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A comparative study of Video laryngoscope vs Macintosh laryngoscope for prehospital tracheal intubation in Hiroshima, Japan

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Abstract

Background In Japan, there are no studies comparing endotracheal intubation performed by emergency medical technicians (EMTs) during out-of-hospital cardiac arrest (OHCA) using a Macintosh laryngoscope and a video laryngoscope. Objective The purpose of this study was to compare the success rate, complication rate, return of spontaneous circulation (ROSC), neurological prognosis (CPC1-2) and regional differences between Video laryngoscope (VL) and Macintosh laryngoscope (ML) for OHCA patients. Method This study is a retrospective cohort study using 10,067 OHCA data extracted from the national Utstein Form and emergency medical transport data. The primary endpoint was the success rate of tracheal intubation and the complication rate and the secondary endpoints were the incidence of ROSC and CPC1-2. Results A total of 885 tracheal Intubated OHCA patients were enrolled in this study. The success rate was 94.1% (490/521) in the VL group and 89.3% (325/364) in the ML group (RR, 1.05; 95%CI, 1.01–1.10, P = 0.01), the VL group shows significantly higher success rate than that of the ML group. In the complication rates, oesophageal intubation occurred in 0.2% (1/521) of in the VL group and in 6.0% (22/364) in the ML group, Indicating significantly higher complication rates in the ML group compared with the VL group (RR, 1.06; 95% CI, 1.03–1.09, P < 0.001). The ROSC rate and CPC1-2 rate are similar among the groups. Conclusion Our data suggest that using VL had a little advantage with a higher success rate and lower complication rate. Further discussion is necessary for the future development of Emergency Medical Services (EMS) intubation devices.
Clinical paper
A comparative study of Video laryngoscope vs
Macintosh laryngoscope for prehospital tracheal
intubation in Hiroshima, Japan
N. Santou
a,*
, H. Ueta
a
, K. Nakagawa
b
, K. Hata
b,e
, S. Kusunoki
c
, T. Sadamori
d
,
H. Takyu
b
, H. Tanaka
a,b
Abstract
Background: In Japan, there are no studies comparing endotracheal intubation performed by emergency medical technicians (EMTs) during out-of-
hospital cardiac arrest (OHCA) using a Macintosh laryngoscope and a video laryngoscope.
Objective: The purpose of this study was to compare the success rate, complication rate, return of spontaneous circulation (ROSC), neurological
prognosis (CPC1-2) and regional differences between Video laryngoscope (VL) and Macintosh laryngoscope (ML) for OHCA patients.
Method: This study is a retrospective cohort study using 10,067 OHCA data extracted from the national Utstein Form and emergency medical trans-
port data. The primary endpoint was the success rate of tracheal intubation and the complication rate and the secondary endpoints were the inci-
dence of ROSC and CPC1-2.
Results: A total of 885 tracheal Intubated OHCA patients were enrolled in this study. The success rate was 94.1% (490/521) in the VL group and
89.3% (325/364) in the ML group (RR, 1.05; 95%CI, 1.01–1.10, P= 0.01), the VL group shows significantly higher success rate than that of the ML
group. In the complication rates, oesophageal intubation occurred in 0.2% (1/521) of in the VL group and in 6.0% (22/364) in the ML group, Indicating
significantly higher complication rates in the ML group compared with the VL group (RR, 1.06; 95% CI, 1.03–1.09, P< 0.001). The ROSC rate and
CPC1-2 rate are similar among the groups.
Conclusion: Our data suggest that using VL had a little advantage with a higher success rate and lower complication rate. Further discussion is
necessary for the future development of Emergency Medical Services (EMS) intubation devices.
Keywords: Video laryngoscope, OHCA, Prehospital tracheal intubation, ROSC rate, CPC1-2, EMS, EMT, Medical Control
Introduction
In Japan, EMTs have been allowed tracheal intubation in out-of-
hospital cardiac arrest (OHCA) patients since 2004. Yet, in recent
years, its efficacy has been controversial.
Benoit et al.
2
reported that the odds ratio for ROSC was signifi-
cantly higher in OHCA patients who received tracheal intubation than
in OHCA patients received supraglottic airway devices, indicating the
benefit of tracheal intubation. Hirasawa
3
also compared the survival
rates of OHCA patients with supraglottic airway devices and intu-
bated patients, and summarized that tracheal intubation worsening
survival rate of OHCA and that there is no medical evidence that tra-
cheal intubation contributes to improved survival in OHCA. Further-
more, some studies indicate better survival-discharge rates and
neurological outcomes with mask ventilation than with tracheal intu-
bation,
4
Hasegawa et al.
5
In this context, CoSTR2020 proposes the use of supraglottic air-
way devices or tracheal intubation for advanced airway clearance in
emergency systems with a high success rate of tracheal intubation in
OHCA, and the use of supraglottic airway devices for advanced air-
way clearance in emergency systems with a low success rate of tra-
cheal intubation.
1
In Japan, a demonstration study was conducted in Hiroshima
Prefecture in 2010, and the effectiveness and safety of VL use by
https://doi.org/10.1016/j.resplu.2022.100340
Received 29 September 2022; Received in revised form 16 November 2022; Accepted 28 November 2022
2666-5204/Ó2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.
org/licenses/by-nc-nd/4.0/).
* Corresponding author at: Research Institute of Disaster Management and EMS, Kokushikan University, 7-3-1, Nagayama, Tama city, Tokyo 205-
8515, Japan.
E-mail address: nobuos@kokushikan.ac.jp (N. Santou).
RESUSCITATION PLUS13 (2023) 100340
Available online at www.sciencedirect.com
Resuscitation Plus
journal homepage: www.elsevier.com/locate/resuscitation-plus
EMTs for patients scheduled for surgery were confirmed (success
rate: 97%).
6
Based on these results, tracheal intubation using a VL has been
available since August 2011, and certified VL EMTs have been
trained since 2012.
7
However, the status of training and tracheal
intubation protocols differ among prefectural Medical control commit-
tees, which is reported to be related to regional disparities in hospital
practice, medical resources, and operability compared to conven-
tional laryngoscopes.
8
Comparative studies of tracheal intubation with ML and VL
include a study report by a physician at a medical institution
9
and
a study report by a mannequin.
