Article

Investigation of the pharmaceutical warehouse locations under COVID-19—A case study for Duzce, Turkey

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Abstract

Pharmaceutical warehouses are among the centers that play a critical role in the delivery of medicines from the producers to the consumers. Especially with the new drugs and vaccines added during the pandemic period to the supply chain, the importance of the regions they are located in has increased critically. Since the selection of pharmaceutical warehouse location is a strategic decision, it should be handled in detail and a comprehensive analysis should be made for the location selection process. Considering all these, in this study, a real-case application by taking the problem of selecting the best location for a pharmaceutical warehouse is carried out for a city that can be seen as critical in drug distribution in Turkey. For this aim, two effective multi-criteria decision-making (MCDM) methodologies, namely Analytic Hierarchy Process (AHP) and Evaluation based on Distance from Average Solution (EDAS), are integrated under spherical fuzzy environment to reflect fuzziness and indeterminacy better in the decision-making process and the pharmaceutical warehouse location selection problem is discussed by the proposed fuzzy integrated methodology for the first time. Finally, the best region is found for the pharmaceutical warehouse and the results are discussed under the determined criteria. A detailed robustness analysis is also conducted to measure the validity, sensibility and effectiveness of the proposed methodology. With this study, it can be claimed that literature has initiated to be revealed for the pharmaceutical warehouse location problem and a guide has been put forward for those who are willing to study this area.

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... Erdoganand Ayyildiz [14] suggested pharmaceutical warehouses were critical for delivering medicines, particularly during a pandemic. Choosing the optimum site for a pharmaceutical warehouse requires careful consideration. ...
... The proposed solution involves the introduction of a mathematical model and algorithm that optimize the location of rescue facilities and the zoning of territories to manage evacuation traffic effectively. The study [9] investigates the best location for a pharmaceutical warehouse in one of the major Turkish cities using the analytic hierarchy process and EDAS method, which evaluate locations around an average solution within a spherical fuzzy environment. This unique approach is applied for the first time to this problem. ...
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... Employing diverse validation analyses is a favorable approach to evidencing the robustness of an MCDM technique. These analyses offer insights into parameter and approach variations on the solution (Erdogan and Ayyildiz, 2022). For this purpose, a twophase validation analysis is employed. ...
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Agriculture 4.0 is the usage of advanced technologies for ensuring sustainability and efficient use of resources in agriculture, which can be accepted one of the biggest challenges of mankind. With Agriculture 4.0 technologies, it is aimed to raise productivity, reduce waste and costs. To ensure that agriculture 4.0 technologies are adopted by farmers as soon as possible, the perspective and perception of farmers to these technologies should be analyzed firstly. For this purpose, we propose a decision-making framework to measure farmers' view of Agriculture 4.0 technologies and to perform a prioritization study based on the perception of use among these technologies. Multicriteria decision analysis is also utilized to deal with all qualitative and quantitative factors in the decision process. Within the scope of this study, interval-valued spherical fuzzy numbers are used to model the vagueness in the process in the best manner and to be able to reflect the uncertainty arising from the usage of linguistic variables in the decision process. The SWARA and MAIRCA multicriteria decision making (MCDM) methods, which have been used frequently in the literature and are applied very successfully in MCDM problems, have been firstly extended by spherical fuzzy sets (SFSs) and the advantages for these methods have been utilized within the framework of fuzzy logic. The proposed method allows decision-makers to mirror their hesitations in decision-making using a linguistic evaluation scale established upon interval-valued SFSs. A comparative analysis based on the ordinary fuzzy sets is also performed for the obtained results and the clear superiority of the proposed approach is presented. In addition, the robustness of the model is tested with sensitivity analysis. After these analyzes it is obtained that this paper provides a unique perspective to the literature due to its originality in both the subject and adopted fuzzy methodology.
