Health Benefits and Modern Applications of Apple Cider Vinegar: A Four-Decade Review of the Scientific Literature (Review Article on Bibliometric Investigation of Apple Cider Vinegar)
Abstract and Figures
Apple cider vinegar (ACV) is among the most frequently used condiments for its health benefits. ACV studies discovered anti-obesity, anti-bacterial, antifungal, cardiovascular, anti-cancer, and anti-Alzheimer's properties. Thus, ACV research enhances human health in every way. In the present research, we will conduct a bibliometric exploration and analysis of vast quantities of unstructured scientific data. This method enables us to comprehend the evolutionary complexities of the topic when conducting ACV research. The dominant themes of the analysis supported our assertion that ACV has multiple health benefits. This research covered diabetes, oxidative stress, immunomodulation, and antifungal, antimicrobial, and antiviral activities. Based on our findings, we also recommend incorporating bioinformatics, molecular target research, and interdisciplinary cooperation into ACV research. This literature review examines the pharmacological actions and health benefits of ACV. This survey will also enlighten researchers about global ACV research and the areas where they should concentrate their future efforts.
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... As people's awareness of their health has grown, so has the use of ACV, which is made from fresh fruits. ACV provides several positive health impacts for cardiovascular conditions, including obesity, diabetes, cancer, hyperlipidemia, and hypercholesterolemia (12)(13)(14)(15). ...
... Acetate released by hepatocytes triggers AMPK, inhibiting the synthesis of FA Garlic essential oil, fenugreek seed, red raspberry extract, soyabean seed coat (9,10) and sterols (47). Fruit vinegar like apple cider vinegar, grape vinegar, pomegranate vinegar, and olive vinegar, contains antioxidants, flavonoids like chlorogenic acid, catechin, epicatechin and polyphenols -hydroxytyrosol, along with acetic acid (82)(83)(84)(85)(86)(87). Hydroxytyrosol is majorly present in olive vinegar, which reduces oxidative stress and improves lipid metabolism by down-regulating SREBp-1c and FAS. ...
The coronavirus disease 2019 (COVID-19) epidemic has evolved into an international public health concern. Its causing agent was SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), a lipid bilayer encapsulated virus. Lipids have relevance in the host's viral cycle; additionally; viruses have been speculated to manipulate lipid signaling and production to influence the lipidome of host cells. SARS-CoV-2 engages the host lipid pathways for replication, like fatty acid synthesis activation via upregulation of AKT and SREBP pathway and inhibiting lipid catabolism by AMPK and PPAR deactivation. Consequently, lipoprotein levels are altered in most cases, i.e., raised LDL, TG, VLDL levels and reduced HDL levels like a hyperlipidemic state. Apo lipoproteins, a subsiding structural part of lipoproteins, may also impact viral spike protein binding to host cell receptors. In a few studies conducted on COVID-19 patients, maintaining Apo lipoprotein levels has also shown antiviral activity against SARS-CoV-2 infection. It was speculated that several potent hypolipidemic drugs, such as statins, hydroxychloroquine, and metformin, could be used as add-on treatment in COVID-19 management. Nutraceuticals like Garlic, Fenugreek, and vinegar have the potency to lower the lipid capability acting via these pathways. A link between COVID-19 and post-COVID alteration in lipoprotein levels has not yet been fully understood. In this review, we try to look over the possible modifications in lipid metabolism due to SARS-CoV-2 viral exposure, besides the prospect of focusing on the potential of lipid metabolic processes to interrupt the viral cycle.
