χ(1 φ)µ)ψ+f1in Q, (2.37)
β∂tψψν=χρ F′′ (φ)ψ+f2in Q, (2.38)
tρρ+χψ=P(φ)(ρχψ ν)P(φ)(σ+χ(1 φ)µ)ψ+f3in Q, (2.39)
nν=nψ=nρ= 0 on Σ,(2.40)
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 9
ν(0) = ψ(0) = ρ(0) = 0 in ,(2.41)
and which is again of the form (2.16)–(2.20) with λ1=λ3= 1 and λ2=λ4= 0, where
f1:= f3:= P(φ)ξk(θhχξhηh) + ξh(θkχξkηk)
+P′′(φ)ξkξh(σ+χ(1 φ)µ),(2.42)
f2:= F(3)(φ)ξhξk.(2.43)
Now assume that h,kL2(Q)2are given. Then the expressions (ηh, ξh, θh) := S(u)[h] and (ηk, ξk, θk) :=
S(u)[k] are well-defined elements of the space Z×e
X×Z, where S(u) now denotes the extension of the
Fechet derivative introduced in Remark 2.5. We now claim that there is a constant b
C > 0 that depends only
on Rand the data, such that
f1L2(Q)+f2L2(Q)b
ChL2(Q)2kL2(Q)2.(2.44)
Indeed, arguing as in the derivation of the estimates (2.33)–(2.36), we obtain
f12
L2(Q)CZT
0
ξk2
4θh2
4+ξh2
4+ηh2
4ds
+CZT
0
ξh2
4θk2
4+ξk2
4+ηk2
4ds
+Cσ2
L(Q)+φ2
L(Q)+µ2
L(Q)+ 1ZT
0
ξk2
4ξh2
4ds
C∥S(u)[h]2
C0([0,T ];V)∥S(u)[k]2
C0([0,T ];V)Ch2
L2(Q)2k2
L2(Q)2,
f22
L2(Q)CZT
0
ξh2
4ξk2
4ds Ch2
L2(Q)2k2
L2(Q)2,
which proves the claim. At this point, we can conclude from Lemma 2.4 that the system (2.37)–(2.41) has for
every h,kL2(Q)2a unique solution (ν, ψ, ρ)Z×e
X×Z. Moreover, we have, with a constant K6>0 that
depends only on Rand the data,
(ν, ψ, ρ)Z×
e
X×ZK6hL2(Q)2kL2(Q)2h,kL2(Q)2.(2.45)
Remark 2.7. Similarly as in Remark 2.5, the operator S′′ (u) L(U,L(U,Y)) can be extended continuously
to an element of L(L2(Q)2,L(L2(Q)2, Z ×e
X×Z)) without changing its operator norm. Denoting the extended
operator still by S′′(u), we see that the identity S′′(u)[h,k] = (ν, ψ , ρ) is also valid for every h,kL2(Q)2,
only that (ν, ψ, ρ)Z×e
X×Z, in general. In addition, we have
∥S′′ (u)[h,k]Z×
e
X×ZK6hL2(Q)2kL2(Q)2for all u URand h,kL2(Q)2.(2.46)
We conclude our preparatory work by showing a Lipschitz property for the extended operator S′′ that
resembles (2.23).
10 J. SPREKELS AND F. TR ¨
OLTZSCH
Lemma 2.8. The mapping S′′ :U L(L2(Q)2,L(L2(Q)2, Z ×e
X×Z)),u7→ S′′ (u), is Lipschitz continuous
in the following sense: there is a constant K7>0, which depends only on Rand the data, such that, for all
controls u1,u2 URand all increments h,kL2(Q)2,
(S′′(u1) S ′′(u2)) [h,k]ZK7u1u2L2(Q)2hL2(Q)2kL2(Q)2.(2.47)
Proof. We put (µi, φi, σi) := S(ui), (ηh
i, ξh
i, θh
i) := S(ui)[h], (ηk
i, ξk
i, θk
i) := S(ui)[k], (νi, ψi, ρi) :=
S′′(ui)[h,k], for i= 1,2, as well as
u:= u1u2, µ := µ1µ2, φ := φ1φ2, σ := σ1σ2,
ηh:= ηh
1ηh
2, ξh:= ξh
1ξh
2, θh:= θh
1θh
2,
ηk:= ηk
1ηk
2, ξk:= ξk
1ξk
2, θk:= θk
1θk
2,
ν:= ν1ν2, ψ := ψ1ψ2, ρ := ρ1ρ2.
Then it follows from (2.10) and (2.23) that
(µ, φ, σ)ZCuL2(Q)2,(ηh, ξh, θh)ZCuL2(Q)2hL2(Q)2,
(ηk, ξk, θk)ZCuL2(Q)2kL2(Q)2.(2.48)
We also recall the estimates (2.22) and (2.46). Moreover, (ν, ψ, ρ) solves the problem
α∂tν+tψν=P(φ1)(ρχψ ν) + P(φ1)(σ1+χ(1 φ1)µ1)ψ+g1in Q, (2.49)
β∂tψψ=χρ F′′ (φ1)ψ+g2in Q, (2.50)
tρρ+χψ=P(φ1)(ρχψ ν)P(φ1)(σ1+χ(1 φ1)µ1)ψ+g3in Q, (2.51)
nν=nψ=nρ= 0 on Σ,(2.52)
ν(0) = ψ(0) = ρ(0) = 0 in ,(2.53)
which is again of the form (2.16)–(2.20) with λ1=λ3= 1 and λ2=λ4= 0, where
g1:= g3:= ((P(φ1)P(φ2))(ρ2χψ2ν2) + P(φ1)(σχφ µ)ψ2
+ (P(φ1)P(φ2))(σ2+χ(1 φ2)µ2)ψ2+ (P(φ1)P(φ2)) ξk
1(θh
1χξh
1ηh
1)
+P(φ2)ξk(θh
1χξh
1ηh
1) + P(φ2)ξk
2(θhχξhηh)
+ (P(φ1)P(φ2)) ξh
1(θk
1χξk
1ηk
1) + P(φ2)ξh(θk
1χξk
1ηk
1)
+P(φ2)ξh
2(θkχξkηk)+(P′′(φ1)P′′(φ2)) ξh
1ξk
1(σ1+χ(1 φ1)µ1)
+P′′(φ2)ξkξh
1(σ1+χ(1 φ1)µ1) + P′′(φ2)ξk
2ξh(σ1+χ(1 φ1)µ1)
+P′′(φ2)ξk
2ξh
2(σχφ µ) =:
13
X
i=1
Bi,(2.54)
g2:= (F′′(φ1)F′′ (φ2))ψ2F(3)(φ1)F(3)(φ2)ξh
1ξk
1F(3)(φ2)ξhξk
1+ξh
2ξk,(2.55)
where Bidenotes the ith summand on the right-hand side of (2.54).