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Internal audit is an independent and objective assurance and consulting activity that aims to improve the operations of an organization and add value to them. Planning internal audit by prioritizing the units to be audit is critical in terms of effective use of available audit and financial resources. In this paper, a new ELimination and Choice Translating Reality (ELECTRE) based decision support model is developed for addressing an internal audit prioritization problem. Spherical fuzzy sets are used for modeling the uncertainty in the nature of the problem and three different approaches are proposed within the study. The first approach is constructed with gradual concordance and discordance sets by comparing spherical fuzzy membership, non-membership, and hesitancy degrees of alternatives; the second approach is developed based on a single type of outranking relation obtained by utilizing score and accuracy functions of spherical fuzzy sets, and the third approach provides an increased fuzziness modeling capacity by using interval-valued spherical fuzzy sets. In the application part of the study, the units of an organization are prioritized for internal audit activity based on five components of the internationally recognized Committee of Sponsoring Organizations (COSO) framework. Sensitivity analyses for decision-maker and criterion weights and a comparative analysis with six other state-of-the-art multi-criteria decision making (MCDM) models are also presented to analyze the consistency and validity of the proposed spherical fuzzy ELECTRE model.
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A dangerous infectious disease of the current century, the COVID-19 has apparently originated in a city in China and turned into a widespread pandemic within a short time. In this paper, a novel method has been presented for improving the screening and classification of COVID-19 patients based on their chest X-Ray (CXR) images. This method eliminates the severe dependence of the deep learning models on large datasets and the deep features extracted from them. In this approach, we have not only resolved the data limitation problem by combining the traditional data augmentation techniques with the generative adversarial networks (GANs), but also have enabled a deeper extraction of features by applying different filter banks such as the Sobel, Laplacian of Gaussian (LoG) and the Gabor filters. To verify the satisfactory performance of the proposed approach, it was applied on several deep transfer models and the results in each step were compared with each other. For training the entire models, we used 4560 CXR images of various patients with the viral, bacterial, fungal, and other diseases; 360 of these images are in the COVID-19 category and the rest belong to the non-COVID-19 diseases. According to the results, the Gabor filter bank achieves the highest growth in the values of the defined evaluation criteria and in just 45 epochs, it is able to elevate the accuracy by up to 32%. We then applied the proposed model on the DenseNet-201 model and compared its performance in terms of the detection accuracy with the performances of 10 existing COVID-19 detection techniques. Our approach was able to achieve an accuracy of 98.5% in the two-class classification procedure; which makes it a state-of-the-art method for detecting the COVID-19.
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Blockchain technology (BT), which provides to record transactions among many computers as a distributed ledger, is commonly utilized by companies to develop and manage business processes. Since it is a multi-process and multi-agent complex system, the implementation process of BT contains many risk factors. Identifying and analyzing these risks in order to minimize their adverse effects during the implementation process is also completely critical for companies. Since evaluating these risks must be handled by considering many different perspectives, the evaluation of risk factors for BT can be considered as a multi-criteria decision-making (MCDM) problem. To cope with uncertainty in this process, the fuzzy set theory (FST) can be effectively utilized with MCDM methods to increase their ability to obtain more concrete and realistic results. Therefore, this paper proposes an MCDM methodology consisting of Decision-Making Trail and Evaluating Laboratory (DEMATEL) and cognitive mapping methods based on FST. These methods have been reconstructed with hesitant fuzzy Z-numbers that enable not only to state impreciseness of the assessments but also to consider indeterminacy and hesitancy of the experts to evaluate risk factors with respect to BT implementation. While the dependencies of risk factors have been determined via the hesitant fuzzy Z-DEMATEL method, their weights have been obtained through the hesitant fuzzy Z-cognitive mapping method. As a result, this study aims to prioritize risk factors related to the BT implementation process with a novel fuzzy decision-making methodology and provide a road map for companies. With this study, which is the first paper in the literature in terms of the subject of the study and the method adopted, an integrated, comprehensive fuzzy approach is introduced for the first time in evaluating BT risks. As a result of detailed research, risk factors that companies may encounter in BT use and the degree of their importance have been determined. Through that, essential decision analysis has been put forward that companies can apply for their strategic decisions. A sensitivity analysis based on changes in the initial vector values has also been adapted to analyze the effects of the risk factors.
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The spherical fuzzy set (SFS), as a generalization of Picture fuzzy set, can express and process uncertainty much better. In this article, we first reveal the comparison issues in spherical fuzzy setting and then formulate a novel score function to remedy the drawbacks of the existing score functions. Some of its interesting properties have also been verified in detail. Next, we research two novel spherical fuzzy operations, i.e., subtraction and division operations, and their relevant characteristics. Further, based on the proposed score function, a formula for the conversion process of decision-makers weight information from the spherical fuzzy form to classical form is formulated. In addition, criteria importance through intercriteria correlation model is extended to the spherical fuzzy environment to tackle the situation where the criteria weight information is completely unknown. Following this, measurement of alternatives and ranking according to the compromise solution method is built under the background of SFSs. After that, an illustrative example of smartphone selection problem is considered to show the implication and supremacy of the presented study. Meanwhile, sensitivity analysis, a validity test and a detailed comparison are carried out to evaluate the supremacy and the validity of the created method.
