In Pakistan, the most common side effects observed after SARS-CoV-2 vaccination are myalgia, soreness in the arm where the vaccine was delivered, fever, and weakness. There have been no proven occurrences of menstrual cycle or reproductive system alterations in women who received the immunization, according to reports submitted to the Italian Medicine Agency. There was an increase in the frequency of transient adverse drug reactions associated with the menstrual cycle, as shown by clinical data following the administration of both mRNA and Adenovirus vectored COVID-19 vaccinations. We conducted the first retrospective study of Italian patients who received the SARS-CoV-2 vaccine between April 2021 and April 2022 in order to learn more about the cause, the likely duration of side effects, and the scale of the occurrence. We sent a 12-question multiple-choice survey about the possible effects of SARS-CoV-2 vaccination on fertility to one hundred women aged 18-45 who had received the vaccine. The vaccination was administered in three doses to 37 of them, and two doses to the remaining 63. Symptoms such as delayed menstruation and irregular uterine bleeding were reported by 23% and 77% of women, respectively, in the first three weeks after immunization, especially after the second dosage (metrorrhagia, menometrorrhagia, and menorrhagia). These preliminary results suggest the problem may be more prevalent and call for more investigation.