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Base de Datos “Nuevos Medicamentos Homeopáticos”

  • September 2022
Authors:
Marcus Zulian Teixeira at University of São Paulo, School of Medicine
Marcus Zulian Teixeira
  • University of São Paulo, School of Medicine
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Abstract

Desde 1998, siguiendo la lógica deductiva aristotélica empleada por Samuel Hah-nemann para sustentar científicamente el principio de la similitud terapéutica, ve-nimos justificando el principio de cura homeopática (acción secundaria o reacción vital del organismo) frente a la farmacología moderna, a través del estudio sistemático del efecto rebote de numerosas clases de fármacos mo-dernos, descrito en varias publicaciones científicas. Desde 2003, de manera similar a la practicada por Hahnemann en la im-plementación de la Homeopatía, venimos proponiendo el uso de fármacos mo-dernos según el principio de la similitud terapéutica (aplicación del efecto rebote curativo de los fármacos modernos), descrito en otras publicaciones científicas y con su eficacia probada en ensayo clínico aleatorizado, doble cie-go y controlado con placebo.
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36 LA HOMEOPATÍA DE MÉXICO. Volumen 91, número 730, julio - septiembre 2022, p.36-38.
Marcus Zulian Teixeira
Desde 1998, siguiendo la lógica deductiva aristotélica empleada por Samuel Hah-
nemann para sustentar cientícamente el principio de la similitud terapéutica, ve-
nimos justicando el principio de cura homeopática (acción secundaria o
reacción vital del organismo) frente a la farmacología moderna, a través del
estudio sistemático del efecto rebote de numerosas clases de fármacos mo-
dernos, descrito en varias publicaciones cientícas1-19.
Desde 2003, de manera similar a la practicada por Hahnemann en la im-
plementación de la Homeopatía, venimos proponiendo el uso de fármacos mo-
dernos según el principio de la similitud terapéutica (aplicación del efecto
rebote curativo de los fármacos modernos), descrito en otras publicaciones
cientícas20-28 y con su ecacia probada en ensayo clínico aleatorizado, doble cie-
go y controlado con placebo29-34.
Para hacer factible esta propuesta, compilamos una Materia Médica Ho-
meopática de los Medicamentos Modernos, agrupando todos los efectos pri-
marios o patogenéticos (terapéuticos, adversos y secundarios) de 1.250 medica-
mentos modernos descritos en The United States Pharmacopeia Dispensing
Information (USP DI, 2004)35 de acuerdo con lo dispuesto en los capítulos de las
materias médicas homeopáticas clásicas, valorando la frecuencia de manifesta-
ción de los signos/síntomas observados en las fases de estudio de los fármacos
convencionales (ensayos clínicos fases 1-4).
Como segundo paso, con el n de facilitar la selección del medicamento
homeopático individualizado (similitud con la totalidad de signos y síntomas del pa-
ciente), premisa indispensable para el éxito terapéutico de la Homeopatía, elabora-
mos un Repertorio Homeopático de los Medicamentos Modernos, disponiendo
los signos/síntomas y sus respectivos fármacos de forma similar a los repertorios
homeopáticos clásicos.
Intitulada Nuevos Medicamentos Homeopáticos: uso de los medica-
mentos modernos según el principio de la similitud, esta propuesta fue des-
crita y sistematizada en tres trabajos distintos: 1. Fundamento Cientíco del
Principio de la Similitud en la Farmacología Moderna; 2. Materia Médica Ho-
meopática de los Medicamentos Modernos; 3. Repertorio Homeopático de
los Medicamentos Modernos.
En 2010, para que todos tuvieran acceso a esta propuesta y su base de
Base de Datos “Nuevos Medicamentos
Homeopáticos”
Dr. Marcus Zulian Teixeira
www.homeozulian.med.br
Actualidad
www.latindex.unam.mx periodica.unam.mx lilacs.bvsalud.org/es/ www.imbiomed.com
• Disponibleen3eBooks bilingüesenformatosPDFyKindle.
37
LA HOMEOPATÍA DE MÉXICO. Volumen 91, número 730, julio - septiembre 2022, p. 36-38.