10
However, comp parative studies
by prehospital EMTs have been reported in the United States
11
and Europe,
12
but not in Japan.
Therefore, we have been using a Video laryngoscope (Airway
Scope
Ò
) as the first choice device for tracheal intubation since
2012, and analyzed data from Hiroshima Prefecture, which has a
high rate of Video laryngoscope use, and in OHCA patients, we
hypothesized that tracheal intubation with a Video laryngoscope
would improve the prognosis of the injured patient.
Objective
The purpose of this study was to compare the success rate, compli-
cation rate, ROSC rate, CPC1-2, and regional differences between
Video laryngoscope (VL) and Macintosh laryngoscope (ML) and to
examine the usefulness of VL.
Method
Study design
In this retrospective cohort study, we extracted data on tracheal
intubation in Hiroshima Prefecture from the Utstein style data
nationwide from 2015 to 2019, and added emergency transport
data and Hiroshima Prefecture tracheal intubation verification form
data.
In conducting this study, we applied to the “Ethics Committee on
Research Involving Human Subjects” of Kokushikan University and
obtained their approval (receipt number 21005). The parties involved
in the facilities providing the materials in Hiroshima Prefecture were
fully informed and their consent was obtained in writing. The data
used in this study did not contain any data that would identify the
names of facilities or individuals, and we took sufficient care to pro-
tect the privacy of the data.
Target and extraction conditions
For the extraction of data used in this study, we combined 5 years of
nationwide Utstein style data (627,982 cases) and emergency trans-
port data (26,710,481 cases) collected from January 1, 2015 to
December 31, 2019, from which we extracted cases of OHCA occur-
rence in Hiroshima Prefecture (10,067 cases). We combined the
OHCA cases in Hiroshima Prefecture (10,067 cases) with data from
the Hiroshima Prefecture tracheal intubation verification form (1062
cases), and extracted 979 cases, excluding 83 cases that were not
combined. From the extracted 979 cases of tracheal intubation in Hir-
oshima Prefecture (979 cases), (1) cases with negative values for
time factor (31 cases), (2) cases with outliers for time factor (58
cases), and (3) cases with multiple identical cases (5 cases) were
excluded. The above items were excluded, and 885 cases were
included in this study (Figure 1).
The Medical Control system in Hiroshima Prefecture, the target
prefecture, as of April 1, 2019, consists of 7 regional medical control
committees, 13 fire departments. There are 633 EMTs who are oper-
ational. There are 228 EMTs certified in tracheal intubation and 170
EMTs certified in Video laryngoscopy, and 405 EMTs (64% of the
total) are not certified in tracheal intubation. Advanced airway secur-
ing devices include a supraglottic airway device (Laryngeal Mask,
Laryngeal Tube) and a tracheal intubation tube. Paramedics without
tracheal intubation certification (64%) use supraglottic airway
devices, and EMTs certified in tracheal intubation (36%) use a tra-
cheal intubation tube, attempt tracheal intubation, and use a supra-
glottic airway device if they find it difficult.
Study endpoint
Primary outcomes were success rate of tracheal intubation and com-
plication rate (oesophageal intubation), and secondary outcomes
were ROSC rate and CPC1-2. The good neurological prognosis rate
at 1 month was defined as CPC1: good function and CPC2: moder-
ate impairment in the Glasgow- Pittsburgh Cerebral Performance
Category. The success rate of tracheal intubation and the number
of tracheal intubations performed (per 1 million population) were
compared in each region of Hiroshima Prefecture.
Statistical analysis
Numerical data were expressed as mean (standard deviation; SD).
Student’s t-test for comparison of continuous variables between
each group. Qualitative data measures are presented in % (number
of cases). Pearson’s chi-square test and Fisher’s exact test were
used for comparison, with a significance level of 5%, and relative risk
(RR) and 95% confidence interval (CI) were estimated. Microsoft
Excel 2019 and JMP Pro15 were used for statistical analysis.
Results
Patients background
The background of the injured and ill patients studied is shown in
Table 1.
Age, gender, bystander chest compressions, bystander AED,
waveform type, electroshock, and medication administration were
validated. There was a significant difference between groups in the
presence or absence of bystander chest compressions (P= 0.035).
In terms of initial ECG waveform type, Asystole accounted for the
highest percentage in both groups: 70.8% (369/521) in the Video
group and 71.4% (260/364) in the ML group.
Results of success rates and complication
rates and time to perform tracheal intubation.
A total of 885 tracheal intubated OHCA were enrolled in this study.
The success rate was 94.1%(490/521) in the VL group and 89.3%
(325/364) in the ML group(RR, 1.05;95%CI, 1.01–1.10, P= 0.01).
The first time success rate was 87.7% (457/521) in the VL group
and 81.6% (297/364) in the ML group (RR, 1.07; 95%CI, 1.01–
1.14, P= 0.01), In the VL group shows significantly higher success
rate than that of the ML group. In the complication rates, oesopha-
geal intubation occurred in 0.2% (1/521) of in the VL group and in
2RESUSCITATION PLUS 13 (2023) 100340
6.0% (22/364) in the ML group, Indicating significantly higher compli-
cation rates in the ML group compared with the VL group (RR, 1.06;
95%CI, 1.03–1.09, P< 0.001). The mean time from contact with the
injured person to completion of tracheal intubation was 13.4 (±5.4)
minutes in the VL group and 14.0 (±6.0) minutes in the ML group,
and the mean time from contact with the injured person to hospital
admission was 28.2 (±8.6) minutes in the VL group and 28.6
(±9.1) minutes in the ML group, with no significant difference
(Table 2).
Comparative results of where tracheal intubation was
performed
Regarding the comparison of the location where tracheal intubation
was performed, the cases where it was performed in the field were
significantly higher in the VL group than in the ML group, 58.2%
(303/521) in the VL group and 50.8% (185/364) in the ML group
(RR, 1.14; 95%CI, 1.01–1.30, P= 0.03). The success rate in the field
was 95.0% (288/303) in the VL group and 88.7% (164/185) in the ML
group, which was significantly higher in the VL group than in the ML
group (RR, 1.07; 95%CI, 1.01–1.13, P= 0.01). The success rate
after field departure from the field was 92.7% (202/218) in the VL
group and 89.9% (161/179) in the ML group (RR, 1.03; 95%CI,
0.97–1.10, P= 0.34). When we compared the percentage of ROSC
cases in which tracheal intubation was performed in the field, 77.8%
(21/27) in the VL group and 66.7% (12/18) in the ML group, with no
significant difference between the groups (RR, 1.17; 95% CI, 0.79–
1.71, P= 0.41). Among the CPC1-2 cases, the percentage of tra-
cheal intubation performed in the field was 100% (8/8) in the VL
group and 60.0% (3/5) in the ML group, with no significant difference
between the groups (RR, 1.67; 95% CI, 0.84–3.41, P= 0.13)
(Table 2).
