Amidst the recent surge in natural disasters, it has become increasingly crucial to understand their impact on entrepreneurial activities and decision-making. However, research in this area remains limited. This study aims to explore the resilience of entrepreneurs to flood disasters in Kerala by examining the key determinants of resilience and their impact on business performance. The study proposes that entrepreneurial choices, behavior, and durability significantly differ in a post-disaster context, emphasizing the importance of opportunity-seeking, resource-organizing, financial strategy creation, and risk acceptance. The researcher employs a positivistic qualitative approach, using empirical evidence to investigate the accuracy of observations through the hypothetical-deductive method. Statistical tools such as descriptive statistics, correlation analysis, relative importance index, structural equation modeling of SMART PLS, and the Disaster Resilience Index were used. This study addresses gaps in the existing literature and offers a means of assessing entrepreneurial resilience and firm success dependent on resilience in the aftermath of a disaster. The study found that, in a disaster situation, the primary entrepreneurial activity is focused on reducing losses and managing cash flow. Furthermore, the research compared the resilience of various industries. Overall, this study sheds light on the complexities of the post-disaster market world and emphasizes the need for entrepreneurial resilience to reduce damage and accelerate recovery.