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A Unified Citywide Dashboard for Allocation and Scheduling Dialysis for COVID-19 Patients on Maintenance Hemodialysis

Authors:
  • Independent Researcher
  • Nanavati Max Hospital

Abstract and Figures

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has caused significant global disruption, especially for chronic care like hemodialysis treatments. Approximately 10,000 end-stage kidney disease (ESKD) patients are receiving maintenance hemodialysis (MHD) at 174 dialysis centers in Greater Mumbai. Because of the fear of transmission of infection and inability to isolate patients in dialysis centers, chronic hemodialysis care was disrupted for COVID-19-infected patients. Hence, we embarked on a citywide initiative to ensure uninterrupted dialysis for these patients. Materials and methods: The Municipal Corporation of Greater Mumbai (MCGM) designated 23 hemodialysis facilities as COVID-positive centers, two as COVID-suspect centers, and the rest continued as COVID-negative centers to avoid transmission of infection and continuation of chronic hemodialysis treatment. Nephrologists and engineers of the city developed a web-based-portal so that information about the availability of dialysis slots for COVID-infected patients was easily available in real time to all those providing care to chronic hemodialysis patients. Results: The portal became operational on May 20, 2020, and as of December 31, 2020, has enrolled 1,418 COVID-positive ESKD patients. This initiative has helped 97% of enrolled COVID-infected ESKD patients to secure a dialysis slot within 48 hours. The portal also tracked outcomes and as of December 31, 2020, 370 (27%) patients died, 960 patients recovered, and 88 patients still had an active infection. Conclusions: The portal aided the timely and smooth transfer of COVID-19-positive ESKD patients to designated facilities, thus averting mortality arising from delayed or denied dialysis. Additionally, the portal also documented the natural history of the COVID-19 pandemic in the city and provided information on the overall incidence and outcomes. This aided the city administration in the projected resource needs to handle the pandemic.
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197© 2022 Indian Journal of Nephrology | Published by Wolters Kluwer - Medknow
Introduction
The ongoing coronavirus disease 2019
(COVID-19) pandemic caused by the
severe acute respiratory coronavirus
2 (SARS-COV-2) infection has aected all
populations. Several global and national
agencies have created virtual dashboards
for reporting country-/city-specic data of
COVID-19-infected patients. The outcomes
of COVID-19 disproportionately aect
vulnerable populations such as the elderly,
obese, diabetic, and immunocompromised
people. Patients with end-stage kidney
disease (ESKD) are also at a higher risk for
infection and mortality.[1] These patients are
exposed to each other at dialysis facilities
with limited social distancing. Managing
maintenance hemodialysis (MHD) patients,
Access this article online
Website: www.indianjnephrol.org
DOI: 10.4103/ijn.IJN_48_21
Quick Response Code:
Abstract
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has caused signicant global
disruption, especially for chronic care like hemodialysis treatments. Approximately 10,000 end-stage
kidney disease (ESKD) patients are receiving maintenance hemodialysis (MHD) at 174 dialysis
centers in Greater Mumbai. Because of the fear of transmission of infection and inability to isolate
patients in dialysis centers, chronic hemodialysis care was disrupted for COVID-19-infected patients.
Hence, we embarked on a citywide initiative to ensure uninterrupted dialysis for these patients.
Materials and Methods: The Municipal Corporation of Greater Mumbai (MCGM) designated
23 hemodialysis facilities as COVID-positive centers, two as COVID-suspect centers, and the rest
continued as COVID-negative centers to avoid transmission of infection and continuation of chronic
hemodialysis treatment. Nephrologists and engineers of the city developed a web-based-portal so
that information about the availability of dialysis slots for COVID-infected patients was easily
available in real time to all those providing care to chronic hemodialysis patients. Results: The
portal became operational on May 20, 2020, and as of December 31, 2020, has enrolled 1,418
COVID-positive ESKD patients. This initiative has helped 97% of enrolled COVID-infected ESKD
patients to secure a dialysis slot within 48 hours. The portal also tracked outcomes and as of
December 31, 2020, 370 (27%) patients died, 960 patients recovered, and 88 patients still had an
active infection. Conclusions: The portal aided the timely and smooth transfer of COVID-19-positive
ESKD patients to designated facilities, thus averting mortality arising from delayed or denied
dialysis. Additionally, the portal also documented the natural history of the COVID-19 pandemic
in the city and provided information on the overall incidence and outcomes. This aided the city
administration in the projected resource needs to handle the pandemic.
Keywords: COVID‑19, dashboard, end‑stage kidney disease (ESKD), hemodialysis, Mumbai,
Project Victory, web‑based portal
A Unied Citywide Dashboard for Allocation and Scheduling Dialysis for
COVID-19 Patients on Maintenance Hemodialysis
Original Article
Viswanath Billa1,2,
Santosh Noronha3,
Shrirang Bichu1,2,
Jatin Kothari2,4,
Rajesh Kumar2,5,
Kalpana Mehta6,
Tukaram Jamale7,
Nikhil Bhasin8,
Sayali Thakare7,
Smriti Sinha6,
Geeta Sheth9,
Narayan Rangaraj3,
Venugopal Pai3,
Amaldev Venugopal3,
Akshay Toraskar3,
Zaheer Virani10,
Mayuri Trivedi11,
Divya Bajpai7,
Shrikant Khot2,
Rasika Sirsat4,
Alan Almeida4,
Niwrutti Hase12,
Sundaram13,
Hariharan13,
Swapnil Hiremath14,
Iqbal Singh
Chahal15 on behalf
of the ‘Project
Victory’ consortium
The Project Victory Consortium
1Division of Nephrology,
Bombay Hospital, Mumbai,
Maharashtra, 2Apex Kidney
How to cite this article: Billa V, Noronha S, Bichu S,
Kothari J, Kumar R, Mehta K, et al. A unied citywide
dashboard for allocation and scheduling dialysis for
COVID-19 patients on maintenance hemodialysis.
