The objective of this chapter is to present the role of energy in the Mediterranean agri-food sector and to discuss the possibilities. Agri-food chains require large amounts of energy and produce various wastes that can be utilised for energy generation. Therefore, these chains are both consumers and producers of energy. Additionally , rural areas can explore their renewable energy potential in order to increase energy supply and create additional incomes to the farmers. Improvements in energy efficiency and higher use of renewable energies in this sector can increase its sustainability. Considerations regarding how developed and developing countries differ in terms of energy efficiency and bioenergy are very relevant to discuss links between energy and agri-food systems in the Mediterranean Basin because the region includes both types of countries. After a presentation of global issues, this chapter provides an overview of energy mix and discusses challenges and opportunities regarding energy efficiency and increased renewable energy in the Mediterranean agri-food sector. We briefly address the relevance of the water-energy-food nexus approach to tackle energy issues in the agri-food sector in the region before stressing the importance of gender equality in the production and consumption energy in the sector in order to enhance its sustainability. Global considerations on energy in agri-food systems Current energy consumption in agri-food systems is unsustainable on the long term (FAO, 2011). Food systems currently consume 30% of the world's available energy, with more than 70% occurring beyond the farm gate, and produce over 20% of the world's greenhouse gas emissions (around 31% if land-use change is included). At the same time, about one-third of the food we produce is lost or wasted, and with it about 38% of energy consumed in food systems. Moreover, modern food systems