In this era of the digital world, data play a central role and are continuously challenging spectrum efficiency. With the introduction of enriched multimedia user-generated content, the challenges are even more aggravated. In this vein, uplink caching is considered as one of the promising solutions to effectively cater the user’s demands. One of the main challenges for uplink caching is ... [Show full abstract] duplication elimination. In this paper, a cache enabled uplink transmission with a duplication elimination scheme is proposed. The proposed scheme matches the mobile’s data to be uploaded with the cached contents both at mobile station (MS) and small base station (SBS). In contrast to existing techniques, the proposed scheme broadcasts the cached contents at an SBS to all the MSs under its footprint. This provides MS an opportunity to exploit the list of cached contents before uploading its data. A MS only uploads its data if it is not already cached at an SBS. This significantly reduces duplication before the real transmission takes place. Furthermore, the proposed technique reduces energy consumption in addition to improving spectral efficiency and network throughput. Besides, a higher caching hit ratio and lower caching miss ratio are also observed as compared to other schemes. The simulation results reveal that the proposed scheme saves 97% energy for SBS, whereas 96–100% energy is saved for MS on average.