ROSC rate and CPC1-2 results
The ROSC rate in all cases with tracheal intubation was 5.5%
(27/490) in the VL group and 5.5% (18/325) in the ML group, with
no significant difference between the groups (RR, 0.99; 95%CI,
0.57–1.78, P= 0.99). Similarly, CPC1-2 in tracheal intubation cases
was 1.6% (8/490) in VL group and 1.5% (5/325) in ML group with no
significant difference between the two groups (RR, 1.06; 95%CI,
0.35–3.22, P= 0.91) (Table 3).
Table1 Patients background.
Laryngoscope used Video laryngoscope (n = 521) Macintosh laryngoscope (n = 364) P-value
Age, mean (SD), years 77.9 (13.8) 78.2 (13.3) 0.79
Gender, No. (%) 290 (55.7) 200 (54.9) 0.83
Bystander CPR, No. (%) 253 (57.0) 167 (49.4) 0.0350
Bystander AED, No. (%) 8 (2.1) 3 (0.9) 0.24
Initial ECG, No. (%)
VF 18 (3.5) 16 (4.4) 0.45
VT 4 (0.77) 0 (0)
PEA 126 (24.2) 87 (23.9)
Asystole 369 (70.8) 260 (71.4)
Defibrillation, No. (%) 30 (7.7) 33 (9.7) 0.34
Epinephrine administration (%) 105 (25.5) 67 (19.9) 0.07
CPR: cardiopulmonary resuscitation, AED: Automated external defibrillator, ECG: electro cardiogram, VF: ventricular fibrillation, VT: ventricular tachycardia, PEA:
pulseless electrical activity, SD: standard deviation.
Table 2 Success rate and complication rate.
Video
laryngoscope
Macintosh
laryngoscope
P-value RR (95%CI)
Success rate 94.1% (490/521) 89.3% (325/364) 0.01 1.05 (1.01–1.10)
First time success rate 87.7% (457/521) 81.6% (297/364) 0.01 1.07 (1.01–1.14)
Time from casualty contact to completion of tracheal
intubation. mean (SD).min
13.4 (5.4) 14.0 (6.0) 0.15
Contact to completion of hospital Arrival
Time. mean (SD).min
28.2 (8.6) 28.6 (9.1) 0.47
Complication rate
Incidence of oesophageal intubation 0.2% (1/521) 6.0% (22/364) <0.001 1.06 (1.03–1.09)
Tooth damage 0.2% (1/521) 0.3% (1/364)
Percentage of on-site implementation 58.2% (303/521) 50.8% (185/364) 0.03 1.14 (1.01–1.30)
Success rate 95.0% (288/303) 88.7% (164/185) 0.01 1.07 (1.01–1.13)
Success rate after field departure 92.7% (202/218) 89.9% (161/179) 0.34 1.03 (0.97–1.10)
Successful tracheal intubation rate, tracheal intubation implementation rate, complication rate are expressed as % and (real numbers).
(): The left side is the number of successes implementations / total number.
Group comparisons were made using the Pearson’s chi-square test and Fisher’s exact test to estimate RR and 95% CI.
Intubation time values are expressed as mean (standard deviation), and two-sample t-tests assuming equal variances were used to compare groups.
RESUSCITATION PLUS 13 (2023) 100340 3
Successful intubation rate and number of intubations
performed by each region
The success rate of tracheal intubation in Hiroshima Prefecture was
92.0% (815/885). Success rates were 100% (35/35) in HA, 97.2%
(104/107) in HB, 93.1% (335/360) in HC, 92.1% (210/228) in HD,
87.7% (121/138) in HE and 58.8% (10/17) in HF, regional differences
were found. The number of patients intubated per million population
was 244 in the HA region, 1227 in the HB region, 1394 in the HC
region, 153 in the HD region, 508 in the HE region, and 20 in the
HF region, indicating a disparity in the number of tracheal intubations
performed for OHCA in each MC region. As for the comparison of the
success rates between the VL and ML groups, each area showed the
same success rate between the groups or a higher success rate in
the VL group (Table 4).
Discussion
Discussion of the main results of this study
In the present study, the success rate of tracheal intubation and the
incidence of oesophageal intubation were examined using OHCA data
from Hiroshima Prefecture, suggesting the usefulness of VL. At pre-
sent, the process for obtaining VL certification in Japan is as follows
the Medical control committees first grants ML certification to those
who successfully complete 30 cases of tracheal intubation in hospital
practice, and then grants VL certification to those who successfully
complete 5 cases of VL. Thus, it cannot be denied that VL may have
had a higher success rate than ML because the person who performed
tracheal intubation in VL was a paramedic with sufficient experience in
performing tracheal intubation in ML. On the other hand, the EMTs who
performed the ML were inexperienced in tracheal intubation, which
may have contributed to the lower success rate.
Previous studies on tracheal intubation in OHCA have reported
similar or conflicting results to the present study. Risse et al.
11
reported on a study conducted on German paramedics and found
that there was no significant difference in the success rate compar-
ison between VL (Glidescope
Ò
) and direct viewing laryngoscope
(75% and 68.1%, respectively) (P= 0.63). In addition, Huebinger
et al.
12
reported a study conducted on paramedics in the United
States and found that there was a significant difference in the suc-
cess rate between VL (80.8%) and direct viewing laryngoscope
(73.1%) (95% CI6.4%-9.0%, P< 0.001) and that the increased
ROSC rate was not related to the use of VL (aOR 1.0, 95% CI
0.9–1.1).