Indian J Nephrol 2022;31:197-205.
therefore, remains a challenge due to the
risk of cross-infection and the inability
to isolate the infected patients. There is
also an additional risk of death arising
from missed dialysis due to inaccessible
COVID-19-designated hemodialysis
facilities.
India has 10.2 million conrmed cases of
COVID-19 as of end of December 2020,
with approximately 149,000 deaths. The
city of Mumbai recorded 293,436 conrmed
cases with 11,116 deaths on this date.[2]
Mumbai is the sixth most populous city in
the world with about 20 million inhabitants
spread over 233 square miles (population
density 73,000/square mile).[3] There are
174 hemodialysis facilities in Mumbai
catering to about 10,000 estimated ESKD
patients. Dialysis facilities in Mumbai
operate on dierent models, including
Received: 03-02-2021
Revised: 28-03-2021
Accepted: 03-08-2021
Published: 05-01-2022
This is an open access journal, and arcles are
distributed under the terms of the Creave Commons
Aribuon‑NonCommercial‑ShareAlike 4.0 License, which
allows others to remix, tweak, and build upon the work
non‑commercially, as long as appropriate credit is given and
the new creaons are licensed under the idencal terms.
For reprints contact: WKHLRPMedknow_reprints@wolterskluwer.com
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
198 Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022
charitable trusts, government, municipal, and for-prot
facilities. There is a wide disparity in the economic,
educational, and social class of patients who are treated at
these facilities. In the spring of 2020, the entire nephrology
community of this metropolis was faced with twin
problems – the high mortality associated with COVID-19
infection and the inability to manage the dialysis needs
of an infected patient at the existing dialysis centers.
The national lockdown in India initially resulted in the
shutting down of some hospitals and lack of clear guidance
to balance infection containment while maintaining
life-saving treatments such as dialysis.[4] This was the
stimulus to develop a solution to meet this unprecedented
challenge. Hence, the local public health authority, the
Municipal Corporation of Greater Mumbai (MCGM),
intervened and designated certain dialysis facilities,
strategically distributed across the city to treat only the
COVID-positive/-suspect patients [Figure 1a]. But the onus
of nding a suitable dialysis slot fell on the patients and
their primary nephrologist. However, lack of information
to direct a patient to an available slot at a specic facility
caused widespread anxiety and led to chaos. Despite
the mixed and fragmented model of dialysis services in
Mumbai, the Nephrology community quickly responded by
developing and deploying a strategic citywide dashboard
with a focus on providing hemodialysis in a timely fashion
to all COVID-19-infected ESKD patients across the city.
[Appendix] We report on how this was developed and
implemented with clinical outcomes.
Materials and Methods
Development of portal and dashboard
A real-time web-based portal was developed to oer
COVID-19-infected ESKD patients seamless and timely
access to a COVID-19 (positive/suspect) dialysis facility
within the city. This involved building an information
technology (IT) framework that tracked real-time
information on ESKD patients who tested positive.
The framework was deployed in the following stages.
Planning Stage: This coordinated eort was named “Project
Victory.” The MCGM rst designated 23 dialysis facilities as
dedicated COVID-19 positive centers (11 public centers and
12 private centers), two as COVID-19 suspect centers (one
public and one private), and 149 as COVID-19 (negative)
dialysis centers [Figure 1a]. An advisory was issued that all
COVID-19, positive or suspect, ESKD patients need to be
moved to these dedicated centers to continue their dialysis
care. This initiative was communicated via messaging
in the dedicated WhatsApp (WhatsApp Inc., Menlo
Park, California) Mumbai Nephrology Group to all 160
nephrologists and 174 dialysis centers, wherein the concept
was discussed and accepted by all members.
Establishment of a common portal: A coordination portal
called Covidialysis (https://covidialysis.in) was set up.
Later this portal was closed in Feb 2021, when it was
not required. The portal was designed as a progressive
web application accessible from a variety of operating
systems. A team of engineers from the Indian Institute
of Technology–Bombay (IITB) built, tested, improvised
the portal, and created a dashboard for real-time graph
generation from the data. A dashboard coordinator was
identied who had a comprehensive view of all enrolled
patients and available dialysis slots. His primary role
was to meet the demand for dialysis slots for COVID-19
(positive/suspect) patients in the minimum possible time, in
coordination with the persons in charge of the centers.
Foundation, 3Tata Centre for Technology and Design/Department of Industrial Engineering and Operations Research, Indian Institute of Technology,
Mumbai, Maharashtra, India, 4Division of Nephrology, PD Hinduja Hospital, 5Division of Nephrology, Dr. LH Hiranandani Hospital, 6Division of
Nephrology, BYL Nair Charitable Hospital, 7Division of Nephrology, King Edward Memorial Hospital, 8Division of Nephrology, Seven Hills Hospital,
9Division of Nephrology, Sir JJ Group of Hospitals, 10Division of Nephrology, Saifee Hospital, 11Division of Nephrology, Lokmanya Tilak Municipal
General Hospital, 12Division of Nephrology, Jupiter Hospital, 13Division of Transplantation, University of Pittsburgh Medical Center, USA, 14Division of
Nephrology, Ottawa Hospital, University of Ottawa, Canada, 15Municipal Corporation of Greater Mumbai, India
Address for correspondence:
Dr. Viswanath Billa,
Department of Nephrology, R. No. 6, 2nd Floor, New Wing, Bombay Hospital, Mumbai ‑ 400 020, Maharashtra, India.
