Immunotherapy has recently yielded tremendous progress in the fight against malignancies. Its precise mechanism of action remains controversial. Activated leukocytes release reactive oxygen species which kill cancer cells. In the body, chlorine dioxide, orally ingested degrades into free radicals such as found in neutrophils.
Chlorine dioxide is a potent oxidant with in vitro anticancer activity. Its precise mechanism of action has not been thoroughly explored, but it is proposed that it acts through the redox imbalance of cancer cells. Six patients were treated for metastatic cancer (breast, kidney, prostate, lymphoma, uterus and melanoma), on a compassionate basis. We report lasting tumor response with a combination of oral, enema and/or intravenous chlorine dioxide, without any side effects. This preliminary work suggest that chlorine dioxide and free radicals might be the mediators for immunotherapies. Chlorine dioxide is both a promising and unexpensive anticancer agent. Rigorous clinical trials are needed to confirm these preliminary results.
Keywords : Chlorine dioxide , cancer, immunotherapy, Warburg effect, reactive oxygen species, intermittent fasting, ketogenic diet.