The purpose of this research was to evaluate the efficacy of rectus sheath block (rectus sheath block) against patient-controlled analgesia (patient-controlled analgesia) for pain management following a laparoscopic hysterectomy performed through a single incision. This randomized, single-blind experiment only included women who had undergone a single-port operation. Patients received either a fentanyl patient-controlled analgesia injection or a rectus sheath block injection containing the same patient-controlled analgesia at random. Postoperative fentanyl intake and visual analog scale pain scores were the primary endpoints. The findings show that a total of 36 participants (18 in each of the patient-controlled analgesia and rectus sheath block groups) were analyzed (two patients were excluded). The rectus sheath block group's fentanyl use was much lower than the patient-controlled analgesia group’s 8 hours after surgery (148 61 mg vs. 222 107 mg, respectively). Lower vas scores were seen for patients in the rectus sheath block group upon arrival and again 30 minutes later compared to those in the patient-controlled analgesia group. There were no statistically significant variations in the prevalence of nausea, vomiting, or the use of anti-nausea or -vomiting drugs between the groups. Patients having a single-port Transcatheter aortic valve replacement can benefit from rectus sheath block as part of a multimodal strategy to pain management