Base de datos “Nuevos Medicamentos Homeopáticos”
datos, estas tres obras digitales, que suman un
total de miles de páginas, estuvieron disponibles
gratuitamente en un sitio web bilingüe (portu-
gués e inglés) elaborado en la plataforma Adobe
Flash Player (ver abajo), permitiendo que este pro-
tocolo clínico sea analizado y utilizado por todos los
homeópatas.
Lamentablemente, a partir de 2021, la plata-
forma Adobe Flash Player fue bloqueada sin ofrecer
una alternativa a ella, lo que impidió que los colegas
siguieran teniendo acceso a ese sitio web y su base
de datos, compuesta por los tres trabajos disponibles
en formato digital.
Ofreciendo una alternativa al mantenimiento
de esta propuesta, hemos puesto a disposición las
tres obras mencionadas, en portugués e inglés, en
formato de libros digitales de libre acceso (PDF) y en
dos ediciones independientes (2010 y 2021).
Con la ayuda de la Biblioteca Artur de Almei-
da Rezende Filho (Asociación Paulista de Homeo-
patía), la mayor colección de Homeopatía en Brasil
y América Latina, estos libros fueron indexados en
el Portal Regional de la Biblioteca Virtual en Salud
(OPAS, OMS, BIREME) y ahora son accesibles a to-
das las partes interesadas:
Edición 2010
• I - Fundamentação cientíca do princípio
da similitude na farmacologia moderna (1ª
edição, 2010) [Coleção Novos Medicamentos
Homeopáticos: Volume I].
• I - Scientic basis of the principle of similitude
in modern pharmacology (1st edition, 2010)
[Collection New Homeopathic Medicines: Vo-
lume I].
• II - Matéria médica homeopática dos fármacos
modernos (1ª edição, 2010) [Coleção Novos
Medicamentos Homeopáticos: Volume II].
• II - Homeopathic materia medica of modern
drugs (1st edition, 2010) [Collection New Ho-
meopathic Medicines: Volume II].
• III - Repertório homeopático dos fármacos
modernos (1a edição, 2010) [Coleção Novos
Medicamentos Homeopáticos: Volume III].
• III - Homeopathic repertory of modern drugs
(1st edition, 2010) [Collection New Homeo-
pathic Medicines: Volume III].
Edición 2021
• I - Fundamentação cientíca do princípio
da similitude na farmacologia Imoderna (2ª
edição, 2021) [Coleção Novos Medicamentos
Homeopáticos: Volume I].
• I - Scientic basis of the principle of similitude in
modern pharmacology (2nd edition, 2021) [Co-
llection New Homeopathic Medicines: Volume I].
• II - Matéria médica homeopática dos fármacos
modernos (2ª edição, 2021) [Coleção Novos
Medicamentos Homeopáticos: Volume II].
• II - Homeopathic materia medica of modern
drugs (2nd edition, 2021) [Collection New
Homeopathic Medicines: Volume II].
• III - Repertório homeopático dos fármacos
modernos (2ª edição, 2021) [Coleção Novos
Medicamentos Homeopáticos: Volume III].
• III - Homeopathic repertory of modern drugs
(2nd edition, 2021) [Collection New Homeo-
pathic Medicines: Volume III].
Buscando ampliar las posibilidades de lectu-
ra y búsqueda en la base de datos, los seis libros de
la segunda edición (2021) también se publicaron en
2 series (portugués / inglés) de 3 libros electrónicos
Kindle (Amazon):
• Series “Novos Medicamentos Homeopáticos:
uso dos fármacos modernos segundo o princí-
pio da similitude” (portugués).
• Series “New Homeopathic Medicines: use of
modern drugs according to the principle of simi-
litude” (inglés).
38 LA HOMEOPATÍA DE MÉXICO. Volumen 91, número 730, julio - septiembre 2022, p.36-38.
Marcus Zulian Teixeira
Con la disponibilidad actual de los libros en
formato digital, esperamos que el método pueda ser
difundido, conocido y ampliamente aplicado por la
clase homeopática, con la participación de los clíni-
cos en la aplicación terapéutica y en la descripción de
los resultados (casos clínicos), de los farmacéuticos
en la producción de los medicamentos dinamizados y
de los investigadores en la elaboración de protocolos
de investigación.
