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Craniofacial Sleep Medicine: The Important Role of Dental Providers in Detecting and Treating Sleep Disordered Breathing in Children

Authors:

Abstract

Obstructive sleep apnea (OSA) is a clinical disorder within the spectrum of sleep-related breathing disorders (SRDB) which is used to describe abnormal breathing during sleep resulting in gas exchange abnormalities and/or sleep disruption. OSA is a highly prevalent disorder with associated sequelae across multiple physical domains, overlapping with other chronic diseases, affecting development in children as well as increased health care utilization. More precise and personalized approaches are required to treat the complex constellation of symptoms with its associated comorbidities since not all children are cured by surgery (removal of the adenoids and tonsils). Given that dentists manage the teeth throughout the lifespan and have an important understanding of the anatomy and physiology involved with the airway from a dental perspective, it seems reasonable that better understanding and management from their field will give the opportunity to provide better integrated and optimized outcomes for children affected by OSA. With the emergence of therapies such as mandibular advancement devices and maxillary expansion, etc., dentists can be involved in providing care for OSA along with sleep medicine doctors. Furthermore, the evolving role of myofunctional therapy may also be indicated as adjunctive therapy in the management of children with OSA. The objective of this article is to discuss the important role of dentists and the collaborative approach between dentists, allied dental professionals such as myofunctional therapists, and sleep medicine specialists for identifying and managing children with OSA. Prevention and anticipatory guidance will also be addressed.
Citation: Heit, T.; Tablizo, B.J.; Salud,
M.; Mo, F.; Kang, M.; Tablizo, M.A.;
Witmans, M. Craniofacial Sleep
Medicine: The Important Role of
Dental Providers in Detecting and
Treating Sleep Disordered Breathing
in Children. Children 2022,9, 1057.
https://doi.org/10.3390/
children9071057
Academic Editor: H. Lester Kirchner
Received: 9 June 2022
Accepted: 12 July 2022
Published: 15 July 2022
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4.0/).
children
Review
Craniofacial Sleep Medicine: The Important Role of Dental
Providers in Detecting and Treating Sleep Disordered Breathing
in Children
Tammarie Heit 1, Bea Janine Tablizo 2, Martina Salud 3, Fan Mo 4, Mandip Kang 4, Mary Anne Tablizo 4,5,6
and Manisha Witmans 7,*
1Avalon Dental, Edmonton, AB T6B 3T7, Canada; drtheit@gmail.com
2Department of Pediatrics, Philippine General Hospital, Taft Avenue, Manila 1000, Philippines;
beatablizo@gmail.com
3Ateneo School of Medicine and Public Health, Pasig 1604, Philippines; martisalud220@gmail.com
4Department of Internal Medicine, University of California San Francisco-Fresno, Fresno, CA 93701, USA;
fan.mo@ucsf.edu (F.M.); mbhkang10@gmail.com (M.K.); mtablizomd@gmail.com (M.A.T.)
5Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA
6Division of Pulmonary and Sleep Medicine, Valley Children’s Hospital, Madera, CA 93636, USA
7Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta,
Edmonton, AB T6G 2B7, Canada
*Correspondence: manishawitmans@gmail.com
Abstract:
Obstructive sleep apnea (OSA) is a clinical disorder within the spectrum of sleep-related
breathing disorders (SRDB) which is used to describe abnormal breathing during sleep resulting
in gas exchange abnormalities and/or sleep disruption. OSA is a highly prevalent disorder with
associated sequelae across multiple physical domains, overlapping with other chronic diseases,
affecting development in children as well as increased health care utilization. More precise and per-
sonalized approaches are required to treat the complex constellation of symptoms with its associated
comorbidities since not all children are cured by surgery (removal of the adenoids and tonsils). Given
that dentists manage the teeth throughout the lifespan and have an important understanding of the
anatomy and physiology involved with the airway from a dental perspective, it seems reasonable that
better understanding and management from their field will give the opportunity to provide better
integrated and optimized outcomes for children affected by OSA. With the emergence of therapies
such as mandibular advancement devices and maxillary expansion, etc., dentists can be involved
in providing care for OSA along with sleep medicine doctors. Furthermore, the evolving role of
myofunctional therapy may also be indicated as adjunctive therapy in the management of children
with OSA. The objective of this article is to discuss the important role of dentists and the collaborative
approach between dentists, allied dental professionals such as myofunctional therapists, and sleep
medicine specialists for identifying and managing children with OSA. Prevention and anticipatory
guidance will also be addressed.
Keywords: craniofacial; sleep medicine; dentistry; pediatrics; OSA; polysomnography
1. Introduction
Sleep-related breathing disorders (SRDB) involve a clinical spectrum of respiratory
sleep disorders, which can include chronic snoring, upper airway resistance syndrome
(UARS), and obstructive sleep apnea syndrome (OSAS). These terminologies are collec-
tively used to describe abnormal breathing during sleep that can result in gas exchange
abnormalities and/or sleep disruption. The spectrum of disorders ranges in presentation,
pathophysiology, severity, and associated sequelae based on age. Obstructive sleep apnea
(OSA) is characterized by repeated episodes of partial or complete upper airway collapsi-
bility during sleep, with subsequent repetitive arousals which can result in gas exchange
Children 2022,9, 1057. https://doi.org/10.3390/children9071057 https://www.mdpi.com/journal/children
Children 2022,9, 1057 2 of 16
abnormalities (oxygen desaturations and elevated carbon dioxide). It is estimated that 1–4%
of children suffer from pediatric OSA [
1
]. Untreated OSA in children is associated with
neurobehavioral and cognitive sequelae as well as long-term consequences of metabolic,
endocrine, and cardiovascular disease [
2
,
3
]. Bhattacharjee et al. showed in their retrospec-
tive review across various academic centers that only 27.2% had complete resolution of
OSA post adenotonsillectomy using AHI as the primary determinant. They reported that
residual disease (defined as abnormal overnight polysomnograms) is common in older
children, those with severe OSA pre surgery, and children with asthma. [
4
]. What was not
addressed in that review was the role of family history, craniofacial profile, or malocclusion
identified in dentistry which also could be some other reasons for persistent disease. More
precise and personalized, targeted approaches are required to treat the complex constella-
tion of symptoms with their associated comorbidities since not all children are cured by
surgery (removal of tonsils and adenoids). As treatment strategies are developing for the
spectrum of SRBD, including OSA, dentists and medical professionals can work together to
optimize airway functioning and overall health in children to prevent or alleviate morbidity
and mortality resulting from untreated SBRD. Dental sleep medicine has already emerged
and is involved in treating adults. Recently, more attention is devoted to addressing OSA
in children.
Prevention, early recognition, and reversal of suboptimal development of the mandible
and maxilla and compensatory dental function leading to disease may be a very important
paradigm shift compared to treating disease. Dentists can help with their knowledge of
jaw and facial development to intercede and optimize craniofacial development to change
the phenotype and promote healing and health without medication or surgery [
5
]. Cohorts
involving children are starting to appear in the literature as dentists use their knowledge
from adults to help children [
6
]. The objective of this article is to discuss the collaborative
approach between dentists and sleep medicine specialists for managing children with OSA
to optimize airway function and breathing for restorative sleep.
2. Risk Factors
Adenotonsillar hypertrophy is one of the main risk factors for developing OSA in
children, and its prevalence reaches a peak between the ages of two and eight years when
the lymphoid tissue is disproportionately large in relation to the craniofacial profile [
2
,
7
].
Obesity is also an important risk factor for OSA in children and adults. Mechanisms of
the contribution of obesity are related to the presence of fat at the level of the pharynx as
well as abdominal obesity, which decreases respiratory function [
8
]. Each increment in BMI
above the 50th percentile is associated with a 10% increase in risk for OSA [
7
]. However,
not all obese children have or develop OSA, which implies that there may be other factors
also involved in mitigating the risk for OSA.
Other risk factors that have been reported include lingual tonsil hypertrophy, and
prematurity [
3
]. Ethnicity also seems to play a role, as does lower socioeconomic status.
Inflammation involving the airway from allergic rhinitis [
7
,
9
] or a history of upper and
lower respiratory tract infections as well as environmental tobacco smoke have also been
associated with OSA [
7
]. Many genetic syndromes with associated craniofacial abnormali-
ties are also at higher risk for OSA and include Trisomy 21, Pierre Robin sequence, Prader
Willi syndrome, achondroplasia, Apert syndrome, and Crouzon syndrome [
3
]. SRBD can
occur in any age group, from cradle to grave, and therefore warrants routine screening
and evaluation.
Risk factors for OSA from a dental perspective may involve the craniofacial profile.
Attention to the underlying craniofacial profile and optimizing the structure and function
may play a role in not only preventing lifelong morbidity and mortality associated with
OSA but potentially prevention of the clinical disorder in the first place. One study by
Guillemineault linked apparent life-threatening events, OSA, and facial dysmorphia and
reported that as early as six months, those with sleep apnea were already presenting with
mild facial dysmorphia [
10
]. Some of the children with abnormal breathing early in life
Children 2022,9, 1057 3 of 16
went on to develop OSA by five years of age [
10
]. Malocclusion has been associated with
OSA but is not causally proven.
Dental-medical collaboration is key and oral health care providers can be a first line
screening resource for disease risk as an important component of an integrated public health
initiative [
11
]. Greenberg and Glick identified in 2012 that ‘screening and monitoring for
systemic disease risk in a dental setting were valuable components toward more effective
disease prevention, control, and health care delivery’. In a national survey, dentists felt it
was important to screen for medical conditions and were willing to refer to physicians for
follow-up care [
12
]. This is an ideal situation in the detection, treatment, and prevention of
OSA since dentists are also part of the treatment solution.
