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Case Report: Vertebral Artery Dissection After Use of Handheld Massage Gun

Authors:

Abstract

Introduction: Arterial dissection is well known as a potential cause of stroke in young patients. Vertebral artery dissection occurs most commonly in the setting of minor trauma but has been seen in cases of cervical manipulation. With advances in at-home therapeutic modalities for neck pain came the advent of handheld massage guns. These massage guns have gained considerable popularity in recent years, but their safety for use in the cervical region has not been well studied. Case report: In this case report, we discuss a 27-year-old female who presented with headache, neck pain, and dizziness who was found to have vertebral artery dissection after repetitive use of a handheld massage gun. Conclusion: In young patients presenting with headache, neck pain, and vague neurologic symptoms it is important to consider vertebral artery dissection as a cause of symptoms as it can lead to serious morbidity. When considering an inciting event such as minor trauma, it may also be important to assess whether there has been use of a handheld massage gun. Although causality is difficult to establish, with the increase in use of handheld massage guns we may find more frequent association between their use and vertebral artery dissection.
Article in Press 159 Clinical Practice and Cases in Emergency Medicine



Kathryn Sulkowski, MD*
Georgina Grant, MD*
Thomas Brodie, MD
Section Editor: R. Wilkerson, MD
Submission History: Submitted January 10, 2022; Revision received February 9, 2022; Accepted February 10, 2022
Electronically published April 6, 2022
Full text available through open access at http://escholarship.org/uc/uciem_cpcem
DOI: 10.5811/cpcem.2022.2.56046
Introduction: Arterial dissection is well known as a potential cause of stroke in young patients.
Vertebral artery dissection occurs most commonly in the setting of minor trauma but has been seen in
cases of cervical manipulation. With advances in at-home therapeutic modalities for neck pain came
the advent of handheld massage guns. These massage guns have gained considerable popularity in
recent years, but their safety for use in the cervical region has not been well studied.
Case report: In this case report, we discuss a 27-year-old female who presented with headache, neck
pain, and dizziness who was found to have vertebral artery dissection after repetitive use of a handheld
massage gun.
Conclusion: In young patients presenting with headache, neck pain, and vague neurologic symptoms
it is important to consider vertebral artery dissection as a cause of symptoms as it can lead to serious
morbidity. When considering an inciting event such as minor trauma, it may also be important to assess
whether there has been use of a handheld massage gun. Although causality is di󰀩cult to establish,
with the increase in use of handheld massage guns we may nd more frequent association between
their use and vertebral artery dissection. [Clin Pract Cases Emerg Med. 2022;6(2):159-161.]
Keywords: vertebral artery dissection; handheld massage gun.

The reported incidence of vertebral artery dissection (VAD)
is estimated to be 2.6-3/100,000.1 Vertebral artery dissection is
a known cause of stroke in patients younger than 45 years of
age. Unfortunately, because its clinical features and symptoms
tend to be vague and/or nonspecic, diagnosis may not even be
considered. Upon close review of the literature, we found very
few cases reported of VAD secondary to neck massage and none
related to the use of a handheld massage gun. Given the increase
in popularity of at-home, handheld massage, the importance of
safety while using these devices is of the utmost importance. In
this report we describe a case of VAD in a young woman after the
use of a handheld massage gun. She was treated with aspirin and
discharged with no residual neurological decits.
University of Nevada, Las Vegas, Emergency Medicine Residency Program, Las
Vegas, Nevada
Mike O’Callaghan Federal Medical Center, Department of Emergency Medicine, Las
Vegas, Nevada
*
 
A 27-year-old female presented to the emergency
department (ED) with a two-week history of progressively
worsening dizziness. She described the dizziness as a
combination of vertiginous symptoms as well as disequilibrium.
Over the prior four days she noticed a headache and neck pain.
She denied any recent trauma but had recently begun using a
handheld massage gun on her neck over the preceding three
weeks. The patient denied any past medical history and used no
medications regularly, except for occasional over-the- counter
ibuprofen, which did not alleviate her symptoms. She had a
family history signicant for migraine headaches. She endorsed
occasional alcohol and daily tobacco use but denied any
illicit substance use. She denied fever, diplopia, blurry vision,
Clinical Practice and Cases in Emergency Medicine 160 Volume 6, no. 2: May 2022
Vertebral Artery Dissection After Use of Handheld Massage Gun Sulkowski et al.