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 11
At this point, we infer from the proof of [17], Lemma 4.1 that the assertion follows once we can show that
13
X
i=1
BiL2(Q)+g2L2(Q)CuL2(Q)2hL2(Q)2kL2(Q)2.
We only show the corresponding estimate for the terms B1, B4, B11 and leave the others to the interested
reader. In the following, we make use of the mean value theorem, older’s inequality, the continuity of the
embeddings VL6(Ω) L4(Ω), and the global estimates (2.7), (2.8), (2.22), and (2.46). We have
B12
L2(Q)CZT
0
φ2
4ρ22
4+ψ22
4+ν22
4ds
Cφ2
C0([0,T ];V)∥S′′ (u2)[h,k]2
C0([0,T ];V)3Cu2
L2(Q)2h2
L2(Q)2k2
L2(Q)2,
B42
L2(Q)CZT
0
φ2
6ξk
12
6θh
12
6+ξh
12
6+ηh
12
6ds
Cφ2
C0([0,T ];V)ξk
12
Z∥S(u1)[h]2
ZCu2
L2(Q)2h2
L2(Q)2k2
L2(Q)2,
as well as
B112
L2(Q)Cσ12
L(Q)+φ12
L(Q)+µ12
L(Q)+ 1ZT
0
φ2
6ξh
12
6ξk
12
6ds
Cφ2
C0([0,T ];V)ξh
12
C0([0,T ];V)ξk
12
C0([0,T ];V)Cu2
L2(Q)2h2
L2(Q)2k2
L2(Q)2.
The assertion of the lemma is thus proved.
3. The optimal control problem
We now begin to investigate the control problem (CP). In addition to (A1)(A6), we make the following
assumptions:
(C1) The constants b1, b2are nonnegative, while b3, κ are positive.
(C2) It holds bφH1(Ω) and bφQL2(Q).
(C3) g:L2(Q)2Ris nonnegative, continuous and convex.
Observe that (C3) implies that gis weakly sequentially lower semicontinuous on L2(Q)2. Moreover, denoting
in the following by the subdifferential mapping in L2(Q)2, it follows from standard convex analysis that
∂g is defined on the entire space L2(Q)2and is a maximal monotone operator. In addition, the mapping
((µ, φ, σ),u)7→ J((µ, φ, σ),u) defined by the cost functional (1.1) is obviously continuous and convex (and thus
weakly sequentially lower semicontinuous) on the space L2(Q)×C0([0, T ]; L2(Ω)) ×L2(Q)×L2(Q)2. From a
standard argument (which needs no repetition here) it then follows that the problem (CP) has a solution.
In the following, we often denote by u= (u
1, u
2) Uad a local minimizer in the sense of Uand by
(µ, φ, σ) = S(u) the associated state. The corresponding adjoint state variables solve the adjoint system,
which is given by the backward-in-time parabolic system
tpβ∂tqq+χr+F′′ (φ)qP(φ)(σ+χ(1 φ)µ)(pr)
+χP (φ)(pr) = b1(φbφQ) in Q, (3.1)
α∂tppq+P(φ)(pr) = 0 in Q, (3.2)
12 J. SPREKELS AND F. TR ¨
OLTZSCH
trrχq P(φ)(pr) = 0 in Q, (3.3)
np=nq=nr= 0 on Σ,(3.4)
(p+βq)(T) = b2(φ(T)bφ), αp(T) = 0, r(T) = 0 in .(3.5)
According to [17], Theorem 5.2, the adjoint system has a unique weak solution (p, q, r ) satisfying
p+βq H1(0, T ;V),(3.6)
pH1(0, T ;H)C0([0, T ]; V)L2(0, T ;W0)L(Q),(3.7)
qL(0, T ;H)L2(0, T ;V),(3.8)
rH1(0, T ;H)C0([0, T ]; V)L2(0, T ;W0)L(Q),(3.9)
as well as
t(p+βq), v+Z
q· vχZ
r· v+Z
F′′(φ)q v
Z
P(φ)(σ+χ(1 φ)µ)(pr)v+χZ
P(φ)(pr)v=b1Z
(φbφQ)v, (3.10)
αZ
tp v +Z
p· vZ
q v +Z
P(φ) (pr)v= 0,(3.11)
Z
tr v +Z
r· vχZ
q v Z
P(φ) (pr)v= 0,(3.12)
for every vVand almost every t(0, T ), and
(p+βq)(T) = b2(φ(T)bφ), p(T) = 0, r(T) = 0,a.e. in .(3.13)
Moreover, it follows from the proof of [17], Theorem 5.2 that there exists a constant K8>0, which depends
only on Rand the data (but not on the special choice of u Uad ), such that
pH1(0,T ;H)C0([0,T ];V)L2(0,T ;W0)L(Q)+qH1(0,T ;V)L(0,T ;H)L2(0,T ;V)
+rH1(0,T ;H)C0([0,T ];V)L2(0,T ;W0)L(Q)
K8φbφQL2(Q)+φ(T)bφV.(3.14)
3.1. First-order necessary optimality conditions
In this section, we aim at deriving associated first-order necessary optimality conditions for local minima of
the optimal control problem (CP). We assume that (A1)(A6) and (C1)(C3) are fulfilled and define the
reduced cost functionals associated with the functionals Jand J1introduced in (1.1) by
b
J(u) = J(S(u),u),b
J1(u) = J1(S(u),u).(3.15)
Since Sis twice continuously Fr´echet differentiable from Uinto Yand Yis continuously embedded in
C0([0, T ]; L2(Q)3), Sis also twice continuously Fechet differentiable from Uinto C0([0, T ]; L2(Q)3). It thus
follows from the chain rule that the smooth part b
J1of b
Jis a twice continuously Fr´echet differentiable mapping
from Uinto R, where, for every u= (u
1, u
2) U and every h= (h1, h2) U, it holds with (µ, φ, σ) = S(u)
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 13
that
b
J
1(u)[h] = b1ZZQ
ξh(φbφQ) + b2Z
ξh(T)(φ(T)bφ)
+b3ZZQ
(u
1h1+u
2h2),(3.16)
where (ηh, ξh, θh) = S(u)[h] is the unique solution to the linearized system (2.16)–(2.20), with λ1=λ2= 1
and λ3=λ4= 0, associated with h.
Remark 3.1. Observe that the right-hand side of (3.16) is meaningful also for arguments h= (h1, h2)L2(Q)2,
where in this case (ηh, ξh, θh) = S(u)[h] with the extension of the operator S(u) to L2(Q)2introduced in
Remark 2.5. Hence, by means of the identity (3.16) we can extend the operator b
J
1(u) Uto L2(Q)2. The
extended operator, which we again denote by b
J
1(u), then becomes an element of (L2(Q)2). In this way,
expressions of the form b
J
1(u)[h] have a proper meaning also for hL2(Q)2.