REFERENCIAS
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cionalidade médica e cientíca [Similar cure similar: the principle of homeopathic cure based by medical
and scientic rationality]. São Paulo: Editorial Petrus; 1998. Disponible en:
http://www.homeozulian.med.br/mz/homeozulian_visualizarlivroautor.asp?id=3
2. Teixeira MZ. Similitude in modern pharmacology. British Homeopathic Journal. 1999; 88(3): 112-20.
Disponible en: https://doi.org/10.1054/homp.1999.0301
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2006; 95(4): 229-236. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/17015194
4. Teixeira MZ. NSAIDs, Myocardial infarction, rebound effect and similitude. Homeopathy. 2007; 96(1):
67-68. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/17227752
5. Teixeira MZ. Bronchodilators, fatal asthma, rebound effect and similitude. Homeopathy. 2007; 96(2):
135-137. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/17437943
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2009; 98(2): 114-121. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/19358965
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2010; 99(4): 255-262. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/20970095
8. Teixeira MZ. Rebound acid hypersecretion after withdrawal of gastric acid suppressing drugs: new
evidence of similitude. Homeopathy. 2011; 100(3): 148-156. Disponible en:
http://www.ncbi.nlm.nih.gov/pubmed/21784332
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of homeopathic treatment. International Journal of High Dilution Research. 2012; 11(39): 69-106. Dispo-
nible en: https://www.researchgate.net/publication/263658167_Rebound_effect_of_drugs_Fatal_risk_
of_conventional_treatment_and_pharmacological_basis_of_homeopathic_treatment
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base farmacológica para el tratamiento homeopático. La Homeopatía de México. 2012; 81(681):13-
40. Disponible en: https://www.researchgate.net/publication/263580753_El_efecto_rebote_de_las_dro-
gas_un_riesgo_fatal_para_el_tratamiento_convencional_y_una_base_farmacologica_para_el_trata-
miento_homeopatico
11. Teixeira MZ. Antiresorptive drugs (bisphosphonates), atypical fractures and rebound effect: new
evidence of similitude. Homeopathy. 2012; 101(4): 231-242. Disponible en:
http://www.ncbi.nlm.nih.gov/pubmed/23089219
12. Teixeira MZ. Immunomodulatory drugs (natalizumab), worsening of multiple sclerosis, rebound
effect and similitude. Homeopathy. 2013; 102(3): 215-224. Disponible en:
http://www.ncbi.nlm.nih.gov/pubmed/23870382
13. Teixeira MZ. Rebound effect of modern drugs: serious adverse event unknown by health professio-
nals. Revista da Associação Médica Brasileira. 2013; 59(6): 629-638. Disponible en:
https://www.scielo.br/j/ramb/a/3StmPbRxwB4BzSSV8z6xtSN/?lang=en
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logia moderna. Revista de Medicina (São Paulo). 2013; 92(3): 183-203. Disponible en:
http://www.revistas.usp.br/revistadc/article/view/79999
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effect: new evidence of similitude. Homeopathy. 2016; 105(4): 344-355. Disponible en: https://www.ncbi.
nlm.nih.gov/pubmed/27914574
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Revista de Homeopatia (São Paulo. Online). 2017; 80(1/2): 40-88. Disponible en:
https://pesquisa.bvsalud.org/portal/resource/pt/hom-11970
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de Homeopatia (São Paulo. Online). 2017; 80 (3/4): 36-81. Disponible en:
https://pesquisa.bvsalud.org/portal/resource/pt/hom-12033
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tic basis of the homeopathic healing principle. Revista da Associação Médica Brasileira. 2022; 68(3):
303-307. Disponible en: https://doi.org/10.1590/1806-9282.20211362
ResearchGate has not been able to resolve any citations for this publication.