CPC-EM Capsule
What do we already know about this clinical
entity?
Arterial dissection is a potential cause of stroke
in young patients. Vertebral artery dissection
(VAD) usually occurs with minor trauma but has
been seen with cervical manipulation.
What makes this presentation of disease
reportable?
We could nd no prior reported cases of VAD
associated with use of a handheld massage gun.
What is the major learning point?
In young patients presenting with headache,
neck pain, and vague neurologic symptoms, it is
important to consider VAD as a cause of symptoms.
How might this improve emergency medicine
practice?
Given the rising popularity of handheld massage
guns, emergencv physicians should be aware of
the evaluation and management of VAD.
photophobia, phonophobia, or vomiting but endorsed mild
associated nausea.
Physical examination revealed a young female resting
comfortably. Vital signs were all within normal limits. On
examination, she demonstrated full range of motion of the
neck without pain. She had no audible carotid bruit, no notable
swelling, ecchymosis, or midline cervical spinal tenderness to
palpation. On a detailed neurologic examination, the patient
had a Glasgow Coma Scale of 15 and was alert and oriented to
person, place, and time. She had a normal cranial nerve exam,
full strength in the upper and lower extremities, normal reexes,
and no ataxia. She had a negative Romberg test and normal,
rapid alternating movement testing and nger-to-nose testing.
Initial diagnostic evaluation demonstrated a normal
complete blood count. Comprehensive metabolic panel
demonstrated no abnormalities, and all electrolytes were
within normal limits. Beta human chorionic gonadotropin
was undetectable. She was administered 25 milligrams (mg)
meclizine orally, 1000 mg acetaminophen intravenously, 10
mg prochlorperazine intravenously, and a one-liter bolus of
lactated Ringer’s solution for her symptoms.
Because the patient had prolonged symptoms and endorsed
a history of massage gun use, both a computed tomography
(CT) without contrast of the head and a CT angiogram (CTA)
with intravenous contrast of the head and neck were obtained.
The CT of the head without contrast demonstrated no notable
abnormalities. The CTA of the head and neck revealed a long
segment of irregular stenosis of the right vertebral artery
extending from the second to the fth cervical vertebra, most
compatible with a vertebral artery dissection (VAD).
The patient was administered 324 mg aspirin orally and
was transferred and admitted overnight to a tertiary accepting
center with vascular surgery capability. Vascular surgery was
consulted and recommended non-operative management
and suggested consultation with interventional radiology.
Interventional radiology was consulted and recommended
continuing aspirin, and admission for observation with
neurological checks every four hours. The patient was
neurologically stable during the admission and was discharged
with prescriptions for 324 mg aspirin orally daily as well as 25
mg meclizine orally as needed. She was given follow-up with
neuro-interventional radiology in two weeks as an outpatient.
The patient did not re-present to our hospital for follow-up.

Dissection of the vertebral arteries related to handheld
massage devices is not well documented, and we found no
case reports in the literature of handheld massage devices
potentially leading to VAD. When considering the anatomy of
the extracranial vertebral artery, it is susceptible to dissection
in three segments: its origin at the subclavian artery; as it
traverses the intervertebral foramen; or at the site of entry into
the cranium.2 Neurologic sequelae of VAD vary widely based
on the location of the dissection and the amount of ischemic
damage to the posterior circulation territory (cerebellum,
brainstem, and posterior cerebrum). Early identication of
VAD is crucial to improving outcomes; thus, it is imperative
to maintain a high index of suspicion.
Headache, neck pain, and dizziness are very common
chief complaints that are evaluated in the ED and outpatient
clinics. The clinician must make a distinction between patients
who have benign conditions and patients with life-threatening
conditions. Much of this determination rests upon clinical
suspicion based on a patient’s history as well as the use of
imaging modalities.
Handheld massage guns have risen in popularity and
become more accessible to the everyday user. There are many
new handheld massage guns on the market, ranging in price
from $50 to over $1000 for higher end models.4 Most of
these devices rely on percussive motion (low amplitude, high
frequency) to relieve tension in muscles. On many models,
pulses per minute can be adjusted. While most user instruction
manuals caution against holding the device in one place or
using the device on the neck, they do advertise its use on the
posterior neck, trapezius, and shoulder muscles.