3. Pathophysiology
The pathophysiological factors that contribute to developing OSA are related to the
anatomy, which may result in a reduction of airway caliber and factors that promote airway
collapsibility (intrinsic and extrinsic factors) [
13
]. The pediatric airway has been observed
to correlate with the Starling resistor model and P crit with the degree of upper airway
obstruction [
13
]. Detailed discussions about the pathophysiology of OSA are discussed in
another paper in the pediatric OSA issue.
Emerging evidence suggests that the craniofacial profile also plays a role in the patho-
physiology of OSA since the airway caliber is influenced by the surrounding structures.
Upper air dimensions and craniofacial morphology are closely related. Studies have shown
that a certain subset of children have certain craniofacial features that are linked to OSA.
The dento-craniofacial characteristics in non-syndromic children that may be associated
with increased risk for sleep disordered breathing are anterior open bite, large overjet due
to mandibular retrognathia, cross bite, and narrow and high arch palate. The development
of the jaws and dental occlusion may be affected by a narrow upper airway. Decreased
palatal width may be a risk factor due to decreased upper airway size [14].
It makes sense that the form and function of the upper airway and craniofacial are
interrelated and influence each other. For example, abnormal form (such as a tongue
tie) leads to altered compensatory function (affected sucking and swallowing), which
leads to abnormal form (enlarged posterior tongue muscles affecting the shape and size
of the palate) [
15
]. In addition, it is widely believed that chronic nasal obstruction from
chronic allergies, enlarged adenoids, or turbinate leads to mouth breathing and possibly
narrowed upper palate which contribute to OSA. There may also be a role in the interaction
of genes and the environment as our eating habits have changed so dramatically since
the invention of bottled formula delivered through artificial nipples and soft, processed
foods [
16
]. Although these factors have not been systematically studied in medicine, these
theories are well understood in the dental field and the need for cross collaboration is
becoming more obvious.
4. Clinical Features
Clinical features of OSA can vary greatly based on age group, as can the clinical
presentation. In general, clues to SRBD, including OSA, tend to affect five main domains:
sleep duration and sleep quality, breathing effort, feeding ability, growth, and development.
Most of the concerns are often reported by parents given that the children themselves
either are sleeping or only recognize and report the complaints and symptoms at an older
age when the impairment affects daytime function. Infants with more severe symptoms
tend to present with noisy breathing, apparent life-threatening events [
17
], and/or failure
to thrive. Delayed development (speech, milestones, etc.) may be recognized as a later
sign. Snoring and labored breathing or increased work of breathing are the most reported
symptoms in young children. The definition and frequency of snoring vary in the literature
for determining the presence of OSA. Frequent habitual snoring, defined as the presence
of loud snoring at least three nights/week, is reported [
7
]. However, in the context of low
tone, or neuromuscular weakness, snoring may not be present or obvious. Other reported
Children 2022,9, 1057 4 of 16
symptoms can include nocturnal sweating, paradoxical breathing, mouth breathing, noctur-
nal enuresis, and restlessness with frequent position changes. In addition, clinicians should
also focus on any signs of attention deficit and hyperactivity or any behavioral problems as
these daytime symptoms are commonly present among pediatric populations, especially
in the context of fragmented or non-restorative nighttime sleep [
3
]. Checking the weight
is important as obesity has been an identified risk factor. Night terrors, either related to
developmental age or a function of sleep fragmentation, may also be seen in toddlers and
preschoolers [
13
]. Depending on the severity, there can be associated hypoxemia and/or
hypoventilation with sleep disruption and/or fragmentation which cannot be determined
by clinical evaluation alone. Objective measurement of gas exchange by monitoring breath-
ing during sleep, ideally a sleep study is critical to establish the diagnosis and document
severity as the clinical assessment is insufficient.
Intraoral and Extraoral Examination Findings
Despite the prevalence of OSA in the pediatric population [
1
], there is limited literature
on the topic of findings during dental examination suggestive of OSA in children. Clues
that suggest either orthopedic or craniofacial features are associated with OSA can be quite
variable. It is imperative to have a high index of suspicion to facilitate timely detection and
diagnosis of OSA. It stands to reason that altered airway mechanics or airway obstruction
would affect the craniofacial growth by altering forces and resulting in postural skeletal
abnormalities and soft tissue changes [13].
The phenotype, generally speaking, of an optimal normal airway from an oral per-
spective, is to have a maxilla that is big enough to accommodate 32 fully erupted teeth
that are straight and in class one occlusion by the time they are adolescent [
18
]. Ideally,
the child will be breathing through the nose with the tongue sitting up against the upper
palate. Mouth breathing that is both visible and audible is considered pathologic [
19
].
Nasal breathing with lips lightly resting together is normal and should be silent indicative
of non-resistant airflow. The professional should not be able to see (motion of soft tissues
or exudates) or hear their patient breathe through the nose. The maxilla and the supporting
teeth of the maxilla are a foundational part of the upper jaw, the landing pad for the teeth
of the mandible, and the top block of the craniofacial skeleton. This helps to support the
posture of the body of the face, thereby affecting the optimal function of the adherent soft
tissues. Anything deviating from that is considered compensatory and suboptimal [
20
].
The evidence found in the resulting malocclusion makes the individual subject to reduced
function, further compensation by the body posture, and altered biofeedback mechanisms
that can increase predisposition to OSA [6,19].
Hyponasal speech, chronic mouth breathing and open mouth posture with compen-
satory craniofacial developmental changes should be recognized by clinicians and dentists
as it is a sign of nasal obstruction and adenoidal hypertrophy. The specific cephalometric
stereotypic features that are noted in those with OSA from adenoidal hypertrophy include
a long face. The adenoidal facies are associated with labial incompetence and an increased
mandibular plane angle. Speech delay related to eustachian tube dysfunction or recurrent
ear infections can also be associated with adenoidal hypertrophy. The most common fea-
tures assessed during the oral examination of a child with OSA include hypertrophy of
the tonsils. Tonsillar hypertrophy is associated with mouth breathing, a posterior-rotated
mandible creating a mandibular discrepancy to the cranial base which diminishes the
physical airway behind it. Compensation is seen in the forward posture of the head. Other
features may include an elongated soft palate, a high arched palate, or a longer or larger
tongue [
21
,
22
]. Enlarged tongue muscles (and obstructive) may be seen resulting from
tongue tie or from compensatory work demanded of it in response to the posturing of the
jaw (aberrant tongue posture). This affects optimal function as demonstrated by the release
of the tongue tie to improve breastfeeding in infants [
23
28
] and myofunctional therapy
improving OSA in children and adults [
29
,
30
]. The tongue tie has been shown to be a root
cause of maxillary deficiency and linked to obstructive sleep apnea in children based on
Children 2022,9, 1057 5 of 16
the work of Dr. Christian Guilleminault [
15
]. The presence of mouth breathing may also
negatively affect the development of craniofacial features. As Ngiam et al. and Lee et al.
have demonstrated, features that develop from mouth breathing include a long face, lower
frontal facial height, and a reduced inter-maxillary space [
21
,
22
]. A reduced inter-maxillary
space will reduce space for the tongue in which the tongue will be displaced posteriorly
into the retroglossal airway space. An adapted tongue posture may exhibit as low and
protruded forward. The non-mouth breathing individuals with OSA have a deep bite with
the type II skeletal class and mandibular retraction. There is a high and retracted position of
the tongue. Consistently reported findings in the literature (Rossi et al.) include decreased
mandibular and maxillary lengths and its retrusion, increased total anterior facial height, a
larger craniocervical angle, decreased posterior airway space, and an inferiorly positioned
hyoid bone [31].
The Mallampati score is a score based on anatomical structures that are visualized by
opening the mouth and protrusion of the tongue [
32
]. It can be used as a predictor of OSA
in older school-age children but its value in infants and young children is not known. A
higher score is linked to a higher likelihood of sleep apnea in older children and adults [
33
].
In a recent study, Lee et al. revealed that preschool children with mild OSA are more
likely to present with features such as retrognathic mandible and increased overjet [
34
].
Crooked teeth, crowding, and tongue tie can indicate a small maxilla, narrow palate, and
therefore a small nasal airway (midface deficiency), suggesting increased upper airway
resistance [
35
]. A small or narrow upper arch of teeth in the maxilla suggests that the
mandible is retrognathic if it is occluding behind the teeth of the maxilla. This causes the
tongue to obstruct the oropharyngeal airway and predisposes the child to have OSA [
36
].
A class II malocclusion is often a common finding. These affected children develop a long
craniofacial profile, including retrognathism of the mandible, and midface hypoplasia is
often seen. Maxillary crossbite may also be seen. Other more subtle features may include
speech difficulties.
The relationship between the upper and lower teeth can indicate either maxillary
deficiency or mandibular discrepancy to the cranial base or both and can be diagnosed by
the dentist. This can present as malocclusion or ‘bad bite’. If the maxilla is deficient laterally
(narrow arch), then the mandible is forced posteriorly for the teeth to fit. This is a class 2
malocclusion. If the maxilla is deficient anterio-posteriorly, then the bottom teeth might
either be forced back and tip posteriorly (retroclined) or completely jump past the upper
teeth to form a class 3 malocclusion. The teeth can bend forward or back within the arch of
bone to try to fit together. Ideally, they should be optimally positioned in the alveolar bone
to enable vertical loading during function. Class 1 occlusion is considered normal, however,
if the maxilla and mandible are both posteriorly located (closing the airway), then it is class
1 malocclusion (also referred to as class 4 malocclusion by Dr. Kevin Boyd). Commonly,
there will be no room for wisdom teeth to erupt, rather, there will be cross bites, rotations,
and other forms of crowding because the anatomy (and therefore function) is not optimal.
