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Effect of Light Exposure on Serum Melatonin Levels of
ICU Patients: A Preliminary Observational Study
Α Korompeli1*, L Molcan2*, N Kavrochorianou1*, T Katsoulas1, P Myrianthefs1 and G Fildissis1
1National and Kapodistrian University of Athens, University ICU, Ag. Anargyroi General Hospital, Athens, Greece
2Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia
Research Article Copyright © All rights are reserved by Α Korompeli
ISSN: 2641-1911 DOI: 10.33552/ANN.2022.12.000792
Archives in
Neurology & Neuroscience
This work is licensed under Creative Commons Attribution 4.0 License
ANN.MS.ID.000792.
*Corresponding author: Dr Anna Korompeli, National and Kapodistrian Univer-
sity of Athens, University ICU, Ag. Anargyroi General Hospital, Noufaron & Timiou
Received Date: May 02, 2022
Published Date: May 16, 2022
Abstracts
Aim:
Method:
Results:
Conclusion:
Keywords:
Introduction
Archives in Neurology and Neuroscience Volume 12-Issue 4
Citation:
10.33552/ANN.2022.11.000792
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Intense night lights, something prevalent in the ICU
in ICU patients.
Materials and Methods
Ethical and research approvals
ICU design
at a Greek general hospital in Athens. Total admissions at this ICU
ICU, resulting in a longer mean length of stay. The windows offered
Eligibility criteria
o
irregularities. Measurement of melatonin levels.
Light levels
Data analysis and statistical evaluation
Shapiro-Wilk test of normality was applied, and when proven
Citation:
10.33552/ANN.2022.11.000792
Archives in Neurology and Neuroscience Volume 12-Issue 4
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Table 1: Characteristics of ICU patients.
All patients
(mean ± SEM)
[min – max]
Male
(mean ± SEM)
[min – max]
Female
(mean ± SEM)
[min – max]
p-value (male vs female)
n 10
n, light part 3 1
n, dark part 3 3
70.1
23.0 9.0
25.0
9.5 9.2 10.0
Table 2: Comparison of the light intensity between the dark and light part of the ICU.
Light part, lux
(mean ± SEM)
[min – max]
Dark part, lux
(mean ± SEM)
[min – max]
p-value
220
55
Figure 1: Graphical display of a correlation coecient matrix of selected parameters separately in the “morning” and “evening”. The correlation
matrix contains the correlation coecients. The coloured correlation coecients represent a signicant (p < 0.05) correlation. Male = 1, Female
= 2, Light ICU part = 1, Dark ICU part = 0.
Results
Then, we measured serum melatonin levels in all ICU patients
Archives in Neurology and Neuroscience Volume 12-Issue 4
Citation:
10.33552/ANN.2022.11.000792
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Figure 2: Comparison of serum melatonin measured in the “morning” (8:00; n=10) and in the “evening” (20:00; n=10).
light exposure in the light and dark ICU part, we analysed melatonin
Figure 3: Eects of ICU part (A) and gender (B) and on serum melatonin levels measured in the “morning” (8:00; n=10) and in the “evening”
(20:00; n=10).
Citation:
10.33552/ANN.2022.11.000792
Archives in Neurology and Neuroscience Volume 12-Issue 4
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ICU, although the light intensity was lower than in the light part of
Figure 4: Ratio (“morning” / “evening”) of serum melatonin levels (A) and light intensity (B) expressed for ICU patients separately in the light
and dark part of the ICU.
Discussion
melatonin levels. ICU patients were exposed to environmental
period, in ICU patients.
Towards this purpose, we measured the serum melatonin levels
serum melatonin levels were slightly higher in the ICU patients
relative to those reported in the literature for healthy individuals
Archives in Neurology and Neuroscience Volume 12-Issue 4
Citation:
10.33552/ANN.2022.11.000792
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A previous study showed that plasma melatonin levels were not
[10].
Conclusion
part of the ICU or to the study of melatonin levels at only two time-
the synthesis and release of melatonin were not impeded at the
Limitations
However, melatonin is a hormone predominantly present in plasma
and measure melatonin ideally in the middle of the night. To
Relevance to Clinical Practice
the ICU.
Disclosure of interest
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