Vinegar is a traditional remedy for aliments including diabetes. This study was conducted to investigate the effects of different types of vinegar (sugarcane, apple, grape, coconut, artificial and palm vinegar) on serum Biochemical and Histopathological of pancreas and stomach of diabetic rats for 6 weeks at 15% concentration. The results indicated that, all of vinegar caused significant decrease P< 0.05 in glucose, TC , LDL-c and significant increase in HDL cholesterol. Apple vinegar was the most effective to decrease glucose, TC and LDL-c followed by grape, sugarcane, coconut, artificial and palm vinegar. Apple vinegar contained the higher concentration of organic acid and phenolic compound compared to other vinegar. Apple vinegar and grape vinegar were the most effective to decrease liver and kidney function. Administrating 15% vinegar with diet for 6 weeks decrease the food intake and feed efficiency ratio compared to control group. Moreover, administration different types of vinegar showed that no histopathological change in stomach and has protected effect of pancreas from undesirable change in B cells. In conclusion, using the different types of vinegar with diet for 6 weeks have beneficial effects on diabetic rats and have hypocholesterolemic effect. The vinegar did not effect on stomach histopathological structure and have protective effect of pancreas from damage. [Sahar S.A. Soltan and Manal M. E. M. Shehata. Antidiabetic and Hypocholesrolemic effect of Different Types of Vinegar in Rats. Life Sci J 2012;9(4):2141-2151] (ISSN: 1097-8135). http://www.lifesciencesite.com. 319
Bee pollen is an imperative product for human use. Seven bee pollens were harvested from Morocco, and their chemical, biological and techno-functional properties were studied. All samples showed acceptable physicochemical and nutritional quality with a mean energy value of 239 kcal/100g. FTIR spectra confirmed the presence of major constituents like carbohydrates, lipids, proteins and polyphenols. Moreover, pollens exhibited good techno-functional properties, like carbohydrate solubility (34.47-59.27 g/100g), protein solubility (7.28-23.31 g/100g), emulsifying stability (16.52-45.38 min), emulsifying activity (9.83-25.05 g/m3) water absorption capacity (1.06-2.19 g/g), oil absorption capacity (1.15-3.50 g/g) and water-oil absorption index (0.62-1.25). Bee pollen extracts revealed potent antioxidant capacity and digestive enzyme inhibitory activity associated with the presence of fifteen phenolic compounds belonging to flavons, flavonols, flavanones, flavan-3-ols, hydroxybenzoic and hydroxycinnamic acids, and stilbenes families. Present data indicate the possible application of bee pollen as a useful nutritional, bioactive and anti-foaming ingredient, replacing synthetic products in food industries.
Purpose
Duchenne muscular dystrophy (DMD) is a rare x-linked neuromuscular condition predominantly affecting boys and men. There is a paucity of research qualitatively detailing the lived experience of health-related quality of life (HRQoL) for people with DMD. The aim of this study was to identify a comprehensive framework for better understanding HRQoL in DMD.
Methods
Eighteen boys and men (aged 7 to ≥ 40 years) with DMD were recruited from charity Duchenne UK, a DMD support group, and 5 UK National Health Service Trusts. Semi-structured interviews were conducted using a topic guide informed by a review into HRQoL in DMD. Generic, preference-based, patient-reported outcome measures (PROs) were used as prompts. Interviews were audio recorded, transcribed verbatim and analysed using framework analysis.
Results
Thirty-seven themes were coded, within seven categories. Six categories were conceptualised as components of HRQoL (autonomy, daily activities, feelings and emotions, identity, physical aspects, social relationships) and one considered an input (healthcare, support, and environment). Three additional themes were used to code feedback on the generic PROs (CHU-9D, EQ-5D, HUI). Social relationships received most coverage in the data and was noted as an omission from the PROs.
Conclusion
A 30-item framework for HRQoL in DMD has been developed, which was used as input into a new condition-specific HRQoL PRO and preference-based measure: the DMD-QoL. The data has value in its own right in highlighting the lived experience of HRQoL for people with DMD and as a barometer for assessing the content of HRQoL PROs for use in DMD.
Objective:
Aging is a growing public health concern for people, organizations, and governments. The current study was undertaken to provide insights into the global research output on geriatric nursing.
Methods:
A bibliometric study was implemented using the WoS database for the period from 1900 to 2020. Various tools and measures were used to analyze and visualized.
Results:
The search strategy found 4923 papers. The oldest paper was written by Beverly C. Andre in 1953. As team size increases, so does the number of citations. The USA was the active country and the highest number of coauthors. New York University was an active institution. Stig Karlsson was the most active author in Geriatric Nursing with 28 articles from Sweden, followed by Koen Milisen and Sandman, with 26 articles each from Sweden and Belgium. The most frequent words in this field were depression, malnutrition, education, Alzheimer's disease, and dementia. The latest research themes in this field were COVID-19, interprofessional locomotive syndrome, emergency nursing, and public health. The most influential papers were specified. Journal of the American Geriatrics Society was the most active journal.
Conclusions:
Geriatric nursing is a rooted field and has received special attention in the last decade. Policymakers, especially in developing countries, should pay attention to geriatric nursing as a specialty of nursing to solve aging issues they would face considering the increasing elderly population.