In the following, we assume that u= (u
1, u
2) Uad is a given locally optimal control for (CP) in the sense
of U, that is, there is some ε > 0 such that
b
J(u)b
J(u) for all u Uad satisfying uuUε. (3.17)
Notice that any locally optimal control in the sense of Lp(Q)2with 1 p < is also locally optimal in the
sense of U. Therefore, a result proved for locally optimal controls in the sense of Uis also valid for locally
optimal controls in the sense of Lp(Q)2. It is of course also valid for (globally) optimal controls.
Now, in the same way as in [55], we infer that then the variational inequality
b
J
1(u)[uu] + κ(g(u)g(u)) 0u Uad (3.18)
is satisfied. Moreover, denoting by the symbol the subdifferential mapping in L2(Q)2(recall that gis a
convex continuous functional on L2(Q)2), we conclude from [55], Theorem 4.5 that there is some λ= (λ
1, λ
2)
∂g(u)L2(Q)2such that
b
J
1(u)[uu] + ZZQ
κ(λ
1(u1u
1) + λ
2(u2u
2)) 0u= (u1, u2) Uad.(3.19)
As usual, we simplify the expression b
J
1(u)[uu] in (3.19) by means of the adjoint state variables defined in
(3.1)–(3.5). A standard calculation (see the proof of [17], Thm. 5.4) then leads to the following result.
Theorem 3.2. (Necessary optimality condition) Suppose that (A1)(A6) and (C1)(C3) are fulfilled. More-
over, let u= (u
1, u
2) Uad be a locally optimal control of (CP) in the sense of Uwith associated state
(µ, φ, σ) = S(u)and adjoint state (p, q , r). Then there exists some λ= (λ
1, λ
2)∂g(u)such that, for
all u= (u1, u2) Uad ,
ZZQ
(Hp+κλ
1+b3u
1)(u1u
1) + ZZQ
(r+κλ
2+b3u
2)(u2u
2)0.(3.20)
Remark 3.3. We underline again that (3.20) is also necessary for all globally optimal controls and all controls
which are even locally optimal in the sense of Lp(Q)×Lp(Σ) with p1. Observe also that the variational
inequality (3.20) is equivalent to two independent variational inequalities for u
1and u
2that have to hold
14 J. SPREKELS AND F. TR ¨
OLTZSCH
simultaneously, namely,
ZZQ
(Hp+κλ
1+b3u
1) (u1u
1)0u1U1
ad,(3.21)
ZZQ
(r+κλ
2+b3u
2) (u2u
2)0u2U2
ad,(3.22)
where
Ui
ad := {uiL(Q) : uiuiuia.e. in Q}, i = 1,2.(3.23)
3.2. Sparsity of controls
The convex function gin the ob jective functional accounts for the sparsity of optimal controls, i.e., any
locally optimal control can vanish in some region of the space-time cylinder Q. The form of this region depends
on the particular choice of the functional gwhich can differ in different situations. The sparsity properties can
be deduced from the variational inequalities (3.21) and (3.22) and the form of the subdifferential ∂g. In this
paper, we restrict our analysis to the case of full sparsity which is characterized by the functional (recall (1.1))
g(u) = g(u1, u2) := ZZQ
(|u1|+|u2|).(3.24)
Other important choices leading to the directional sparsity with respect to time and the directional sparsity with
respect to space are not considered here. It is well known (see, e.g., [54]) that the subdifferential of gis given
by
∂g(u) = ∂g(u1, u2)
:=
(λ1, λ2)L2(Q)2:λi
{1}if ui>0
[1,1] if ui= 0
{−1}if ui<0
a.e. in Q, i = 1,2
.(3.25)
The following sparsity result can be proved in exactly the same way as [55], Theorem 4.9.
Theorem 3.4. (Full sparsity) Suppose that the assumptions (A1)(A6) and (C1)(C3) are fulfilled, and
assume that ui<0< ui,i= 1,2. Let u= (u
1, u
2) Uad be a locally optimal control in the sense of Ufor the
problem (CP) with the sparsity functional gdefined in (3.24), and with associated state (µ, φ, σ) = S(u)
solving (1.2)(1.6)and adjoint state (p, q, r)solving (3.1)(3.5). Then there exists some (λ
1, λ
2)∂g(u)
such that (3.21)(3.22)are satisfied. In addition, we have that
u
1(x, t)=0 | H(x, t)p(x, t)| κ, for a.e. (x, t)Q, (3.26)
u
2(x, t)=0 |r(x, t)| κ, for a.e. (x, t)Q. (3.27)
Moreover, if (p, q, r)and (λ
1, λ
2)are given, then (u
1, u
2)is obtained from the projection formulas
u
1(x, t) = max u1,min u1,b1
3(Hp+κ λ
1) (x, t) for a.e. (x, t)Q, (3.28)
u
2(x, t) = max u2,min u2,b1
3(r+κ λ
2) (x, t) for a.e. (x, t)Q.(3.29)
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 15
We remark in this connection that the projection formulas above are standard conclusions from the variational
inequalities (3.21)–(3.22). Moreover, it should be noted that, in order to prove sparsity, the control u= 0 has
to lie in (ui, ui), i= 1,2.
3.3. Second-order sufficient optimality conditions
In this section, we establish the main results of this paper, using auxiliary results collected in the Appendix.
We provide conditions that ensure local optimality of pairs u= (u
1, u
2) obeying the first-order necessary
optimality conditions of Theorem 3.2. Second-order sufficient optimality conditions are based on a condition
of coercivity that is required to hold for the smooth part b
J1of b
Jin a certain critical cone. The nonsmooth
part gcontributes to sufficiency by its convexity. In the following, we generally assume that (A1)(A6),
(C1)(C3), and the conditions u1<0< u1and u2<0< u2are fulfilled. Our analysis will follow closely the
lines of [55], which in turn follows [4], where a second-order analysis was performed for sparse control of the
FitzHugh–Nagumo system. In particular, we adapt the proof of [4], Theorem 3.4 to our setting of less regularity.
To this end, we fix a pair of controls u= (u
1, u
2) that satisfies the first-order necessary optimality conditions,
and we set (µ, φ, σ) = S(u). Then the cone
C(u) = {(v1, v2)L2(Q)2satisfying the sign conditions (3.30) a.e. in Q},
where
vi(x, t)(0 if u
i(x, t) = ui
0 if u
i(x, t) = ui
, i = 1,2,(3.30)
is called the cone of feasible directions, which is a convex and closed subset of L2(Q)2. We also need the
directional derivative of gat uL2(Q)2in the direction v= (v1, v2)L2(Q)2, which is given by
g(u,v) = lim
τ0
1
τ(g(u+τv)g(u)).(3.31)
Following the definition of the critical cone in [4], Section 3.1, we define
Cu={vC(u) : b
J
1(u)[v] + κg(u,v)=0},(3.32)
which is also a closed and convex subset of L2(Q)2. According to [4], Section 3.1, it consists of all v= (v1, v2)
C(u) satisfying
v1(x, t)
= 0 if | H(x, t)p(x, t) + b3u
1(x, t)| =κ
0 if u
1(x, t) = u1or (H(x, t)p(x, t) = κand u
1(x, t) = 0)
0 if u
1(x, t) = u1or (H(x, t)p(x, t) = κand u
1(x, t) = 0)
,(3.33)
v2(x, t)
= 0 if |r(x, t) + b3u
2(x, t)| =κ
0 if u
2(x, t) = u2or (r(x, t) = κand u
2(x, t) = 0)
0 if u
2(x, t) = u2or (r(x, t) = κand u
2(x, t) = 0)
.(3.34)
Remark 3.5. Let us compare the first condition in (3.33) with the situation in the differentiable control problem
without sparsity terms obtained for κ= 0. Then this condition leads to the requirement that v1(x, t) = 0 if
| H(x, t)p(x, t) + b3u
1(x, t)|>0, or, since κ= 0,
v1(x, t) = 0 if | H(x, t)p(x, t) + κλ
1(x, t) + b3u
1(x, t)|>0.(3.35)
16 J. SPREKELS AND F. TR ¨
OLTZSCH
An analogous condition results for v2.
