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Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coffee in an adult male

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Validol (Menthyl valerate) is a menthyl ester of isovaleric acid. It has long been widely used as a sedative for increased nervous tension and stress with a good effect (1,2,3). The maximum relaxing effect of Validol occurs 10 minutes after its sublingual intake (2). Coffee is the most commonly used drink in the world to increase tone and invigorate (4,5,6). The maximum tonic effect of caffeine occurs 45 minutes after its consumption (7). The study of heart rate variability parameters is the most accurate method for quantitative analysis of the sympatho-vagal balance of the autonomic nervous system (4,7). The subject is a 61-year-old man. He weighs 75 kg and is 178 cm tall (BMI=24). To record the heart activity, we used the "Kalenji" Chest Strap (with BLE Bluetooth transmission of heart signals). We analyzed the obtained data with the "Kubios HRV" software. We performed 3 times short term (3 min.) heart rate variability measurements. The first HRV measurement was performed in the morning at 8 h after awakening from sleep under basal conditions. The second HRV measurement was made 10 minutes after sublingual intake of 1 tablet. (0.06 gr.) Validol (Menthyl valerate). The third HRV - measurement is realized 45 minutes after the consumption of 1 cup of instant coffee. All these 3 HRV - measurements were done in a lying position in complete rest and silence. Results The obtained results are presented in Fig. 1, 2, 3, 1A, 2A, 3A, 1B, 2B and 3B. Conclusion The quality sleep is the best relaxant for the body (best heart rate variability and lowest stress index - better result compared to Validol). Coffee increases the sympathetic activity, as a result of which the stress index increases (5,6).
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J Clin Endocrinol Res 2022 Volume 5 Issue 5
1
Image Article
Citation: Domuschiev I. Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coee
in an adult male. J Clin Endocrinol Res. 2022;5(5):121
Heart rate variability and stress index after taking 1 tab. Validol followed
by consumption of 1 cup of instant coee in an adult male.
Ivan Domuschiev*
Department of Internal Diseases, Plovdiv City, Bulgaria
Introduction
Validol (Menthyl valerate) is a menthyl ester of isovaleric
acid. It has long been widely used as a sedative for increased
nervous tension and stress with a good eect [1 2 3]. The
maximum relaxing eect of Validol occurs 10 minutes after its
sublingual intake [2]. Coee is the most commonly used drink in
the world to increase tone and invigorate [4 5 6]. The maximum
tonic eect of caeine occurs 45 minutes after its consumption
[7]. The study of heart rate variability parameters is the most
accurate method for quantitative analysis of the sympatho-vagal
balance of the autonomic nervous system [4 7].
Methodology
The subject is a 61-year-old man. He weighs 75 kg and is
178 cm tall (BMI=24).
To record the heart activity, we used the "Kalenji" Chest
Strap (with BLE Bluetooth transmission of heart signals).
We analyzed the obtained data with the "Kubios HRV"
software.
We performed 3 times short term (3 min.) heart rate
variability measurements.
The rst HRV measurement was performed in the morning
at 8 h after awakening from sleep under basal conditions.
The second HRV measurement was made 10 minutes
after sublingual intake of 1 tablet. (0.06 gr.) Validol
(Menthyl valerate).
The third HRV - measurement is realized 45 minutes after
the consumption of 1 cup of instant coee.
All these 3 HRV - measurements were done in a lying
position in complete rest and silence.
Results
The obtained results are presented in Figure. 1, 2, 3, 1A, 2A,
3A, 1B, 2B and 3B.
*Correspondence to: Ivan Domuschiev, Department of Internal Diseases, Plovdiv City, Bulgaria, E-mail: vopsi@abv.bg
Received: 30-Sep-2022, Manuscript No. AAJCER-22-79258; Editor assigned: 03-Oct-2022, PreQC No. AAJCER-22-79258(PQ); Reviewed: 17-Oct-2022, QC No. AAJCER-22-79258;
Revised: 19-Oct-2022, Manuscript No. AAJCER-22-79258(R); Published: 25-Oct-2022, DOI:10.35841/aajcer-5.5.121
Figure 1: In the morning after waking up before Validol.
Figure 1A: 10 minutes after taking 1 tablet Validol.
Figure 1B: 45 minutes after consuming 1 cup of instant coee.
Figure 2: (In the morning after waking up before Validol).
2
J Clin Endocrinol Res 2022 Volume 5 Issue 5
Citation: Domuschiev I. Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coee
in an adult male. J Clin Endocrinol Res. 2022;5(5):121
Figure 2B: 45 minutes after consuming 1 cup of instant coee.
Figure 2A: 10 minutes after taking 1tablet Validol).after waking up
before Validol). Figure 3: In the morning after waking up before Validol.
Figure 3A: 10 minutes after taking 1 tablet Validol.
3
J Clin Endocrinol Res 2022 Volume 5 Issue 5
Citation: Domuschiev I. Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coee
in an adult male. J Clin Endocrinol Res. 2022;5(5):121
Figure 3B: 45 minutes after consuming 1cup of instant coee.