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Autonomous vehicle driving systems (AVDSs) have independent decision structures from the users to manage and control the operations of the vehicles both in normal conditions and unexpected situations. Although there are some advantages, such as decreasing accidents reasoned by human errors and efficient energy usage, it is obvious that some risks are rooted in this technology usage. Therefore, it will be beneficial to realize a risk assessment application for autonomous vehicles (AVs) and/or driving systems (DSs) since whose risks are crucial to test and solve. In this paper, a multi-criteria decision making (MCDM) methodology integrating DEcision MAking Trial and Evaluation Laboratory (DEMATEL), Analytical Network Process (ANP), and VlseKriterijuska Optimizacija I Komoromisno Resenje (VIKOR) techniques under spherical fuzzy environment have been suggested to evaluate AVDS alternatives in terms of considered risk criteria. Spherical fuzzy sets (SFS), which are the extension of the ordinary fuzzy sets, have been used to consider the hesitancy of experts and decision-makers as well as uncertainty and impreciseness in the available data. In the application, six AVDS alternatives have been evaluated in terms of seven main criteria and forty sub-criteria. The factors “Software Specifications” and “Reliability” have been determined as the most important main and sub-criteria with the weights 0.193 and 0.066, respectively. Additionally, comparative and sensitivity analyses have been applied to present flexibility, validation and verification of the proposed methodology together with the sensitivity of the given decisions. Based on the application results and conducted analyses, possible implications by views of theoretical, managerial, and policy context have been discussed.
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Many studies have used different financial ratios for financial accounting fraud detection. This study focuses on multi criteria decision-making (MCDM) for ranking financial ratios in detecting financial accounting fraud using interval-valued spherical fuzzy sets (IVSFS) and single-valued spherical fuzzy sets (SVSFS) to overcome uncertainties in decision-making process of financial analysts. This study proposes an integrated Analytic Hierarchy Process (AHP) and Multi-Objective Optimization by a Ratio Analysis plus the Full Multiplicative Form (MULTIMOORA) approach using IVSFS and SVSFS. Comparative results are obtained and discussed in prioritization of financial ratios for both IVSFS and SVSFS.
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In today’s highly competitive business market, the issue of sustainable supplier selection attracts great attention due to increased awareness of both social and environmental issues. The power of companies in the supply chain is determined not only by their own performance, but also by the power of other actors in the chain. As a field of study, the selection of sustainable suppliers remains its popularity because it requires developing a systematic procedure that addresses conflicting quantifiable and non-quantifiable factors simultaneously. In this study, one of the advanced fuzzy approaches called Spherical Fuzzy Sets (SFS) has been used to prioritize criteria that affect sustainable supplier selection. The proposed methodology combines the Spherical Fuzzy Sets and the analytic hierarchy process (AHP) and takes into account four main criteria: economic, quality, social and environmental criteria. In order to prioritize the main and sub criteria, questionnaires were conducted with three experts who have valuable experience in this field of study. After then, for the selection of the best sustainable supplier, a real selection problem in an international company was handled. The figured out ranking of the criteria and supplier alternatives can be used as a guide by the researchers and industrial experts who are responsible for sustainable supplier selection. To measure how much unit increase in weights assigned to key criteria affects supplier selection, a sensitivity analysis was carried out. It was noticed that the selection procedure for the selected company is not highly sensitive to changes.
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The membership functions of the intuitionistic fuzzy sets, Pythagorean fuzzy sets, neutrosophic sets and spherical fuzzy sets are based on three dimensions. The aim is to collect the expert’s judgments. Physicians serve patients in the physician selection problem. It is difficult to measure the service’s quality due to the variability in patients’ preferences. The patients physician preference criteria is differing and uncertainties. Thus, solving this problem with fuzzy method is more appropriate. In this study, we considered the physician selection as a multi-criteria decision-making problem. Solving this problem, we proposed a spherical fuzzy TOPSIS method. We used the five alternatives and eight criteria. The application was performed in the neurology clinics of Konya city state hospitals. In addition, we solved the same problem by the intuitionistic fuzzy TOPSIS method. We compared the solutions of two methods with each other. We found that the spherical fuzzy TOPSIS method is effective for solving the physician selection problem.
