This article contributes to the knowledge of the impact that the cultural–heritage relationship has on tourism and sustainable development. Cultural tourism is increasingly relevant in terms of European and national policies, and the growing academic interest is notorious, reflected in the progressive increase in the number of studies in this area. We conduct a systematic literature review using an integrative synthesis of published peer-reviewed literature on patrimonial tourism, cultural tourism and touristic destination. Our search in web of science databases identified 329 publications on this topic of several research areas. Our review of these articles addresses the following three questions: (1) What kind of studies have been developed about culture–heritage relation? (2) What is the possible relationship between them and tourism and sustainable development? (3) What is the impact of studies identified in the literature? To answer these questions, we use a systematic literature review with bibliometric methods of co-word analysis. We conclude that relationship between culture and patrimony seems to be on the research agenda, particularly, studies about the impact of this relation on tourism and sustainable development.