"Similitude in Modern Pharmacology": two decades of studies contributing to the scientific basis of the homeopathic healing principle
Article
Full-text available
When Samuel Hahnemann systematized homeopathy and the effects of drugs on the state of human health, he described the primary action of drugs and the following secondary and opposite reaction of the body. Seeking to apply this secondary action or vital reaction of the body as therapeutic method, he postulated the “principle of cure by similars”, i.e. the prescription to ill individuals of drugs that cause similar symptoms in the healthy (similia similibus curentur). In modern pharmacology, this secondary action (vital reaction) of the body is known as rebound effect or paradoxical reaction. It has been observed after discontinuation of several classes of palliative drugs, namely those that act according to the “principle of cure by contraries” (contraria contrariis curentur). Since 1998, we have been bridging the gap between homeopathic and conventional pharmacology through the systematic study of rebound effect of modern drugs, scientifically confirming the homeopathic postulate (primary action of the drug followed by secondary and opposite reaction of the body) and the homeopathic healing principle. Following the homeopathic premises, conventional drugs can be employed according to the principle of therapeutic similitude provided they cause primary symptoms (therapeutic, adverse and side effects) similar to the symptomatic manifestations of sick individuals. Since 2003, we are proposing the use of the rebound effect of modern drugs in a curative manner, administering to patients, in ultra-diluted doses, drugs that cause a set of similar adverse events. Since 2021, these two decades of studies are made available in three free-access digital books.
Scientific basis of the homeopathic healing principle in modern pharmacology (Special Dossier: "Scientific Evidence for Homeopathy" - Revista de Homeopatia, São Paulo Homeopathic Medical Association, APH - Online Edition)
Article
Full-text available
  • Oct 2017
Introduction: Homeopathy employs the so-called ‘principle of similars’ as therapeutic method, which consists in administering medicines that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curantur)to arouse a secondary and healing reaction by the body against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the body is based on the ‘rebound effect’ of modern drugs, a type of adverse event that occurs following discontinuation of several classes of drugs prescribed according to the ‘principle of contraries’ (contraria contrariis curantur). Aim: The present review sought to scientifically substantiate the homeopathic healing principle vis-à-vis experimental and clinical pharmacology through a systematic study of the rebound effect of modern drugs or paradoxical reaction of the body. Methods: Employing as reference the studies and revisions on the subject that we have published since 1998, we updated the data adding recent studies cited in database PubMed. Results: The rebound effect occurs after discontinuation of several classes of drugs with contrary action to the symptoms of diseases, exacerbating them to levels above the ones present before treatment. Regardless of disease, drug, dose and duration of treatment, the rebound phenomenon manifests in a small proportion of susceptible individuals. Following the homeopathic premises, modern drugs might also be used according to the principle of therapeutic similitude, thus employing the rebound effect (paradoxical reaction) in a curative manner. Conclusions: Evidenced in hundreds of studies that attest to the similarity of concepts and manifestations, the rebound effect of modern drugs scientifically substantiates the principle of homeopathic cure. Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is not known by healthcare professionals, thus depriving doctors of knowledge indispensable for a safe management of drugs.
Semelhante cura semelhante: o princípio de cura homeopático fundamentado pela racionalidade médica e científica [Similar cure similar: the principle of homeopathic cure based by medical and scientific rationality]
Book
Full-text available
  • Jul 2015
Apesar da secular eficácia terapêutica da homeopatia, fator imprescindível na manutenção deste método de tratamento até os dias atuais, o meio acadêmico e científico exige comprovações segundo os seus parâmetros de pesquisa e avaliação. Essa é sempre a tônica das discussões entre homeopatas e 'alopatas', pois esses dois métodos de tratamento estão fundamentados em paradigmas opostos, possuindo metodologias distintas e divergindo sobre inúmeros fatores: verificação dos poderes curativos das drogas utilizando a experimentação em indivíduos humanos sadios ou em doentes (animais); valorização de aspectos psíquicos, emocionais e gerais nessas experimentações; escolha do medicamento através dos princípios da semelhança ou dos contrários; utilização de doses infinitesimais ou ponderais; administração de medicamentos únicos ou combinados, etc. Essa obra foi idealizada na tentativa de aproximar o modelo homeopático à racionalidade médica atual, buscando nas publicações e pesquisas científicas modernas o substrato para fundamentar os principais conceitos da homeopatia, em especial, o princípio terapêutico pela similitude. Em diversas áreas