Unfortunately, despite the increase of popularity, proper
use is not clearly demonstrated. In website image searches
for these devices, many ads show models using the device
around the upper and lateral neck as well as on more anterior
Volume 6, no. 2: May 2022 161 Clinical Practice and Cases in Emergency Medicine
Sulkowski et al. Vertebral Artery Dissection After Use of Handheld Massage Gun
muscle tissues. Users with either no background in medicine
or knowledge of the underlying anatomy may not realize the
signicance of the vasculature beneath these tissues and how
they may be damaged with the use of handheld massage guns.
While the patient in our case did not suer any long-lasting
decits, this may not always be the case. If handheld massage
guns pose a risk when used in improper locations, consumers
must be made aware of these potential consequences.
Management options for VAD are varied and based on
numerous factors such as presentation, time of onset, and
imaging results. Options include antiplatelet or anticoagulation
medications, endovascular management, or vascular surgery.3 In
patients with severe decits, reperfusion therapy is an option to
more immediately restore blood ow to areas of the brain that
can be salvaged. These options include alteplase, tenecteplase, or
mechanical thrombectomy. These therapies are not without risk
as they have the potential to increase the size of the intramural
hematoma. These therapeutic modalities have been studied much
more thoroughly in cases of cervical artery dissections with
minimal literature to support their use in cases of VAD.5,6,7
Anticoagulation or antiplatelet therapy is more widely
used for VAD. 8,9 Medically stable patients, like our patient,
can be started on low molecular weight heparin, direct oral
anticoagulants or antiplatelet therapy based on the ABCD2
score, similar to the risk stratication performed on other
transient ischemic attack/stroke patients. Those deemed
low risk by the ABCD2 score are started on 324 mg of
aspirin daily, whereas high-risk patients are placed on dual
antiplatelet therapy with both aspirin and clopidogrel.10 Most
cases of nontraumatic VAD are shown to heal within the rst
few months of the inciting event. In one study of patients with
VAD, 62% of cases showed complete healing of the dissection
at six months.11

We report the case of a 27-year-old female who presented
with two weeks of worsening dizziness and four days
of neck pain who had recently used a handheld massage
device and was subsequently found to have vertebral artery
dissection. Although rare, VAD is a known cause of stroke,
particularly in young patients. In this patient population with
presenting symptoms of dizziness, headache, and/or neck
pain it is important to consider VAD as early diagnosis is
imperative in improving outcomes. It is also crucial to take a
complete social history to determine whether there were any
provoking factors, such as the use of a handheld massage
device. Treatment with antiplatelet or anticoagulation may be
appropriate in the correct patient population.
With the rise in popularity of handheld massage guns, more
research must be performed in evaluating their safety. Although
causality is dicult to establish, we may nd an increase in
incidence of VAD as popularity of these devices continues to rise.
In some circumstances we may ultimately discover that the use of
handheld massage guns may be implicated as a cause of VAD.
The Institutional Review Board approval has been documented
and led for publication of this case report.
Address for Correspondence: Kathryn Sulkowski, MD, University
of Nevada, Las Vegas, Emergency Medicine Residency Program,
901 Rancho Lane, STE 135, Las Vegas, NV 89106. Email:
kathryn.sulkowski@unlv.edu.
Conicts of Interest: By the CPC-EM article submission
agreement, all authors are required to disclose all a󰀩liations,
funding sources and nancial or management relationships that
could be perceived as potential sources of bias. The authors
disclosed none.
Copyright: © 2022 Sulkowski. This is an open access article
distributed in accordance with the terms of the Creative Commons
Attribution (CC BY 4.0) License. See: http://creativecommons.org/
licenses/by/4.0/
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Neurol. 2019;76(6):657-64.
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... The probability of stroke caused by a neck massager is 1/300-1/400000, which is mostly related to arterial dissection due to the tearing of the vascular inner layer (mainly involving the vertebral artery, followed by the carotid artery) [1][2][3]. Cerebral infarction caused by arterial embolism after a massager is rare [4,5]. ...
... Cerebral infarction caused by neck massage is often secondary to vascular dissection [1][2][3]. Only one case of a free thrombus in the carotid artery has been reported, and the specific etiology is unclear [4]. Another case documented vertebral artery dissection after repetitive use of a handheld massage gun [5]. ...
