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Content uploaded by Ivan Domuschiev
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All content in this area was uploaded by Ivan Domuschiev on Jan 02, 2023
Content may be subject to copyright.
https://www.alliedacademies.org/journal-clinical-endocrionology-research/
J Clin Endocrinol Res 2022 Volume 5 Issue 5
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Image Article
Citation: Domuschiev I. Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coee
in an adult male. J Clin Endocrinol Res. 2022;5(5):121
Heart rate variability and stress index after taking 1 tab. Validol followed
by consumption of 1 cup of instant coee in an adult male.
Ivan Domuschiev*
Department of Internal Diseases, Plovdiv City, Bulgaria
Introduction
Validol (Menthyl valerate) is a menthyl ester of isovaleric
acid. It has long been widely used as a sedative for increased
nervous tension and stress with a good eect [1 2 3]. The
maximum relaxing eect of Validol occurs 10 minutes after its
sublingual intake [2]. Coee is the most commonly used drink in
the world to increase tone and invigorate [4 5 6]. The maximum
tonic eect of caeine occurs 45 minutes after its consumption
[7]. The study of heart rate variability parameters is the most
accurate method for quantitative analysis of the sympatho-vagal
balance of the autonomic nervous system [4 7].
Methodology
• The subject is a 61-year-old man. He weighs 75 kg and is
178 cm tall (BMI=24).
• To record the heart activity, we used the "Kalenji" Chest
Strap (with BLE Bluetooth transmission of heart signals).
We analyzed the obtained data with the "Kubios HRV"
software.
• We performed 3 times short term (3 min.) heart rate
variability measurements.
• The rst HRV measurement was performed in the morning
at 8 h after awakening from sleep under basal conditions.
• The second HRV measurement was made 10 minutes
after sublingual intake of 1 tablet. (0.06 gr.) Validol
(Menthyl valerate).
• The third HRV - measurement is realized 45 minutes after
the consumption of 1 cup of instant coee.
• All these 3 HRV - measurements were done in a lying
position in complete rest and silence.
Results
The obtained results are presented in Figure. 1, 2, 3, 1A, 2A,
3A, 1B, 2B and 3B.
*Correspondence to: Ivan Domuschiev, Department of Internal Diseases, Plovdiv City, Bulgaria, E-mail: vopsi@abv.bg
Received: 30-Sep-2022, Manuscript No. AAJCER-22-79258; Editor assigned: 03-Oct-2022, PreQC No. AAJCER-22-79258(PQ); Reviewed: 17-Oct-2022, QC No. AAJCER-22-79258;
Revised: 19-Oct-2022, Manuscript No. AAJCER-22-79258(R); Published: 25-Oct-2022, DOI:10.35841/aajcer-5.5.121
Figure 1: In the morning after waking up before Validol.
Figure 1A: 10 minutes after taking 1 tablet Validol.
Figure 1B: 45 minutes after consuming 1 cup of instant coee.
Figure 2: (In the morning after waking up before Validol).
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J Clin Endocrinol Res 2022 Volume 5 Issue 5
Citation: Domuschiev I. Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coee
in an adult male. J Clin Endocrinol Res. 2022;5(5):121
Figure 2B: 45 minutes after consuming 1 cup of instant coee.
Figure 2A: 10 minutes after taking 1tablet Validol).after waking up
before Validol). Figure 3: In the morning after waking up before Validol.
Figure 3A: 10 minutes after taking 1 tablet Validol.
3
J Clin Endocrinol Res 2022 Volume 5 Issue 5
Citation: Domuschiev I. Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coee
in an adult male. J Clin Endocrinol Res. 2022;5(5):121
Figure 3B: 45 minutes after consuming 1cup of instant coee.
Conclusion
The quality sleep is the best relaxant for the body (best heart
rate variability and lowest stress index - better result compared
to Validol). Coee increases the sympathetic activity, as a
result of which the stress index increases.
References
1. Bondarenko IP, Liashenko MM, Chirkov SN, et al.
A comparative evaluation of the antianginal action of
commercially and noncommercially produced validol in
neurocirculatory dystonia and stenocardia. Lik Sprava.
1996;3(4):110-3.
2. Tsvetkova B, Pencheva I, Zlatkov A, et al. Validated gc
method for determination of validol in tablet dosage forms.
Asian J Pharm Clin Res. 2012;5(3):96-7.
3. Food and Chemical Toxicology.1982;20:735.
4. Sondermeijer HP, Van marle AG, Kamen P, et al. Acute
eects of caeine on heart rate variability. Am J Card.
2002;90(8):906-7.
5. Corti R, Binggeli C, Sudano I, et al. Coee leads to
activation of the sympathetic nervous system. Eur Heart J.
2000;21(105):24-28.
6. Corti R, Binggeli C, Sudano I, et al. Coee acutely
increases sympathetic nerve activity and blood pressure
independently of caeine content: role of habitual versus
nonhabitual drinking. Circulation. 2002;106(23):2935-40.
7. De Oliveira RA, Araújo LF, De Figueiredo RC, et al.
Coee consumption and heart rate variability: the Brazilian
longitudinal study of adult health (ELSA-Brasil) cohort
study. Nutrients. 2017;9(7):741.