E‑mail: billav@gmail.com
Figure 1: Distribution of hemodialysis facilities and COVID-19 patients
on MHD across the city of Mumbai. (a) Hemodialysis facilities were
strategically classied as COVID‑19 positive/suspect/negative by the
Municipal Corporation, to segregate and isolate COVID‑19‑infected
patients. (b) The density of infected patients as depicted by the heat map
mirrored the population density. (COVID‑19, Coronavirus disease 2019;
MHD, maintenance hemodialysis)
ab
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022 199
Registration and Communication: Each dialysis center
was registered on the portal using a Google Form
(Google Inc., Menlo Park, California), which included
details of its location, capacity, and dialysis shifts. The
designated person in charge of each center updated
the portal with the patient data on a Google Form
and could access it using a range of devices (laptops,
tablets, or smartphones). These persons in-charge were
responsible for transmitting information about new
COVID-19 (positive/suspect) cases to the dashboard
coordinator who guided the patient to a specied dialysis
slot in the city.
As the portal evolved, a data analytics interface was
incorporated. The results were visualized on a dashboard
built using Redash (Redash Ltd., Tel Aviv, Israel). All
tools that were used in putting together this platform were
FOSS (Free and Open-Source Software).
Patient management and transfer
There were no uniform COVID-19 testing policies in
dialysis centers in the city of Mumbai. Each center used
its own discretion to test patients, either as a screening tool
for all patients or testing only symptomatic ones. Once a
COVID-19 (positive/suspect) patient was identied, the
dashboard coordinator was notied, who promptly assigned
the patient to an appropriate COVID-19 facility. Each
patient was given the choice of COVID-positive facility
(public/private) to be transferred to. This eliminated conicts
pertaining to payments. To handle COVID-19 (suspect)
patients, the coordinator followed a similar procedure and
accommodated them within the suspect centers until the
test results became available, then they were triaged either
to a COVID-19 (positive) facility or back to their home
center based on the result. By capturing the PIN code of
each patient registered on the portal, every attempt was
made to accommodate these patients at the COVID-positive
facilities closest to their respective home PIN codes.
When there were bed availability issues, they were given
more distant options. The MCGM made arrangements
for dedicated COVID-positive vehicles to transport such
patients. There were also private paid services available for
the same. One of these available transportation options was
adopted.
Until July 2020, the RT-PCR (reverse transcription
polymerase chain reaction) test turnaround times (TAT) was
3 to 4 days. Later, as the TAT decreased to 24 hours, the
need for suspect facilities waned, and by August 2020, few
patients needed this service leading to decommissioning of
machines at these suspect centers.
Once patients became noninfective, they were
transferred back to their primary center. The duration
of stay at the designated COVID-19 facility changed
over time as the guidance changed from a test-based
isolation to a symptom- and duration-based framework.
Initially, every COVID-19 (positive) patient had to test
RT-PCR negative before being transferred out of the
COVID-19 (positive) facility.[5] However, in May 2020,
this guideline was modied, and any COVID-19 (positive)
patient who was asymptomatic and spent 14 days in the
COVID-19 (positive) facility could be transferred back
to their primary center without mandatory retesting. The
citywide population density of COVID-19 (positive)
patients on MHD is shown in Figure 1b. The schematic
in Figure 2a depicts the process of universal screening
of all patients at the dialysis centers, identication
of symptomatic patients, and transferring them into
COVID-19 (positive/suspect) facilities. Figure 2b depicts
the transfer process of COVID-19 (positive) patients
from the community dialysis centers into the designated
COVID-19 (positive) facilities assisted by the portal.
Data collection, analysis, and outcome
Data collection: All clinical data (age; gender;
comorbidities including hypertension, diabetes mellitus,
and ischemic heart disease; and duration on dialysis),
COVID-19 PCR status, testing dates, and hospitalization
details were recorded. In addition, transfer dates,
follow-up PCR test dates and transfers to primary dialysis
units, and death data were also recorded. The dashboard
captured data of the infected and suspect patients and
documented their mortality, recovery, and activity status
throughout the period of the pandemic. It also computed
the eciency of assigning COVID-19 (positive) patients
to suitable dialysis centers. This provided precise data of
case growth and projected resource needs. All collected
data were stored in a PostgreSQL database management
system on the Amazon Web Services (Amazon Inc.,
Seattle, Washington) cloud computing platform. The data
presented in this study include all COVID-19 (positive)
ESKD patients who were enrolled on the portal between
May 20, 2020, and December 31, 2020. Institutional
review board approval from IITB was taken to conduct
this study.
Analysis: All continuous variables were described as mean
with standard deviation, and categorical variables were
described as frequency and percentages. The mortality
rate was captured as a ratio of the number of deaths due
to COVID-19 to the total number of COVID-19 (positive)
cases. The analysis of outcomes between the survivors
and non-survivors of COVID-19 infection in the ESKD
population was done using the Fisher’s exact test.
Outcomes: The data from the portal described the
demographics of the aected population, mortality, risk
factors, transfer time to designated dialysis centers, and the
infection trend over time.
Oversight: The MCGM backed this eort. It sent a
mandate to all dialysis centers to ensure compliance with
full participation with this project.