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Digitalization is the key trend of the Industry 4.0 revolution. Industrial companies are transforming the way they design and maintain their products and solutions. The user requirements become more demanding. Competition among the manufacturing companies is at its limits and transforms the products to be more complex. Yet, other challenges such as faster time to market, higher quality requirements and legislation force enterprises to provide new ways of design, manufacture and service their end products. Product Lifecycle Management (PLM) is a key solution to track the entire lifespan of the product from idea to design, design to manufacture and manufacture to service. Besides the complexity of products and production, the selection of the right PLM solution which will become the backbone of enterprises is an open problem. In this paper, a thorough literature review is conducted to analyze the most important features for selecting the right PLM solution for manufacturing firms. Moreover, to overcome the challenge of decision makers’ (DM) subjective judgments, a novel interval value spherical fuzzy COPRAS (IVSF-COPRAS) multi-criteria decision making (MCDM) method is introduced. The paper aims to help enterprises rapidly identify the best alternative vendor/solution to be selected based on the need of the organization. In order to show the applicability, DM inputs are collected from a leading defense company where the PLM selection process is ongoing. The industrial case study is provided to demonstrate the success of the proposed selection framework.
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Linguistic terms are quite suitable to make evaluations in multiple criteria decision making problems since humans prefer them rather than sharp evaluations. When linguistic evaluations are used in the decision matrix instead of exact numerical values, fuzzy set theory can capture the vagueness in the linguistic evaluations. Ordinary fuzzy sets have been extended to many new types of fuzzy sets such as intuitionistic fuzzy sets, neutrosophic sets, spherical fuzzy sets and picture fuzzy sets. Spherical fuzzy sets are an extension of picture fuzzy sets whose squared sum of their parameters is at most equal to one. This paper develops a novel spherical fuzzy CRiteria Importance Through Intercriteria Correlation (CRITIC) method and applies it for prioritizing supplier selection criteria. Supplier selection is one of the most critical aspects of any organization since any mistake in this process may cause poor supplier performance and inefficiencies in the business processes. Supplier selection is a multi-criteria decision making problem involving several conflicting criteria and alternatives. A numerical illustration of the proposed method is also given for this problem.
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In line with the increase in consciousness on sustainability in today’s global world, great emphasis has been attached to food waste management. Food waste is a complex issue to manage due to uncertainties on quality, quantity, location, and time of wastes, and it involves different decisions at many stages from seed to post-consumption. These ambiguities re-quire that some decisions should be handled in a linguistic and ambiguous environment. That forces researchers to benefit from fuzzy sets mostly utilized to deal with subjectivity that causes uncertainty. In this study, as a novel approach, the spherical fuzzy analytic hierarchy process (SFAHP) was used to select the best food treatment option. In the model, four main criteria (infrastructural, governmental, economic, and environmental) and their thirteen sub-criteria are considered. A real case is conducted to show how the proposed model can be used to assess four food waste treatment options (composting, anaerobic digestion, landfilling, and incineration). Also, a sensitivity analysis is generated to check whether the evaluations on the main criteria can change the results or not. The proposed model aims to create a subsidiary tool for decision makers in relevant companies and institutions.
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Process mining (PM) supports organizations by improving their processes using event log data collected from information technology systems. Its primary purposes are discovering actual process models, monitoring and comparing actual and desired workflows, and enhancing processes by considering the discovered model and desired flow. Because process mining gains attraction day by day, various technology companies developed process mining tools to support organizations managing their business processes with data science. Technology selection is a complicated multi-criteria decision-making (MDCM) problem under several criteria and experts’ evaluation, including uncertainty and subjectivity. Spherical fuzzy set is a powerful concept to cope with uncertainty by presenting a wider decision-making area and identifying hesitancy. A fuzzy MDCM approach based on spherical fuzzy AHP is offered in this study to manage the problem of selecting process mining technology under uncertain and ambiguous conditions. Then, one-at-a-time sensitivity analysis is applied to reduce the decision-makers’ subjectivity. This study results in that Price, Process Discovery, Process Analysis&Analytics are the most relevant criteria to decide PM technology. It is interesting that even although Operational Support is one of the less important criteria, it may change the decision on selecting the best PM technology.