Objective
Monoamine Oxidase (MAO), which catalyzes the oxidative deamination of amines present in the brain and peripheral tissues, is involved in the metabolism of monoamines and is vital for cognition. This study was designed to examine the protective effect of Apple Cider Vinegar (ACV) on MAO and amine neurotransmitters such as dopamine (DA), serotonin (5-HT), non-adrenaline (NA) levels.
Method
In this experiment, out of five groups, three groups of animals were pretreated with one of the test drugs each i.e., Chrysin (10 mg/kg), ACV (0.7% v/v) and Rivastigmine (2.5 mg/kg) along with Zn with high fat diet (HFD) for 3 months and the rest two groups were that of control and disease induced. After the treatment period, mice were examined for MAO-A & B, DA, 5-HT and NA level estimation.
Results
The results showed that Zn with HFD had induced a significant increase (p < 0.01, p < 0.001) in MAO-A & B levels and a significant decrease (p < 0.001) in the levels of 5-HT, DA, and NA. Pretreatment of test drugs with Zn with HFD caused a restoration activity and a significant decrease (p < 0.01, p < 0.05) in MAO-A & B levels and a significant increase (p < 0.05, p < 0.01, p < 0.001) in the level of DA, 5HT and NA as compared to the Zn treated group. Amongst all three test drugs mentioned above, the ACV-treated group showed the most improvement during pretreatment.
Conclusions
The findings suggest that ACV, might prove to be a beneficial nutraceutical & provide a protective effect against Alzheimer’s disease (AD)-like neurological diseases.
Oxidative stress is the critical marker of neurological complications such as Alzheimer's disease (AD). Apple cider vinegar (ACV) is known to have health benefits due to its antidiabetic, anti‐inflammatory, and high antioxidant properties. Therefore, we hypothesized that regular consumption of ACV would protect against AD‐like neurological diseases via inhibition of oxidative stress. Authors have compared the efficacy of ACV with that of Chrysin and Rivastigmine in cellular and animal studies. In the cellular study, oxidative stress was induced in Neuro2A cells (1 × 107) via H2O2 (50 μM) treatment. Subsequently, acetylcholinesterase (AChE) activity was performed, and cell viability, SOD, GSH, lipid peroxidation (MDA) levels were measured. Similarly, in the animal study, oxidative stress was introduced in Swiss albino mice (10–11 weeks old, 20–25 g, n = 30) via scopolamine (1 mg/kg). Subsequently, histopathological experiments were performed; cognitive ability, AChE activity, and SOD, GSH, and MDA levels were measured. The in vitro results indicated that ACV (2 μM) provided better protection than Chrysin and Rivstigmine in cell viability. ACV has also performed better in restoring the antioxidants markers (SOD, GSH levels) and reducing MDA and AChE levels. In the in vivo study, test compounds (ACV, Chrysin, and Rivastigmine) improved cognitive impairment, increased the SOD and GSH level, reduced the MDA level and AChE activity, and protected the cortex‐hippocampal neurons from degeneration. Here also, ACV (0.7%) showed better neuroprotection than the other two compounds. Therefore, these results supported our hypothesis that moderate consumption of ACV might prove to be beneficial prophylaxis against AD‐like neurological diseases.
Amyloid aggregation and neurofibrillary pathology is the characteristic feature of Alzheimer's disease (AD). Streptozotocin (STZ) is a glucosamine nitrosourea compound that is toxic to the cells, impairs insulin signaling in the brain. STZ induces DNA damage and oxidative stress, which leads to cognitive impairments. In this experimental study, STZ treatment induces Alzheimer's pathology in mouse neuroblastoma (N2A) cells. The study also explored the protection of cellular damage by pre-treatment with test drugs Apple cider vinegar (ACV), chrysin and rivastigmine. This study had been concentrated mainly on the cellular mechanism of neuromodulation and anti-oxidant potency of test drugs to attenuate cellular toxicity induced by STZ treatment. The 100 µM concentration of STZ was used for treatment in N2A cells for 24 h and 48 h and multiple studies were performed. The STZ causes tau phosphorylation, amyloid aggregation and increased acetyl cholinesterase (AChE) activity. Along with STZ at a concentration of 100 µM, the cells were pre-treated with ACV, chrysin and rivastigmine at a concentration of 2, 10, 50 µM each. The results show that 2 µM test drug concentration presented considerable protection, against STZ generated neurocytotoxicity via. restoration of anti-oxidant enzymes, MDA and AChE level, compared to the other two concentrations.