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
200 Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022
Results
Study population
Of an estimated 10,000 ESKD patients on MHD in
the city of Mumbai, 1,418 (14%) patients developed
COVID-19 infection over the period of study.
COVID-19-infected patients originated from 106 of the
174 (61%) hemodialysis facilities across the city and
were transferred to 23 designated COVID-19 (positive)
centers. Figure 1a shows the distribution of hemodialysis
centers in the city. The heat map of the concentration of
COVID-19 (positive) cases across the city is shown in
Figure 1b. The origin of infected patients roughly mirrored
the population density across the city. There were 870
men (61%, mean age = 56 ± 15 years) and 548 women
(39%, mean age = 53 ± 13 years). Symptomatic patients
constituted 67% of all infected patients.
Incidence of COVID‑19 infection
The number of incident COVID-19 (positive) patients
peaked by late June and declined thereafter. There have
been minor spikes in the number of new cases during
certain periods, without a noticeable second wave as of
December 2020. The portal’s primary objective was to
allocate a COVID-19 (positive) hemodialysis slot to every
enrolled patient. This was met within 24 hours for 73%
patients, 48 hours for 97% patients, and 72 hours for all
patients. As shown in Figure 3, there was an initial surge of
COVID-19 (positive) cases in May, 2020. This was because
of the inclusion of not just the incident but also the prevalent
cases when the portal initially rolled out. Over time, there
was a general decline in the number of new cases.
COVID‑19 suspect cases
There were 156 patients who were COVID-19 (suspect)
over the period, of which 78 (50%) eventually tested
COVID-19 (positive).
Follow‑up COVID‑19 testing
During the study period, 47% of COVID-19 (positive)
patients underwent retesting by RT-PCR based on the
prevalent guidelines. In these patients, repeat COVID test
was negative after a median of 12 days (interquartile range
7–20 days).
Figure 2: COVID‑19 positive/suspect MHD patient handling and assignment to designated hemodialysis facilities. (a) Flow diagram – primary screening,
testing, enrollment, and transfer. (b) Schematic of portal‑directed assignment of patients to designated hemodialysis facilities. (COVID‑19, Coronavirus
disease 2019; MHD, maintenance hemodialysis; RT‑PCR, reverse transcription polymerase chain reaction)
b
a
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022 201
Outcomes
Outcomes over time in all patients are depicted in
Figures 4a and 4b. Of the 1,351 patients with known
outcomes, 370 died giving a mortality rate of 27% in
COVID-19 (positive) patients on MHD. This is against
a rate of 4% in the general population [Figure 4b].[2]
The mean age of patients who died was 60 ± 13 years
as compared with 52 ± 14 years in survivors. Time
to death was 7 days (interquartile range 2–15). There
was no statistical dierence in mortality between
the genders. Those patients who had one or more
comorbidities (hypertension, diabetes, or ischemic heart
disease) had a mortality of 51% as against 17% in those
without comorbidities. Mortality gures varied among
dierent COVID-19 (positive) health care facilities
ranging from 20% to 48%.
COVID‑19 infection among dialysis sta: The portal
also gathered information on COVID-19 infection
in hemodialysis personnel from 116/174 dialysis
centers (67%). COVID-19 infection occurred in
191 of 1,725 hemodialysis personnel (11%) from these
116 centers, with no deaths.
Thus, our prospective study showed a COVID-19
infection rate of 14% among a large cohort of chronic
MHD patients from multiple centers in a big metropolitan
city. The mortality rate in this group was 27%. The
IT platform and a collaborative approach between
nephrologists with oversight from the city Municipal
Corporation helped ensure the continuation of dialysis
care for these patients.
Discussion
Across the world, dashboards have taken a center stage
during the COVID-19 pandemic. The online interactive
dashboard from the Johns Hopkins University, Baltimore,
was the rst such publicly shared resource.[6] It has helped
researchers, public health authorities, and the public to
visualize and track reported cases of COVID-19 infections
and assisted with critical policy decision making as the
outbreak unfolded.[7-10]
We have previously reported a high incidence of infection
among ESKD patients on MHD in Mumbai.[1] In this study,
the crude incidence of COVID-19 is at least 14% with
possible ascertainment bias due to changing testing criteria
over time. The creation and deployment of the COVID-19
dashboard allowed the relatively seamless provision of
dialysis services across the public and private sector dialysis
facilities within the city, with 97% provision within 48 hours
and 100% within 72 hours for all COVID-19 suspect and
positive cases. This is in stark contrast to reports from
other places in the country where approximately 28%
patients missed one or more dialysis sessions, about
3% required emergency dialysis sessions, and about 4%
stopped reporting for dialysis.[11] The portal closely tracked
the outcomes of each of the 1,418 patients registered on it.
It ensured that each one received timely dialysis. None of
these patients, therefore, dropped out from dialysis owing
to this appropriate and timely intervention.
The portal concurrently compiled data of these patients
developing into a useful data resource for COVID-19
infection in hemodialysis patients in the city. In the
present study, 1,418 COVID-19 (positive) ESKD patients
in Mumbai constituted approximately 14% of all MHD
patients and 0.48% of the total number of infected cases
in the city as of December 31, 2020. The infection was
reported from 61% of all hemodialysis centers in the city.
Figure 3: Weekly enrollments of symptomatic/asymptomatic/suspect
patients onto the portal
Figure 4: Outcomes of COVID‑19 positive hemodialysis patients.