Conclusion
The quality sleep is the best relaxant for the body (best heart
rate variability and lowest stress index - better result compared
to Validol). Coee increases the sympathetic activity, as a
result of which the stress index increases.
References
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A comparative evaluation of the antianginal action of
commercially and noncommercially produced validol in
neurocirculatory dystonia and stenocardia. Lik Sprava.
1996;3(4):110-3.
2. Tsvetkova B, Pencheva I, Zlatkov A, et al. Validated gc
method for determination of validol in tablet dosage forms.
Asian J Pharm Clin Res. 2012;5(3):96-7.
3. Food and Chemical Toxicology.1982;20:735.
4. Sondermeijer HP, Van marle AG, Kamen P, et al. Acute
eects of caeine on heart rate variability. Am J Card.
2002;90(8):906-7.
5. Corti R, Binggeli C, Sudano I, et al. Coee leads to
activation of the sympathetic nervous system. Eur Heart J.
2000;21(105):24-28.
6. Corti R, Binggeli C, Sudano I, et al. Coee acutely
increases sympathetic nerve activity and blood pressure
independently of caeine content: role of habitual versus
nonhabitual drinking. Circulation. 2002;106(23):2935-40.
7. De Oliveira RA, Araújo LF, De Figueiredo RC, et al.
Coee consumption and heart rate variability: the Brazilian
longitudinal study of adult health (ELSA-Brasil) cohort
study. Nutrients. 2017;9(7):741.
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A validated method for the determination of validol in tablet dosage forms using gas chromatography with flame-ionization detection and n-octanol as the internal standard is developed. Validol represents a 25-30% solution of menthol in the menthyl ester of isovaleric acid. The separation of both compounds was achieved on a HP-FFAP (nitroterephthalic acid modified polyethylene glycol) fused silica capillary column, 30 m x 0.53 mm i.d. with 1 μm stationary film thickness. The linearity was established in the range from 0.448 to 2.240 mg/ml for menthol and from 1.152 to 5.762 mg/ml for menthyl isovalerate, respectively. Validation results showed that the method is selective, linear, accurate and precise.
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Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safety remains controversial. Possible health hazards have been related to its main ingredient, caffeine. Activation of the sympathetic nervous system by coffee may enhance cardiovascular risk; however, it is unclear whether this effect of coffee is related to caffeine or other substance(s) also contained in decaffeinated coffee. In 15 healthy volunteers (6 habitual and 9 nonhabitual coffee drinkers) arterial blood pressure (BP), heart rate, and muscle sympathetic nervous activity (MSA) were continuously recorded before and after drinking a triple espresso or a decaffeinated triple espresso or after intravenous administration of caffeine (250 mg) or placebo (saline) in the same subjects. There was a significant time x condition interaction for the intravenous caffeine and placebo conditions for MSA, with caffeine showing a significant increase in MSA at 60 minutes (53.2+/-14.1% total activity) and the placebo group showing no effect. A similar significant time effect was found for coffee drinking (54.1+/-22.5% total activity). Habitual and nonhabitual coffee drinkers demonstrated similar changes in MSA and BP after intravenous caffeine, whereas coffee drinking increased BP in nonhabitual drinkers only, despite comparable increases of MSA and plasma caffeine levels. Nonhabitual coffee drinkers showed similar activation of MSA and BP after caffeine infusion, coffee, or decaffeinated coffee. Acutely, coffee and caffeine induced comparable increases in MSA and BP in nonhabitual coffee drinkers, whereas habitual coffee drinkers exhibited lack of BP increase despite MSA activation to coffee. Because decaffeinated coffee also increases BP and MSA in nonhabitual drinkers, ingredients other than caffeine must be responsible for cardiovascular activation.
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As many as 20 patients with neurocirculatory dystonia (NCD) and 10 IHD patients presenting with stable exertional angina were evaluated for an effectiveness of antianginal action of validol tablets commercially- and noncommercially produced, the above tablets being of the changed composition in the latter case. Validol of both changed and unchanged composition had a similar transient antianginal effect which was higher in NCD than it was in angina pectoris. Economical as well as clinical effects of validol of the changed make up warrant it to be commercially produced.
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Acute caffeine ingestion has been found to increase blood pressure and sympathetic activity in nonhabitual coffee drinkers; however, the effects. of caffeine on parasympathetic nervous system activity have seldom been explored. After acute ingestion of caffeine in 10 normal subjects, we found blood pressures to be significantly increased, and measures of parasympathetic nervous system activity significantly decreased compared with measures after placebo ingestion.
Coffee leads to activation of the sympathetic nervous system
  • R Corti
  • C Binggeli
  • I Sudano
Corti R, Binggeli C, Sudano I, et al. Coffee leads to activation of the sympathetic nervous system. Eur Heart J. 2000;21(105):24-28.