In Hiroshima Prefecture, the Ministry of Health, Labor, and Wel-
fare has notified the Ministry that five successful cases of hospital
training are required as prior training for VL certification, and that
after certification, re-training at a hospital is conducted every-two
to three years. In addition, since the protocol specifies VL as the first
choice device for tracheal intubation, many EMTs have experience in
performing tracheal intubation with VL, which may be one of the rea-
sons for the higher success rate compared to previous studies.
In addition, the Video laryngoscope makes it relatively easy to
see the larynx and insert the tube even during chest compressions,
and the monitor allows multiple people to check the tube, which is
thought to be one reason for the low incidence of esophageal intuba-
tion and the high success rate. Esophageal intubation is fatal, and in
this study, esophageal intubation was greatly reduced in the VL
group compared to the ML group. Timmermann et al.
13
reported that
emergency physicians performed tracheal intubation in 149 OHCA
cases and esophageal intubation was observed in 10 cases
(6.7%). Since esophageal intubation may occur with a certain fre-
quency even if a physician performs tracheal intubation in OHCA,
we would assume that the incidence of esophageal intubation is also
higher when EMTs perform tracheal intubation in OHCA.
There are currently no precise values or definitions to distinguish
between high and low success rates of tracheal intubation for OHCA;
the studies by Wang et al.
14
and Benger et al.
15
considered the suc-
cess rate of tracheal intubation to be low (51.6% and 69.8%, respec-
tively), while the study by Jabre et al.
16
judged the success rate of
tracheal intubation to be high (97.9%). The success rate of VL in this
study was 94.0%, and that of ML was 89.8%. We believe that both
can be judged as having a high success rate for tracheal intubation.
The JRC (Japan Resuscitation Council) Resuscitation Guidelines
2020 also states that validation based on regional tracheal intubation
success rates (and the need for uniform definitions) is necessary in
order to recommend which advanced airway securing devices to
use
1
.
Consideration of the timing of tracheal intubation
The timing of tracheal intubation for OHCA has been much debated,
and CoSTR2020 points out that in addition to the airway maneuver,
the timing of the maneuver is also important, as observational stud-
ies have shown that advanced airway securement is associated with
poor neurological outcomes and decreased survival if the timing is
delayed.
1
Kajino et al.
17
and Nakagawa et al.
18
reported that the later the
paramedic tracheal intuba tion, the worse the prognosis, and early
tracheal intubation correlated with a favorable neurological outcome,
respectively.
In this study, approximately 60% of the VL group and 50% of the
ML group were performed early on prior to ambulance admission,
Table 3 ROSC rate, CPC1-2.
Video laryngoscope Macintosh laryngoscope P-value RR (95%CI)
Percentage of ROSC cases intubated in the field 77.8% (21/27) 66.7% (12/18) 0.41 1.17(0.79–1.71)
Percentage of CPC 1–2 cases intubated in the field 100% (8/8) 60.0% (3/5) 0.13 1.67(0.84–3.41)
ROSC rate 5.5% (27/490) 5.5% (18/325) 0.99 0.99(0.57–1.78)
CPC1-2 1.6% (8/490) 1.5% (5/325) 0.91 1.06(0.35–3.22)
ROSC:return of spontaneous circulation. CPC:cerebral performance category.
ROSC rate and CPC1-2 are expressed as % and (real numbers).
(): The left side is the number of successes implementations / total number.
Group comparisons were made using the Pearson’s chi-square test and Fisher’s exact test to estimate RR and 95% CI.
4RESUSCITATION PLUS 13 (2023) 100340
and the ROSC rate for these early cases was 77.8% for the VL group
and 100% for CPC1-2. It was found that performing tracheal intuba-
tion at the scene before in-vehicle housing increased both the ROSC
rate and CPC1-2 rate. The reason for this was that after tracheal
intubation, high quality chest compressions could be continued with
minimal interruption of chest compressions.
Furthermore, a comparative of the results of tracheal intubation
performed in the field showed that the success rate was 95.0% for
the VL group and 88.7% for the ML group, with the VL group having
a significantly higher success rate than the ML group. The ROSC
rate,CPC1-2 relationship also suggested the usefulness of VL.
Successful intubation rate and number of intubations
performed by each region
The success rates of the VL group and the ML group were 94.1%
and 89.3%, respectively. However, when comparing the success
rate and number of tracheal intubations performed in each region,
the success rate of tracheal intubation varied from 58.8% to 100%.
In terms of the number of tracheal intubations attempted per million
population, there was a large disparity in the number of tracheal intu-
bations performed for OHCA in each region, ranging from 33 to 1498.
Success rates were also extremely low in areas where the number of
intubations performed per million population was extremely low. One
of the factors contributing to this significant difference is thought to
be the influence of differences in physicians’ orders and activity poli-
cies according to the tracheal intubation protocol in each area Med-
ical control committees even within the same prefecture. Based on
the results of tracheal intubation in each region, it is necessary for
the Medical control committees to develop a protocol and discuss
a course of action. As for the comparison between VL and ML in
each area, the success rate of VL was higher than that of ML in all
areas except for the area where the success rate was 100% in both
groups, suggesting the usefulness of VL.
Limitations of the study
ROSC rates and CPC1-2 in this study were observational studies
using Utstein style data and emergency transport data, and there
may be confounding in the background of OHCA injuries. The study
also has a number of limitations: it is a retrospective study limited to
Hiroshima Prefecture; the skills of the EMTs who performed tracheal
intubation were not evaluated; and the quality of chest compressions
was not assessed.
Conclusion
Our data suggest that using VL had a little advantage with a higher
success rate and lower complication rate. Further discussion is
needed on the development of EMS intubation devices for rapid
and safe endotracheal intubation in OHCA, based on clinical results
on tracheal intubation in various regions.
Conflict of interest
All authors of this paper have no defined COI.
Acknowledgement
We would like to express my deepest gratitude and appreciation to
the people involved in the Hiroshima Prefecture Medical Control
committees, the Hiroshima Prefecture Fire Department, and
Kokushikan University.
Author details
a
Research Institute of Disaster Management and EMS, Kokushikan
University,Tokyo, Japan
b
Department of Emergency Medical System,
Graduate School, Kokushikan University , Tokyo, Japan
c
Hiroshima
Prefectural Hospital Emergency and Critical Care Medici-
ne
d
Emergency and Intensive Care Medicine, Hiroshima Universi-
ty
e
Research Center for Mathematical Medicine, Tokyo, Japan
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Table 4 Success rate and number of implementations by region.