One might be tempted to define the critical cone using (3.35) and its counterpart for v2also in the case κ > 0.
This, however, is not a good idea, because it leads to a critical cone that is larger than needed, in general. As an
example, we mention the particular case when the control u=0satisfies the first-order necessary optimality
conditions and when | Hp|< κ and |r|< κ hold a.e. in Q. Then the upper relation of (3.33), and its
counterpart for v2, lead to Cu={0}, the smallest possible critical cone.
However, thanks to u
1= 0, the variational inequality (3.21) implies that Hp+κλ
1+b3u
1= 0 a.e. in Q,
i.e., the condition | H(x, t)p(x, t) + κλ
1(x, t) + b3u
1(x, t)|>0 can only be satisfied on a set of measure zero.
Moreover, also the sign conditions (3.30) do not restrict the critical cone. Hence, the largest possible critical
cone Cu=L2(Q)2would be obtained, provided that analogous conditions hold for u
2and rin Q.
In this example, the quadratic growth condition (3.43) below is valid for the choice (3.32) as critical cone
even without assuming the coercivity condition (3.42) below (here the so-called first-order sufficient conditions
apply), while the use of a cone based on (3.35) leads to postulating (3.42) on the whole space L2(Q)2for the
quadratic growth condition to be valid. This shows that the choice of (3.32) as critical cone is essentially better
than of one based on (3.35).
At this point, we derive an explicit expression for b
J′′
1(u)[v,w] for arbitrary u= (u1, u2),v= (v1, v2),w=
(w1, w2) U. In the following, we argue similarly as in [58], Section 5.7 (see also [17], Sect. 6). At first, we
readily infer that, for every ((µ, φ, σ),u)(C0([0, T ]; H))3× U and v= (v1, v2, v3),w= (w1, w2, w3) such that
(v,h),(w,k)(C0(0, T ;H))3× U , we have
J′′
1((µ, φ, σ),u)[(v,h),(w,k)] = b1ZZQ
v2w2+b2Z
v2(T)w2(T) + b3ZZQ
h·k,(3.36)
where the dot denotes the Euclidean scalar product in R2. For the second-order derivative of the reduced cost
functional b
J1at a fixed control uwe then find with (µ, φ, σ) = S(u) that
b
J′′
1(u)[h,k] = D(µ,φ,σ)J1((µ, φ, σ),u)[(ν, ψ , ρ)]
+J′′
1((µ, φ, σ),u)[((ηh, ξh, θh),h),((ηk, ξk, θk),k)],(3.37)
where (ηh, ξh, θh), (ηk, ξ k, θk), and (ν, ψ, ρ) stand for the unique corresponding solutions to the linearized system
associated with hand k, and to the bilinearized system, respectively. From the definition of the cost functional
(1.1) we readily infer that
D(µ,φ,σ)J1((µ, φ, σ),u)[(ν, ψ , ρ)] = b1ZZQ
(φbφQ)ψ+b2Z
(φ(T)bφ)ψ(T).(3.38)
We now claim that, with the associated adjoint state (p, q, r),
b1ZZQ
(φbφQ)ψ+b2Z
(φ(T)bφ)ψ(T)
=ZZQP(φ)ξk(θhχξhηh) + ξh(θkχξkηk)(pr)
+P′′(φ)ξkξh(σ+χ(1 φ)µ)(pr)F(3) (φ)ξhξkq.(3.39)
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 17
To prove this claim, we multiply (2.37) by p, (2.38) by q, (2.39) by r, add the resulting equalities, and
integrate over Q, to obtain that
0 = ZZQ
phα∂tν+tψνP(φ)(ρχψ ν)
P(φ)(σ+χ(1 φ)µ)ψf1i
+ZZQ
qhβ∂tψψνχρ +F′′ (φ)ψ+F(3)(φ)ξhξki
+ZZQ
rhtρρ+χψ+P(φ)(ρχψ ν)
+P(φ)(σ+χ(1 φ)µ)ψ+f1i
with the function f1defined in (2.42). Then, we integrate by parts and make use of the initial and terminal
conditions (2.41) and (3.13) to find that
0 = ZZQ
νhα∂tppq+P(φ)(pr)i
+ZT
0
⟨−t(p+βq)(t), ψ(t)dt +b2Z
(φ(T)bφ)ψ(T)
+ZZQ
ψhq+χr+F′′(φ)q+χP (φ)(pr)
P(φ)(σ+χ(1 φ)µ)(pr)i
+ZZQ
ρhtrrχqP(φ)(pr)i
+ZZQhP(φ)ξk(θhχξhηh) + ξh(θkχξkηk)(pr)
P′′(φ)ξkξh(σ+χ(1 φ)µ)(pr) + F(3) (φ)ξhξkqi,
whence the claim follows, since (p, q, r) solves the adjoint system (3.10)–(3.13). From this characterization,
along with (3.37) and (3.38), we conclude that
b
J′′
1(u)[h,k] = b1ZZQ
ξhξk+b2Z
ξh(T)ξk(T) + b3ZZQ
h·k
+ZZQhP(φ)ξk(θhχξhηh) + ξh(θkχξkηk)(pr)
+P′′(φ)(σ+χ(1 φ)µ)(pr)ξhξkF(3) (φ)ξhξkqi.(3.40)
Observe that the expression on the right-hand side of (3.40) is meaningful also for increments h,k
L2(Q)2. Indeed, in this case the expressions (ηh, ξh, θh) = S(u)[h], (ηk, ξk, θk) = S(u)[k], and (ν, ψ , ρ) =
S′′(u)[h,k] have an interpretation in the sense of the extended operators S(u) and S′′(u) introduced in
Remark 2.5 and Remark 2.7. Therefore, the operator b
J′′
1(u) can be extended by the identity (3.40) to the
space L2(Q)2×L2(Q)2. This extension, which will still be denoted by b
J′′
1(u), will be frequently used in the
18 J. SPREKELS AND F. TR ¨
OLTZSCH
following. We now show that it is continuous. Indeed, we claim that for all h,kL2(Q)2it holds
b
J′′
1(u)[h,k]b
ChL2(Q)2kL2(Q)2,(3.41)
where the constant b
C > 0 is independent of the choice of u UR. Obviously, only the last integral on the
right-hand side of (3.40) needs some treatment, and we estimate just its third summand, leaving the others as
an exercise to the reader. We have, by virtue of older’s inequality, the continuity of the embedding VL4(Ω),
and the global bounds (2.9), (2.22), and (3.14),
ZZQ
F(3)(φ)ξhξkqCZT
0
ξh4ξk4q2dt
CξhC0([0,T ];V)ξkC0([0,T ];V)qL(0,T ;H)ChL2(Q)2kL2(Q)2,
as asserted.