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Background: There are few reported cases of intracranial large artery embolism due to carotid thrombosis caused by a neck massager. Herein we report such a case. Case summary: A 49-year-old woman presented with left limb weakness and dysarthria after a history of neck massage for 1 mo. Neurological examination showed left central facial paralysis and left hemiparesis with a National Institutes of Health Stroke Scale score of 12. Brain magnetic resonance imaging revealed restricted diffusion on diffusion-weighted imaging in the right parietal and temporal lobes. Computed tomography angiography (CTA) indicated M3 segment embolism of the right middle cerebral artery. Neck CTA revealed thrombosis of the bilateral common carotid arteries. Carotid ultrasound showed thrombosis in the bilateral common carotid arteries (approximately 2 cm below the proximal end of the carotid sinus), and contrast-enhanced ultrasound did not suggest enhancement. No hypertension, diabetes, heart disease, vasculitis, or thrombophilia was found after admission. After 1 wk of treatment with aspirin 200 mg and atorvastatin 40 mg, a carotid ultrasound reexamination showed that the thrombosis had significantly reduced. Conclusion: Neck massager may cause carotid artery thrombosis.
... Fluoroquinolone antibiotics are also advised against, due to the recent warning issued by the Food and Drug Administration (FDA) that these antibiotics carry an increased risk of spontaneous arterial dissection in patients with arteriopathy [45•]. Finally, we consider any spontaneous arterial dissection to be a manifestation of systemic arteriopathy; therefore, patients are advised to avoid chiropractic neck manipulation or neck massage due to risk of cervical artery dissection [46][47][48]. ...
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... While massage guns are generally considered safe, there are some contraindications or situations where their use may not be recommended [49,59,[76][77][78][79][80]: (1) recent scars, open wounds, sunburns, rashes, bruises, bleeding or skin infections, as this can further damage the affected tissue(s) and increase the risk of infection; (2) recent fractures or bone chronic conditions (such as osteoporosis or rheumatoid arthritis), as the percussive force can interfere with the healing process or increase the risk of fracture; (3) deep-vein thrombosis or blood clotting disorders, as the pressure might dislodge blood clots and cause serious health complications; (4) diabetes and neuralgias, as it can result in numbness or loss of sensation, limiting the detection of further injury; (5) avoid using on sensitive areas of the body, such as the face, eyes, ears, head, neck, chest, spine, superficial nerves and vessels, or surgery/joint replacement (plates, metal pins, corneal or cochlear), as this can lead to serious injury and pain; (6) do not use repeatedly and aggressively, on the same area, for long periods of time (e.g., >30 min), as it can lead to muscle fiber damage, blood vessel dissections and internal bleeding (such as intra-muscular, hemartrosis, hemothorax or rhabdomyolysis); (7) for some medical conditions, its use can also be limited, such as pregnant women, fibromyalgia, migraines, hernias, hypertension, epilepsy, cancer/tumor, seizures or individuals with an implanted medications or medical devices (such as a pacemaker). ...
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The use of massage guns has become increasingly popular in recent years. Although their use is more and more common, both in a clinical and sports context, there is still little information to guide the practitioners. This systematic review aimed to determine the effects of massage guns in healthy and unhealthy populations as pre- and post-activity or part of a treatment. Data sources used were PubMed, PEDro, Scopus, SPORTDiscus, Web of Science, and Google Scholar, and the study eligibility criteria were based on "healthy and unhealthy individuals", "massage guns", "pre-activity, post-activity or part of a treatment" and "randomized and non-randomized studies" (P.I.C.O.S.). Initially, 281 records were screened, but only 11 could be included. Ten had a moderate risk of bias and one a high risk of bias. Massage guns could be effective in improving iliopsoas, hamstrings, triceps suralis, and the posterior chain muscles' flexibility. In strength, balance, acceleration, agility, and explosive activities, it either did not have improvements or it even showed a decrease in performance. In the recovery-related outcomes, massage guns were shown to be cost-effective instruments for stiffness reduction, range of motion and strength improvements after a fatigue protocol. No differences were found in contraction time, rating of perceived exertion or lactate concentration. Massage guns can help to improve short-term range of motion, flexibility, and recovery-related outcomes, but their use in strength, balance, acceleration, agility and explosive activities is not recommended.
