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A. Nambiema1*, Q. Lisan1, MC. Perier1, F. Thomas2, N. Danchin2, P. Boutouyrie1, X. Jouven1, JP. Empana1
1INSERM, Paris Cardiovascular Research Center (PARCC), Paris, France, Paris, France; 2Investigations Preventives et Cliniques, Paris, France
*Corresponding author: E-mail: email@example.com
Healthy sleep score and incident cardiovascular diseases:
the Paris Prospective Study III (PPS3)
To examine the joint effect of
several dimensions of sleep
habits with incident
cardiovascular diseases (CVD)
events in acommunity‐based
▪PPS3is an ongoing prospective cohort of 10 157 healthy men and women aged 50 to 75 years recruited in a large preventive health centre between 2008-
2012 in Paris (France)
▪Incident CVD events (coronary heart disease or stroke) reported every two years were clinically validated after the review of the medical records for 10 years
▪Main exposure:Healthy sleep score including 5 sleep habits: early chronotype, sleep duration of 7–8 h/day, never/rarely insomnia, no sleep apnea, no
frequent excessive daytime sleepiness
▪Association of the baseline and change over time in healthy sleep score with incident events using a Cox regression analysis
▪Estimation of population attributable fractions (PAFs)
In this community-based prospective cohort, a higher healthy sleep score combining 5 sleep dimensions was associated with a lower risk of CVD. This study supported strong collaboration between
sleep medicine and CVD medicine.
Healthy sleep score includes early chronotype, sleep duration of 7–8 h/day, never/rarely insomnia, no sleep apnea, and no frequent excessive daytime sleepiness.
Cases: incident cases of coronary heart disease or stroke. The adjustment variables in Cox proportional hazards models were as follows: sex, age (continuous),
alcohol consumption, physical activity, smoking status, socioprofessional categories, diabetes mellitus, family history of heart diseases (stroke or myocardial
infarction or sudden death), low–density lipoprotein cholesterol and high–density lipoprotein cholesterol. CI: confidence interval. HR: hazard ratio. PAF: population
Results (1/2) –Baseline healthy sleep score
Healthy sleep score includes early chronotype, sleep duration of 7–8 h/day, never/rarely insomnia, no sleep apnea, and no frequent excessive
daytime sleepiness. Change: absolute difference between the follow-up score and the baseline score. Cases: incident cases of coronary heart
disease or stroke. HR: hazard ratio. Continuous change healthy sleep score: HR for a 1 point increase in the change score.
Results (2/2) –Change over time in the healthy sleep score