In the following, we will employ the following coercivity condition:
b
J′′
1(u)[v,v]>0vCu\ {0}.(3.42)
Condition (3.42) is a direct extension of associated conditions that are standard in finite-dimensional nonlinear
optimization. In the optimal control of partial differential equation, it was first used in [5]. As in [4], Theorem
3.3 or [5], it can be shown that (3.42) is equivalent to the existence of a constant δ > 0 such that b
J′′
1(u)[v,v]
δv2
L2(Q)2for all vCu.
We have the following result.
Theorem 3.6. (Second-order sufficient condition) Suppose that (A1)(A6) and (C1)(C3) are fulfilled and
that ui<0< ui,i= 1,2. Moreover, let u= (u
1, u
2) Uad, together with the associated state (µ, φ, σ) =
S(u)and the adjoint state (p, q, r), fulfill the first-order necessary optimality conditions of Theorem 3.2. If,
in addition, usatisfies the coercivity condition (3.42), then there exist constants ε > 0and ζ > 0such that
the quadratic growth condition
b
J(u)b
J(u) + ζuu2
L2(Q)2(3.43)
holds for all u Uad with uuL2(Q)2< ε. Consequently, uis a locally optimal control in the sense of
L2(Q)2.
Proof. The proof follows that of [4], Theorem 3.4. We argue by contradiction, assuming that the claim of the
theorem is not true. Then there exists a sequence of controls {uk}⊂Uad such that, for all kN,
ukuL2(Q)2<1
kwhile b
J(uk)<b
J(u) + 1
2kuku2
L2(Q)2.(3.44)
Noting that uk=ufor all kN, we define
τk=ukuL2(Q)2and vk=1
τk
(uku).
Then vkL2(Q)2= 1 and, possibly after selecting a subsequence, we can assume that
vkvweakly in L2(Q)2
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 19
for some vL2(Q)2. As in [4], the proof is split into three parts.
(i) vCu: Obviously, each vkobeys the sign conditions (3.30) and thus belongs to C(u). Since C(u) is
convex and closed in L2(Q)2, it follows that vC(u). We now claim that
b
J
1(u)[v] + κg(u,v) = 0.(3.45)
Notice that by Remark 3.1 the expression b
J
1(u)[v] is well defined. For every ϑ(0,1) and all v= (v1, v2),u=
(u1, u2)L2(Q)2, we infer from the convexity of gthat
g(v)g(u)g(u+ϑ(vu)) g(u)
ϑg(u,vu)
= max
(λ12)∂g(u)ZZQλ1(v1u1) + λ2(v2u2).(3.46)
In particular, with uk= (uk1, uk2),
b
J
1(u)[v] + κg(u,v)b
J
1(u)[v] + ZZQ
κλ
1v1+λ
2v2
=ZZQ(Hp+b3u
1+κλ
1)v1+ (r+b3u
2+κλ
2)v2
= lim
k→∞
1
τkZZQ(Hp+b3u
1+κλ
1)(uk1u
1)+(r+b3u
2+κλ
2)(uk2u
2)
0,(3.47)
by the variational inequality (3.20). Next, we prove the converse inequality. By (3.44), we have
b
J1(uk)b
J1(u) + κ(g(uk)g(u)) <1
2kτ2
k,
whence, owing to the mean value theorem, and since uk=u+τkvk, we get
b
J1(u) + τkb
J
1(u+θkτkvk)[vk] + κg(u+τkvk)<b
J1(u) + κg(u) + 1
2kτ2
k
with some 0 < θk<1. From (3.46), we obtain κ(g(u+τkvk)g(u)) κg(u, τkvk), and thus
τkb
J
1(u+θkτkvk)[vk] + τkκg(u,vk)<τ2
k
2k.
We divide this inequality by τkand pass to the limit k . Here, we invoke Corollary A.2 of the Appendix,
and we use that lim inf k→∞ g(u,vk)g(u,v). We then obtain the desired converse inequality
b
J
1(u)[v] + κg(u,v)0,
which completes the proof of (i).
(ii) v=0: We again invoke (3.44), now performing a second-order Taylor expansion on the left-hand side,
b
J1(u) + τkb
J
1(u)[vk] + τ2
k
2b
J′′
1(u+θkτkvk)[vk,vk] + κg(u+τkvk)
20 J. SPREKELS AND F. TR ¨
OLTZSCH
<b
J1(u) + κg(u) + τ2
k
2k.
We subtract b
J1(u) + κg(u) from both sides and use (3.46) once more to find that
τkb
J
1(u)[vk] + κg(u,vk)+τ2
k
2b
J′′
1(u+θkτkvk)[vk,vk]<τ2
k
2k.(3.48)
From the right-hand side of (3.46), and the variational inequality (3.20), it follows that
b
J
1(u)[vk] + κg(u,vk)0,
and thus, by (3.48),
b
J′′
1(u+θkτkvk)[vk,vk]<1
k.(3.49)
Passing to the limit k , we apply Lemma A.3 and deduce that b
J′′
1(u)[v,v]0.Since we know that
vCu, the second-order condition (3.42) implies that v=0.
(iii) Contradiction: From the previous step we know that vk0weakly in L2(Q)2. Moreover, (3.40) yields
that
b
J′′
1(u)[vk, vk] = b3ZZQ
|vk|2+b1ZZQ
|ξk|2+b2Z
|ξk(T)|2
+ZZQh2P(φ)ξk(θkχξkηk)(pr)F(3)(φ)q|ξk|2i
+ZZQ
P′′(φ)(σ+χ(1 φ)µ)(pr)|ξk|2,(3.50)
where we have set (ηk, ξk, θk) = S(u)[vk], for kN. By virtue of Lemma A.3, the sum of the last four integrals
on the right-hand side converges to zero. On the other hand, vkL2(Q)2= 1 for all kN, by construction.
The weak sequential semicontinuity of norms then implies that
lim inf
k→∞ b
J′′
1(u)[vk,vk]lim inf
k→∞ b3ZZQ
|vk|2=b3>0.
On the other hand, it is easily deduced from (3.49) and Lemma A.3 that
lim inf
k→∞ b
J′′
1(u)[vk,vk]0,
a contradiction. The assertion of the theorem is thus proved.