Overall
success rate
Video
laryngoscope
Macintosh
laryngoscope
P-value RR (95%CI) Number of
implementation
per million
population
All of Hiroshima Prefecture 92.0% (815/885) 94.1% (490/521) 89.3% (325/364) 0.01 1.05 (1.01–1.10) 345
HA Region 100% (35/35) 100% (30/30) 100% (5/5) 0 244
HB Region 97.2% (104/107) 97.9% (95/97) 90.0% (9/10) 0.26 1.09 (0.88–1.34) 1,263
HC Region 93.1% (335/360) 95.0% (134/141) 91.8% (201/219) 0.24 1.03 (0.98–1.09) 1,498
HD Region 92.1% (210/228) 92.2% (130/141) 91.9% (80/87) 0.95 1.00 (0.93–1.08) 166
HE Region 87.7% (121/138) 91.3% (94/103) 77.1% (27/35) 0.03 1.18 (0.97–1.43) 580
HF Region 58.8% (10/17) 77.8% (7/9) 37.5% (3/8) 0.15 2.07 (0.79–5.42) 33
HAHF: 6 areas in Hiroshima Prefecture.
The success rate of each tracheal intubation is expressed as a % (real number).
(): The left side is the number of successes Implementations / Total number.
Group comparisons were made using the Pearson’s chi-square test and Fisher’s exact test to estimate RR and 95% CI.
Based on the total population of each area, the number of people for whom tracheal intubation was attempted was converted to a number per million population.
RESUSCITATION PLUS 13 (2023) 100340 5
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6RESUSCITATION PLUS 13 (2023) 100340
... (Figure 3). Seventeen out of 25 studies were included in this analysis (19,26,27,29,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43). ...
... Eighteen out of 25 studies were included in the meta-analysis for overall intubation success ( Figure 4) (15,(19)(20)(21)23,24,(26)(27)(28)31,(33)(34)(35)(36)(37)(38)41,43), but a pooled estimate was not reported due to substantial heterogeneity (I 2 ¼ 87%). There was no difference in overall success between VL and DL among CCP/CCRNs (OR ¼ 1.89, 0.96-3.72, ...
Article
Objective: To determine the effect of video and direct laryngoscopy on first-pass success rates for out-of-hospital orotracheal intubation. Methods: MEDLINE, Embase, and Cochrane databases were searched from inception to January 2023. Out-of-hospital studies comparing video and direct laryngoscopy on either first-pass or overall intubation success were included. A random effects meta-analysis was performed with a primary outcome of first-pass success stratified by clinician type and laryngoscope blade geometry. The secondary outcomes were overall intubation success stratified by clinician type, and intubation time. All hypotheses and subgroup analyses were determined a priori. Results: Twenty-five studies involving 35,489 intubations met inclusion criteria. Substantial heterogeneity (>75%) precluded reporting point estimates for nearly all analyses. For our primary outcome, video laryngoscopy was associated with improved first-pass success in 3/5 physician studies, 4/6 critical care paramedic/registered nurse studies, and 7/10 paramedic studies. Video laryngoscope devices with Macintosh blade geometry were associated with improved first-pass success in 7/10 studies, while devices with hyperangulated geometry were associated with improved first-pass success in 3/7 studies. Overall intubation success was greater with video laryngoscopy in 2/6 studies in the physician subgroup and 9/10 studies in the paramedic subgroup. Video laryngoscopy was not associated with overall intubation success among critical care paramedics/nurses (OR = 1.89, 0.96 to 3.72, I2 = 34%). Lastly, 4/5 studies found video laryngoscopy to be associated with longer intubation times. Conclusions: We found substantial heterogeneity among out-of-hospital studies comparing video laryngoscopy to direct laryngoscopy on first-pass success, overall success, or intubation time. This heterogeneity was not explained with stratification by study design, clinician type, video laryngoscope blade geometry, or leave-one-out meta-analysis. A majority of studies showed that video laryngoscopy was associated with improved first pass success in all subgroups, but only for paramedics and not physicians when looking at overall success. This improvement was more common in studies that used Macintosh blades than those that used hyperangulated blades. Future research should explore the heterogeneity identified in our analysis with an emphasis on differences in training, clinical milieu, and specific video laryngoscope devices.
... Performing endotracheal intubation (ETI) remains a crucial skill for the management of airways, and it is performed both under elective cases, as in the operating room during the induction of general anesthesia, and in more complex situations, for instance, in rapidly deteriorating hospitalized patients, as well as in the out-of-hospital setting. Hence, both anesthesiologists and other healthcare professionals (i.e., emergency physicians and paramedics) dealing with airway management require regular training to develop ETI skills [1,2]. ...
Article
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Simulation for airway management allows for acquaintance with new devices and techniques. Endotracheal intubation (ETI), most commonly performed with direct laryngoscopy (DL) or video laryngoscopy (VLS), can be achieved also with combined laryngo-bronchoscopy intubation (CLBI). Finally, an articulating video stylet (ProVu) has been recently introduced. A single-center observational cross-sectional study was performed in a normal simulated airway scenario comparing DL, VLS-Glidescope, VLS-McGrath, CLBI and ProVu regarding the success rate (SR) and corrected time-to-intubation (cTTI, which accounts for the SR). Up to three attempts/device were allowed (maximum of 60 s each). Forty-two consultants with no experience with ProVu participated (15 ± 9 years after training completion). The DL was significantly faster (cTTI) than all other devices (p = 0.033 vs. VLSs, and p < 0.001 for CLBI and Provu), no differences were seen between the two VLSs (p = 0.775), and the VLSs were faster than CLBI and ProVu. Provu had a faster cTTI than CLBI (p = 0.004). The DL and VLSs showed similar SRs, and all the laryngoscopes had a higher SR than CLBI and ProVu at the first attempt. However, by the third attempt, the SR was not different between the DL/VLSs and ProVu (p = 0.241/p = 0.616); ProVu was superior to CLBI (p = 0.038). In consultants with no prior experience, ProVu shows encouraging results compared to DL/VLSs under simulated normal airway circumstances and further studies are warranted.
