Data are facts or figures from which conclusions can be drawn. There are several steps involved in turning data into information, and these steps are known as data processing. This chapter describes data processing and how computers perform these steps efficiently and effectively. It will be indicated that many of these processing activities may be undertaken using R programming, or performed in an R environment with the aid of available R packages – where R functions and datasets are stored. Quality control is a regulatory procedure through which one may measure quality, with pre‐set standards, and then act on any differences. To learn to do statistical analysis and computations, one may start by considering the R programming language as a simple calculator! In epidemiology, after preparing the collected datasets to undertake biostatistical analysis, the first step is to enter the datasets into the R environment.