Remark 3.7. We note at this place that the formula (6.5) in [17], which resembles (3.50), contains three sign
errors: indeed, the term in the second line of [17], (6.5) involving P′′ should carry a “plus” sign, while the two
terms in the third line should carry “minus” signs. These sign errors, however, do not have an impact on the
validity of the results established in [17].
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 21
Appendix A.
In the following, we assume that (A1)(A6) and (C1)(C3) are fulfilled and that u Uad is fixed with
associated state (µ, φ, σ ) = S(u) and adjoint state (p, q, r). We also recall the definitions of the spaces
used below given in (2.11), (2.14), and (2.15).
Lemma A.1. Let {uk}⊂Uad converge strongly in L2(Q)2to u, and let (µk, φk, σk) = S(uk)and (pk, qk, rk),
kN, denote the associated states and adjoint states. Then, as k ,
µkµstrongly in Z, (A.1)
φkφstrongly in ZC0(Q),(A.2)
σkσstrongly in Z, (A.3)
pkpweakly-star in Zand strongly in C0([0, T ]; Lp(Ω)) for 1p < 6,(A.4)
qkqweakly-star in H1(0, T ;V)L(0, T ;H)L2(0, T ;V),(A.5)
rkrweakly-star in Zand strongly in C0([0, T ]; Lp(Ω)) for 1p < 6.(A.6)
Proof. The strong convergence ∥S(uk) S (u)Z0 follows directly from (2.10). In addition, the global
bound (2.7) implies that {φk}is bounded in the space e
Xdefined in (2.11), which, thanks to the compactness
of the embedding W0C0(Ω) and [53], Section 8, Corollary 4, is compactly embedded in C0(Q). Therefore it
holds φkφC0(Q)0 (at first only for a suitable subsequence, but then, owing to the uniqueness of the
limit point, eventually for the entire sequence). The convergence properties (A.1)–(A.3) of the state variables
are thus shown. In addition, it immediately follows from the mean value theorem and (2.9) that, as k ,
max
i=1,2,3F(i)(φk)F(i)(φ)C0(Q)0,
max
i=0,1,2P(i)(φk)P(i)(φ)C0(Q)0.(A.7)
Next, we conclude from the bounds (3.14) and (2.7) that there are a subsequence, which is again labeled by
kN, and some triple (p, q, r ) such that, as k ,
pkpweakly-star in ZL(Q),(A.8)
qkqweakly-star in H1(0, T ;V)L(0, T ;H)L2(0, T ;V),(A.9)
rkrweakly-star in ZL(Q).(A.10)
Moreover, by [53], Section 8, Corollary 4 and the compactness of the embedding VLp(Ω) for 1 p < 6, we
also have
pkp, rkr, both strongly in C0([0, T ]; Lp(Ω)) for 1 p < 6.(A.11)
From these estimates and (A.7) we can easily conclude that, as k ,
F′′(φk)qkF′′ (φ)q, P (φk)(pkrk)P(φ)(pr),
P(φk)(σkχ(1 φk)µk)(pkrk)P(φ)(σχ(1 φ)µ)(pr),(A.12)
all weakly in L2(Q).
At this point, we consider the time-integrated version of the adjoint system (3.10)–(3.13) with test functions in
L2(0, T ;V), written for φk, µk, σk, pk, qk, rk,kN. Passage to the limit as k , using the above convergence
results, immediately leads to the conclusion that (p, q, r) solves the time-integrated version of (3.10)–(3.13)
22 J. SPREKELS AND F. TR ¨
OLTZSCH
with test functions in L2(0, T ;V), which is equivalent to saying that (p, q , r) is a solution to (3.10)–(3.13). By
the uniqueness of this solution, we must have (p, q, r) = (p, q, r). The convergence properties (A.4)–(A.6)
are therefore valid for a suitable subsequence, and since the limit is uniquely determined, also for the entire
sequence.
Corollary A.2. Let {uk}⊂Uad converge strongly in L2(Q)2to u, and let {vk}converge weakly to vin
L2(Q)2. Then
lim
k→∞ b
J
1(uk)[vk] = b
J
1(u)[v].(A.13)
Proof. We have, with uk= (uk1, uk2) and vk= (vk1, vk2),
b
J
1(uk)[vk] = ZZQ
(Hpk+b3uk1)vk1+ZZQ
(rk+b3uk2)vk2.
Owing to Lemma A.1, we have, in particular, that {−Hpk+b3uk1}and {rk+b3uk2}converge strongly in
L2(Q) to Hp+b3u
1and r+b3u
2, respectively, whence the assertion immediately follows.
Lemma A.3. Let {uk}and {vk}satisfy the conditions of Corollary A.2, and assume that b3= 0. Then
lim
k→∞ b
J′′
1(uk)[vk,vk] = b
J′′
1(u)[v,v].(A.14)
Proof. Let vk= (vk1, vk2), v= (v1, v2), (ηk, ξk, θk) = S(uk)[vk], and (η, ξ , θ) = S(u)[v]. Since b3= 0, we
infer from (3.50) that we have to show that, as k ,
b1ZZQ
|ξk|2+b2Z
|ξk(T)|2+ZZQ
2P(φk)ξk(θkχξkηk)(pkrk)
+ZZQhP′′(φk)(σk+χ(1 φk)µk)|ξk|2F(3) (φk)qk|ξk|2i
b1ZZQ
|ξ|2+b2Z
|ξ(T)|2+ZZQ
2P(φ)ξ(θχξη)(pr)
+ZZQhP′′(φ)(σ+χ(1 φ)µ)(pr)|ξ|2F(3) (φ)q|ξ|2i,(A.15)
where (pk, qk, rk) and (p, q, r) are the associated adjoint states. By Lemma 4.1 and its proof, the convergence
properties (A.1)–(A.6) and (A.7) are valid. Moreover, we have
(ηk, ξk, θk)(η, φ, θ)=(S(uk) S(u)) [vk] + S(u)[vkv].
By virtue of (2.23) and the boundedness of {vk}in L2(Q)2, the first summand on the right-hand side of this
identity converges strongly to zero in Z. The second converges to zero weakly in Z×e
X×Z. Hence, thanks to
the compactness of the embedding ZC0([0, T ]; Lp(Ω)) for 1 p < 6 (see, e.g., [53], Sect. 8, Cor. 4),
(ηk, ξk, θk)(η, ξ, θ) strongly in C0([0, T ]; Lp(Ω))3for 1 p < 6.(A.16)
In particular, as k ,
b1ZZQ
|ξk|2+b2Z
|ξk(T)|2b1ZZQ
|ξ|2+b2Z
|ξ(T)|2.(A.17)
SECOND-ORDER SUFFICIENT CONDITIONS IN THE SPARSE OPTIMAL CONTROL 23
Moreover, owing to the strong convergences in C0([0, T ]; Lp(Ω)) for 1 p < 6, it is easily checked, using older’s
inequality, that
P(φk)ξk(θkχξkηk)(pkrk)P(φ)ξ(θχξη)(pr),
P′′(φk)(σk+χ(1 φk)µk)(pkrk)|ξk|2P′′ (φ)(σ+χ(1 φ)µ)(pr)|ξ|2,(A.18)
both strongly in L1(Q). It remains to show that, as k ,
ZZQ
F(3)(φk)qk|ξk|2ZZQ
F(3)(φ)q|ξ|2.