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Vertebral artery dissection (VAD) is a common cause of stroke in middle-aged individuals. Patients with VAD usually describe a trivial minor neck trauma preceding the event. Such traumas may be associated with spinal manipulation or sudden movements of the neck. Our case is a 43-year-old lady who presented with a history of sudden-onset dizziness, dysarthria, nausea/vomiting, tinnitus, and imbalance. Two days prior to her presentation, she experienced a new-onset moderate to severe intensity headache along with neck pain. The patient mentioned a first-time use of a home massage device three weeks prior to headache onset. After investigations, the patient was diagnosed with VAD, and treatment was initiated. She was discharged in stable condition. With the recent increased popularity of home massage devices, we report this case to raise awareness about the safe use of massage devices in order to prevent the occurrence of such injuries and complications.
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Background Extracranial carotid and vertebral artery dissection is an important cause of stroke, especially in young people. In some observational studies it has been associated with a high risk of recurrent stroke. Both antiplatelet drugs and anticoagulant drugs are used to reduce risk of stroke but whether one treatment strategy is more effective than the other is unknown. We compared their efficacy in the Cervical Artery Dissection in Stroke Study (CADISS), with the additional aim of establishing the true risk of recurrent stroke. Methods We did this randomised trial at hospitals with specialised stroke or neurology services (39 in the UK and seven in Australia). We included patients with extracranial carotid and vertebral dissection with onset of symptoms within the past 7 days. Patients were randomly assigned (1:1) by an automated telephone randomisation service to receive antiplatelet drugs or anticoagulant drugs (specific treatment decided by the local clinician) for 3 months. Patients and clinicians were not masked to allocation, but investigators assessing endpoints were. The primary endpoint was ipsilateral stroke or death in the intention-to-treat population. The trial was registered with EUDract (2006-002827-18) and ISRN (CTN44555237). Findings We enrolled 250 participants (118 carotid, 132 vertebral). Mean time to randomisation was 3.65 days (SD 1.91). The major presenting symptoms were stroke or transient ischaemic attack (n=224) and local symptoms (headache, neck pain, or Homer's syndrome; n=26). 126 participants were assigned to antiplatelet treatment versus 124 to anticoagulant treatment. Overall, four (2%) of 250 patients had stroke recurrence (all ipsilateral). Stroke or death occurred in three (2%) of 126 patients versus one (1%) of 124 (odds ratio [OR] 0.335, 95% CI 0.006-4.233; p=0.63). There were no deaths, but one major bleeding (subarachnoid haemorrhage) in the anticoagulant group. Central review of imaging failed to confirm dissection in 52 patients. Preplanned per-protocol analysis exduding these patients showed stroke or death in three (3%) of 101 patients in the antiplatelet group versus one (1%) of 96 patients in the anticoagulant group (OR 0.346,95% CI 0-006-4.390; p=0-66). Interpretation We found no difference in efficacy of antiplatelet and anticoagulant drugs at preventing stroke and death in patients with symptomatic carotid and vertebral artery dissection but stroke was rare in both groups, and much rarer than reported in some observational studies. Diagnosis of dissection was not confirmed after review in many cases, suggesting that radiographic criteria are not always correctly applied in routine clinical practice. Funding Stroke Association. Copyright (C)Markus et al. Open Access article distributed under the terms of CC BY.