Article
Endotracheal intubation is a common lifesaving procedure that often is performed outside the operating room in a variety of clinical scenarios. Providers who perform intubation outside the operating room have variable degrees of training, skill development, and experience. A large number of studies were published in 2023 on the topic of intubations outside the operating room across a wide variety of settings and patient populations. Here, we review relevant papers on this topic published in 2023.
Article
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Aim It is unclear whether endotracheal intubation in the prehospital setting improves outcomes following out‐of‐hospital cardiac arrest. The purpose of this study was to evaluate the association between endotracheal intubation time (time from patient contact to endotracheal intubation) and favorable neurological outcomes on out‐of‐hospital cardiac arrest. Methods We extracted patients who underwent endotracheal intubation on the scene from a nationwide out‐of‐hospital cardiac arrest database registered between 2014 and 2017 in Japan. We included 14,969 witnessed and intubated adult out‐of‐hospital cardiac arrest cases. Patients were divided into Shockable (n = 1,102) and Non‐shockable (n = 13,867) cohorts. We first drew the logistic curve due to predicting the association between endotracheal intubation time and favorable neurological outcome defined as Cerebral Performance Category (CPC) 1 or 2. Secondary, multivariable logistic regressions were used to estimate the association between the endotracheal intubation time (1‐min unit increase), CPC 1 or 2. Results The logistic curve for CPC 1 or 2 showed similar shapes and indicated a decreasing outcome over time. From the results of multivariable logistic regression, in the Shockable cohort, endotracheal intubation time delay was correlated with decreasing favorable outcomes: CPC 1 or 2 (adjusted odds ratio, 0.89; 95% confidence interval, 0.82–0.87). Results were the same for the Non‐shockable cohort: CPC 1 or 2 (adjusted odds ratio, 0.94; 95% confidence interval, 0.89–0.99). Conclusion Early endotracheal intubation was correlated with favorable neurological outcome. Training for intubation skills and improving protocols are needed for carrying out early endotracheal intubation.
Article
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Background: Videolaryngoscopy (VL) has become a popular method of intubation (ETI). Although VL may facilitate ETI in less-experienced rescuers there are limited data available concerning ETI performed by paramedics during CPR. The goal was to evaluate the impact VL compared with DL on intubation success and glottic view during CPR performed by German paramedics. We investigated in an observational prospective study the superiority of VL by paramedics during CPR compared with direct laryngoscopy (DL). Methods: In a single Emergency Medical Service (EMS) in Germany with in total 32 ambulances paramedics underwent an initial instruction from in endotracheal intubation (ETI) with GlideScope® (GVL) during resuscitation. The primary endpoint was good visibility of the glottis (Cormack-Lehane grading 1/2), and the secondary endpoint was successful intubation comparing GVL and DL. Results: In total n = 97 patients were included, n = 69 with DL (n = 85 intubation attempts) and n = 28 VL (n = 37 intubation attempts). Videolaryngoscopy resulted in a significantly improved visualization of the larynx compared with DL. In the group using GVL, 82% rated visualization of the glottis as CL 1&2 versus 55% in the DL group (p = 0.02). Despite better visualization of the larynx, there was no statistically significant difference in successful ETI between GVL and DL (GVL 75% vs. DL 68.1%, p = 0.63). Conclusions: We found no difference in Overall and First Pass Success (FPS) between GVL and DL during CPR by German paramedics despite better glottic visualization with GVL. Therefore, we conclude that education in VL should also focus on insertion of the endotracheal tube, considering the different procedures of GVL. Trial registration: German Clinical Trial Register DRKS00020976, 27. February 2020 retrospectively registered.
Article
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Importance The optimal approach to airway management during out-of-hospital cardiac arrest is unknown. Objective To determine whether a supraglottic airway device (SGA) is superior to tracheal intubation (TI) as the initial advanced airway management strategy in adults with nontraumatic out-of-hospital cardiac arrest. Design, Setting, and Participants Multicenter, cluster randomized clinical trial of paramedics from 4 ambulance services in England responding to emergencies for approximately 21 million people. Patients aged 18 years or older who had a nontraumatic out-of-hospital cardiac arrest and were treated by a participating paramedic were enrolled automatically under a waiver of consent between June 2015 and August 2017; follow-up ended in February 2018. Interventions Paramedics were randomized 1:1 to use TI (764 paramedics) or SGA (759 paramedics) as their initial advanced airway management strategy. Main Outcomes and Measures The primary outcome was modified Rankin Scale score at hospital discharge or 30 days after out-of-hospital cardiac arrest, whichever occurred sooner. Modified Rankin Scale score was divided into 2 ranges: 0-3 (good outcome) or 4-6 (poor outcome; 6 = death). Secondary outcomes included ventilation success, regurgitation, and aspiration. Results A total of 9296 patients (4886 in the SGA group and 4410 in the TI group) were enrolled (median age, 73 years; 3373 were women [36.3%]), and the modified Rankin Scale score was known for 9289 patients. In the SGA group, 311 of 4882 patients (6.4%) had a good outcome (modified Rankin Scale score range, 0-3) vs 300 of 4407 patients (6.8%) in the TI group (adjusted risk difference [RD], −0.6% [95% CI, −1.6% to 0.4%]). Initial ventilation was successful in 4255 of 4868 patients (87.4%) in the SGA group compared with 3473 of 4397 patients (79.0%) in the TI group (adjusted RD, 8.3% [95% CI, 6.3% to 10.2%]). However, patients randomized to receive TI were less likely to receive advanced airway management (3419 of 4404 patients [77.6%] vs 4161 of 4883 patients [85.2%] in the SGA group). Two of the secondary outcomes (regurgitation and aspiration) were not significantly different between groups (regurgitation: 1268 of 4865 patients [26.1%] in the SGA group vs 1072 of 4372 patients [24.5%] in the TI group; adjusted RD, 1.4% [95% CI, −0.6% to 3.4%]; aspiration: 729 of 4824 patients [15.1%] vs 647 of 4337 patients [14.9%], respectively; adjusted RD, 0.1% [95% CI, −1.5% to 1.8%]). Conclusions and Relevance Among patients with out-of-hospital cardiac arrest, randomization to a strategy of advanced airway management with a supraglottic airway device compared with tracheal intubation did not result in a favorable functional outcome at 30 days. Trial Registration ISRCTN Identifier: 08256118
