This chapter will present and refute the most frequently claimed empirical and philosophical objections that impede giving the survival hypothesis a fair trial: (1) neuroscience “proves” that the brain generates mind; (2) Principle of Parsimony—we should explain mind solely on a material basis; (3) there is no mechanism for how the mind would influence the brain; (4) science has proved physicalism and survival implies supernaturalism; and (5) survival implies Cartesian dualism that is rejected by learned people. These objections are usually based on misguided metaphysical and philosophical assumptions and often related to previous ideological commitment to physicalism. There is no sound argument or empirical evidence to force us to an a priori rejection of survival as an explanatory hypothesis for the anomalous and spiritual experiences we discuss at this book. In light of that, survival hypothesis should be taken in consideration by a rigorous but open-minded and fair examination. Rejecting to consider this possibility would be dogmatic and, thus, anti-scientific.KeywordsSurvival after deathLife after deathPrejudiceDogmatismSkepticismSurvivalNeuroscienceOccam’s razorMechanismPhysicalismDualismSuperstition