Currently, there is an urgent need for developing cutting-edge port infrastructure monitoring solutions which exploit different multi-modal data towards timely optimal port management strategies and decision making. In fact, advanced monitoring applications allow for optimizing maintenance, rehabilitation and upgrade actions by assessing structural integrity of port structures which is affected by a vast variety of stressors such as aging, imposed loads, inadequate maintenance treatments, human-induced factors, natural hazards and the ever-changing climate. To this end, the purpose of this research is to enhance Remote Sensing (RS) port monitoring practices by investigating the potential of combining different types of RS methods to record and assess infrastructure condition. Therefore, two RS type of data: a) satellite imagery and b) aerial imagery from Unmanned Aerial Vehicle (UAV), were considered for structural monitoring at a Greek port, namely Lavrio port, located at northeastern Attica, Greece. In particular, the applied monitoring program was focused on its windward rubble mound structure where temporal changes in the armour layer were detected. Significant parameters regarding spatial resolution and UAV flight characteristics were further investigated aiming at ensuring high quality data. The overall research indicated that RS synergies were proved to be a promising practice for acquiring advanced spatial and temporal information of port infrastructure condition.