(a) Cumulative number of enrollments, recoveries, deaths, and active
patients over the study period. (b) Mortality rate due to COVID‑19 infection in
hemodialysis patients (blue curve) and in the general population (red curve)
during the study period. (COVID‑19, Coronavirus disease 2019)
a
b
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
202 Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022
The overall mortality of COVID-19 in this MHD setting
was 27%, in line with the reported literature.
The incidence of COVID-19 in published literature varies
from 2% (Wuhan) to 20% (London).[12,13] The cumulative
cases of COVID-19 in MHD patients in England ranged
from 0.9% to 33% in the individual region/centers, with
an overall incidence of 11%.[14] This variability could be
dependent on the community prevalence, testing policies
wherein all or only symptomatic patients were tested,
and other confounding factors. There were no uniform
COVID-19 testing policies in dialysis centers in the city
of Mumbai. Each center used its own discretion to test
patients, either as a screening tool for all patients or testing
only symptomatic ones. Of the patients registered on the
portal, 33% were asymptomatic. In the Brescia study, 19%
of COVID-19 (positive) patients were asymptomatic.[15]
This is in sharp contrast to a previous study from Mumbai
where all dialysis patients were tested and 74% of infected
patients were found to be asymptomatic.[1] It is yet unclear
whether the proportion of symptomatic and asymptomatic
patients is related to an impaired immune response due to
underlying CKD.[16]
The time to retest negative after enrollment was
16 ± 14 days (median 12 days). A previous study in
Mumbai that was done in the early epidemic period when
retesting was the rule, reported a 96% viral clearance rate
by Day 17.[1] Data from the United Kingdom reported that
on retesting in MHD patients after COVID-19 diagnosis,
only 59% tested negative by Day 15.[17] The available
data suggest that prolonged viral RNA (ribonucleic
acid) shedding after symptom resolution is not clearly
associated with prolonged infectiousness and may reect
replication-incompetent SARS-CoV-2.[18-20]
The mortality due to COVID-19 was 18% in the previous
study done in Mumbai and 16% in the Wuhan study.[1,21]
Several case series from Europe and the United States
with varying follow-up suggest a high mortality rate in
the dialysis population with rates ranging from 20% to
41%.[22-25] The mortality rate of 27% in MHD patients in
our study captures a longer duration of the pandemic and a
larger caseload than published data to date and is within the
range reported from the high-income countries mentioned
above.
The mortality rate was initially low when the portal was
deployed in late May 2020 (5%) possibly due to more
aggressive testing for the virus during this period with a
dilution of the numbers from milder and asymptomatic
cases that could lower the mortality rate.[26,27] This reached
a peak in July 2020 and then maintained a plateau
until December 2020, when the rate stood at 27%. This
stability of the number subsequently might also indicate
a degree of expertise in handling these patients as well as
standardization in testing protocols after July 2020.
It is now known that older age, cardiovascular disease,
diabetes, chronic respiratory disease, hypertension, and
cancer are associated with an increased risk of death in
COVID-19 infection.[28] Patients on MHD are at high risk
as they share similar comorbidities.[29] In our study, patients
who had at least one of three comorbidities (hypertension,
diabetes, or ischemic heart disease) had a mortality of 51%
as against 17% in those with none, reecting published
literature. The mortality in the top 10 hospitals that serviced
the maximum number of COVID-19 (positive) patients
ranged from 20% to 48%. This wide range in mortality
could be attributed to a referral bias, overburdening of
selective hospitals, and variation in treatment protocols.
Although 11% of the dialysis personnel contracted
COVID-19 infection, none of them died. The Wuhan
study had a lower rate of infection in hemodialysis
sta (3%).[30] This higher infection rate among sta in
our study is likely because it covered a longer duration of
the epidemic (7 months) compared with the Wuhan study
(2 weeks), as well as a higher community prevalence in
Mumbai compared with Wuhan. Younger age and lack of
comorbidities could potentially have contributed to the zero
mortality in dialysis caregivers.
This report has certain inherent limitations. Patients with
acute kidney injury due to COVID-19 were not included
in this study. This study was focused on ESKD patients
on MHD alone. We did not have the exact gure of the
number of patients undergoing MHD in the city. Also,
“Project Victory” was primarily aimed at ensuring the
allotment of dialysis slots to COVID-19 (positive) ESKD
patients; hence, the portal did not capture granular data
on hospitalization or intensive care admissions, ventilator
needs, or response to specic anti-COVID-19 therapies.
In conclusion, “Project Victory” is unique in being the
only such citywide, centralized, large, collective eort
utilizing a web-based portal to help COVID-19-infected
MHD patients secure a quick dialysis slot. It has the largest
number of reported cases of COVID-19 (positive) ESKD
patients from a single city. This project has helped health
care providers and administrators guide patients to access
chronic MHD services eciently. The overall incidence
of infection was 14% with a mortality of 27% among
COVID-19 positive cases. This mortality was due to the
complications arising out of COVID-19 infection and not
due to delayed or denied dialysis. With isolation, we may
have prevented the patient-to-patient and patient-to-sta
spread of the infection. The nephrology community and
the city administration embraced this multidimensional
initiative for a common cause, demonstrating the value of
collaborative health care management during a pandemic.
Acknowledgments
The authors would like to acknowledge the eorts of
the dialysis sta and health care workers in the city, the
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022 203
Municipal Corporation of Greater Mumbai, and the Indian
Institute of Technology, Bombay.
Financial support and sponsorship
Nil.
Conicts of interest
There are no conicts of interest.