Since qkqweakly in L2(Q) by (A.9), it thus suffices to show that F(3)(φk)|ξk|2F(3)(φ)|ξ|2strongly
in L2(Q). However, this is a simple consequence of (A.7) and (A.16). The assertion is thus proved.
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... This method was originally introduced for a class of semilinear second-order parabolic problems with smooth nonlinearities. In the recent papers [56,57] two of the present authors have demonstrated that it can be adapted correspondingly to the sparse optimal control of Allen-Cahn systems with dynamic boundary conditions and to a large class of systems modeling tumor growth, Applied Mathematics & Optimization (2024) 90:47 Applied Mathematics & Optimization (2024) 90:47 ...
... It is the main aim and novelty of this work to show that also systems having a Cahn-Hilliard structure can be treated accordingly (at least in the viscous case τ > 0). This is by no means obvious, since, in contrast to the second-order systems investigated in [56,57], the Cahn-Hilliard structure studied here leads to a fourthorder PDE for the order parameter ϕ [which readily follows from insertion for μ from (1.3) in (1.2)]. As a consequence, a number of additional technical difficulties have to be overcome, both in the proof of the Fréchet differentiability of the controlto-state operator and in the analysis of the properties of the adjoint variables. ...
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In this paper we study the optimal control of a parabolic initial-boundary value problem of viscous Cahn–Hilliard type with zero Neumann boundary conditions. Phase field systems of this type govern the evolution of diffusive phase transition processes with conserved order parameter. It is assumed that the nonlinear functions driving the physical processes within the spatial domain are double-well potentials of logarithmic type whose derivatives become singular at the boundary of their respective domains of definition. For such systems, optimal control problems have been studied in the past. We focus here on the situation when the cost functional of the optimal control problem contains a nondifferentiable term like the L1L^1-norm, which leads to sparsity of optimal controls. For such cases, we establish first-order necessary and second-order sufficient optimality conditions for locally optimal controls. In the approach to second-order sufficient conditions, the main novelty of this paper, we adapt a technique introduced by Casas et al. in the paper (SIAM J Control Optim 53:2168–2202, 2015). In this paper, we show that this method can also be successfully applied to systems of viscous Cahn–Hilliard type with logarithmic nonlinearity. Since the Cahn–Hilliard system corresponds to a fourth-order partial differential equation in contrast to the second-order systems investigated before, additional technical difficulties have to be overcome.
... This method was originally introduced for a class of semilinear second-order parabolic problems with smooth nonlinearities. In the recent papers [22,49,50] it has been demonstrated that it can be adapted correspondingly to the sparse optimal control of Allen-Cahn systems with dynamic boundary conditions [49], to a large class of systems modeling tumor growth [50], and to the viscous Cahn-Hilliard system [22], where in all of these papers logarithmic nonlinearities could be admitted. ...
... This method was originally introduced for a class of semilinear second-order parabolic problems with smooth nonlinearities. In the recent papers [22,49,50] it has been demonstrated that it can be adapted correspondingly to the sparse optimal control of Allen-Cahn systems with dynamic boundary conditions [49], to a large class of systems modeling tumor growth [50], and to the viscous Cahn-Hilliard system [22], where in all of these papers logarithmic nonlinearities could be admitted. ...
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In this paper we study the optimal control of an initial-boundary value problem for the classical nonviscous Cahn-Hilliard system with zero Neumann boundary conditions. Phase field systems of this type govern the evolution of diffusive phase transition processes with conserved order parameter. For such systems, optimal control problems have been studied in the past. We focus here on the situation when the cost functional of the optimal control problem contains a sparsity-enhancing nondifferentiable term like the L1-norm. For such cases, we establish first-order necessary and second-order sufficient optimality conditions for locally optimal controls, where in the approach to second-order sufficient conditions we employ a technique introduced by E. Casas, C. Ryll and F. Tr\"oltzsch in the paper [SIAM J. Control Optim. 53 (2015), 2168-2202]. The main novelty of this paper is that this method, which has recently been successfully applied to systems of viscous Cahn-Hilliard type, can be adapted also to the classical nonviscous case. Since in the case without viscosity the solutions to the state and adjoint systems turn out to be considerably less regular than in the viscous case, numerous additional technical difficulties have to be overcome, and additional conditions have to be imposed. In particular, we have to restrict ourselves to the case when the nonlinearity driving the phase separation is regular, while in the presence of a viscosity term also nonlinearities of logarithmic type turn could be admitted. In addition, the implicit function theorem, which was employed to establish the needed differentiability properties of the control-to-state operator in the viscous case, does not apply in our situation and has to be substituted by other arguments.
... [23,24] for a Brinkman version with nutrient) as well as to extend our analysis to nonlocal variants of the system (1.4). Another interesting issue would be the analysis of sparse optimal control problems (see, e.g., [25,26] and references therein). ...
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We study a Cahn-Hilliard-Darcy system with mass sources, which can be considered as a basic, though simplified, diffuse interface model for the evolution of tumor growth. This system is equipped with an impermeability condition for the averaged velocity u as well as homogeneous Neumann boundary conditions for the phase function ϕ and the chemical potential µ. The source term in the convective Cahn-Hilliard equation contains a control R that can be thought as a drug or a nutrient in applications. Our goal is to study a distributed optimal control problem in the two-dimensional setting with a cost functional of tracking-type. In the physically relevant case with unmatched viscosities for the binary fluid mixtures and a singular potential, we first prove the existence and uniqueness of a global strong solution with ϕ being strictly separated from the pure phases ±1. This well-posedness result enables us to characterize the control-to-state mapping S: R→ϕ. Then we obtain the existence of an optimal control, the Frechet differentiability of S and first-order necessary optimality conditions expressed through a suitable variational inequality for the adjoint variables. Finally, we prove the differentiability of the control-to-costate operator and establish a second-order sufficient condition for the strict local optimality.
... [7,8] for a Brinkman version with nutrient) as well as to extend our analysis to nonlocal variants of the system (1.4). Another interesting issue would be the analysis of sparse optimal control problems (see, e.g., [31,32] and references therein). ...
