Citrus fruits are commonly consumed fruits that are known for its nutrient content, energy source, and health supplements. Citrus fruits are rich sources of several secondary metabolites like limonoids, alkaloids, coumarins, flavonoids, carotenoids, essential oils, and phenolic acids that are responsible for its beneficiary effect against various diseases. These include anti-inflammatory, cardiovascular-protective, anticancer, antioxidative, and neuroprotective effects. Present-day pharmacological therapies for the AD are deficient. Unfortunately, other strategies such as neural transplantation and stem cell transplantation remain in the experimental stage. Numerous cellular, animal, and human studies have delineated the neuroprotective effects of citrus fruits owning to their active components. Increased consumption of citrus fruits is associated with higher antioxidant status and phytochemical constituents, thus helpful against oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis that play an important role in the cause and progression of neurological disorders. The multifactorial etiology of neurodegenerative diseases suggests that drugs with multiple targets could have therapeutical potential for these pathologies.