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Significantly Lower Insulin Resistance (According to
TyG Index) with Higher Vitamin D Levels up to 200 ng/
ml
Dr. med. Raimund von Helden, Consumer Consulting, Private VitaminDelta
Institute, 57368 Lennestadt, Original Study in german
www.vitaminDjournal.de
https://www.vitaminDservice.de/node/6579
2023-05-09
1) Question
Many people ask themselves, "What happens to my lab values when my vitamin
D levels increase?"
In this study, we focus on the question of what happens to glucose metabolism.
High blood sugar (glucose) and high triglyceride values are indicative of
problems with Type 2 Diabetes Mellitus.
So far, there is no larger study with patients from the tropical range of vitamin D
levels above 50 ng/ml.
2) Method
Data sets from the years 2020 + 2021 + 2022
General Practice, Lennestadt, NRW
Numerous patients with high-dose intake of vitamin D, under medical
instruction
Hence, more patients with a "tropical" vitamin D level can be found here.
A "tropical vitamin D level" is defined as a physiological value, as can be
observed in tropical regions.
n= 844
Vitamin D levels up to 210 ng/ml
Data pairs (X;Y) = Vitamin D level [ng/ml], TyG Index [without unit]
Scatter plot
Statistics: Python package SciPy according to the method of the Chi-Square
distribution for a probability of error of 5%
3) Results
The majority of patients had vitamin D levels up to 150 ng/ml.
Some vitamin D levels were up to 210 ng/ml.
A better metabolism was shown at higher vitamin D levels.
The TyG Index significantly decreased.
p = 0.00005
Falling line of linear regression
With a vitamin D level of 10 ng/ml, the TyG Index is about 5.8
This value is reached, for example, with a glucose value of 126 in combination
with a triglyceride value of 126.
With a vitamin D level of 150 ng/ml, the TyG Index is about 4.6
This value is reached, for example, with a glucose value of 102 in connection
with a triglyceride value of 102
4) Conclusions
The average influence of high vitamin D levels on glucose/fat metabolism can
therefore be assessed as beneficial.
A discussion of disadvantage for diabetics due to tropical vitamin D levels is off
the table.
On the contrary, the ineffectiveness of insulin is reduced.
The decrease in the TyG Index associated with the line shown calls for an
illustration.
For example, let's take a simplified special case, that blood sugar and
triglycerides (fats) were equally high.
Then a decrease of the two values blood sugar and triglycerides from 126 to
102 mg/dl would be expected.
For the long-term value, this would be an advantage of 1.0, e.g: from Hba1c 7 to
6%
An intervention study that strengthens the benefits of Vitamin D for treating
diabetes should meet these criteria:
Target vitamin D level at 90 ng/ml +/- 20 ng/dl
Determination of vitamin D level at the beginning
Individual correction according to body weight with the
www.VitaminDSimulator.de®
Progress control of the vitamin D level until the end of the study.
What sounds so self-evident here has not yet been implemented by a single
study.
A particularly glaring example of unscientific procedure is the VITAL study: no
vitamin D level at the end of the study.
additional content:
More about the TyG Index:
https://www.vitamindservice.de/INSULINVERSAGEN
Calculation:
The TyG Index is calculated as follows:
[ 0.5 x ln(Tri*Gluc) ]
Identical: ln(Tri*Gluc) /2
However, with this notation, it is not immediately clear whether the halving is
performed before (wrong) or after (correct) application of the logarithm.
Therefore, we have used the above notation here.
Plot:
https://www.vitamindservice.de/node/6580