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
204 Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022
Appendix:
Other members of the Mumbai Nephrology
Group (Project Victory)
Shakir, Ahmad
Haridas, Ashwathy
Madan, Bahadur
Varun, Bansal
Vikas, Bharati
Amol, Bhawane
Harshal, Bhole
Nitin, Bhosale
Sandip, Bhurke
Pooja, Binani
Samuel, Chakola
Avinash, Chaudhari
Chandan, Chaudhari
Anup, Chaudhari
Hemant, Chaugule
Gaurav, Daga
Sudhiranjan, Dash
Keyur, Dave
Narendra, Dedhia
Paras, Dedhia
Jayesh D, Desai
Jayesh N, Desai
Rahul, Deshpande
Rushi, Deshpande
Martin, Desouza
Vaibhav, Dharap
Atit, Dharia
Haresh, Dodeja
Arun, Doshi
Rekha, Dubey
Bhupendra, Gandhi
Sohum, Gohil
Rajendra, Gunjotikar
Sachin, Gupta
Arun, Halankar
Atul, Ingale
Swapnil, Jadhav
Amit, Jain
Pankaj, Jawandhiya
Deepa, Jayaram
Makhija, Jhoomar
Vidya, Kadam
Shailesh, Kakde
Nikhil, Kedia
Vaibhav, Keskar
Jitendra, Khandge
Umesh, Khanna
Mustafa, Khokawala
Ashok, Kirpalani
Dilip, Kirpalani
Sachin, Kodgire
Amar, Kulkarni
Mihir, Kulkarni
Chaitanya, Kulkarni
Niranjan, Kulkarni
Arvind, Kunde
Siddharth, Lakhani
Amit, Langote
Dinesh, Mahajan
Jhoomar, Makhija
Raman, Malik
Hemant, Mehta
Mahendra, Merchant
Majid, Momin
Amit, Nagrik
Ravindra, Nikalji
Atim, Pajai
Aashay, Pandya
Harish, Pathak
Amjadkhan, Pathan
Ashwin, Patil
Rohan, Pradhan
Mahesh, Prasad
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Billa, et al.: Mumbai’s dashboard approach for COVID‑19‑positive maintenance hemodialysis
Indian Journal of Nephrology | Volume 32 | Issue 3 | May-June 2022 205
Prashant, Rajput
Akash, Ranka
Alka, Rao
Ramesh, Rao
Ruchi, Samdhani
Salman, Sayyed
Neha, Shah
Sohil, Shah
Arun, Shah
Bharat, Shah
Hemal, Shah
Rechal, Shah
Hardik, Shah
Wasiyeeullah, Shaikh
Suyash, Sharma
Mukesh, Shete
Sharad, Sheth
Ashay, Shingare
Abhishek, Shrikhande
Anurag, Shukla
Akash, Singhada
Nitin, Sonawane
Lohitaksh, Suratkal
Rudramani, Swami
Shruti, Tapiawala
Aseem, Thamba
Parag, Tilve
Kirti, Upadhyay
Deepa, Usulumarthy
Bhavesh, Vora
Harshal, Vora
Sameer, Vyahalkar
Menal, Wali
Jyotsna, Zope
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... We and others have reported successful use of citywide dashboard for timely allocation of the dialysis slots and hospital beds. [30] Quick expansion of the facilities to cater to the increasing number of admitted ESRD patients, colocalizing infected dialysis patients to a single ward or floor, bedside dialysis facility, and dedicated COVID-19 dialysis staff is needed to optimally care for these patients as discussed later in our experience of High Dependency Renal Unit (HDRU). ...
... Another novel initiative which addressed this crisis in Mumbai was the multicenter 'Project Victory', where a citywide dashboard was created to facilitate timely allocation of dialysis slots to patients on maintenance dialysis as soon as they were detected COVID-19 positive. [30] More than 1,000 patients could be allocated a slot at a COVID-19 dialysis facility within 48 hours through this portal. This served the purpose of optimum utilization of existing dialysis resources. ...
... An example of such a solution is setting up a unified dashboard for allocating and scheduling dialysis for COVID-19 patients in Mumbai, which successfully averted mortality from delayed or denied dialysis. [10] It is imperative that health systems, particularly in lower-and middle-income countries, build up their human resources, create sustainable policies, and establish strategic partnerships to be adequately prepared to handle potential threats to the renal community. This is particularly important and relevant in India, where little thought and attention has been given to this issue. ...
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Introduction: There are several studies of symptomatic hemodialysis patients with proven COVID-19 infection. However, there is paucity of data on asymptomatic COVID-19 infection in the outpatient hemodialysis population. The true prevalence and transmission of this infection in hemodialysis centres is unknown. This study was conducted across hemodialysis centers by testing all patients and staff for COVID-19 PCR and later for IgG antibody, irrespective of their symptoms. Methods: All 705 hemodialysis patients and 103 dialysis staff across nine centres, were tested for COVID-19 over a period of 54 days of the pandemic, and for COVID IgG antibody of available enrolled staff and patients, after 8 weeks of study termination. Results: The period prevalence of infection in patients and staff was 7.1% and 14.6% respectively. Mortality in patients was 18%, and all staff recovered. Clustering of patients and staff occurred at 3 of 9 centers. Of 26 HIV positive patients, only one contracted the COVID-19 infection and has recovered. Of those infected, seroconversion occurred in 80% of patients and 83% of staff. Seroconversion also occurred in 16% of patients and 37% of staff, who were asymptomatic and COVID PCR negative during the study period. Conclusions: Testing a patient only when symptomatic, identified only 26% (13/50) of infected patients. For every single symptomatic patient who tested positive, there were 3 other asymptomatic infected ones. There was a high seroconversion rates in infected subjects. But antibodies also developed in asymptomatic subjects, indicating silent transmission and antibody generation in this population.