do conhecimento humano, da física à fisiologia humana, assim como em centenas de medicamentos empregados pela farmacologia clássica, encontramos a confirmação dos pressupostos homeopáticos, semelhantemente ao citado por Hahnemann há mais de dois séculos. Buscando a aproximação científica da medicina homeopática com a medicina convencional, esperamos num futuro próximo poder participar conjuntamente na formação de uma Medicina única, na qual o benefício ao paciente esteja acima de qualquer outro objetivo. Principais tópicos O método de cura homeopático reiterado pelo conhecimento científico moderno. O princípio terapêutico homeopático observado na história da medicina. Relatos de curas homeopáticas por médicos de todas as épocas. Estudo minucioso dos pilares fundamentais da homeopatia: lei dos semelhantes e experimentação no homem são. O princípio da similitude segundo a racionalidade científica dos séculos XVI a XIX: lei dos semelhantes como lei natural. O princípio da semelhança evidenciado em outras áreas do conhecimento humano (física, psicoterapia). Conceitos homeopáticos abordados segundo os fundamentos da fisiologia moderna. O mecanismo de ação das drogas homeopáticas evidenciado pela farmacologia clínica e experimental: fundamentação dos preceitos homeopáticos na observação dos efeitos secundários de centenas de fármacos modernos. Sugestões de pesquisa homeopática com drogas convencionais. Available at: http://homeozulian.med.br/homeozulian_visualizarlivroautor.asp?id=3
Rebound effect of drugs: Fatal risk of conventional treatment and pharmacological basis of homeopathic treatment
Article
Full-text available
  • Jul 2012
The homeopathic model applies the secondary action or vital reaction of the organism as a therapeutic method and thus prescribes treatment by similitude, which consists in administering to ill individuals substances that cause similar symptoms in healthy individuals. The vital, homeostatic or paradoxical reaction of the organism might be explained scientifically by means of the rebound effect of modern drugs, which might cause fatal iatrogenic events after discontinuation of antipathic (a term used in alternative medicine for palliative treatment, also known as enantiopathic) treatment. Although the rebound effect is studied by modern pharmacology, it is poorly communicated to and discussed among healthcare professionals, who are thus deprived of information needed for the safe management of modern drugs. This article presents an up-to-date review on the rebound effect of modern drugs that grounds the homeopathic principle of healing and calls the attention of doctors to this type of adverse effect that is usually unnoticed. The rebound effect of modern palliative drugs, which was pointed out by Hahnemann more than two centuries ago, might cause fatal adverse events and is illustrated by the examples of acetylsalicylic acid, anti-inflammatory agents, bronchodilators, antidepressants, statins, proton-pump inhibitors, etc. Although the rebound effect is expressed by a small fraction of (susceptible) individuals and might be avoided by gradual tapering of antipathic drugs, it exhibits epidemiologic importance as a function of the massive use of such palliative drugs and the lack of knowledge in its regard.
El efecto rebote de las drogas: un riesgo fatal para el tratamiento convencional y una base farmacológica para el tratamiento homeopático
Article
Full-text available
  • Oct 2012
El modelo homeopático considera la acción secundaria o la reacción vital del organismo como un método terapéutico y, por lo tanto prescribe tratamientos por el principio de similitud; éste consiste en administrar a los individuas enfermos sustancias que han causado síntomas similares en individuas sanas. La reacción vital homeostática o paradójica de un organismo puede ser explicada científicamente en base al efecto de rebate de los medicamentos modernos, el cual puede causar eventos iatrogénicos fatales posteriores a la suspensión de un tratamiento antipático (un término utilizado en medicina alternativa para el tratamiento paliativo, también conocido como enantiopático). Aunque el efecto de rebate ha sido estudiado por la farmacología moderna, este ha sido poco difundido y discutido entre los profesionales de la salud, quienes en muchas ocasiones han sido privados de información crucial necesaria para el manejo seguro de los medicamentos actuales. En este artículo se presenta una revisión actual sobre el efecto de rebate de los medicamentos modernos que fundamentan el principio homeopático de curación y alerta a los médicos sobre este tipo de efecto adverso que usualmente no se notifica. EI efecto de rebate de los medicamentos modernos paliativos fue señalado por Hahnemann hace más de dos siglas, mencionando que éste puede causar efectos adversos fatales, los cuales pueden ser evidenciados como en el caso del ácido acetilsalicílico, los agentes antiinflamatorios, antidepresivos, broncodilatadores, las estatinas, los inhibidores de la bomba de protones, etc. Aunque el efecto de rebate solamente se presenta en una pequeña fracción de individuas (susceptibles) y puede ser evitado mediante una disminución gradual de los medicamentos antipáticos, este ha de mostrado una importancia epidemiológica significativa como resultado del uso masivo de tales drogas paliativas y la falta de conocimiento a este respecto.