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Undoubtedly, dams are one of the projects developed by people to make optimal water use and generate hydroelectric energy power. In addition to the importance of detailed project planning, faultless production, and optimal working conditions in dam constructions, it is equally important to identify and analyze the risks from the occupational health and safety (OHS) perspective that may arise during construction and operation. In this context, hazard identification, risk analysis, and control, which are the main issues of dam safety, have gained importance. In this study, a novel approach is developed for dam construction safety. Two newly proposed multi-criteria decision-making (MCDM) methods of “Best-Worst Method-BWM” and “measurement of alternatives and ranking to Compromise solution-MARCOS”, are merged under the context of interval type-2 fuzzy sets (IT2FSs). Severity and probability, two essential parameters of the risk score, have been weighted using BWM. Subsequently, the priority orders of hazards have been determined by the MARCOS. In implementing the approach to the blasting process in dam construction, several control measures are suggested for stakeholders. Some comparative works and sensitivity analyses are performed to test the approach's validity and solidity from the methodological viewpoint.
Conference Paper
Bottlenecks and wastes are prevalent issues in warehouses, particularly in the pharmaceutical industry with large stock volumes. Value stream mapping (VSM) is a powerful lean instrument to detect value-adding and process efficient feasibilities in a production chain. It has the ability to connect all the stakeholders in the chain and manage customer demand. Optimum information and material flow are needed in a pharmaceutical warehouse supply chain without backlogs to avoid the supply chain lead time build-up. In this study, a pharmaceutical warehouse has been studied by dividing it into two major segments and the VSMs for both present state and future state were drawn to find out possible feasibility of lean implementation to improve the warehouse operations. There was a 20.22 % increase in the value-added time and 23.17 % decrease in the non-value added time based on the lean proposals and assumptions in the future state. But still, more quantifiable methods are needed to dynamically visualize the proposed lean tools in the supply chain.
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The hybrid of AHP and TOPSIS has led researchers to integrate the combination with different extensions of fuzzy sets. The recently developed three-dimensional spherical fuzzy set is an extension of the fuzzy set, which is effective in handling uncertainty and quantifying expert judgements. In this paper, a novel framework is elaborated which combines AHP and TOPSIS with a spherical fuzzy set. Spherical fuzzy AHP is used to calculate the spherical fuzzy weights of the criteria, while spherical fuzzy TOPSIS is used to find the final rank of the alternatives. A new spherical fuzzy geometric mean formula is proposed for calculating the spherical fuzzy criteria weights. A new eleven-point spherical fuzzy linguistic term scale is presented, which can be used by the experts to quantify the preference. The proposed framework is applied to an advanced manufacturing system selection problem with six evaluation criteria and four alternatives. It is found that spherical fuzzy AHP-TOPSIS is effective in handling uncertainty in decision making and leads to robust and competitive results compared with state-of-the-art multi-criteria decision-making (MCDM) approaches.
Article
In this paper, we propose a novel Interval Type-2 (IT2) Fuzzy Cognitive Map (FCM)-based flight control system to solve the altitude, attitude and position control problems of quadcopters. The proposed IT2-FCM encompasses all concepts related to drone for a satisfactory path-tracking and stabilizing control performance. The degree of mutual influences of the concepts is designed with opinions of three experts that take account the dynamics of drone and rules governing proportional integral derivative (PID) controllers. To model the inter-uncertainty of the experts’ opinions, IT2 fuzzy logic systems are utilized as they are powerful tools to model high level of uncertainties. Thus, the proposed IT2-FCM has a qualitative representation as it merges the advantages of IT2 fuzzy logic systems and FCMs. We present comparative simulations results in presence of uncertainties where the superiority of the proposed IT2-FCM-based flight control system is shown in comparison with its type-1 fuzzy counterpart.