Abnormal craniofacial morphology has been linked to obstructive sleep apnea [37].
Abnormal features in infants as early as six months that shows a long face, retropo-
sition of the mandible, small triangular chin, long uvula clearly behind the tongue, low
placed hard palate, overall small upper airway, tonsils present, flaring nostrils when supine
and breathing through the nose were all features associated with apparent life threatening
events and sleep apnea early in childhood [10].
Abnormal postures of oral circumferential muscles may lead to malocclusion in early
childhood. These postures include forward tongue thrust, tongue biting, and low tongue
at rest. Maxillofacial structure, oral function, and oral posture are interrelated factors
that work together to maintain normal occlusion. Disruption of any of these factors may
contribute to malocclusion and impact dentition in children [
38
,
39
]. Furthermore, low
tongue position can also be seen in OSA patients. Low tongue position is associated with
the development of abnormal palate shape and narrowed maxillary dental arch [40,41].
Children 2022,9, 1057 6 of 16
There are studies that have shown that OSA patients also have an extended head
posture. This can influence the development of abnormal craniofacial skeleton and dental
occlusion. Although children with malocclusion have the same characteristics as patients
with OSA, to our knowledge there is no literature that proves the relationship between
these two conditions [40,41].
Functional Airway Evaluation Screening Tool (FAIREST-6) is a validated tool used to
identify red flags for SDB in children during extra oral and intra oral dental examinations.
The following factors had the strongest impact on the Sleep Disturbance Scale for Children
(SDSC): mouth-breathing (functional), mentalis strain (extra-oral), tonsillar hypertrophy
and ankyloglossia (intraoral soft tissue), dental wear, and narrow palate (intraoral hard
tissue). This concise and validated clinical assessment tool may be beneficial in reviewing
potential red flags of the craniofacial complex to screen for SDB, aiding in early diagnosis
and intervention [42].
Along with the primary care provider, the dentist is also an ideal healthcare provider
who can screen for OSA and intervene early since not only can they screen healthy in-
dividuals in their dental clinics, but can also assess these craniofacial features that are
associated with OSA. Dentists can help collaboratively and proactively in the diagnosis
of OSA along with physicians. Clinical features and history can be easily captured in a
routine dental admission history to complete the screening of potential sleep apnea and
initiate collaboration with sleep medicine specialists.
5. The Role of the Dentist
Patients go to their dentist when they are healthy to prevent problems with their
teeth and optimize the aesthetics of their smile. This includes evaluating the role of the
teeth, muscles, and jaws as they contribute to the size, which is captured in routine dental
photography and assessment on admission to a dental clinic. The airway is routinely
assessed and followed up as the craniofacial region grows and develops in children once
or twice per year when the child appears for regular dental care. Dentists are in the
ideal position to capture growth points photographically early on and compare them to
previously documented subtleties and help the child get on/stay on track, along with the
primary care provider or pediatrician, for optimal health. Dentists are also ideally situated
to identify deviations from normal early on, including screening for medical problems as
dentists routinely do a medical history on admission and update it at each visit. This is
ideal for patients who do not see a medical doctor routinely and goes only as needed [11].
Dentists can recognize and help prevent abnormal development of the jaws and help
people keep all their teeth until old age. Since they are regularly involved in oral health,
they are also important team players for the early detection of features associated with
OSA. Dentists could detect abnormal anatomy and signs and symptoms of abnormal
function that is a risk factor for OSA (enlarged tongue, tongue-tie, missing teeth, small and
malpositioned jaws) and other signs of the possible cause of sleep disruption (bruxism,
temporomandibular joint disorders) [4345].
A policy statement from the American Academy of Dental Sleep Medicine states that
dentists play an integral role in reducing the public health burden of undiagnosed and
untreated sleep-related breathing disorders [
46
]. Dentists are encouraged to document
abnormal anatomy of the jaws, teeth, and upper airway, screen patients for OSA with
questionnaires, and collaborate with physicians for diagnosis and treatment. Physicians
are responsible for the diagnosis and prescribing appropriate treatment [
7
] while also con-
sidering the implications of underdeveloped craniofacial anatomy. Collaboration between
the sleep medicine physician and the dentists is ideal to address the form and function of
the airway, and document and assess the impact on the possible reversal and prevention of
obstructive sleep apnea.
This connection between optimal jaw development, position, and optimal function
has been demonstrated in adults clinically in several single case studies and small cohorts
by dentists [35,4750] based on basic anatomy and physiology [20,51].
Children 2022,9, 1057 7 of 16
6. Diagnosis of OSA
The diagnosis of obstructive sleep apnea is based on a comprehensive evaluation that
includes a history and physical exam as well as investigations to confirm OSA, including an
overnight polysomnogram reviewed by a sleep medicine physician. A detailed medical and
sleep history, as well as an oral cavity examination is needed. Dentists as well as primary
care providers and/or pediatricians play a crucial role in screening for OSA as they often
see the patient twice a year for an exam. In general, sleep-trained dentists are familiar and
do play an active role, but general dentists may not. Non-sleep-trained dentists may not
routinely screen for OSA yet, but it is encouraged by the American Dental Association [
31
].
The best two questionnaires such as Chervin’s sleep questionnaire (PSQ) and OSAS-18 in
pediatrics only have a sensitivity and specificity for detecting OSA of
72–87%
. Some dentists
have started using such questionnaires in practice in an effort to screen for OSA. Medical
questionnaires do not take into account dental findings that may support a diagnosis
of OSA. Even the best available questionnaires do not account for features related to
the craniofacial profile, such as malocclusion discussed above, asthma, allergies, and/or
gastroesophageal reflux. Questionnaires alone are not sufficient to diagnose OSA but can
be a good screening tool in an office setting [52].
Overnight polysomnographic studies are still considered the gold standard for diag-
nosis in addition to a comprehensive sleep assessment as mentioned. Polysomnography
thresholds for OSA differ in pediatrics compared to adults. The apnea index for children > 1
or apnea hypopnea index > 1.5 are considered abnormal. The commonly used classification
scheme for OSA in children is as follows: Mild AHI 1–5, moderate > 5–10, and
severe > 10
.
These are arbitrary thresholds and have not been linked to end-organ dysfunction. In
addition to an overnight polysomnogram, diagnostic imaging, including cone-beam CT
can be helpful to evaluate the craniofacial airway in more detail when dental treatment
options are considered. The concern about the amount of radiation over a lifetime and
risks versus benefits of CBCT should be considered [
53
]. Drug-induced sleep endoscopy
is gaining popularity in children with residual OSA and children with increased risk of
persistent OSA despite T&A and helps determine the role of adenotonsillectomy [54].
Gozal et al. proposed several criteria, classified into major and minor, for the diagnosis
of OSA in children and to assess the need for treatment. The major ones include an AHI > 2,
RDI > 2, Nadir SpO2 < 90%, excessive daytime sleepiness, academic difficulties, hyperactive
behavior, hypertension, enuresis, and obesity. Among the minor ones, there are high levels
of c-reactive protein (CRP), low density lipoprotein (LDL), fasting insulin, and low levels of
high density lipoprotein (HDL), recurrent middle ear otitis, and adenotonsillar
grade > 1
.
The positivity of five major criteria, or three major criteria plus three minor criteria, indicates
the need for therapeutic procedures [
55
]. Their paradigm, although promising, has not
been systematically evaluated prospectively.
The most recent guidelines from the American Academy of Pediatrics still endorse
a comprehensive evaluation followed by an overnight polysomnogram to establish the
diagnosis of OSA. Polysomnography represents the gold standard and involves overnight
monitoring of respiratory and sleep-related parameters with direct visualization of the
patient during sleep study by the sleep technologist [
56
]. The cumbersome nature and cost
of this test has resulted in innovation to develop more easily accessible ways to diagnose
OSA in children. Although pulse oximetry has limited sensitivity and specificity, it has been
used to diagnose OSA in children when PSG is not available [
57
]. The use of the pediatric
sleep questionnaire with pulse oximetry has been recommended when polysomnography is
not available. However, pulse oximetry can miss OSA in upwards of 40% of children. More
recent advancements in wearable technology using cardiopulmonary coupling such as
Sleep Image have yielded results similar to that of overnight polysomnography in children,
and it is a validated tool approved by the United States Food and Drug Administration
(FDA) and Health Canada. Its role in the general clinical setting is not yet established [
58
,
59
].
Newer technology is emerging that may allow a clinically acceptable and timely sleep
study result for diagnosis and monitoring of treatment. Physicians may be able to diagnose
Children 2022,9, 1057 8 of 16
OSA and counsel patients via telemedicine to allow for an easy referral from the dentist for
collaborative diagnosis and treatment for the patient.
7. Medical Management of OSA
Medical management (non-dental treatments) of OSA in children involves adenoton-
sillectomy as the first line of treatment. Early systematic reviews suggested that adeno-
tonsillectomy resulted in the normalization of polysomnographic findings in 79% of the
children in the Childhood Adenotonsillectomy Trial (CHAT) study [60]. The CHAT study
also showed that in children with mild OSA, 46% of the sleep studies normalized in seven
months with watchful waiting. However, the study did not show significant improvement
in attention or executive function as measured by neuropsychological testing. So, the option
to either have the surgery done or perform ‘watchful waiting’ still exists depending on
the provider’s preference. Orthodontic treatment was not mentioned in the paper and
maxillary development may need to be considered. In this context, the treatment approach
for mild OSA is now fraught with debate as to what is considered optimal treatment.
