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Abstract

Our Company is collaborating with Cutia Therapeutics based in Shanghai, China, a pharmaceutical Company. Like in Europe an anti-hair-loss serum or hair growth serum is on the border of a cosmetic product and a medication. To see if our product fits for the Chinese market they performed 2 studies. One performed by a third party and one on own employees or their family. In the pdf you can find the results. 100% satisfaction and 55% decrease of hair loss on mild alopecia androgenetica. Also, density and hair thickness improved. The scalp environment improved as well. In the pictures you will see the results both on top of the head as well as at the hairline temples. I’m proud that all my claims about my formula are confirmed.
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Function tests
©Cutia Therapeutics
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Test 1
Performed by a third party
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TEST 1-STUDY DESIGN
Purpose: Testing the efficacy of continuous use of Esthecin®for 6 months
Enrollment: 26 participants and 22 completed the test
Outcome Measures:
Evaluate the change in hair loss count and hair density
Evaluate the change in hair diameter
Evaluate the change in receding hairline
Evaluate the effect of scalp moisturizing and oil control
CRITERIA
Inclusion Criteria:
18~60 years old, Male and Female (M:F=1:2)
Have mild to moderate alopecia (M0-M2, C0-C2, F1-F2, V1-V2)
In good general health, Willing and able to attend all study visits
Hair loss count is greater than 10 (as 60 times comb method) and still greater than 10 after 2 weeks of washing
Exclusion Criteria:
Pregnancy and lactating women
Patients with severe androgenic alopecia, alopecia areata, inflammatory scar alopecia or other scalp / hair diseases
Presence of major mental or psychological diseases
Perm and dye the hair within 1 month
Use of any products (prescription, OTC or natural health products) or devices reported and used to promote scalp hair growth (e.g.,
finasteride or minoxidil, L-Tyrosine) within 6 months prior to the Baseline Visit
Reference:
1. Safety and Technical Standards for Cosmetics in China(2015) _Chapter 8 Evaluation & Test method about Human Efficacy _Efficacy test method of anti-hair loss cosmetic product.
2.Effect of a new topical treatment on androgenetic and telogen hair loss in womenJ.C. van Montfort, MD, Van Montfort Laboratories BV, Brightlands Maastricht Health Campus, Maastricht.
Report from How-to science & technology (shanghai) co ltd
Note: The 2nd treatment course was affected by the COVID in Shanghai in 2022H1, including the follow-up visit of W22 W26 was missing, and the test of W26 was postponed to W31.
Esthecin®2 times/week/tubeN=26
Screening &
Enrollment Follow-up Visit & Data collection
W0 W31
W9 W13
W4 W17 W22
-W2
(N=22)
W28
Participants
Cutia
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Vs. baseline (W0), significantly reduced the hair loss count, the reduction rate reached to 31% in
the 1st treatment course and up to 55% by W31.(p<0.001)
W0 W4 W9 W13 W17 W31
AVG # of hair loss count 29 18 20 20 16 13
Redu cti on % vs. b asel i ne 38% 31% 31% 45% 55%
0%
10%
20%
30%
40%
50%
60%
0
5
10
15
20
25
30
35
W0 W4 W9 W13 W17 W31
AVG hair!density
(n/cm2) 139 145 145 143 147 132
Increase % vs. baseline 4,3% 4,7% 2,8% 4,9% -4,8%
-6%
-4%
-2%
0%
2%
4%
6%
120
125
130
135
140
145
150
Hair Loss Count Hair Density
Vs. baseline (W0), increased the hair density, the increase rate was about 2.8% ~ 4.7% in
the 1st treatment course. (p<0.05
Hair Diameter
W0 W4 W9 W13 W17 W31
Hair Diameter 9,85 10,27 10,36 10,21 10,67 9,53
Increase % vs. baseline 4,3% 5,2% 3,7% 8,3% -3,2%
-4%
-2%
0%
2%
4%
6%
8%
10%
8,8
9
9,2
9,4
9,6
9,8
10
10,2
10,4
10,6
10,8
Vs. baseline (W0), increased the hair diameter, the increase rate was about 3.7% ~ 5.2%in the
1st treatment course. (p<0.01
Improvement -CRF 014
Density & diameter -CRF 011
TEST 1-OUTCOMES (1)
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Receding Hairline
W4 W9 W13 W17 W31
a - shorten % vs. baseline 1,5% 3,0% 3,0% 4,4% 6,0%
b - shorten % vs . baseline 1,1% 1,1% 2,2% 4,3% 4,4%
0,0%
1,0%
2,0%
3,0%
4,0%
5,0%
6,0%
7,0%
AVG of the di stance to the front a l hair line
(N=22)
Week W0 W4 W9 W13 W17 W31
a(cm) 6.7 6.6 6.5 6.5 6.5 6.3
b (cm) 9.1 9.0 9.0 8.9 9.0 8.7
-0.4cm
-0.4cm
Scalp Environment
W4 W9 W13 W17 W31
Oil decrease % vs.