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Background Extracranial carotid and vertebral artery dissection is an important cause of stroke, especially in young people. In some observational studies it has been associated with a high risk of recurrent stroke. Both antiplatelet drugs and anticoagulant drugs are used to reduce risk of stroke but whether one treatment strategy is more effective than the other is unknown. We compared their efficacy in the Cervical Artery Dissection in Stroke Study (CADISS), with the additional aim of establishing the true risk of recurrent stroke. Methods We did this randomised trial at hospitals with specialised stroke or neurology services (39 in the UK and seven in Australia). We included patients with extracranial carotid and vertebral dissection with onset of symptoms within the past 7 days. Patients were randomly assigned (1:1) by an automated telephone randomisation service to receive antiplatelet drugs or anticoagulant drugs (specific treatment decided by the local clinician) for 3 months. Patients and clinicians were not masked to allocation, but investigators assessing endpoints were. The primary endpoint was ipsilateral stroke or death in the intention-to-treat population. The trial was registered with EUDract (2006-002827-18) and ISRN (CTN44555237). Findings We enrolled 250 participants (118 carotid, 132 vertebral). Mean time to randomisation was 3·65 days (SD 1·91). The major presenting symptoms were stroke or transient ischaemic attack (n=224) and local symptoms (headache, neck pain, or Horner's syndrome; n=26). 126 participants were assigned to antiplatelet treatment versus 124 to anticoagulant treatment. Overall, four (2%) of 250 patients had stroke recurrence (all ipsilateral). Stroke or death occurred in three (2%) of 126 patients versus one (1%) of 124 (odds ratio [OR] 0·335, 95% CI 0·006–4·233; p=0·63). There were no deaths, but one major bleeding (subarachnoid haemorrhage) in the anticoagulant group. Central review of imaging failed to confirm dissection in 52 patients. Preplanned per-protocol analysis excluding these patients showed stroke or death in three (3%) of 101 patients in the antiplatelet group versus one (1%) of 96 patients in the anticoagulant group (OR 0·346, 95% CI 0·006–4·390; p=0·66). Interpretation We found no difference in efficacy of antiplatelet and anticoagulant drugs at preventing stroke and death in patients with symptomatic carotid and vertebral artery dissection but stroke was rare in both groups, and much rarer than reported in some observational studies. Diagnosis of dissection was not confirmed after review in many cases, suggesting that radiographic criteria are not always correctly applied in routine clinical practice. Funding Stroke Association.
Article
Efficacy and safety of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) due to intracranial artery dissection (IAD) are currently not established. We aimed to present a single-center experience on IAD-related AIS treated by IVT. We selected all consecutive patients with IAD-related AIS treated by IVT from a prospectively constructed single-center acute stroke registry from 2003 to 2017. We reviewed demographical, clinical and neuroimaging data and recorded hemorrhagic complications, mortality within 7 days and modified Rankin Scale at 3-months. Out of 181 AISs related to cervicocephalic dissections, 10 (5.5%) were due to IAD and five of these patients received IVT. Among these five patients, median age was 62 years; hypertension and dyslipidemia were the most frequent vascular risk factors. IAD locations were distal internal carotid artery, middle cerebral artery (M1), anterior cerebral artery (A2), and, in two cases, the basilar artery. All anterior circulation IADs were occlusive or subocclusive, while the two basilar artery IADs caused arterial stenosis. After IVT, there were no subarachnoid or symptomatic intracranial hemorrhages. One patient had an asymptomatic hemorrhagic infarct type 1. Two patients died within 7 days from ischemic mass effect. The other three patients had favorable clinical outcomes at 3-months. In this small single-center case series of IAD-related AIS, thrombolysis seemed relatively safe. However, IVT efficacy and the likelihood of arterial recanalization are still uncertain in this context. Further studies are needed to assess the safety and efficacy of IVT in these patients.
Article
Importance Extracranial carotid and vertebral artery dissection is an important cause of stroke, particularly in younger individuals. In some but not all observational studies, it has been associated with a high risk of recurrent stroke. Both antiplatelet agents (APs) and anticoagulants (ACs) are used to reduce stroke risk, but whether 1 treatment strategy is more effective is unknown. Objective To determine whether AP or AC therapy is more effective in preventing stroke in cervical dissection and the risk of recurrent stroke in a randomized clinical trial setting. A secondary outcome was to determine the effect on arterial imaging outcomes. Design, Setting and Participants Randomized, prospective, open-label international multicenter parallel design study with central blinded review of both clinical and imaging end points. Recruitment was conducted in 39 stroke and neurology secondary care centers in the United Kingdom and 7 centers in Australia between February 24, 2006, and June 17, 2013. One-year follow-up and analysis was conducted in 2018. Two hundred fifty participants with extracranial