Inflammation is reported to be present in the adenotonsillar tissues and upper airways
in children with obstructive sleep apnea [
61
]. Medical management of mild sleep disordered
breathing can include administration of targeted anti-inflammatory therapy. Several studies
have used intranasal steroids and leukotriene receptor antagonists to treat mild OSA over
the past 15 years [
62
]. CPAP or continuous positive airway pressure therapy has also
been used to treat OSA in children and has been linked to improved sleep quality and
neurocognitive outcomes. The compliance rates reported in the literature for PAP therapy
for OSA are variable and can range from 30% to 85% [
63
65
]. The long-term impact on
the craniofacial skeleton is a concern. Weight loss is recommended for obese children as
adenotonsillectomy alone is less likely to result in a complete cure in obese children.
Given the reported sequelae linked to OSA in various physical domains, it stands
to reason that early identification and treatment are imperative to prevent morbidity
and potentially mortality linked to OSA. OSA should be treated as early as possible to
reduce behavioral issues in children [
66
]. In a large population based study, early life
SDB symptoms had strong effects on subsequent behavior in childhood [
67
]. Potentially
mitigating this trajectory with collaboration between medicine and dentistry is promising.
8. Dental Treatments
Dental treatments for OSA include many forms of dental devices or oral appliance
therapy (OAT). These include growth modifiers of the maxillary region and/or mandibu-
lar region, mandibular advancement appliances (M.A.D.), tongue retaining devices, and
myofunctional appliances. Some of these devices help make room for teeth using tooth
mechanics involving inflammation, while other devices, such as a M.A.D., simply work
by holding the lower jaw forward [
68
]. Characteristic facies of children with OSA often
include maxillary constriction, high arched palate, narrow maxillary arch width (with
accompanying distalization of the mandible and its soft tissues toward the airway), and
maxillary crowding, as well as midfacial hypoplasia, as discussed previously. There are lim-
ited studies on the use of dental devices in children, however, novel treatments to prevent
braces in dentistry, such as early interceptive treatment to help optimize jaw growth and
craniofacial development, are increasing. The premise is to assist the growth of the upper
jaw and optimize the position of the lower jaw. The intercuspation of the teeth provides the
stimulation of the gnathological biofeedback system [
20
]. This allows the tongue to have
enough space to function optimally and the teeth to come together comfortably into class 1
occlusion. This may reduce accommodation and the need for inflammatory intervention
(surgery, pain) ultimately permitting better anatomy for sleep optimization.
8.1. A. Rapid MaxillaryExpansion or Rapid Palatal Expansion
Rapid maxillary expansion (RME) or Rapid palatal expansion (RPE) is an orthodontic
procedure that uses a fixed or a removable appliance that widens the two halves of the
Children 2022,9, 1057 9 of 16
maxilla at the mid-palatal suture line in children with maxillary arch constriction. The
expansion screw is progressively adjusted to open the palatal suture. Osteiods develop at
the borders of the palate, which results in an increase in the transverse width of the airway.
The expected result will increase in oropharyngeal volume and intranasal diameter and
decrease nasal resistance, by improving laminar airflow in the nose, which will help in the
treatment of OSA. This procedure is used in children when the palatal suture is still open,
until around the age of 12 yrs. However, it is accompanied by a loss of anterior-posterior
dimension [
69
]. This would cause the distalization of the mandible moving the tongue
back into the airway. Another caveat is that there must be teeth for the expander to anchor
to so very young children would not be able to be treated with this. The data on the age of
the patient that can be treated using this dental device is limited to children over 4 yrs.
The use of RME in children has shown favorable results, especially in the treatment
of residual OSA post T&A for patients with narrowed upper palate [
70
]. A meta-analysis
in 2017 by Guilleminault has shown that RME is effective in substantially reducing the
AHI and improving oxygen saturation in children (7.6
±
2 years old) with OSA and high
arch and/or narrow hard palates, especially in the short term (<3 years) follow-up. The
improvement was seen more in children with previous adenotonsillectomy or small tonsils
than in children with large tonsils [70].
A more recent meta-analysis published in 2021 involving 5- to 13-year-old children
showed RME increased the internasal and inter-zygomatic distances and oropharyngeal
volume after RME treatment. The effectiveness of RME varies at what age it is done.
Although this meta-analysis showed that the quality of the evidence for each outcome in
the study was very low, the report of the clinical improvement appears to be favorable.
One study included in this meta analysis indicated that in those over 14 years of age, RME
would not achieve ideal results due to the degree of established ossification at this age. In
adults where the ossification process has occurred in the mid palatal suture, RME can only
be achieved by surgically assisted RME [71].
Several long term studies in children have shown that the RME is able to decrease
the AHI in children with OSA as well as increase oxygen saturation. One study evaluated
RME as a long-term treatment option for OSA and found that there were consistent im-
provements in polysomnography values after a 12-year follow-up in children with OSA
without enlarged tonsils and adenoids [
72
]. Another study showed long-term follow-up on
children for up to 24 months and showed no relapse after treatment of OSA with RME [
70
].
Adenotonsillectomy, as well as RME, were both done for complete resolution of OSA in one
study [
73
]. Thus, RME may be considered as an alternative to adenotonsillectomy or can
be offered when there is residual OSA post T and A in the treatment of OSA in pediatric
patients with transverse maxillary deficiency [70].
A study that used RME to treat sleep bruxism was performed on 32 patients between
8–14 years old and showed that it reduced bruxism, but the sleep and respiratory variables
remained unchanged [74].
The responsibility for the effectiveness of RME includes not only the provider but
also the patient and the parent or caregiver to manage intramural activation of expansion
screws, appliance dislodgement, retention of correction after expansion, and complications.
After the appliance is applied, the caregiver/parent needs to activate the expansion screw
by turning it once or twice a day according to the practitioner’s recommendations. To
avoid loss of correction, a retention protocol must be followed. This includes keeping
the expander in place until comprehensive orthodontics evaluation is undertaken. Since
expansion forces are applied to the teeth at a distance coronal to their rotation center, teeth
will tip buccally. The absence of suture release during expansion will lead to buccal crown
tipping attached to the expander and minimal to no skeletal expansion, making it prone to
relapse of the accomplished expansion. Overall, the majority of the approaches involving
RME from tads (screws) to surgery can improve results and do show durability but are also
inflammatory in nature [75,76].
Children 2022,9, 1057 10 of 16
Little research has been carried out when it comes to the risk of root fenestrations
or dehiscence as the roots of teeth are displaced buccally toward the cortical plate. The
bone is less mature and mineralized among young patients; hence, it was speculated that
there is a greater risk of expansion, however, less force is needed to separate midline
palatal sutures, and children may tolerate such forces better than patients with mature
alveolar bone. Clearly, more research is needed to guide decisions about the timing of early
intervention [70].
8.2. B. Complete Airway Repositioning and/or Expansion (CARE)
Another novel treatment option that involves maxillary development is the DNA
device by Vivos therapeutics, CARE (Complete Airway Repositioning and/or Expansion)
previously called Biomimetic Oral Appliance Therapy (BOAT Therapy) which uses con-
cepts of non-inflammatory body modification by tapping into the biofeedback systems. This
treatment will optimize one’s genetic potential [
77
] and can address midfacial deficiency
and narrow palates that can result in tooth crowding and possibly obstructive sleep apnea.
CARE can stimulate the body’s natural feedback mechanisms to change form (increase
the size of the maxilla) and optimize function (for eating, increased nasal airway, forward
posture of the mandible increasing the oral pharyngeal airway for breathing) [
78
]. The
hypothesized mechanism of action is non-inflammatory distraction osteogenesis combined
with signal transduction. This enhances the biofeedback mechanisms of the craniomandibu-
lar system to allow for de-accommodation of the phenotype and movement toward the
genetic potential, which is to have 32 fully erupted teeth in a class 1 occlusion with a
healthy upper airway [
78
]. Evidence of noninflammatory protocols is starting to emerge as
beneficial for bone development in the craniofacial region [79].
The DNA device (used in CARE) is FDA-registered as a class 1 device for maxillary
expansion and can be used to provide therapy to assist with the development of the
maxilla by function in children in a non-inflammatory way. It is worn 12–16 h/day. It
has been observed that OSA in children decreases as the maxilla develops to fit the teeth
(unpublished data, Heit et al.). This device can also be used in adults to treat OSA [35].
Braces or Invisalign are used in phase 2 to straighten the teeth within the alveolar
bone and finish the occlusion once maximum medical improvement is achieved (less pain
measured by HIT-6 scores and less obstructive sleep apnea measured by AHI). When CARE
therapy is implemented, the final physiologic rest position of the jaw can be determined
using EMGs, jaw tracking, and sonography. Then, the teeth are mechanically aligned,
cusp to fossa to support the healthier jaw position. The hope is that less compensation is
required when the hard tissues (all bones and teeth) are fully developed and aligned. Braces
and maintenance of the occlusion are required for long-term stability because relapse is
very common in orthodontics [
80
]. The explanation for relapse is that the patient has not
attained functional balance in the physiologic rest state. More definitive studies including
clinical trials are underway to determine the role of this therapy in treating OSA.
8.3. C. Mandibular Advancement Devices (MADs)
Mandibular advancement devices (MAD) or mandibular advancement splints (MAS)
can prevent upper airway collapse by means of protruding the mandible forward, hence
altering the jaw and tongue position in adults, potentially in older teens, but not in young
children. This is currently only approved in adults with mild to moderate OSA. However,
with the advent of easier sleep study approaches, dentists can test the effectiveness and
support the addition of mandibular advancement device (adding a lower device) in children
if it improves their symptoms, the metrics in their sleep study and allows for the developing
maxilla and its dentition.