Article
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It is unclear whether advanced airway management such as endotracheal intubation or use of supraglottic airway devices in the prehospital setting improves outcomes following out-of-hospital cardiac arrest (OHCA) compared with conventional bag-valve-mask ventilation. To test the hypothesis that prehospital advanced airway management is associated with favorable outcome after adult OHCA. Prospective, nationwide, population-based study (All-Japan Utstein Registry) involving 649,654 consecutive adult patients in Japan who had an OHCA and in whom resuscitation was attempted by emergency responders with subsequent transport to medical institutions from January 2005 through December 2010. Favorable neurological outcome 1 month after an OHCA, defined as cerebral performance category 1 or 2. Of the eligible 649,359 patients with OHCA, 367,837 (57%) underwent bag-valve-mask ventilation and 281,522 (43%) advanced airway management, including 41,972 (6%) with endotracheal intubation and 239,550 (37%) with use of supraglottic airways. In the full cohort, the advanced airway group incurred a lower rate of favorable neurological outcome compared with the bag-valve-mask group (1.1% vs 2.9%; odds ratio [OR], 0.38; 95% CI, 0.36-0.39). In multivariable logistic regression, advanced airway management had an OR for favorable neurological outcome of 0.38 (95% CI, 0.37-0.40) after adjusting for age, sex, etiology of arrest, first documented rhythm, witnessed status, type of bystander cardiopulmonary resuscitation, use of public access automated external defibrillator, epinephrine administration, and time intervals. Similarly, the odds of neurologically favorable survival were significantly lower both for endotracheal intubation (adjusted OR, 0.41; 95% CI, 0.37-0.45) and for supraglottic airways (adjusted OR, 0.38; 95% CI, 0.36-0.40). In a propensity score-matched cohort (357,228 patients), the adjusted odds of neurologically favorable survival were significantly lower both for endotracheal intubation (adjusted OR, 0.45; 95% CI, 0.37-0.55) and for use of supraglottic airways (adjusted OR, 0.36; 95% CI, 0.33-0.39). Both endotracheal intubation and use of supraglottic airways were similarly associated with decreased odds of neurologically favorable survival. CONCLUSION AND RELEVANCE: Among adult patients with OHCA, any type of advanced airway management was independently associated with decreased odds of neurologically favorable survival compared with conventional bag-valve-mask ventilation.
Article
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Both supraglottic airway devices (SGA) and endotracheal intubation (ETI) have been used by emergency life-saving technicians (ELST) in Japan to treat out-of-hospital cardiac arrests (OHCAs). Despite traditional emphasis on airway management during cardiac arrest, its impact on survival from OHCA and time dependent effectiveness remains unclear. All adults with witnessed, non-traumatic OHCA, from 1 January 2005 to 31 December 2008, treated by the emergency medical services (EMS) with an advanced airway in Osaka, Japan were studied in a prospective Utstein-style population cohort database. The primary outcome measure was one-month survival with neurologically favorable outcome. The association between type of advanced airway (ETI/SGA), timing of device placement and neurological outcome was assessed by multiple logistic regression. Of 7,517 witnessed non-traumatic OHCAs, 5,377 cases were treated with advanced airways. Of these, 1,679 were ETI while 3,698 were SGA. Favorable neurological outcome was similar between ETI and SGA (3.6% versus 3.6%, P = 0.95). The time interval from collapse to ETI placement was significantly longer than for SGA (17.2 minutes versus 15.8 minutes, P < 0.001). From multivariate analysis, early placement of an advanced airway was significantly associated with better neurological outcome (Adjusted Odds Ratio (AOR) for one minute delay, 0.91, 95% confidence interval (CI) 0.88 to 0.95). ETI was not a significant predictor (AOR 0.71, 95% CI 0.39 to 1.30) but the presence of an ETI certified ELST (AOR, 1.86, 95% CI 1.04 to 3.34) was a significant predictor for favorable neurological outcome. There was no difference in neurologically favorable outcome from witnessed OHCA for ETI versus SGA. Early airway management with advanced airway regardless of type and rhythm was associated with improved outcomes.
Article
Introduction Endotracheal intubation is an import component of out-of-hospital cardiac arrest (OHCA) resuscitation. In this analysis, we evaluate the association of video laryngoscopy (VL) with first pass success and return of spontaneous circulation (ROSC) using a national OHCA cohort. Methods We analyzed 2018 data from ESO Inc. (Austin, TX), a national prehospital electronic health record. We included all adult, non-traumatic cardiac arrests undergoing endotracheal intubation. We defined VL and direct laryngoscopy (DL) based on paramedic recorded intubation device. The primary outcomes were first pass success, ROSC, and sustained ROSC. Using multivariable, mixed models, we determined the association between VL and first pass success rate, ROSC, and sustained ROSC (survival to ED or ROSC in the field for greater than 20 minutes), fitting agency as a random intercept and adjusting for confounders. Results We included 22,132 patients cared for by 914 EMS agencies, including 5,702 (25.7%) VL and 16,430 (74.2%) DL. Compared to DL, VL had a lower rate of bystander CPR, but other characteristics were similar between the groups. VL exhibited higher first pass success than DL (75.1% v 69.5%, p < .001). On mixed model analysis, VL was associated with a higher first pass success (OR 1.5, CI 1.3-1.6) but not ROSC (OR 1.1, CI 0.97-1.2) or sustained ROSC (OR 1.1, CI 0.9-1.2). Conclusion While associated with higher FPS, VL was not associated with increased rate of ROSC. The role of VL in OHCA remains unclear.