baseline -12,9% -4,3% 15,3% 29,6% 60,7%
Water increase % vs.
baseline 1,4% 1,4% 17,1% -7 ,2% 97,1%
-20,0 %
0,0%
20,0%
40,0%
60,0%
80,0%
100,0%
Shorten the distance to the frontal hairline by 4mm after using Esthecin for 6 month.
a
b
Vs. baseline (W0), showed the trend of improving scalp environment,
decreased oil content and increase water content of scalp. (the last data of
W31 was excluded as an outlier)
AVG of scalp oil and water content (N=22)
Week W0 W4 W9 W13 W17 W31
Oil content 163 184 170 138 107 64
Water
content 70 71 71 82 64 138
Use-feeling feedback from the subjects questionnaires: 100% of subjects liked the product, and all claims were supported.
TEST 1-OUTCOMES (2)
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Test 2
Performed with Cuta Therapeutics employees or family members
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Purpose: Use testing of continuous use of Esthecin ® for 3 months
Screening & Enrollment: Screening 44 Users and 40 users (male 19; Female 21) completed this trial
Inclusion Criteria:
Male or Female with mild to moderate alopecia (From Cutia employees or family members)
Good health, no basic diseases
No alopecia treatment in half a year
Data collection by: pictures and questionariesW0/W4/W8/W12
Screening &
Enrollment Follow-up Visit & Data collection
W0 W12
W4 W8
Esthecin ® 2times /week /tubeN=44
User
Tester
TEST 2-STUDY DESIGN
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Bef
ore
Aft
er
Bef
ore
Aft
er
Bef
ore
Af
ter
Bef
ore
Aft
er
Bef
ore
Aft
er
Bef
ore
Aft
er
Top of
the
head
templesHairline
Showed effect of improving hair loss started from week 4 to week 12 after using Esthecin,
mainly from the comparison of 3 areas as below pictures.
Use-feeling Feedback: 82.5% users recommend
27%
45,45%
Easy to
use
72%
20,45%
52,27%
Easy to
absorb
73%
52,27%
45%
Geniality, not
stimulating
97%
27,27%
39%
Moisture &
comfortable
66%
Hair not
greasy
68%
36%
34%
Refreshing
scalp
70%
82.5%
Effect FeedbackImprove Hair Loss
TEST 2-OUTCOMES
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Efficacy: It has a practical effect on hair growth, hair quality improvement and scalp
environment
Feeling: easy to use, fresh, not greasy, easy to absorb, and 82.5% users recommended
Mild: no irritation and no adverse reactions, only itching may existing
From the test of Efficacy From product-use Feeling
Effectively improve hair loss, improve hair volume
Say goodbye to the "light forehead" and shorten the hairline by 4mm
Adjust the scalp environment, control oil and increase water
Mild, feel at ease and no side effects
Recommended by 82.5% of Testers
Anti-hair loss plus improve hair volume, multi-effect integration
Convenient and comfortable, easy to use
Safe and mild, low discomfort
CONCLUSION OF TWO FUNCTION TESTS
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