Similia similibus curentur: o princípio de cura homeopático fundamentado na farmacologia moderna [Similia similibus curentur: the homeopathic healing principle based on modern pharmacology]
Article
Full-text available
  • Sep 2013
The homeopathic model of treatment of diseases uses the ‘principle of similarity’ as therapeutic method, employing drugs that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curentur), seeking to stimulate a healing reaction of the organism against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the organism is based on the study of the ‘rebound effect’ of modern drugs, iatrogenic event that can cause serious disorders after the discontinuation of several classes of conventional treatments that use the ‘principle of contraries’ as therapeutic practice (contraria contrariis curentur). Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is unknown by health professionals, depriving the medical class of a necessary and fundamental knowledge to the safe management of drugs. Despite expressing itself in a small proportion of susceptible individuals, the rebound effect assumes epidemiological importance in view of the enormous consumption of drugs by the population and the lack of clarity on the phenomenon. This article presents an updated review on the rebound effect of drugs, relating it to the homeopathic healing principle. RESUMO: O modelo homeopático de tratamento das doenças utiliza o ‘princípio da semelhança’ como método terapêutico, empregando medicamentos que causam determinados sintomas em indivíduos sadios para tratar sintomas semelhantes em indivíduos doentes (similia similibus curentur), com o intuito de estimular uma reação curativa do organismo contra os seus próprios distúrbios. Esta reação secundária (vital, homeostática ou paradoxal) do organismo está fundamentada no estudo do ‘efeito rebote’ dos fármacos modernos, evento adverso que pode causar transtornos graves após a descontinuação de diversas classes de tratamentos convencionais que utilizam o ‘princípio dos contrários’ como prática terapêutica (contraria contrariis curentur). Embora o fenômeno rebote seja um evento adverso estudado pela farmacologia moderna, ele é desconhecido pelos profissionais da saúde, privando a classe médica de um conhecimento necessário e fundamental ao manejo seguro dos fármacos. Apesar de se expressar numa pequena proporção de indivíduos suscetíveis, o efeito rebote assume importância epidemiológica em vista do enorme consumo de medicamentos pela população e da falta de esclarecimentos sobre o fenômeno. Este artigo apresenta uma revisão atualizada sobre o efeito rebote das drogas, relacionando-o ao princípio de cura homeopático.
Rebound effect of modern drugs: serious adverse event unknown by health professionals
Article
Full-text available
  • Nov 2013
Supported in the Hippocratic aphorism primum non nocere, the bioethical principle of non-maleficence pray that the medical act cause the least damage or injury to the health of the patient, leaving it to the doctor to assess the risks of a particular therapy through knowledge of possible adverse events of drugs. Among these, the rebound effect represents a common side effect to numerous classes of modern drugs, may cause serious and fatal disorders in patients. This review aims to clarify the health professionals on clinical and epidemiological aspects of rebound phenomenon. A qualitative, exploratory and bibliographic review was held in the PubMed database using the keywords 'rebound', 'withdrawal', 'paradoxical', 'acetylsalicylic acid', 'anti-inflammatory', 'bronchodilator', 'antidepressant', 'statin', 'proton pump inhibitor' and 'bisphosphonate'. The rebound effect occurs after discontinuation of numerous classes of drugs that act contrary to the disease disorders, exacerbating them at levels above those prior to treatment. Regardless of the disease, the drug and duration of treatment, the phenomenon manifests itself in a small proportion of susceptible individuals. However, it may cause serious and fatal adverse events should be considered a public health problem in view of the enormous consumption of drugs by population. Bringing together a growing and unquestionable body of evidence, the physician needs to have knowledge of the consequences of the rebound effect and how to minimize it, increasing safety in the management of modern drugs. On the other hand, this rebound can be used in a curative way, broadening the spectrum of the modern therapeutics. http://ramb.elsevier.es/pt/linkresolver/efeito-rebote-dos-farmacos-modernos/90259384/
Biological therapies (immunomodulatory drugs), worsening of psoriasis and rebound effect: new evidence of similitude
Article