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Purpose Locating disaster response centers is one of the key elements of efficient relief operations. The location and infrastructure of the candidate facilities usually conform to the required criteria at different levels. This study aims to identify the criteria for the main and local distribution center location problem separately and prioritize each candidate distribution center using a hybrid multiple criteria decision-making approach. Design/methodology/approach The proposed model incorporates analytic hierarchy process (AHP) and Technique for Order Preference by Similarity to Ideal Solutions (TOPSIS) under interval type-2 fuzzy sets (IT2FSs) to overcome the uncertainty of experts` judgments and expressions in the evaluations of candidate distribution centers. In the proposed approach, weights of the criteria are determined using type-2 fuzzy AHP and the candidate distribution centers are prioritized using type-2 fuzzy TOPSIS. Findings Transportation, cost, infrastructure and security are determined as the main criteria for the main distribution center location criteria. Cost, warehouse facilities and security are the main criteria for local distribution center location selection. Prioritization enables decision-makers to assess each alternative accordingly to be able to select the best locations/facilities for efficient disaster response operations. Originality/value This study proposes new multi-criteria decision support models for prioritizing disaster response distribution centers. IT2FSs are used to be able to reflect both the complexity and vagueness of disaster environment and expert opinions. Different support models are suggested for main and local distribution centers considering their different missions. The proposed methodology is applied in Istanbul city, Turkey, where a high-magnitude earthquake is expected.
Article
Spherical fuzzy sets (SFSs) were recently introduced to reflect experts’ judgements explicitly and in a more informative manner. TOmada de Decisão Interativa e Multicritério (TODIM) is one of the multi-criteria decision-making techniques. It is founded on the prospect theory that considers the decision-makers psychological behaviours under risk. In this article, TODIM is extended using the novel concept of SFSs to exploit its superior features to incorporate a new point of view in fuzzy decision-making under risk, allowing the decision-makers to express their hesitation independently. To establish the TODIM strategy, two evaluation functions are employed to form the partial dominance degree matrices: the importance evaluation function and the performance evaluation function. A practical example in supplier selection is solved, and a case study on selecting green occupational health and safety (OHS) equipment supplier is given. The results are compared with the results of the spherical fuzzy Technique of Order Preference by Similarity to an Ideal Solution (SF-TOPSIS) and the spherical fuzzy VIsekriterijumska optimizacija i KOmpromisno Resenje (SF-VIKOR). The effect of the attenuation factor of losses on the solution is examined. Finally, a different implementation of the SF-TODIM is used and the processing time of the two implementations is compared.
Article
Purpose Lean implementation is vastly incorporated in core manufacturing processes; however, its applicability in the supply chain and service industry is still in its infancy. To acquire performance excellence and thrive in the global competitive market, many firms are adopting newer methodologies. But, there is a stringent need for production simulation systems to analyze supply chains both inbound and outbound. The era of face validation is slowly disappearing. Lean tools and procedures that provide future state assumptions need advanced tools and techniques to measure, quantify, analyze and validate them. The purpose of this study is to enable dynamic quantification and visualization of the future state of a warehouse supply chain value stream map using discrete event simulation (DES) technique. Design/methodology/approach This study aimed to apply an integrated approach of the value stream mapping (VSM) and DES in a Malaysian pharmaceutical production warehouse. The main focus is diverted towards reducing the warehouse supply chain lead time by initially constructing a supply chain value stream map (both present state and future state) and integrating its data in a DES modelling and simulation software to dynamically visualize the changes in future state value stream map. Findings The DES simulation was able to mimic the future state lead time reductions successfully, which assists in better decision-making. Improvements were seen related to total lead time, process time, value and non-value-added percentage. Warehouse performance metrics such as receiving, put away and storage rates were substantially improved along with pallet processing time, worker and forklift throughput usage percentage. Detailed findings are clearly stated at the end of this paper. Research limitations/implications This study is limited to the warehouse environment and further additional process models and functional upgrades in the DES software systems are very much needed to directly visualize and quantify all the possible Lean assumptions such as radio frequency image identification/Andon (Jidoka), 5S, Kanban, Just-In-Time and Heijunka. However, DES has a leading edge in extracting dynamic characteristics out of a static VSM timeline and capture details on discrete events precisely by picturizing facility modification and lead time related to it. Practical implications This paper includes all the fundamental pharmaceutical warehouse supply chain processes and the simulations of the future state VSM in a real-life context by successfully reducing supply chain lead time and allowing managers in inculcating near-optimal decision-making, controlling and coordinating warehouse supply chain activities as a whole. Social implications This integrated approach of DES and VSM can involve managers and top management to support the adoption of anticipated changes. This study also has the potential to engage practitioners, researchers and decision-makers in the warehouse industry. Originality/value This study involves a powerful DES software package that can mimic the real situation as a virtual simulation and all the data and model building are based on a real warehouse scenario in the pharmaceutical industry.