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We study a Cahn-Hilliard-Darcy system in two dimensions with mass sources, unmatched viscosities and singular potential. This system is equipped with no-flux boundary conditions for the (volume) averaged velocity u\mathbf{u}, the difference of the volume fractions φ\varphi, and the chemical potential μ\mu, along with an initial condition for φ\varphi. The resulting initial boundary value problem can be considered as a basic, though simplified, model for the evolution of solid tumor growth. The source term in the Cahn-Hilliard equation contains a control R that can be thought, for instance, as a drug or a nutrient. Our goal is to study an optimal control problem with a tracking type cost functional given by the sum of three L2L^2 norms involving φ(T)\varphi(T) (T>0T>0 is the final time), φ\varphi and R. We first prove the existence and uniqueness of a global strong solution with φ\varphi being strictly separated from the pure phases ±1\pm 1. Thanks to this result, we are able to analyze the control-to-state mapping S:Rφ\mathcal{S}: R \mapsto \varphi, obtaining the existence of an optimal control, the Fr\'{e}chet differentiability of S\mathcal{S} and first-order necessary optimality conditions expressed through a suitable variational inequality for the adjoint variables. Finally, we show the differentiability of the control-to-costate operator and establish a second-order sufficient condition for the strict local optimality.
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We analyze a phase field model for tumor growth consisting of a Cahn–Hilliard–Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The main novelty of the paper concerns the discussion of the existence of weak solutions to the system covering all the meaningful cases for the nonlinear potentials; in particular, the typical choices given by the regular, the logarithmic, and the double obstacle potentials are admitted in our treatise. Compared to previous results related to similar models, we suggest, instead of the classical no-flux condition, a Dirichlet boundary condition for the chemical potential appearing in the Cahn–Hilliard-type equation. Besides, abstract growth conditions for the source terms that may depend on the solution variables are postulated.
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This paper treats a distributed optimal control problem for a tumor growth model of Cahn–Hilliard type. The evolution of the tumor fraction is governed by a variational inequality corresponding to a double obstacle nonlinearity occurring in the associated potential. In addition, the control and state variables are nonlinearly coupled and, furthermore, the cost functional contains a nondifferentiable term like the L1L1L^1-norm in order to include sparsity effects which is of utmost relevance, especially time sparsity, in the context of cancer therapies as applying a control to the system reflects in exposing the patient to an intensive medical treatment. To cope with the difficulties originating from the variational inequality in the state system, we employ the so-called deep quench approximation in which the convex part of the double obstacle potential is approximated by logarithmic functions. For such functions, first-order necessary conditions of optimality can be established by invoking recent results. We use these results to derive corresponding optimality conditions also for the double obstacle case, by deducing a variational inequality in terms of the associated adjoint state variables. The resulting variational inequality can be exploited to also obtain sparsity results for the optimal controls.
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This paper concerns a distributed optimal control problem for a tumor growth model of Cahn–Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we discuss the weak well-posedness of the system under very general assumptions for the potentials, which may be singular and nonsmooth. Then, we establish the strong well-posedness of the system in a reduced setting, which however admits the logarithmic potential: this analysis will lay the foundation for the study of the corresponding optimal control problem. Concerning the optimization problem, we address the existence of minimizers and establish both first-order necessary and second-order sufficient conditions for optimality. The mathematically challenging second-order analysis is completely performed here, after showing that the solution mapping is twice continuously differentiable between suitable Banach spaces via the implicit function theorem. Then, we completely identify the second-order Fr ́echet derivative of the control-to-state operator and carry out a thorough and detailed investigation about the related properties.
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This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. These integro-partial differential equations model cell-to-cell adhesion by a non-local term and may be seen as non-local variants of the corresponding local model proposed by Garcke et al (2016). The model in consideration couples a non-local Cahn-Hilliard equation for the tumor phase variable with a reaction-diffusion equation for the nutrient concentration, and takes into account also significant mechanisms such as chemotaxis and active transport. The system depends on two relaxation parameters: a viscosity coefficient and parabolic-regularization coefficient on the chemical potential. The first part of the paper is devoted to the analysis of the system with both regularizations. Here, a rich spectrum of results is presented. Weak well-posedness is first addressed, also including singular potentials. Then, under suitable conditions, existence of strong solutions enjoying the separation property is proved. This allows also to obtain a refined stability estimate with respect to the data, including both chemotaxis and active transport. The second part of the paper is devoted to the study of the asymptotic behavior of the system as the relaxation parameters vanish. The asymptotics are analyzed when the parameters approach zero both separately and jointly, and exact error estimates are obtained. As a by-product, well-posedness of the corresponding limit systems is established.
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A Correction to this paper has been published: https://doi.org/10.1007/s00245-019-09618-6
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We extend previous weak well-posedness results obtained in Frigeri et al. (2017, Solvability, Regularity, and Optimal Control of Boundary Value Problems for PDEs , Vol. 22, Springer, Cham, pp. 217–254) concerning a non-local variant of a diffuse interface tumour model proposed by Hawkins-Daarud et al. (2012, Int. J. Numer. Method Biomed. Engng. 28 , 3–24). The model consists of a non-local Cahn–Hilliard equation with degenerate mobility and singular potential for the phase field variable, coupled to a reaction–diffusion equation for the concentration of a nutrient. We prove the existence of strong solutions to the model and establish some high-order continuous dependence estimates, even in the presence of concentration-dependent mobilities for the nutrient variable in two spatial dimensions. Then, we apply the new regularity results to study an inverse problem identifying the initial tumour distribution from measurements at the terminal time. Formulating the Tikhonov regularised inverse problem as a constrained minimisation problem, we establish the existence of minimisers and derive first-order necessary optimality conditions.
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In this paper, we give an overview of results for Cahn–Hilliard systems involving fractional operators that have re-cently been established by the authors of this note. We address problems concerning existence, uniqueness, and regularity of the solutions to the system equations, and we study optimal control problems for the systems. The well-posedness results are valid for a wide class of fractional operators of spectral type and for the typi-cal double-well nonlinearities appearing in the Cahn–Hilliard system equations, namely the classical differentiable, the logarithmic, and the nondifferentiable double obstacle potentials. While this also ap-plies to the existence of optimal controls in the related optimal control problems, the establishment of first-order necessary optimality conditions requires imposing much stronger assumptions on the ad-missible class of fractional operators. One main reason for this is the necessity of deriving suitable differentiability properties for the associated control-to-state mapping. Nevertheless, it turns out that also in the singular case of logarithmic potentials, the first-order necessary optimality conditions can be established under suitable assumptions, and a “deep quench” approximation, based on the results derived for logarithmic nonlinearities makes even the case of double obstacle potentials accessible.
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In this paper, we study an optimal control problem for a macroscopic mechanical tumor model based on the phase field approach. The model couples a Cahn-Hilliard-type equation to a system of linear elasticity and a reaction-diffusion equation for a nutrient concentration. By taking advantage of previous analytical well-posedness results established by the authors, we seek optimal controls in the form of a boundary nutrient supply as well as concentrations of cytotoxic and antiangiogenic drugs that minimize a cost functional involving mechanical stresses. Special attention is given to sparsity effects, where with the inclusion of convex nondifferentiable regularization terms to the cost functional, we can infer from the first-order optimality conditions that the optimal drug concentrations can vanish on certain time intervals.