Dementia linked with cognitive impairments is the most prominent indication of Alzheimer's disease (AD). In the current investigation, we have examined the streptozotocin‐ (STZ) induced cellular toxicity in mouse neuroblastoma (N2A) cells, and Zn with the high‐fat diet‐ (HFD) induced neurotoxicity in mouse brain. These cells and animals were pretreated with apple cider vinegar (ACV), Chrysin, and Rivastigmine to examine their protection against cellular toxicity and neurotoxicity. Experiments have affirmed that pretreatment of ACV, Chrysin, and Rivastigmine has displayed protective outcomes in MTT reduction, tau phosphorylation, amyloid aggregation, attenuated memory impairment as well as oxidative stress, and protected cholinergic hippocampal neurons from degeneration. ACV showed better antioxidant and neuroprotection potential as compared with Chrysin and Rivastigmine. So the existence of excitatory/inhibitory enzymatic activity and higher antioxidant potential indicate that ACV, as a food beverage in a regular diet, could be promising and effective against neurological complications such as AD.
Practical applications
In the Urban lifestyle, HFD and stress are the critical factors of various chronic and prevalent diseases, including diabetes, obesity, cardiovascular, and neurodegenerative disorders like AD. We are already familiar with the multiple benefits of ACV, such as weight loss, antimicrobial activity, diabetes, skin disorders. So in the current research work, we have gauged the effectiveness of ACV against neurological complications in comparison with a synthetic flavonoid (Chrysin) and an anti‐Alzheimer's drug (Rivastigmine). To enhance the pragmatic orientation of our results, we have used the ACV in our study, which is readily available in the market for domestic consumption. All the cellular, biochemical, behavioral, and histopathological data revealed that ACV had high antioxidant potential. Our findings suggest that the addition of ACV as a food additive in the daily diet may reduce the threat of multiple neurodegenerative diseases. Therefore, our study could be the precursor of a new pharmacological therapeutic approach via ACV toward cognitive impairments associated with Alzheimer's disease.
Purpose
This study investigates the relationship between the level of sustainability reporting and Food Industry Performance (operational, financial and market).
Design/methodology/approach
Using data culled from 1426 observations from 31 different countries for ten years (2008–2017), an independent variable derived from environmental, social, and corporate governance (ESG) score is regressed against dependent manufacture performance indicator variables [return on assets (ROA), Return on Equity (ROE) and Tobin’s Q (TQ)]. Two types of control variables complete the regression analysis in this study: firm-specific and macroeconomic.
Findings
The findings elicited from the empirical results demonstrate that there is a significant relationship between ESG and financial performance (ROE). However, there is no significant relationship between ESG and operational performance (ROA) and market performance (TQ).
Originality/value
This paper presents a new framework that considers sustainability reporting as an innovation tool, examining innovation in terms of its positive or negative impact on financial performance. It contributes to research on the innovation paradigm and knowledge management by highlighting the significance of sustainability reporting as a tool of innovation in enhancing the financial performance.
Spotted-Wing Drosophila (SWD), Drosophila suzukii Matsumura is an invasive fruit fly pest of soft-skinned fruits that causes serious economic losses in the berry growing areas of central Mexico. Effective attractants are necessary to detect its presence, to monitor populations where established, and to explore new strategies for pest control. The capture of D. suzukii in four food-based attractants was compared with apple cider vinegar (ACV) as the reference attractant in blackberry, raspberry, and blueberry crops. An active yeast-based lure, Fly Buster Powder®, resulted the most effective attractant capturing SWD flies in blackberry and blueberry. However, this attractant was similar to SuzukiiTrap® Max Captures, ACV and Pherocon® SWD, but less effective than a two-component attractant (2C trap) in raspberry. The specificity of attractants was variable among crops and experiments but Fly Buster Powder® tends to be highly selective in the capture of SWD with up to 70% of D. suzukii from all drosophilids captured. Fly Buster Powder® and 2C trap attractants were more effective trapping D. suzukii when aged for 7 days than when aged for 1 or 15 days. The specificity of both yeast-based attractants was significantly reduced when aged for 15 days than when aged for 1 or 7 days.