Article
Importance Emergency medical services (EMS) commonly perform endotracheal intubation (ETI) or insertion of supraglottic airways, such as the laryngeal tube (LT), on patients with out-of-hospital cardiac arrest (OHCA). The optimal method for OHCA advanced airway management is unknown. Objective To compare the effectiveness of a strategy of initial LT insertion vs initial ETI in adults with OHCA. Design, Setting, and Participants Multicenter pragmatic cluster-crossover clinical trial involving EMS agencies from the Resuscitation Outcomes Consortium. The trial included 3004 adults with OHCA and anticipated need for advanced airway management who were enrolled from December 1, 2015, to November 4, 2017. The final date of follow-up was November 10, 2017. Interventions Twenty-seven EMS agencies were randomized in 13 clusters to initial airway management strategy with LT (n = 1505 patients) or ETI (n = 1499 patients), with crossover to the alternate strategy at 3- to 5-month intervals. Main Outcomes and Measures The primary outcome was 72-hour survival. Secondary outcomes included return of spontaneous circulation, survival to hospital discharge, favorable neurological status at hospital discharge (Modified Rankin Scale score ≤3), and key adverse events. Results Among 3004 enrolled patients (median [interquartile range] age, 64 [53-76] years, 1829 [60.9%] men), 3000 were included in the primary analysis. Rates of initial airway success were 90.3% with LT and 51.6% with ETI. Seventy-two hour survival was 18.3% in the LT group vs 15.4% in the ETI group (adjusted difference, 2.9% [95% CI, 0.2%-5.6%]; P = .04). Secondary outcomes in the LT group vs ETI group were return of spontaneous circulation (27.9% vs 24.3%; adjusted difference, 3.6% [95% CI, 0.3%-6.8%]; P = .03); hospital survival (10.8% vs 8.1%; adjusted difference, 2.7% [95% CI, 0.6%-4.8%]; P = .01); and favorable neurological status at discharge (7.1% vs 5.0%; adjusted difference, 2.1% [95% CI, 0.3%-3.8%]; P = .02). There were no significant differences in oropharyngeal or hypopharyngeal injury (0.2% vs 0.3%), airway swelling (1.1% vs 1.0%), or pneumonia or pneumonitis (26.1% vs 22.3%). Conclusions and Relevance Among adults with OHCA, a strategy of initial LT insertion was associated with significantly greater 72-hour survival compared with a strategy of initial ETI. These findings suggest that LT insertion may be considered as an initial airway management strategy in patients with OHCA, but limitations of the pragmatic design, practice setting, and ETI performance characteristics suggest that further research is warranted. Trial Registration ClinicalTrials.gov Identifier: NCT02419573
Article
Importance Bag-mask ventilation (BMV) is a less complex technique than endotracheal intubation (ETI) for airway management during the advanced cardiac life support phase of cardiopulmonary resuscitation of patients with out-of-hospital cardiorespiratory arrest. It has been reported as superior in terms of survival. Objectives To assess noninferiority of BMV vs ETI for advanced airway management with regard to survival with favorable neurological function at day 28. Design, Settings, and Participants Multicenter randomized clinical trial comparing BMV with ETI in 2043 patients with out-of-hospital cardiorespiratory arrest in France and Belgium. Enrollment occurred from March 9, 2015, to January 2, 2017, and follow-up ended January 26, 2017. Intervention Participants were randomized to initial airway management with BMV (n = 1020) or ETI (n = 1023). Main Outcomes and Measures The primary outcome was favorable neurological outcome at 28 days defined as cerebral performance category 1 or 2. A noninferiority margin of 1% was chosen. Secondary end points included rate of survival to hospital admission, rate of survival at day 28, rate of return of spontaneous circulation, and ETI and BMV difficulty or failure. Results Among 2043 patients who were randomized (mean age, 64.7 years; 665 women [32%]), 2040 (99.8%) completed the trial. In the intention-to-treat population, favorable functional survival at day 28 was 44 of 1018 patients (4.3%) in the BMV group and 43 of 1022 patients (4.2%) in the ETI group (difference, 0.11% [1-sided 97.5% CI, −1.64% to infinity]; P for noninferiority = .11). Survival to hospital admission (294/1018 [28.9%] in the BMV group vs 333/1022 [32.6%] in the ETI group; difference, −3.7% [95% CI, −7.7% to 0.3%]) and global survival at day 28 (55/1018 [5.4%] in the BMV group vs 54/1022 [5.3%] in the ETI group; difference, 0.1% [95% CI, −1.8% to 2.1%]) were not significantly different. Complications included difficult airway management (186/1027 [18.1%] in the BMV group vs 134/996 [13.4%] in the ETI group; difference, 4.7% [95% CI, 1.5% to 7.9%]; P = .004), failure (69/1028 [6.7%] in the BMV group vs 21/996 [2.1%] in the ETI group; difference, 4.6% [95% CI, 2.8% to 6.4%]; P < .001), and regurgitation of gastric content (156/1027 [15.2%] in the BMV group vs 75/999 [7.5%] in the ETI group; difference, 7.7% [95% CI, 4.9% to 10.4%]; P < .001). Conclusions and Relevance Among patients with out-of-hospital cardiorespiratory arrest, the use of BMV compared with ETI failed to demonstrate noninferiority or inferiority for survival with favorable 28-day neurological function, an inconclusive result. A determination of equivalence or superiority between these techniques requires further research. Trial Registration clinicaltrials.gov Identifier: NCT02327026
Article
Overall survival from out-of-hospital cardiac arrest (OHCA) is less than 10%. After initial bag-valve mask ventilation, 80% of patients receive an advanced airway, either by endotracheal intubation (ETI) or placement of a supraglottic airway (SGA). The objective of this meta-analysis was to compare patient outcomes for these two advanced airway methods in OHCA patients treated by Emergency Medical Services (EMS). A dual-reviewer search was conducted in PubMed, Scopus, and the Cochrane Database to identify all relevant peer-reviewed articles for inclusion in the meta-analysis. Exclusion criteria were traumatic arrests, pediatric patients, physician/nurse intubators, rapid sequence intubation, video devices, and older airway devices. Outcomes were (1) return of spontaneous circulation (ROSC), (2) survival to hospital admission, (3) survival to hospital discharge, and (4) neurologically intact survival to hospital discharge. Results were adjusted for covariates when available and combined using the random effects model. From 3,454 titles, 10 observational studies fulfilled all criteria, representing 34,533 ETI patients and 41,116 SGA patients. Important covariates were similar between groups. Patients who received ETI had statistically significant higher odds of ROSC (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.05-1.55), survival to hospital admission (OR 1.34, CI 1.02-1.75), and neurologically intact survival (OR 1.33, CI 1.09-1.61) compared to SGA. Survival to hospital discharge was not statistically different (OR 1.15, CI 0.97-1.37). Patients with OHCA who receive ETI by EMS are more likely to obtain ROSC, survive to hospital admission, and survive neurologically intact when compared to SGA. Copyright © 2015. Published by Elsevier Ireland Ltd.