MAD can increase airway volume at the velopharynx. Studies involving MAD mostly
defined treatment success as achieving AHI of usually
5–10/h or a certain percentage
reduction in AHI (usually 50%), and studies have shown a mean AHI reduction of between
30% and 72%. Comparing it to CPAP, results demonstrate that CPAP is more effective than
Children 2022,9, 1057 11 of 16
MAD at reducing OSA and achieving complete control of OSAHS (AHI < 5), but it is not
more effective when it comes to health outcomes since the higher efficacy of CPAP is offset
by greater MAD compliance [
81
]. Long term side effects of MAD therapy are dental and
skeletal changes, which are progressive over time [
82
]. It stands to reason that combination
therapy of CPAP and MAD may also be considered as the CPAP might be more comfortable
at lower therapeutic pressures resulting in improved sleep metrics [83].
The MADs hold the lower jaw forward and do not work if they are not in situ [
84
].
They help to keep the airway open during sleep by using the top jaw as an anchor. However,
long term, there are potential craniofacial and bite changes as the body compensates for the
design of the constant forces of the device itself that do not address the root cause of the
structural problem in the tissues (i.e., a tongue tie or deficient maxilla). Craniofacial features
that include retrognathism of the mandible are also associated with OSA. Studies that have
looked at increasing the retropharyngeal space or overall airway size with mandibular
advancement devices using different modalities have also been studied. The different
devices used have included modified monobloc or activated headgear. Amended analysis
performed to evaluate functional appliances on upper airway dimensions and growing
children with class II malocclusion showed that functional appliances can also increase
airway dimensions and may decrease the risk of obstructive sleep apnea. Functional
appliances that minimize surgical interventions are preferred as they are non-invasive
and can address the size of the upper jaw, thereby affecting the posture of the lower
jaw. Maxillary development increases nasal functional space and allows the lower jaw to
come forward, opening the upper airway system in two spots—the nasal airway and the
oropharyngeal airway. This is thought to improve OSA [81].
9. Role of Myofunctional Therapy as an Adjunct to the Dental Plan
Orofacial myofunctional therapy (OMT) is an exercise-based therapy to re-train proper,
eating, chewing, swallowing, speaking, and normalizing resting postures that include lip
closure, tongue fully seated on the palate, teeth slightly apart, and nasal breathing. It
is designed to re-establish the normal oral function of the tongue and orofacial muscles.
OMT also works to eliminate maladaptive habits such as thumb sucking, nail-biting, and
tongue thrusting that can have negative effects on the craniofacial structure. This, in
conjunction with other medical and/or dental therapies, can be an adjunct to treating OSA.
Orofacial myofunctional disorder (OMD) involves dysfunction of the tongue, lips, jaw,
and other oral structures acquired from critical factors in the growth and development
of the orofacial complex from infancy to childhood. Possibly affected functions from
abnormal oromotor functioning may include difficulty breastfeeding, airway obstruction,
soft tissue restriction, mouth breathing, altered or abnormal oral resting postures, abnormal
oral habits, swallowing dysfunction, and altered mastication [
85
]. Many disregard the
importance of the orofacial muscles, however, these muscles are part of the upper airway
anatomy and need to be considered. The tongue can play a major role in airway obstruction
in OSA. Orofacial myofunctional exercises are designed to improve airway function and
balance of the facial muscles that are involved in swallowing, breathing, speaking, and
chewing [
86
]. These isometric and isotonic exercises aim to promote proprioception, range
of motion, coordination, and strength of the orofacial muscles to work towards establishing
proper eating, chewing, and swallowing which can have a positive effect on craniofacial
growth in children. During a normal swallow, the back and base of the tongue connects
with the soft palate which aids in keeping patency to the muscles of the soft palate [
87
]. The
aim of myofunctional therapy is to cause the soft palate to elevate, which recruits different
upper airway muscles, and muscle training is involved. The exercises are meant to improve
muscle fatigue in OSA patients and help improve muscle strength in different pharyngeal
segments. One of the ultimate goals of OMT is to allow the tongue to retain the gains
from the rapid palatal expansion procedure discussed earlier. Myofunctional therapy can
also reduce the volume and fat in the pharyngeal structure and muscles, thus decreasing
upper airway collapsibility [
88
]. Additionally, weight loss has been found to improve OSA
Children 2022,9, 1057 12 of 16
through the reduction of adipose tissue in the upper airway–tongue fat–and abdominal fat,
as mentioned previously. The decrease in tongue fat aids in the improvement of the apnea
hypopnea index, alleviating symptoms of OSA [8].
Myofunctional therapy has been explored as a nonsurgical approach to managing
OSA. In a study of 54 children with OSA, myofunctional therapy led to improvements
in mean oxygen saturation and the desaturation index in the treatment group [
88
]. One
meta-analysis study showed a decrease in AHI by 50% in adults and 62% in children.
Furthermore, polysomnographic studies indicated a 72.4% reduction in snoring and im-
provement in oropharyngeal muscle tone, suggesting the use of myofunctional therapy as a
possible adjunct to OSA treatment [
89
]. Treatment using these exercises is aimed to reduce
mouth breathing and improve the tongue position at rest and during sleep, especially in the
context of dental skeletal malocclusion. There have been improvements noted when nasal
breathing has been recovered [
90
92
]. The idea behind these interventions is that function
alters form and form affects function, and these interventions support a bidirectional model
of care. An additional benefit of myofunctional therapy is demonstrated in a study of
adults, reporting compliance to CPAP in combination with myofunctional therapy (65%)
versus CPAP alone (30%). Thus, myofunctional therapy may provide benefits in promoting
quality of life and adherence to CPAP in patients with OSA [88].
10. Interdisciplinary Approach
The early screening of pediatric OSA is paramount for timely diagnosis and manage-
ment. Dentists play a vital part in this preventative role as they can provide another portal
for screening for OSA. According to Greenberg and Glick, dentists are confused about the
contradictory data in publications and are hesitant to change their practice until more data
is available [
11
]. Recent interdisciplinary collaborations to get appropriate data driven pro-
tocols and publications in place will help the conundrum of protocols without data and data
needed to make protocols. Screening is best achieved by dentists, primary care providers,
and pediatricians involved in regular childcare. For children, it is a timely diagnosis that if
not intercepted can affect them for the rest of their lives. Dentists and orthodontists play a
critical role in the early identification of craniofacial problems associated with pediatric
OSA. They may also play a role in the management of craniofacial abnormalities identified
in children that have been diagnosed and treated with OSA post-tonsillectomy. The collab-
oration of medical and dental professionals is imperative to optimize airway functioning
and prevent associated morbidities.
The gap in current dental literature regarding pediatric OSA will improve once these
collaborative efforts are realized, documented, and published. Education for medical
doctors and dentists will evolve quickly when the licensing bodies are able to legislate
data-driven training guidelines for their members in the medical and dental professions.
Patients want to be healthier and feel better. Parents want to prevent problems developing
in their children while reducing dental costs from complex treatment plans that result
from underdeveloped jaws. Often providers caring for the same patient may differ in
their understanding of what the other can contribute. It will be a helpful practice if the
communication of the patient’s condition from the dental perspective is provided to the
medical doctor taking care of the patient. This will result in well-coordinated care of the
individual patient as well as overall organization and tracking of multiple patients in a
busy dental practice.
Overall, OSA is a very hot topic in both medicine and dentistry, but the uptake of
mass training is currently lagging as the majority of the members await a protocol that is
data-driven and has significant scientific evidence. It is shown that the difficulties dentists
have are related to a lack of up-to-date evidence for treatment, conflicting evidence in
the literature, and a lack of clear answers to clinical questions [
93
]. Dentists and medical
doctors need to work together by referring to each other, gathering data together to assess
the effectiveness of treatment, and publishing their results together to help dentists become
part of the front line in screening for sleep disordered breathing.
Children 2022,9, 1057 13 of 16
11. Conclusions
Children suffering from OSA and various forms of SRBD are best managed by
a multidisciplinary team consisting of a pediatrician, ENT specialist, a pediatric den-
tist/orthodontist, a myofunctional therapist, and a sleep medicine physician to manage
all the downstream effects of abnormal anatomy and function that have led to the dis-
ease. Dentists can help via early detection of these anatomical changes and intercept with
treatment to optimize anatomy and function during a child’s growth and development.
Properly trained dentists can play a critical collaborative role in OSAS detection, prevention,
and management of the dental-skeletal factors, while the medical and surgical aspects are
managed by sleep medicine physicians and surgical colleagues, respectively.
Everyone should screen for obstructive sleep apnea and know where their patients
can get help.
Author Contributions:
Conceptualization, T.H., B.J.T., M.S., M.A.T. and M.W.; methodology, T.H.,
B.J.T., F.M., M.K., M.A.T. and M.W.; software, T.H. and M.W.; validation, T.H., M.S., M.A.T. and
M.W.; formal analysis, T.H., M.S., B.J.T., F.M., M.K., M.A.T. and M.W.; investigation, T.H., M.S., M.A.T.
and M.W.; resources, T.H., M.S., B.J.T., F.M., M.K., M.A.T. and M.W.; data curation, T.H., B.J.T., M.S.,
M.A.T. and M.W.; writing—original draft preparation, T.H., B.J.T., M.S., F.M., M.K., M.A.T. and M.W.;
writing—review and editing, T.H., M.S., M.A.T. and M.W.; visualization, T.H., M.S., M.A.T. and M.W.;
supervision, M.A.T. and M.W.; project administration, M.A.T. and M.W. All authors have read and
agreed to the published version of the manuscript.
