Introduction: Musculo-skeletal disorders (MSDs) are highly prevalent globally with 1.71 billion people in 160 countries, and patients need rehabilitation therapies to recover. This paper presents four cases of MSD that were healed successfully using Yoga Prana Vidya (YPV) protocols. Method: This is a case study method, and the process of investigation consists of going through the case details of each patient and the healer's records. Results: A review of these four cases indicate that the patients recovered from their Musculo-skeletal conditions within 2 to 4 weeks of healing done daily, using YPV advanced treatment protocols. Conclusions: Being no-drug no-touch method of energy healing, YPV offers great scope in the treatment of MSD conditions as alternative low-cost treatment modality. Recommendations include looking into the possibilities of training doctors, nurses and other healthcare workers in the practice of YPV healing system, and conduct further research on the application of YPV in treating MSDs using appropriate sample size and methodology.