Article
Leftover/end of life (EOL) medications not only cause financial losses for the pharmacy but also lead to disposal costs and high governmental penalties for the pharmaceutical supplier. In this study, a two-echelon pharmaceutical supply chain (PSC), including a single pharmaceutical supplier (pharma-supplier) and a single pharmaceutical retailer (pharmacy) with one type of fixed shelf-life medicine, is analyzed. A reducing pharmaceutical wastes scheme is developed to decrease relevant costs of leftover/EOL medicines, avoid governmental penalties, and also ensure patient service level (PSL). In the proposed model, excess medications are collected from the pharmacy warehouse based on the realized demand at a specific time before the expiration date to be resold in the secondary/alternative market. The introduced model is investigated in decentralized and centralized model structures. A novel combination of buyback and shortage risk-sharing contract (B&SRS) is proposed to attain channel coordination, maximize the whole PSC profits, and motivate members to participate in the scheme. The numerical investigation demonstrates that the proposed B&SRS contract can coordinate the developed PSC, enhance the whole channel profit, and also guarantee both channel members’ profitability. Besides, the investigated model helps pharmaceutical managers to decrease EOL/expired medicines related costs and ensure PSL by making decision properly on buyback quantity.
Article
Purpose The purpose of this study is to apply value stream mapping (VSM) in Malaysian pharmaceutical production warehouse. A current and future state value stream map from the raw material receiving end to the production unit was developed to find out waste and unwanted lead time. It was very much essential to cut down the supply chain lead time at the initial phase as the raw material unloading, sorting, temporary storage and dispatch to production were seen contributing to a huge lead time build-up. Design/methodology/approach The study was initiated with the selection of a product family, construction of the current state map, identification of various wastes and the development of future state map. Findings The expected outcomes of the study include the quantification of wastes, improvement in value-added percentage and lead time reduction. Research limitations/implications The study was carried out in a single pharmaceutical company. The results of the study are deployable and can be functional in similar production organizations. Contrary to common VSMs that capture core production processes, this study provides strong insights that shall help design lean supply chains, especially in the pharmaceutical domain. This paper has also addressed the viability of the lean in the pharmaceutical warehouse and the reduction in lead time to improve demand forecasting, marketing and sales. Practical implications The results of this study have indicated that a significant reduction in pharmaceutical warehouse supply chain lead time is possible as a result of the implementation of VSM from the supply chain’s perspective. Social implications The insights from this study help in understanding the pharmaceutical supply chain risks and their outcomes. Originality/value The paper reports a real-time study conducted in a warehouse of a pharmaceutical organization. Hence, the contributions are original.
Article
In this study, a new approach based on fuzzy cognitive map (FCM) and neuro-fuzzy inference system (NFIS), called the neuro-fuzzy cognitive map (NFCM), is proposed. Here, the NFCM is used for diagnosis of autoimmune hepatitis (AIH). AIH is a chronic inflammatory liver disease. AIH primarily affects women and typically responds to immunosuppressive therapy with clinical, biochemical, and histological remission. An untreated AIH can lead to scarring of the liver and ultimately to liver failure. If rapidly diagnosed, AIH can often be controlled by medication. NFCM is a new extension of FCM, which employs a NFIS to determine the causal relationships between concepts. In the proposed approach, weights are calculated using the knowledge and experience of experts as well as the advantages of NFIS. This makes the presented model more accurate. Having a high convergence speed, the proposed NFCM model performs well by achieving an AIH diagnosis accuracy of 89.81%. The superiority of the proposed NFCM model over the conventional FCM is that, it uses the NFIS to determine the link weights which train system parameters.
Conference Paper
Vehicle routing plays an important role in Home Health Care (HHC) logistics. In this paper, HHC concerns the delivery of medical commodities from pharmacy to patient, delivery of special drugs from hospital to patient, pickup of unused medical commodities from patients. The remaining capacity in the journey from pharmacy to hospital of all route is calculated which can be used for the transportation from pharmacy to hospital. The problem can be considered as a special vehicle routing problem with simultaneous pickup and delivery and time windows, with three types of demands: delivery from pharmacy to the patient, delivery from hospital to patient, pick up from patient to pharmacy. The vehicles are associated with capacity and demands of patients with time windows. In this way, a mixed integer programming model is proposed for optimal scheduling in HHC. The model is linearized and then solved by applying an optimization software named GUROBI. The output of the model contains an optimal vehicle routes assignment which helps the HHC Company making a good decision for patient visits.