Funding: This research received no external funding.
Data Availability Statement: Not applicable.
Conflicts of Interest:
Tammarie Heit and Manisha Witmans are paid consultants and on medical
advisory board for Vivos therapeutics.
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... Em sequência, foram definidos os critérios de inclusão, sendo eles artigos de revisão da literatura, textos disponíveis integralmente no meio digital, artigos que abordassem a temática central e artigos escritos nas linguagens portuguesa, inglesa e espanhola. (SCHROEDER, GURENLIAN, 2019;ANWER et al., 2021;HEIT et al., 2022) ...
... Por outro lado, os autores destacam que os profissionais de odontologia, quando conhecem da AOS, podem auxiliar na identificação de indivíduos com potencial para AOS, através do histórico de saúde e dos sinais e sintomas vistos no exame clínico do paciente, além de estar apto a encaminhar profissionais de alto risco para realização do diagnóstico com especialista através da polissonografia. (BERGGREN et al., 2021;HEIT et al., 2022) Academia Americana de Medicina Dentária do Sono afirma que o Cirurgião-Dentista possui uma grande importância no que tange à redução da carga de saúde pública dos distúrbios respiratórios relacionados ao sono em situação de não diagnosticados e não tratados. Desse modo, é incentivado que o CD realize a documentação em casos de anatomia anormal dos maxilares, assim como dos dentes e vias aéreas superiores, além de triar os pacientes para AOS através de questionários e, inclusive, colaborar com os médicos para diagnóstico e tratamento dos pacientes. ...
... Desse modo, é incentivado que o CD realize a documentação em casos de anatomia anormal dos maxilares, assim como dos dentes e vias aéreas superiores, além de triar os pacientes para AOS através de questionários e, inclusive, colaborar com os médicos para diagnóstico e tratamento dos pacientes. (HEIT et al., 2022) Além disso, a utilização do questionário de sono de Chervin (PSQ) e OSAS-18, para crianças, tem sido utilizados cada vez mais pelos CD com intuito de rastrear os pacientes com AOS, haja vista que o questionário não leva em consideração dos aspectos dentários para colaborar com o diagnóstico. Todavia, mesmo com a utilização dos melhores questionários disponíveis atualmente, eles não contemplam todas as características ligadas a síndrome, a exemplo do perfil craniofacial, bem como a má oclusão dentária, além da asma, alergias e/ou refluxo gastroesofágico, de modo que somente os questionários não são suficientes para diagnosticar a AOS, mas são de fundamental importância na triagem dos pacientes nos consultórios e para encaminhamento para diagnóstico definitivo. ...
Article
Full-text available
A Apneia Obstrutiva do Sono (AOS) é um distúrbio respiratório relacionado ao sono (SRDB) que se caracteriza por recorrentes episódios de obstrução total e/ou parcial das vias aéreas superiores, ocorrem, em sua maioria, durante o sono, o que resulta em intermitentes incidentes de hipoxemia e hipercapnia, bem como despertares recorrentes e ruptura do sono. A AOS possui etiologia multifatorial e está principalmente associada à hipertrofia adenotonsilar, embora fatores funcionais e anatômicos contribuam para seu desenvolvimento. Nesse sentido, é de suma importância a realização do diagnóstico dessa condição, levando em consideração suas características e riscos, de modo que a atuação do Cirurgião-Dentista (CD) se torna imprescindível no diagnóstico através da anamnese, exame físico extraoral e intraoral. Objetivou-se demonstrar a importância do CD no diagnóstico da AOS através de uma revisão de literatura realizada por meio de um levantamento bibliográfico nas bases de dados PubMed, MEDLINE e LILACS, utilizando os descritores “Sleep Apnea, Obstructive” e “Dental Care” com o auxílio do operador booleano “and”, além de delimitar a pesquisa para estudos do tipo revisão na linguagem portuguesa, inglesa e espanhola, entre os anos de 2016 a 2022. Obteve-se um total de 563 registros que, após a aplicação dos critérios de elegibilidade, resultaram em apenas 8 artigos incluídos. A AOS acomete qualquer fase da vida, porém especialmente a terceira idade, com prevalência de 42%, sem ter predileção significativa pelo sexo, exceto entre os adolescentes do sexo masculino. Pessoas diagnosticadas com AOS possuem modificações na qualidade do sono, ronco rotineiro, dificuldades para dormir, respiração bucal, sudorese noturna e interrupção do sono. O diagnóstico ocorre através de uma boa anamnese e da qualidade do sono, além da análise da cavidade oral pelo CD, o qual deve questionar a respeito dos sinais e dos sintomas da AOS, como roncos e mudanças frequentes na postura durante o sono. No entanto, para confirmar seu diagnóstico deve-se solicitar o exame denominado polissonografia que avalia a qualidade e identifica complicações no sono. As variações craniofaciais possuem papel no seu desenvolvimento, o que significa que alteração na anatomia, como fissura labiopalatina e hipoplasia do terço médio da face, podem ser fatores determinantes. Assim, o CD precisa analisar a face e a cavidade oral do paciente para auxiliar no diagnóstico. Conclui-se que a AOS é uma condição que apresenta riscos, visto que a pessoa para de respirar transitoriamente e que o Cirurgião-Dentista possui um papel fundamental no diagnóstico clínico.
... In young healthy children, the main etiology of OSA is related to adenoid and/or tonsillar hypertrophy [10]. However, other factors such as malocclusion or other causes of inflammation such as allergic rhinitis and asthma may also play a significant role [10,11]. Obesity is increasingly more prevalent in the pediatric population and is a significant risk factor for OSA especially in the adolescent group [10]. ...
... If the cardiopulmonary coupling can be assessed apriori, this could result in a fundamental shift in the way childhood OSA is managed and treated as the authors point out. Dr. Guillemineault and colleagues had shown that children with OSA required both rapid maxillary expansion and adenotonsillectomy for a complete cure of OSA in children with malocclusion and associated OSA symptoms [11]. Preventative care to optimize the normal development of maxillofacial skeleton and function to decrease risk of developing OSA is also discussed. ...
... Preventative care to optimize the normal development of maxillofacial skeleton and function to decrease risk of developing OSA is also discussed. Advances in oral appliances for children continue to evolve which indicates the importance of interdisciplinary synergistic collaboration with the field of dentistry and medicine to treat OSA [11]. There is a need for increased awareness and education about pediatric OSA in both medical and dental schools [18]. ...
Article
Full-text available
Obstructive sleep apnea (OSA) is described as intermittent partial or complete upper airway obstruction that can disrupt respiratory and ventilatory patterns during sleep [...]
... Surgical interventions such as uvulopalatopharyngoplasty, maxillomandibular advancement, and hypoglossal nerve stimulation may be considered for patients with severe OSA who fail conservative treatments. 30,31 It's important to consider the potential effects of these treatment modalities on masticatory muscle function, as some interventions may exacerbate or alleviate existing masticatory muscle dysfunction. ...
... This may involve a combination of therapies, including CPAP or oral appliance therapy, masticatory muscle exercises, lifestyle modifications (e.g., weight loss, dietary changes), and adjunctive therapies for TMDs, such as physical therapy, pain management, and occlusal splint therapy. 31,32 By adopting an interdisciplinary approach, healthcare providers can address the complex interplay between OSA and masticatory muscle function and provide personalized care tailored to the needs of individual patients. ...
... Dental specialists can help in the early screening or diagnosis of the OSA and referral to the medical specialists for timely and appropriate management of OSA in children. [9,50,51] There are several aspects of dental treatment approaches for addressing the OSA which can be properly accomplished by dental professionals/ dentists. [9,50,51] However, several studies have reported the low knowledge about OSA and satisfactory/favorable attitude toward OSA among the dental professionals. ...
... [9,50,51] There are several aspects of dental treatment approaches for addressing the OSA which can be properly accomplished by dental professionals/ dentists. [9,50,51] However, several studies have reported the low knowledge about OSA and satisfactory/favorable attitude toward OSA among the dental professionals. [52][53][54][55] Hence, an updated and specific education and clinical training at undergraduate and postgraduate dental students, whereas continuing medical/ dental education programs, symposiums and webinars for dental practitioners are of utmost importance in the effective management of OSA with a multidisciplinary approach. ...
Article
Full-text available
Obstructive sleep apnea (OSA) is negatively affecting the health of people and their quality of life. This breathing disorder has a multifactorial etiology. However, orofacial factors in OSA patients have been reported to be relatively more significant factors for its etiopathogenesis and its progression. Polysomnography has been a conventional diagnostic modality for OSA. However, in recent years, various novel and modern detection and diagnostic options have been reported in the current literature. Adenotonsillectomy, positive airway pressure therapy, oral appliances (e.g. mandibular advancement device), and pharmacological drugs (intranasal corticosteroids, etc.) have been known as some of the common treatment modalities for OSA. However, recently several modern therapeutic ways for OSA have been reported in the current literature. The aim of this review article is to comprehensively appraise and highlight the current and recent literature about several aspects of OSA, particularly its modern and novel detection methods and therapeutic options.
... In previous studies that employed the BEARS questionnaire to identify obstructive sleep apnea (OSA) in children, however, it was observed that while the BEARS questionnaire was effective in detecting sleep disturbances, it did not provide any information about other clinical factors that are associated with OSA [21][22][23]. On the other hand, in studies that utilized the FAIRST questionnaire to diagnose OSA in children, the authors reached the conclusion that it is a concise, validated tool that solely relies on clinical evaluation [11,24]. Therefore, in order to determine sleep disruptions and clinical variables connected to the occurrence of OSA, the current study implemented the utilization of the BEARS and FAIRST questionnaires. ...