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The aim of this study was to investigate 28-day mortality after COVID-19 diagnosis in the European kidney replacement therapy population. In addition, we determined the role of patient characteristics, treatment factors, and country on mortality risk using ERA-EDTA Registry data on patients receiving kidney replacement therapy in Europe between February 1, 2020 and April 30, 2020. Additional data on all patients with a diagnosis of COVID-19 were collected from seven European countries encompassing 4298 patients. COVID-19 attributable mortality was calculated using propensity-score matched historic controls and after 28 days of follow-up was 20.0% (95% confidence interval 18.7%-21.4%) in 3285 patients receiving dialysis, and 19.9% (17.5%-22.5%) in 1013 recipients of a transplant. We identified differences in COVID-19 mortality across countries, and an increased mortality risk in older patients receiving kidney replacement therapy and male patients receiving dialysis. In recipients of kidney transplants older than 75 years of age 44.3% (35.7%-53.9%) did not survive COVID-19. Mortality risk was 1.28 (1.02-1.60) times higher in transplant recipients compared with matched dialysis patients. Thus, the pandemic has had a substantial effect on mortality in patients receiving kidney replacement therapy; a highly vulnerable population due to underlying chronic kidney disease and high prevalence of multimorbidity.
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Objective Since the outbreak of the coronavirus disease 2019 (COVID-19) in December of 2019 in China, the estimation of the pandemic’s case fatality rate (CFR) has been the focus and interest of many stakeholders. In this manuscript, we prove that the method of using the cumulative CFR is static and does not reflect the trend according to the daily change per unit of time. Methods A proportion meta-analysis was carried out on CFR in every country reporting COVID-19 cases. Based on the results, we performed a meta-analysis for global COVID-19 CFR. Each analysis was performed on two different calculations of CFR: according to calendar date and according to days since the outbreak of the first confirmed case. We thus explored an innovative and original calculation of CFR concurrently based on the date of the first confirmed case as well as on a daily basis. Results For the first time, we showed that using meta-analyses, according to calendar date and days since the outbreak of the first confirmed case were different. Conclusion We propose that CFR according to days since the outbreak of the first confirmed case might be a better predictor of the current CFR of COVID-19 and its kinetics.
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Digital technologies are being harnessed to support the public-health response to COVID-19 worldwide, including population surveillance, case identification, contact tracing and evaluation of interventions on the basis of mobility data and communication with the public. These rapid responses leverage billions of mobile phones, large online datasets, connected devices, relatively low-cost computing resources and advances in machine learning and natural language processing. This Review aims to capture the breadth of digital innovations for the public-health response to COVID-19 worldwide and their limitations, and barriers to their implementation, including legal, ethical and privacy barriers, as well as organizational and workforce barriers. The future of public health is likely to become increasingly digital, and we review the need for the alignment of international strategies for the regulation, evaluation and use of digital technologies to strengthen pandemic management, and future preparedness for COVID-19 and other infectious diseases. The COVID-19 pandemic has resulted in an accelerated development of applications for digital health, including symptom monitoring and contact tracing. Their potential is wide ranging and must be integrated into conventional approaches to public health for best effect.
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Introduction The Coronavirus disease-19 (COVID-19) pandemic has affected the care of patients with non-communicable diseases, including those suffering from kidney-related ailments. Many parts of the world, including India, adopted lockdown to curb community transmission of disease. The lockdown affected transportation, access to healthcare facilities, availability of medicines, and consumables as well as out and inpatient services. We aimed to analyze the effect of lockdown imposed due to COVID-19 pandemic on the care of patients with kidney diseases in India. Methods We surveyed 19 major hospitals (8 in public and 11 in private sector) to determine the effect of lockdown on the care of patients with kidney disease, including those on dialysis after the first 3 weeks of lockdown. Results The total number of dialysis patients in these centres came down from 2517 to 2404. About 710(28.2%) of patients missed one or more dialysis sessions, 69 (2.74%) required emergency dialysis sessions, 104 (4.13%) stopped reporting for dialysis, and 9 (0.36%) were confirmed to have died. Outpatient attendance in the surveyed hospital came down by 92.3%, and inpatient service reduced by 61%. Tele-consultation was started but accessed by only a small number of patients. Conclusion Lack of preparedness before lockdown resulted in an interruption in health care services and posed an immediate adverse effect on the outcome of dialysis and kidney disease patients in India. The long-term impact on the health of patients with less severe forms of kidney disease remains unknown.
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Background: During the coronavirus disease 2019 (COVID-19) epidemic, many countries have instituted population-wide measures for social distancing. The requirement of patients on dialysis for regular treatment in settings typically not conducive to social distancing may increase their vulnerability to COVID-19. Methods: Over a 6-week period, we recorded new COVID-19 infections and outcomes for all adult patients receiving dialysis in a large dialysis center. Rapidly introduced control measures included a two-stage routine screening process at dialysis entry (temperature and symptom check, with possible cases segregated within the unit and tested for SARS-CoV-2), isolated dialysis in a separate unit for patients with infection, and universal precautions that included masks for dialysis nursing staff. Results: Of 1530 patients (median age 66 years; 58.2% men) receiving dialysis, 300 (19.6%) developed COVID-19 infection, creating a large demand for isolated outpatient dialysis and inpatient beds. An analysis that included 1219 patients attending satellite dialysis clinics found that older age was a risk factor for infection. COVID-19 infection was substantially more likely to occur among patients on in-center dialysis compared with those dialyzing at home. We observed clustering in specific units and on specific shifts, with possible implications for aspects of service design, and high rates of nursing staff illness. A predictive epidemic model estimated a reproduction number of 2.2; cumulative cases deviated favorably from the model from the fourth week, suggesting that the implemented measures controlled transmission. Conclusions: The COVID-19 epidemic affected a large proportion of patients at this dialysis center, creating service pressures exacerbated by nursing staff illness. Details of the control strategy and characteristics of this epidemic may be useful for dialysis providers and other institutions providing patient care.
