This chapter presents the main scientific evidence relevant to the hypothesis of survival of consciousness after the death of the body: studies on mediumship, near-death and out-of-body experience, and cases of the reincarnation type. First, we present a brief history and cultural aspects concerning these subjects. Then, the main scope of this chapter, we present and discuss the main scientific evidence encompassing studies from the second half of the nineteenth century until nowadays. Finally, we discuss the strengths and limitations of the main explanations alternative to the survival hypothesis (e.g., fraud, chance, neuropsychological automatisms or disorders, and extrasensory perception) regarding the presented studies. Well-conducted studies (with strict controls and statistical analysis) show that mediums can provide accurate information and demonstrate nonverbal skills and that these pieces of information hardly could be explained by leakage, chance, extrasensory perception, or emotional fragility of a bereaved sitter. Large longitudinal studies and in-depth consistent reports of sharp mental function and veridical perceptions in out-of-body experiences during near-death experiences, despite a severely dysfunctional or nonfunctional brain, corroborate the hypothesis of an independent mind. Thousands of similar cases around the globe of very young children who spontaneously start making accurate statements about alleged previous lives, exhibiting behavior, emotional reactions, skills, and birth defects in accordance with the alleged personality (often unknown to them) strengthen the hypothesis of survival of consciousness.KeywordsSurvivalSoulMindConsciousnessDeathMediumshipNear-death experienceOut-of-body experienceReincarnationLife after deathEvidencePast lives