Article
Full-text available
Background and Objective The prevalence of sleep-disordered breathing is extremely high, yet it is largely ignored. Significant adverse medical and psychological outcomes are associated with sleep-related respiratory disorders, including obstructive sleep apnea (OSA). Treatment and an early diagnosis will aid in averting additional severe consequences. Our study aimed to assess prevalence of OSA among 6–9-year-old children in Visnagar.Methods The approval of the school authorities and ethics committee was received. A sample size of 455 was determined. Clinical inspection was used to determine the prevalence of OSA in children aged 6 to 9 years using the “FAIREST-6” and BEARS criteria. The cases were classified as mild, moderate, or severe. By employing the chi-square test and Fisher’s exact test, inferential statistics were calculated.Results Prevalence of 8.13% (n = 37) among sample of 453 participants was observed. Gender predilection was found to be in 43.2% (n = 16) among females and 56.8% (n = 21) among males. Those diagnosed with OSA were categorized as mild 17 (45.94%), moderate 12 (32.43%), and severe 8 (21.62%).Conclusions OSA prevalence was determined 8.13% in the Visnagar population of children and adolescents aged 6 to 9 years using the FAIREST and BEARS questionnaire.
... Functional dentistry can utilize the Functional Airway Evaluation Screening Tool (FAIREST-6) to aid identification of these SDB patients [41]. Besides mandibular advancement devices and maxillary expansion, myofunctional therapy is an additional tool that helps to ensure patients will have strong tongue muscles and correct tongue posture that maintains completed treatment [42]. Ear, nose, and throat (ENT) physicians are a pivotal piece in the identification and management of SDB (due to the importance of a patient's ability to breathe easily through the nose during REM sleep), as ENT physicians can help with the persistent oronasal dysfunctions that can significantly worsen as age increases [43]. ...
Article
Full-text available
The obesity paradox is seen in all body mass indexes (BMI), where normal weight individuals can be metabolically unhealthy, and obese individuals can still be metabolically healthy. BMI has never fully explained a reason for the obesity paradox, whereas sleep-disordered breathing (SDB) predicts metabolic and inflammation changes that occur, regardless of BMI status. This paper reviews SDB challenges, sleep quality, and fragmented rapid eye movement (REM), a key time of sleep when the immune system is boosted and hormone levels are stabilized, and how SDB predicts and identifies obesity paradox individuals. Journal articles were searched through PubMed, EBSCOhost, Google Scholar, and Directory of Open Access Journals, and chosen if they discussed sleep-disordered breathing, sleep quality, rapid eye movement sleep, sleep efficiency, metabolic syndrome, obesity paradox, or the U-shape disease risk model. An individual with untreated SDB has significantly higher healthcare costs, morbidity, and mortality, especially 3 to 10 years prior to diagnosis. The presence of untreated SDB fragments REM sleep, decreasing sleep quality and sleep efficiency. Nasal disuse when the body is paralyzed during REM predicts higher inflammation and abnormal metabolic parameters, regardless of BMI. Untreated SDB (mouth breathing) leads to significant inflammatory and metabolic health challenges that over time increase chronic health problems for both normal/underweight individuals and for those severely obese, whereas if an overweight or slightly obese individual does not have untreated SDB, they can still be metabolically healthy, identifying a reason for the obesity paradox.
Article
Zusammenfassung Zahnärztliche Schlafmedizin ist das derzeit „medizinischste“ aller zahnmedizinischen Themen. Gemeinhin als Schnarchen bezeichnet, betrifft die Schlafapnoe weltweit ca. 1 Milliarde Menschen und entwickelt sich somit zunehmend zu einer der großen Volkskrankheiten. Hinter der lästigen nächtlichen Ruhestörung verbirgt sich oftmals das Schlafapnoe-Syndrom, welches bei längerem Bestehen häufig gravierende Folgen für die allgemeine Gesundheit hervorruft. Schlaf ist ein lebenswichtiger, physiologischer Ruhezustand des Körpers. Da in der Mundhöhle der von Schlafstörung betroffenen Patienten häufig klinische Hinweise in Form von Schlafbruxismus, Zahnfrakturen oder Erosionen vorliegen, können manchmal auch Zahnärzte in Kombination mit einfachen Fragebögen die wichtige Verdachtsdiagnose stellen. Aber auch therapeutisch sind zahnmedizinische Ansätze in der oftmals multidisziplinären Behandlung abgebildet: Kieferorthopädische skelettale und auch funktionelle Therapiekonzepte können hinsichtlich des posterioren Rachenraums stabilisierend und/oder formverändernd wirken und somit präventionsorientiert angreifen. Die Versorgung erwachsener Patienten mit einer Unterkieferprotrusionsschiene (UPS) ist in aktuellen Leitlinien festgelegt und dort als Zweitlinientherapie fixiert. Schlaf bezogene Atmungsstörungen können langfristig erfolgreich häufig nur interdisziplinär unter Berücksichtigung des Patientenalters, der Ätiologie und Ausprägung behandelt werden. Die Zahnmedizin ist hierbei zu einem wichtigen Bestandteil geworden.
Article
Introduction/Objective. Upper air dimensions are associated with morphological facial features. The objective of study is to test the hypothesis that the sagittal size of the upper respiratory pathways in children aged 8?12 years with hyperdivergent class II/1 malocclusion is smaller compared to the general population of the same age. This may be associated with an increased risk of developing obstructive sleep apnea syndrome in these individuals later in life. Methods. Using profile teleradiograms of 31 children average age being 9.02 ? 1 years with hyperdivergent class II/1 malocclusion, sagittal dimensions of the pharyngeal respiratory pathway at the levels of naso-, oro-, and hypopharynx were measured. These dimensions were compared with measurements from 35 children with an average age of 8.97 ? 0.6 years with other types of malocclusions. Results. Statistically significant smaller sagittal dimensions of the upper respiratory pathways were found in children with hyperdivergent class II/1 malocclusion compared to the general population of the same age at all three measured levels. Conclusion. The hypothesis was confirmed that in children with hyperdivergent class II/1 malocclusion, the dimensions of the pharyngeal respiratory pathways are significantly smaller compared to the general population of the same age. The width of the oropharynx contributes most to this difference, followed by the width of the nasopharynx, with the least contribution from the hypopharynx.
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Background Dental sleep medicine education (DSME) should be emphasised in postgraduate orthodontic training; however, there appears to be no clear guideline for its implementation into the curriculum. Objective The aim was to investigate the current status of DSME as well as its feasibility and implementation in postgraduate orthodontic programmes. Methods A structured interview with predetermined response options was chosen as a data collection method to gather relevant information from representatives of all accredited postgraduate orthodontic programmes in Thailand. These interviews were conducted online via the Cisco Webex Meeting platform. A combination of data analysis techniques was employed to achieve a thorough comprehension of the research findings, including descriptive statistics, quantitative content analysis, thematic analysis, and alignment analysis. Results All participating programmes reported the inclusion of DSME in their curricula. A didactic approach was adopted by all programmes. However, only 2 out of 7 programmes offered clinical sessions for their students. Several challenges in implementing DSME within orthodontic programmes were identified, including a shortage of expertise and limited patient access. The participants also suggested that knowledge and resource sharing amongst institutions could serve as a potential solution to enhance the feasibility of DSME. Conclusions This research highlighted the significant disparities and inadequacy of DSME within postgraduate orthodontic programmes in Thailand due to various challenges. Consequently, there is a compelling need to place greater emphasis on DSME and establish a national-level standardisation within orthodontic programmes. This effort is essential for enhancing the awareness and competency of orthodontists in the field of DSME.
Article
Background Pediatric dentists should play an essential role in obstructive sleep apnea (OSA) screening, referral, and management of their child patients. However, few studies have investigated pediatric dentists’ knowledge, attitude, and practice aspects regarding different domains of pediatric OSA. Aim of the Study This cross-sectional survey aimed to assess the knowledge, attitude, and practice aspects of different domains of pediatric OSA among pediatric dentists from Kerala. Methods This cross-sectional study was conducted in Kerala. The sample frame consisted of 163 dentists, and the minimum required was 115. Ethical approval was obtained before starting the study. Settings and Design An invitation E-mail explaining the purpose of the study with a survey link was sent to the pediatric dentists from Kerala ( n = 163). Nonrespondents were contacted at timely intervals. Statistical Analysis Categorical and quantitative variables were expressed as frequency (percentage) and mean ± standard deviation, respectively. Chi-square test was used to find an association between categorical variables. Statistical analysis was performed using a statistical software package, SPSS, version 20.0. Results and Conclusion This cross-sectional study showed that pediatric dentists in Kerala have a moderate-to-good level of knowledge, along with a positive attitude toward different domains of pediatric OSA, but lag behind in the practice aspects. Hence, they are required to direct themselves toward continuing dental education programs in order to boost their routine practice. For this, steps must be taken to ensure proper networking of the practitioners and amendments in the dental billing system similar to the medical counterpart.