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Background: Little is known about the natural history of asymptomatic SARS-CoV-2 infection or its contribution to infection transmission. Methods: We conducted a prospective study at a quarantine center for COVID-19 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with RT-PCR-confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrolment and daily nasopharyngeal throat swabs (NTS) for RT-PCR testing. We compared the natural history and transmission potential of asymptomatic and symptomatic individuals. Results: Between March 10th and April 4th, 2020, 14,000 quarantined people were tested for SARS-CoV-2; 49 were positive. Of these, 30 participated in the study: 13(43%) never had symptoms and 17(57%) were symptomatic. 17(57%) participants acquired their infection outside Vietnam. Compared with symptomatic individuals, asymptomatic people were less likely to have detectable SARS-CoV-2 in NTS samples collected at enrolment (8/13 (62%) vs. 17/17 (100%) P=0.02). SARS-CoV-2 RNA was detected in 20/27 (74%) available saliva; 7/11 (64%) in the asymptomatic and 13/16 (81%) in the symptomatic group (P=0.56). Analysis of the probability of RT-PCR positivity showed asymptomatic participants had faster viral clearance than symptomatic participants (P<0.001 for difference over first 19 days). This difference was most pronounced during the first week of follow-up. Two of the asymptomatic individuals appeared to transmit the infection to up to four contacts. Conclusions: Asymptomatic SARS-CoV-2 infection is common and can be detected by analysis of saliva or NTS. NTS viral loads fall faster in asymptomatic individuals, but they appear able to transmit the virus to others.
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Background The recent SARS-CoV-2 coronavirus pandemic has signified a significant effect on the health of the population worldwide. Patients on chronic RRT have been affected by the virus, and they are at higher risk due to the frequent comorbid conditions. Here, we show the results of the COVID-19 Registry of the Spanish Society of Nephrology during the first 6 weeks of the outbreak. Methods This study is an analysis of the data recorded on a registry of patients with ESKD on RRT who tested positive for COVID-19. The aim was to evaluate clinical conditions, therapeutic management, and consequences, including outcome. The registry began on March 18th, 2020. It includes epidemiologic data, cause of CKD, signs and symptoms of the infection, treatments, and outcomes. Patients were diagnosed with SARS-CoV-2 infection on the basis of the results of PCR of the virus obtained from nasopharyngeal/oropharyngeal swabs. The tests were performed on symptomatic patients and on those who mentioned contact with infected patients. Results As of May 2, the registry included data on 1397 patients (in-center hemodialysis [IC-HD], 63%; kidney transplant [Tx], 34%; peritoneal dialysis [PD], 3%; and home hemodialysis, 0.3%). The mean age was 67±15 years, and two-thirds were men. Dialysis vintage was 46±41 months, and the time after transplantation was 59±54 months. Eighty-five percent of the patients required hospital admission, and 8% had to be transferred to intensive care units. Overall mortality was 25% (IC-HD, 27%; Tx, 23%; and PD, 15%), and significant proportions of deceased patients have advanced age, are on IC-HD, and presented pneumonia. Age and pneumonia were independently associated with the risk of death. Conclusions SARS-CoV-2 infection affected a significant number of Spanish patients on RRT, mainly those on IC-HD. Hospitalization rates and mortality were high. The factors more closely related to mortality were age and pneumonia.
Article
Background: The relative immunosuppression and high prevalence of comorbidities in patients with ESKD on dialysis raise concerns that they may have an elevated risk of severe coronavirus disease 2019 (COVID-19), but outcomes for COVID-19 in such patients are unclear. Methods: To examine presentation and outcomes of COVID-19 in patients with ESKD on dialysis, we retrospectively collected clinical data on 59 patients on dialysis who were hospitalized with COVID-19. We used Wilcoxon rank sum and Fischer exact tests to compare patients who died versus those still living. Results: Two of the study's 59 patients were on peritoneal dialysis, and 57 were on hemodialysis. Median age was 63 years, with high prevalence of hypertension (98%) and diabetes (69%). Patients who died were significantly older than those still living (median age, 75 versus 62 years) and had a higher median Charlson comorbidity index (8 versus 7). The most common presenting symptoms were fever (49%) and cough (39%); initial radiographs most commonly showed multifocal or bilateral opacities (59%). By end of follow-up, 18 patients (31%) died a median 6 days after hospitalization, including 75% of patients who required mechanical ventilation. Eleven of those who died had advanced directives against intubation. The remaining 41 patients (69%) were discharged home a median 8 days after admission. The median initial white blood cell count was significantly higher in patients who died compared with those still living (7.5 versus 5.7×103/μl), as was C-reactive protein (163 versus 80 mg/L). Conclusions: The association of COVID-19 with high mortality in patients with ESKD on dialysis reinforces the need to take appropriate infection control measures to prevent COVID-19 spread in this vulnerable population.