Background: Employing the secondary action or adaptative reaction of the organism as therapeutic response, homeopathy uses the treatment by similitude (similia similibus curentur) administering to sick individuals the medicines that caused similar symptoms in healthy individuals. Such homeostatic or paradoxical reaction of the organism is scientifically explained through the rebound effect of drugs, which cause worsening of symptoms after withdrawal of several palliative treatments. Despite promoting an improvement in psoriasis at the beginning of the treatment, modern biological therapies provoke worsening of the psoriasis (rebound psoriasis) after discontinuation of drugs. Method: Exploratory qualitative review of the literature on the occurrence of the rebound effect with the use of immunomodulatory drugs [T-cell modulating agents and tumor necrosis factor (TNF) inhibitors drugs] in the treatment of psoriasis. Results: Several researches indicate the rebound effect as the mechanism of worsening of psoriasis with the use of efalizumab causing the suspension of its marketing authorization in 2009, in view of some severe cases. Other studies also have demonstrated the occurrence of rebound psoriasis with the use of alefacept, etanercept and infliximab. Conclusion: As well as studied in other classes of drugs, the rebound effect of biologic agents supports the principle of similitude (primary action of the drugs followed by secondary action and opposite of the organism).
Immunomodulatory drugs (natalizumab), worsening of multiple sclerosis, rebound effect and similitude
Article
Homeopathic treatment is based on the principle of similitude ('like cures like') administering to sick individuals substances that cause similar symptoms in healthy individuals, employing the paradoxical or biphasic action of the organism as therapeutic response. This homeostatic, vital or secondary action of the organism is scientifically explained by the rebound effect of drugs, resulting in worsening of symptoms after enantiopathic treatment withdrawal. Natalizumab reduces relapses in patients with active multiple sclerosis (MS), but recent studies report severe worsening of MS after suspension of treatment, as a consequence of the rebound effect. Extending this source of evidence, this work reviews research that demonstrates secondary worsening of MS after discontinuation of natalizumab, a human monoclonal antibody that suppresses the disease inflammatory activity as primary action. Several studies refer to the immune reconstitution inflammatory syndrome (IRIS) as a plausible explanation of reactivation of MS after withdrawal of natalizumab: a rebound effect or secondary action of the organism in response to the primary immunosuppression caused by the drug. Relapses of MS after discontinuation of natalizumab treatment indicate rebound of disease activity, supporting the homeopathic principle and warning healthcare professionals about this serious iatrogenic event.
Antiresorptive drugs (bisphosphonates), atypical fractures and rebound effect: New evidence of similitude
Article
Homeopathy is based on treatment by similitude ('like cures like') administering to sick individuals substances that cause similar symptoms in healthy individuals, employing the secondary and paradoxical action of the organism as therapeutic response. This vital or homeostatic reaction of the organism can be scientifically explained by the rebound effect of drugs, resulting in worsening of symptoms after suspension of treatment. Bisphosphonates (BPs) reduce 'typical' fractures in patients with osteoporosis, but recent studies report 'atypical' fractures of the femur after stopping the BPs, a rebound effect may be the causal mechanism. Review of the literature concerning the relationship between atypical femoral fractures and antiresorptive drugs (bisphosphonates), identifying the pathogenesis of this adverse event. Several studies have described multiple cases of 'atypical' low-impact subtrochanteric stress fractures or complete fractures of the femur. These fractures are often bilateral, preceded by pain in the affected thigh, may have a typical X-ray appearance, and may delayed healing. Rebound of osteoclastic activity after suspension of antiresorptive drugs is a plausible mechanism to explain this phenomenon. As for other classes of drugs, the rebound effect of antiresorptive drugs supports Hahnemann's similitude principle (primary action of the drugs followed by secondary and opposite action of the organism), and clarifies this 'unresolved' issue. Unfortunately, the rebound effect is little discussed among health professionals, depriving them of important knowledge ensure safe management of drugs.