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Maxillofacial bone defects are commonly seen in clinical practice. A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone regeneration. The fibroblast growth factor (FGF) signalling pathway is critical for the development of maxillofacial bone. Klotho, a type I transmembrane protein, is an important components of FGF receptor complexes. Recent studies have reported the presence of Klotho expression in bone. However, the role of Klotho in cranioskeletal development and repair remains unknown. Here, we use a genetic strategy to report that deletion of Klotho in Osx-positive mesenchymal progenitors leads to a significant reduction in osteogenesis under physiological and pathological conditions. Klotho-deficient mensenchymal progenitors also suppress osteoclastogenesis in vitro and in vivo. Under conditions of inflammation and trauma-induced bone loss, we find that Klotho exerts an inhibitory function on inflammation-induced TNFR signaling by attenuating Rankl expression. More importantly, we show for the first time that Klotho is present in human alveolar bone, with a distinct expression pattern under both normal and pathological conditions. In summary, our results identify the mechanism whereby Klotho expressed in Osx+-mensenchymal progenitors controls osteoblast differentiation and osteoclastogenesis during mandibular alveolar bone formation and repair. Klotho-mediated signaling is an important component of alveolar bone remodeling and regeneration. It may also be a target for future therapeutics.
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Obstructive Sleep Apnea (OSA) is a form of sleep-disordered breathing characterized by upper airway collapse during sleep resulting in recurring arousals and desaturations. However, many aspects of this syndrome in children remain unclear. Understanding underlying pathogenic mechanisms of OSA is critical for the development of therapeutic strategies. In this article, we review current concepts surrounding the mechanism, pathogenesis, and predisposing factors of pediatric OSA. Specifically, we discuss the biomechanical properties of the upper airway that contribute to its primary role in OSA pathogenesis and examine the anatomical and neuromuscular factors that predispose to upper airway narrowing and collapsibility.
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Precision medicine requires coordinated and integrated evidence-based combinatorial approaches so that diagnosis and treatment can be tailored to the individual patient. In this context, the treatment approach to mild obstructive sleep apnea (OSA) is fraught with substantial debate as to what is mild OSA, and as to what constitutes appropriate treatment. As such, it is necessary to first establish a proposed consensus of what criteria need to be employed to reach the diagnosis of mild OSA, and then examine the circumstances under which treatment is indicated, and if so, whether and when anti-inflammatory therapy (AIT), rapid maxillary expansion (RME), and/or myofunctional therapy (MFT) may be indicated.
Article
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Abstract Background Mouth breathing is closely related to the facial skeletal development and malocclusion. The purpose of this systematic review and meta-analysis was to assess the effect of mouth breathing on facial skeletal development and malocclusion in children. Methods An electronic search in PubMed, the Cochrane Library, Medline, Web of Science, EMBASE and Sigle through February 23rd, 2020, was conducted. Inclusion criteria were children under 18 years of age with maxillofacial deformities due to mouth breathing. The risk of bias in nonrandomized studies of interventions (ROBINS-I) tool for controlled clinical trials. The Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach was used for the quality assessment. The included indicators were SNA, SNB, ANB, SN-OP, SN-PP, PP-MP, SNGoGn, MP-H, 1-NA, 1. NA, 1. NB, 1-NB, Overjet, Overbite, SPAS, PAS, and C3-H. Data concerning the mean difference in mesial molar movement and extent of canine retraction were extracted for statistical analysis. The mean differences and 95% confidence intervals were analyzed for continuous data. Review Manager 5.3, was used to synthesize various parameters associated with the impact of mouth breathing on facial skeletal development and malocclusion. Results Following full-text evaluations for eligibility, 10 studies were included in the final quantitative synthesis. In Sagittal direction, SNA (MD: − 1.63, P
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Introduction Craniofacial growth is modified by chronic mouth breathing. Rapid maxillary expansion leads to separation of the mid-palatal suture, improving the occlusion and the upper airway size. Aim Systematically evaluate scientific articles on the effects of rapid maxillary expansion on airway dimensions and classify the quality of the evidence of the information. Methods Searches on PUBMED, LILACS, EMBASE, SCOPUS, WEB OF SCIENCE and COCHRANE, as well as in the grey literature were performed. The articles found were selected and evaluated both for the risk of bias (ROBINS-I) and for the quality of evidence (GRADE). Results Of the 309 works found, 26 papers were selected for full reading, of which 22 were excluded. Data compilation and analysis were performed in four papers, two being controlled non-randomized clinical trials and two non-randomized and uncontrolled clinical trials. No randomized clinical trial was found. Conclusions The meta-analysis found an increase in the inter-alar and inter-zygomatic distances and oropharyngeal volume after rapid maxillary expansion, which, together with clinical findings, makes the recommendation favorable to the intervention. The quality of the evidence for each outcome was considered very low.
Article
Aim: Tongue tie is a common problem affecting breastfeeding due to poor infant latch and/or maternal pain. Evidence of whether treatment improves breastfeeding outcomes is conflicting. We conducted a systematic review and meta-analysis to examine the effectiveness of tongue tie treatment on breastfeeding difficulties. Methods: We searched peer-reviewed and grey literature in MEDLINE (OVID), PubMed, CINAHL Plus, EMBASE and PsycINFO, from 01/1970 to 09/2019. Inclusion: randomized and non-randomized clinical trials, and quasi-experimental study designs, involving breastfeeding interventions for full-term singleton infants, using standardized measure of breastfeeding difficulty. Exclusion: qualitative and purely observational studies, lacked operational definition of breastfeeding difficulty, lacked control/comparison group. We assessed risk of bias, summarized study quality and results, and conducted meta-analysis using random effects modelling. Results: Six studies on tongue tie division were included (4 randomized, 2 non-randomized). Meta-analysis of standardized mean differences in breastfeeding difficulty scores in four studies showed statistically significant differences in favour of frenotomy (Pooled SMD +2.12, CI:(0.17-4.08)p=0.03). Similarly, a statistically significant difference in favour of frenotomy was observed for pain (Pooled SMD -1.68, 95% CI:(-2.87- -0.48). Conclusion: Results support that infant frenotomy is effective for improving standardized scores on breastfeeding difficulty and maternal pain scales and could improve breastfeeding outcomes.
Article
Aim To ascertain and illustrate specific clinical dento-craniofacial characteristics associated with sleep-disordered breathing (SDB) in non-syndromic children. Methods Narrative review of literature on SDB, dental occlusion and craniofacial morphology retrieved through online literature database search for these terms. The review focused on clinical examples and graphical illustrations in order to ascertain the association between dento-craniofacial characteristics and SDB. Only publications concerning healthy non-syndromic children without any somatic or psychological diagnosis were included. Results Dento-craniofacial characteristics like anterior open bite, large overjet, cross bite and facial appearance such as convex profile due to mandibular retrognathia and inclination, narrow and high palate can predispose to SDB in non-syndromic children. Furthermore, extended head posture, mouth breathing and general adenoidal face may be symptoms or predisposing factors to SDB in non-syndromic children. Conclusion Dento-craniofacial characteristics as anterior open bite, large overjet due to mandibular retrognathia, cross bite, and narrow and high palate can predispose to SDB in non-syndromic children. Facial characteristics predisposing to SDB can be a convex facial profile, extended head posture, mouth breathing and general adenoidal face. Interdisciplinary collaboration between medical doctors and dentists can prove valuable in diagnostics, prevention and treatment of SDB in non-syndromic children.
Article
Purpose: The purpose of this study was to identify patterns of functional, extraoral, and intraoral examination characteristics that correlate with increased risk of sleep disturbances and develop a functional airway screening tool to help clinicians for early diagnosis of pediatric sleep-disordered breathing. Methods: From March 2018 until March 2019, a cross-sectional study was conducted of 96 mixed dentition children during dental examinations at the UCLA pediatric dental clinic. Outcome measures included a sleep index score by the Sleep Disturbance Scale for Children (SDSC) completed by parents. Clinical assessment tool measurements assessing functional, extraoral, intraoral soft tissue, and intraoral hard tissue determinants were recorded during a routine dental examination by pediatric dental residents. Results: The mean age was 8.9 years (±1.9 years standard deviation), with 46 males and 50 females participating. Mouth-breathing (functional), mentalis strain (extra-oral), tonsillar hypertrophy and ankyloglossia (intraoral soft tissue), dental wear, and narrow palate (intraoral hard tissue) were found to be the most clinically deterministic of higher SDSC scores (P<0.01). A clinical assessment tool for sleep-disordered breathing in pediatric dental patients (FAIREST-6) was developed, comprising these six clinical factors. Conclusions: The FAIREST-6 is a concise and validated clinical assessment tool that may aid in early diagnosis and intervention of pediatric sleep-disordered breathing.
Book
This textbook provides a comprehensive introduction to the novel concepts of pneumopedics and craniofacial epigenetics. Clinically, these mechanisms are delivered through biomimetic oral appliance therapy. The text, therefore, covers both genetics and epigenetics of craniofacial development, as well as growth and development of the craniofacial architecture. Despite being complex subjects, the style of writing allows the general reader to assimilate this information and sets the scene for how these principles might best be utilized. For example, the clinical application of biomimetic tooth movement achieved through epigenetic orthodontics is presented. Prior to pneumopedic treatment, the significance of craniofacial diagnostics and treatment planning is discussed, before detailing the principles of designing a biomimetic oral appliance. Next, the book goes over the practicalities of clinical adjustments of oral biomimetic devices. Moving onto patient selection and management, the book also provides an overview and introduction to pediatric craniofacial epigenetics, which touches upon the preventive aspects of healthcare, including nutrition. This section is followed by an introduction to sleep and sleep disordered breathing in both children and adults, which includes a comprehensive approach to the potential elimination of obstructive sleep apnea. Finally, clinical biomimetic correction is illustrated with examples of non-surgical upper airway remodeling using various cases. The book also contains a Glossary containing definitions of common terms as well as an Appendix of documents that might be useful for both implementation and further study. © 2021 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.