carotid and vertebral dissection with symptom onset within the last 7 days were recruited. Follow-up data at 1 year were available for all participants. Interventions Randomization to AP or AC (heparin followed by warfarin) for 3 months, after which the choice of AP and AC agents was decided by the local clinician. Main Outcomes and Measures The primary end point was ipsilateral stroke and death. A planned per protocol (PP) analysis was performed in patients meeting the inclusion criteria following central review of imaging to confirm the diagnosis of dissection. A secondary end point was angiographic recanalization in those with imaging confirmed dissection. Results Two hundred fifty patients were randomized (118 carotid and 132 vertebral), 126 to AP and 124 to AC. Mean (SD) age was 49 (12) years. Mean (SD) time to randomization was 3.65 (1.91) days. The recurrent stroke rate at 1 year was 6 of 250 (2.4%) on ITT analysis and 5 of 197 (2.5%) on PP analysis. There were no significant differences between treatment groups for any outcome. Of the 181 patients with confirmed dissection and complete imaging at baseline and 3 months, there was no difference in the presence of residual narrowing or occlusion between those receiving AP (n = 56 of 92) vs those receiving AC (n = 53 of 89) (P = .97). Conclusions and Relevance During 12 months of follow-up, the number of recurrent strokes was low. There was no difference between treatment groups in outcome events or the rate of recanalization. Trial Registration ISRCTN.com Identifier: CTN44555237
Article
Background: Vertebral artery dissection (VAD) is an important cause of stroke in young and a known complication of spinal manipulation procedures, although dissection following neck massage has rarely been reported in literature. Head and neck massage by improperly trained salon employees is very popular and widely practiced in developing countries like India. In the present report we present a case of VAD following neck massage. Material and methods: We present an unusual case of VAD in a 30-year-old male patient following an episode of neck massage. He developed headache, nausea, vomiting, blurred vision, diplopia, dizziness, and ataxia following the procedure. Initial history and examination suggested that the patient's symptoms were vascular in origin. We also discuss a brief review of the pathology, diagnosis, symptomatology, treatment, prognosis, and occurrence of this rare entity. Results: Computed tomography and magnetic resonance imaging of the brain revealed acute infarction of the left cerebellar hemisphere. Digital subtraction angiography showed narrowing and dilatation of the V3 segment of the left vertebral artery with narrowing of the V4 segment consistent with dissection, along with a cavernous segment aneurysm of the contralateral internal carotid artery. Conclusion: This report illustrates the potential hazards associated with neck massage. The vertebral arteries are at risk for dissection, which can lead to acute stroke. This case also suggests that careful history taking and awareness of the symptoms of VAD are necessary to diagnose this entity as timely diagnosis and treatment can prevent permanent disability or even death.
Article
We report a case of a right vertebral artery dissection in a 35-year-old woman, 3 weeks post partum, with manifestations of vertebrobasilar disease. She was 3 weeks out from the uneventful delivery of her fourth child, with presentation of acute neurological symptoms, predominantly intractable vertigo. Vertigo can have many non-specific generalised symptoms and clinical findings. Postpartum women have a lengthy list of possible aetiologies of vertigo not limited to our initially suspected preeclampsia, dural venous thrombosis and vertebral dissection.
Article
The safety and efficacy of thrombolysis in cervical artery dissection (CAD) are controversial. The aim of this meta-analysis was to pool all individual patient data and provide a valid estimate of safety and outcome of thrombolysis in CAD. We performed a systematic literature search on intravenous and intra-arterial thrombolysis in CAD. We calculated the rates of pooled symptomatic intracranial hemorrhage and mortality and indirectly compared them with matched controls from the Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register. We applied multivariate regression models to identify predictors of excellent (modified Rankin Scale=0 to 1) and favorable (modified Rankin Scale=0 to 2) outcome. We obtained individual patient data of 180 patients from 14 retrospective series and 22 case reports. Patients were predominantly female (68%), with a mean±SD age of 46±11 years. Most patients presented with severe stroke (median National Institutes of Health Stroke Scale score=16). Treatment was intravenous thrombolysis in 67% and intra-arterial thrombolysis in 33%. Median follow-up was 3 months. The pooled symptomatic intracranial hemorrhage rate was 3.1% (95% CI, 1.3 to 7.2). Overall mortality was 8.1% (95% CI, 4.9 to 13.2), and 41.0% (95% CI, 31.4 to 51.4) had an excellent outcome. Stroke severity was a strong predictor of outcome. Overlapping confidence intervals of end points indicated no relevant differences with matched controls from the Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register. Safety and outcome of thrombolysis in patients with CAD-related stroke appear similar to those for stroke from all causes. Based on our findings, thrombolysis should not be withheld in patients with CAD.